Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2

Journal of Biological Chemistry

Volumn 283, Issue 23, 2008, Pages 15789-15798

  Green, Todd ^a   Grigorian, Alexei ^b   Klyuyeva, Alla ^b   Tuganova, Alina ^b   Luo, Ming ^a   Popov, Kirill M ^b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; CRYSTAL STRUCTURE; ENZYMES; NUCLEIC ACIDS;

BINDING CAVITIES; DO-MAINS; MITOCHONDRIAL PROTEIN KINASES; MOLECULAR MECHANISMS; POTASSIUM IONS; PYRUVATE; PYRUVATE DEHYDROGENASE COMPLEXES; PYRUVATE DEHYDROGENASE KINASE 2; STRUCTURAL SUPPORTS; TRANSACETYLASE; WITH OR WITHOUT;

BINDING SITES;

ADENYLYLIMIDODIPHOSPHATE; DIHYDROLIPOAMIDE ACETYLTRANSFERASE; POTASSIUM ION; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 2; UNCLASSIFIED DRUG; MITOCHONDRIAL PROTEIN; POTASSIUM; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE COMPLEX;

ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; ENZYME STRUCTURE; PRIORITY JOURNAL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MITOCHONDRIAL PROTEINS; PHOSPHORYLATION; POTASSIUM; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47049091759     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800311200     Document Type: Article

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