Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2

Biochemistry

Volumn 46, Issue 29, 2007, Pages 8592-8602

  Tuganova, Alina ^a   Klyuyeva, Alla ^a   Popov, Kirill M ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROLIPOYL TRANSACETYLASE; MITOCHONDRIAL PROTEIN KINASE; PYRUVATE DEHYDROGENASE KINASE 2 (PDHK2);

ASSOCIATION REACTIONS; COMPLEXATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTIONS; MOLECULAR MODELING; MUTAGENESIS;

ENZYMES;

ACYLTRANSFERASE; ANTIDIABETIC AGENT; AZD 7545; DIHYDROLIPOYL TRANSACETYLASE; LIPID; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE KINASE 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

ANILIDES; ANIMALS; BINDING SITES; CIRCULAR DICHROISM; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; HUMANS; HYPOGLYCEMIC AGENTS; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RATS; THIOCTIC ACID;

EID: 34547124821     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700650k     Document Type: Article

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