Autophagy and pancreatic β-cells

Vitamins and Hormones

Volumn 95, Issue , 2014, Pages 145-164

  Mazza, Simona ^a   Maffucci, Tania ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Atg; Autophagy; Diabetes; LC3; Pancreatic cells

Indexed keywords

INSULIN;

ANIMAL; AUTOPHAGY; BIOLOGICAL MODEL; CYTOLOGY; HUMAN; INSULIN RESISTANCE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS; PANCREAS ISLET BETA CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MODELS, BIOLOGICAL; PANCREAS; SIGNAL TRANSDUCTION;

EID: 84894053505     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800174-5.00006-5     Document Type: Chapter

References (70)

1. Alers S., Löffler A.S., Wesselborg S., Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks. Molecular and Cellular Biology 2012, 32:2-11.
2. Bachar-Wikstrom E., Wikstrom J.D., Ariav Y., Tirosh B., Kaiser N., Cerasi E., et al. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes 2013, 62:1227-1237.
3. Bachar-Wikstrom E., Wikstrom J.D., Kaiser N., Cerasi E., Leibowitz G. Improvement of ER stress-induced diabetes by stimulating autophagy. Autophagy 2013, 9:626-628.
4. Back S.H., Kang S.W., Han J., Chung H.T. Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes. Experimental Diabetes Research 2012, 2012:618396.
5. Bagust A., Beale S. Deteriorating beta-cell function in type 2 diabetes: A long-term model. QJM 2003, 96:281-288.
6. Carling D. The AMP-activated protein kinase cascade-A unifying system for energy control. Trends in Biochemical Sciences 2004, 29:18-24.
7. Cebollero E., Reggiori F., Kraft C. Reticulophagy and ribophagy: Regulated degradation of protein production factories. International Journal of Cell Biology 2012, 2012:182834.
8. Chen Z.F., Li Y.B., Han J.Y., Wang J., Yin J.J., Li J.B., et al. The double-edged effect of autophagy in pancreatic beta cells and diabetes. Autophagy 2011, 7:12-16.
9. Choi S.E., Lee S.M., Lee Y.J., Li L.J., Lee S.J., Lee J.H., et al. Protective role of autophagy in palmitate-induced INS-1 beta-cell death. Endocrinology 2009, 150:126-134.
10. Choi A.M., Ryter S.W., Levine B. Autophagy in human health and disease. The New England Journal of Medicine 2013, 368:651-662.
11. Codogno P., Mehrpour M., Proikas-Cezanne T. Canonical and non-canonical autophagy: Variations on a common theme of self-eating?. Nature Reviews. Molecular Cell Biology 2011, 13:7-12.
12. Dall'Armi C., Devereaux K.A., Di Paolo G. The role of lipids in the control of autophagy. Current Biology 2013, 23:R33-R45.
13. Del Prato S., Bianchi C., Marchetti P. beta-cell function and anti-diabetic pharmacotherapy. Diabetes/Metabolism Research and Reviews 2007, 23:518-527.
14. Ebato C., Uchida T., Arakawa M., Komatsu M., Ueno T., Komiya K., et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metabolism 2008, 8:325-332.
15. Efeyan A., Zoncu R., Chang S., Gumper I., Snitkin H., Wolfson R.L., et al. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 2013, 493:679-683.
16. Eskelinen E.L., Illert A.L., Tanaka Y., Schwarzmann G., Blanz J., Von Figura K., et al. Role of LAMP-2 in lysosome biogenesis and autophagy. Molecular Biology of the Cell 2002, 13:3355-3368.
17. Fujimoto K., Hanson P.T., Tran H., Ford E.L., Han Z., Johnson J.D., et al. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. The Journal of Biological Chemistry 2008, 284:27664-27673.
18. Fujitani Y., Ebato C., Uchida T., Kawamori R., Watada H. β-cell autophagy: A novel mechanism regulating β-cell function and mass: Lessons from β-cell-specific Atg7-deficient mice. Islets 2009, 1:151-153.
19. Fujitani Y., Kawamori R., Watada H. The role of autophagy in pancreatic beta-cell and diabetes. Autophagy 2009, 5:280-282.
20. Fujitani Y., Ueno T., Watada H. Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes. American Journal of Physiology Cell Physiology 2010, 299:C1-C6.
21. Gonzalez C.D., Lee M.S., Marchetti P., Pietropaolo M., Towns R., Vaccaro M.I., et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy 2011, 7:2-11.
22. Gottlieb R.A., Carreira R.S. Autophagy in health and disease. 5. Mitophagy as a way of life. American Journal of Physiology Cell Physiology 2010, 299:C203-C210.
23. Gozuacik D., Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004, 23:2891-2906.
24. Han D., Yang B., Olson L.K., Greenstein A., Baek S.H., Claycombe K.J., et al. Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose. Biochemical Journal 2010, 425:541-551.
25. He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annual Review of Genetics 2009, 43:67-93.
26. Hur K.Y., Jung H.S., Lee M.S. Role of autophagy in β-cell function and mass. Diabetes, Obesity and Metabolism 2010, 12(Suppl. 2):20-26.
27. Jung H.S., Chung K.W., Won Kim J., Kim J., Komatsu M., Tanaka K., et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metabolism 2008, 8:318-324.
28. Jung H.S., Lee M.S. Macroautophagy in homeostasis of pancreatic beta-cell. Autophagy 2009, 5:241-243.
29. Kang R., Zeh H.J., Lotze M.T., Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death & Differentiation 2011, 18:571-580.
30. Kaniuk N.A., Kiraly M., Bates H., Vranic M., Volchuk A., Brumell J.H. Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 2007, 56:930-939.
31. Kaushik S., Cuervo A.M. Chaperone-mediated autophagy: A unique way to enter the lysosome world. Trends in Cell Biology 2012, 22:407-417.
32. Kirkin V., Lamark T., Johansen T., Dikic I. NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009, 5:732-733.
33. Klionsky D.J. Autophagy: From phenomenology to molecular understanding in less than a decade. Nature Reviews. Molecular Cell Biology 2007, 8:931-937.
34. Komatsu M., Waguri S., Ueno T., Iwata J., Murata S., Tanida I., et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. The Journal of Cell Biology 2005, 169:425-434.
35. Komiya K., Uchida T., Ueno T., Koike M., Abe H., Hirose T., et al. Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochemical and Biophysical Research Communications 2010, 401:561-567.
36. Kraft C., Deplazes A., Sohrmann M., Peter M. Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nature Cell Biology 2008, 10:602-610.
37. Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., et al. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036.
38. Kwiatkowski D.J., Manning B.D. Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways. Human Molecular Genetics 2005, 14:R251-R258.
39. Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
40. Las G., Serada S.B., Wikstrom J.D., Twig G., Shirihai O.S. Fatty acids suppress autophagic turnover in β-cells. The Journal of Biological Chemistry 2011, 286:42534-42544.
41. Las G., Shirihai O.S. The role of autophagy in β-cell lipotoxicity and type 2 diabetes. Diabetes, Obesity and Metabolism 2010, 12(Suppl. 2):15-19.
42. Li W.W., Li J., Bao J.K. Microautophagy: Lesser-known self-eating. Cellular and Molecular Life Sciences 2012, 69:1125-1136.
43. Li W., Yang Q., Mao Z. Chaperone-mediated autophagy: Machinery, regulation and biological consequences. Cellular and Molecular Life Sciences 2011, 68:749-763.
44. Liu Y., Shi S., Gu Z., Du Y., Liu M., Yan S., et al. Impaired autophagic function in rat islets with aging. Age (Dordrecht, Netherlands) 2013, 35:1531-1544.
45. Marchetti P., Masini M. Autophagy and the pancreatic beta-cell in human type 2 diabetes. Autophagy 2009, 5:1055-1056.
46. Marsh B.J., Soden C., Alarcón C., Wicksteed B.L., Yaekura K., Costin A.J., et al. Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Molecular Endocrinology 2007, 21:2255-2269.
47. Martino L., Masini M., Novelli M., Beffy P., Bugliani M., Marselli L., et al. Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS One 2012, 7:e36188.
48. Masini M., Bugliani M., Lupi R., del Guerra S., Boggi U., Filipponi F., et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 2009, 52:1083-1086.
49. Masini M., Lupi R., Bugliani M., Boggi U., Filipponi F., Masiello P., et al. A role for autophagy in β-cell life and death. Islets 2009, 1:157-159.
50. Mehrpour M., Esclatine A., Beau I., Codogno P. Autophagy in health and disease. 1. Regulation and significance of autophagy: An overview. American Journal of Physiology. Cell Physiology 2010, 298:C776-C785.
51. Mehrpour M., Esclatine A., Beau I., Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Research 2010, 20:748-762.
52. Meijer A.J., Codogno P. Regulation and role of autophagy in mammalian cells. The International Journal of Biochemistry & Cell Biology 2004, 36:2445-2462.
53. Nazio F., Strappazzon F., Antonioli M., Bielli P., Cianfanelli V., Bordi M., et al. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nature Cell Biology 2013, 15:406-416.
54. Pattingre S., Espert L., Biard-Piechaczyk M., Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 2008, 90:313-323.
55. Quan W., Hur K.Y., Lim Y., Oh S.H., Lee J.C., Kim K.H., et al. Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice. Diabetologia 2012, 55:392-403.
56. Quan W., Jung H.S., Lee M.S. Role of autophagy in the progression from obesity to diabetes and in the control of energy balance. Archives of Pharmacal Research 2013, 36:223-229.
57. Quan W., Lim Y.M., Lee M.S. Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells. Experimental and Molecular Medicine 2012, 44:81-88.
58. Rivera J.F., Gurlo T., Daval M., Huang C.J., Matveyenko A.V., Butler P.C., et al. Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: Protective role of p62-positive cytoplasmic inclusions. Cell Death & Differentiation 2011, 18:415-426.
59. Rubinsztein D.C., Codogno P., Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nature Reviews. Drug Discovery 2012, 11:709-730.
60. Sengupta S., Peterson T.R., Sabatini D.M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Molecular Cell 2010, 40:310-322.
61. Tanemura M., Ohmura Y., Deguchi T., Machida T., Tsukamoto R., Wada H., et al. Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo. American Journal of Transplantation 2012, 12:102-114.
62. Twig G., Elorza A., Molina A.J., Mohamed H., Wikstrom J.D., Walzer G., et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. The EMBO Journal 2008, 27:433-446.
63. Twig G., Hyde B., Shirihai O.S. Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view. Biochimica et Biophysica Acta 2008, 1777:1092-1097.
64. Wang M., Crager M., Pugazhenthi S. Modulation of apoptosis pathways by oxidative stress and autophagy in β cells. Experimental Diabetes Research 2012, 2012:647914.
65. Weyer C., Tataranni P.A., Bogardus C., Pratley R.E. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 2001, 24:89-94.
66. Wu J.J., Quijano C., Chen E., Liu H., Cao L., Fergusson M.M., et al. Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging 2009, 1:425-437.
67. Xie Z., Klionsky D.J. Autophagosome formation: Core machinery and adaptations. Nature Cell Biology 2007, 9:1102-1109.
68. Yang Z., Klionsky D.J. An overview of the molecular mechanism of autophagy. Current Topics in Microbiology and Immunology 2009, 335:1-32.
69. Yang Z., Klionsky D.J. Mammalian autophagy: Core molecular machinery and signaling regulation. Current Opinion in Cell Biology 2010, 22:124-131.
70. Zhang X., Yuan Q., Tang W., Gu J., Osei K., Wang J. Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells. PLoS One 2011, 6:e27647.