Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket

Journal of Biological Chemistry

Volumn 289, Issue 7, 2014, Pages 4432-4443

  Tso, Shih Chia ^a   Qi, Xiangbing ^a   Gui, Wen Jun ^a   Wu, Cheng Yang ^a   Chuang, Jacinta L ^a   Wernstedt Asterholm, Ingrid ^a   Morlock, Lorraine K ^a   Owens, Kyle R ^a   Scherer, Philipp E ^a   Williams, Noelle S ^a   Tambar, Uttam K ^a   Wynn, R Max ^a   Chuang, David T ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIABETES; DRUG DEVELOPMENT; ENZYME INHIBITORS; GLUCOSE METABOLISM; HEPATIC STEATOSIS; MITOCHONDRIAL PROTEIN KINASE; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE KINASE; STRUCTURE-BASED INHIBITOR DESIGN;

ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME INHIBITORS; FATTY LIVER; HSP90 HEAT-SHOCK PROTEINS; HUMANS; ISOENZYMES; ISOINDOLES; MALE; MICE; MICE, OBESE; OBESITY; PROTEIN-SERINE-THREONINE KINASES; SULFONES;

EID: 84894127873     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.533885     Document Type: Article

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