Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 2, 2014, Pages 993-1005

  Lee, Dongwook ^a,b   Shim, Myoung Sup ^a   Kim, Keun Young ^a   Noh, You Hyun ^a   Kim, Heemin ^a   Kim, Sang Yeop ^a   Weinreb, Robert N ^a   Ju, Won Kyu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

Coenzyme Q10; Excitotoxicity; Glaucoma; Mitochondrial alteration; Oxidative stress

Indexed keywords

CYTOCHROME C OXIDASE; GENOMIC DNA; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; HEME OXYGENASE 1; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN BAD; PROTEIN BAX; UBIDECARENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; GLAUCOMA; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE FIBER; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA DEGENERATION; RETINA GANGLION CELL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

COENZYME Q10; EXCITOTOXICITY; GLAUCOMA; MITOCHONDRIAL ALTERATION; OXIDATIVE STRESS;

ANIMALS; AXONS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FEMALE; GLAUCOMA; GLUTAMIC ACID; HEME OXYGENASE-1; IN SITU NICK-END LABELING; MEMBRANE PROTEINS; MICE; MICE, INBRED DBA; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, N-METHYL-D-ASPARTATE; RETINAL DEGENERATION; RETINAL GANGLION CELLS; SUPEROXIDE DISMUTASE; UBIQUINONE; VITAMINS;

EID: 84894025144     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-12564     Document Type: Article

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