Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 13, 2012, Pages 8295-8302

  Lulli, Matteo ^a   Witort, Ewa ^a   Papucci, Laura ^a   Torre, Eugenio ^a   Schipani, Christian ^a   Bergamini, Christian ^b   Monte, Massimo Dal ^c   Capaccioli, Sergio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; COQUN; KAINIC ACID; UBIDECARENONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOFLUORESCENCE TEST; MALE; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RETINA GANGLION CELL; RETINA INJURY;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIMYCIN A; APOPTOSIS; CASPASE 3; CASPASE 7; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORNEA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUTAMIC ACID; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OPHTHALMIC SOLUTIONS; RABBITS; RATS; RATS, WISTAR; RETINA; RETINAL DISEASES; RETINAL GANGLION CELLS; TIME FACTORS; UBIQUINONE; VITAMINS;

EID: 84873378188     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10374     Document Type: Article

References (46)

1. Chen PP. Risk and risk factors for blindness from glaucoma. Curr Opin Ophthalmol. 2004;15:107-111.
2. Henson DB, Thampy R. Preventing blindness from glaucoma. BMJ. 2005;331:120-121.
3. Nucci C, Schiavone N, Carella E, Capaccioli S, Carella G. Ganglionic cell apoptogenesis in glaucoma. Acta Ophthalmol Scand. 2000;7:24-27.
4. Harada T, Harada C, Nakamura K, et al. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. Clin Invest. 2007;117:1763-1770.
5. Lynch DR, Guttmann RP. Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther. 2002;300:717-723.
6. Nucci C, Tartaglione R, Rombolà L, Morrone LA, Fazzi E, Bagetta G. Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat. Neurotoxicology. 2005;26:935-941.
7. Sucher NJ, Limpton SA, Dreyer EB. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res. 1997; 37:3843-3849.
8. Mali RS, Cheng M, Chintala SK. Plasminogen activators promote excitotoxicity-induced retinal damage. FASEB J. 2005;19:1280-1289.
9. Johnson TV, Tomarev SI. Rodent models of glaucoma. Brain Res Bull. 2010;81:349-358.
10. Rasola A, Bernardi P. The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis. 2007;5:815-833.
11. Kinnally KW, Antonsson B. A tale of two mitochondrial channels, MAC and PTP, in apoptosis. Apoptosis. 2007;12:857-868.
12. Brancato R, Schiavone N, Siano S, et al. Prevention of corneal keratocyte apoptosis after argon fluoride excimer laser irradiation with the free radical scavenger ubiquinone Q10. Eur J Ophthalmol. 2000;10:32-38.
13. Brancato R, Fiore T, Papucci L, et al. Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits. J Refract Surg. 2002;18:135-139.
14. Papucci L, Schiavone N, Witort E, et al. Coenzyme Q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem. 2003;278:28220-28228.
15. Chen PP. Risk and risk factors for blindness from glaucoma. Curr Opin Ophthalmol. 2004;15:107-111.
16. Henson DB, Thampy R. Preventing blindness from glaucoma. BMJ. 2005;331:120-121.
17. Nucci C, Schiavone N, Carella E, Capaccioli S, Carella G. Ganglionic cell apoptogenesis in glaucoma. Acta Ophthalmol Scand. 2000;7:24-27.
18. Harada T, Harada C, Nakamura K, et al. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. Clin Invest. 2007;117:1763-1770.
19. Lynch DR, Guttmann RP. Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther. 2002;300:717-723.
20. Nucci C, Tartaglione R, Rombolà L, Morrone LA, Fazzi E, Bagetta G. Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat. Neurotoxicology. 2005;26:935-941.
21. Sucher NJ, Limpton SA, Dreyer EB. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res. 1997; 37:3843-3849.
22. Mali RS, Cheng M, Chintala SK. Plasminogen activators promote excitotoxicity-induced retinal damage. FASEB J. 2005;19:1280-1289.
23. Johnson TV, Tomarev SI. Rodent models of glaucoma. Brain Res Bull. 2010;81:349-358.
24. Rasola A, Bernardi P. The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis. 2007;5:815-833.
25. Kinnally KW, Antonsson B. A tale of two mitochondrial channels, MAC and PTP, in apoptosis. Apoptosis. 2007;12:857-868.
26. Brancato R, Schiavone N, Siano S, et al. Prevention of corneal keratocyte apoptosis after argon fluoride excimer laser irradiation with the free radical scavenger ubiquinone Q10. Eur J Ophthalmol. 2000;10:32-38.
27. Brancato R, Fiore T, Papucci L, et al. Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits. J Refract Surg. 2002;18:135-139.
28. Papucci L, Schiavone N, Witort E, et al. Coenzyme Q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem. 2003;278:28220-28228. IOVS, December 2012, Vol. 53, No. 13 CoQ10 Eye Drops Protect Retinal Cells from Apoptosis 8301
29. Walter L, Nogueira V, Leverve X, Heitz MP, Bernardi P, Fontaine E. Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site. J Biol Chem. 2000;275:29521-29527.
30. Devun F, Walter L, Belliere J, Cottet-Rousselle C, Leverve X, Fontaine E. Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death. PLoS One. 2010;5:e11792.
31. Fato R, Bergamini C, Leoni S, et al. Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy. Acta Ophthalmol. 2009;3: 1-2.
32. Feher J, Kovacs I, Artico M, Cavallotti C, Papale A, Balacco Gabrieli C. Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging. 2006;27:983-993.
33. Distelmaier F, Koopman WJ, Testa ER, et al. Life cell quantification of mitochondrial membrane potential at the single organelle level. Cytometry. 2008;73:129-138.
34. Takada A, Urano T, Yoshida M, Takada Y. Comparison of changes in serotonergic measures in whole blood or plasma and brain in rats given nicotine and/or stresses. Pol J Pharmacol. 1996;48:173-177.
35. Tempestini A, Schiavone N, Papucci L, et al. The mechanisms of apoptosis in biology and medicine: a new focus for ophthalmology. Eur J Ophthalmol. 2003;13:11-18.
36. Nadal-Nicolás FM, Jiménez-López M, Sobrado-Calvo P, et al. Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerveinjured retinas. Invest Ophthalmol Vis Sci. 2009;50:3860-3868.
37. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol. 2000;1:120-129.
38. Sureda FX, Junyent F, Verdaguer E, et al. Antiapoptotic drugs: a therapeutic strategy for the prevention of neurodegenerative diseases. Curr Pharm Des. 2011;17:230-245.
39. Nucci C, Tartaglione R, Cerulli A, et al. Retinal damage caused by high intraocular pressure-induced transient ischemia is prevented by coenzyme Q10 in rat. Int Rev Neurobiol. 2007; 82:397-406.
40. Feher J, Papale A, Mannino G, Gualdi L, Balacco Gabrieli C. Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study. Ophthalmologica. 2003;217:351-357.
41. Nakajima Y, Inokuchi Y, Nishi M, Shimazawa M, Otsubo K, Hara H. Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. Brain Res. 2008;1226:226-233.
42. Russo R, Cavaliere F, Rombolà L, et al. Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection. Prog Brain Res. 2008;173:575-582.
43. Kumada M, Niwa M, Hara A, et al. Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade. Invest Ophthalmol Vis Sci. 2005;46:1504-1507.
44. Bhagyalaxmi SG, Shravan KC. Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells. PloS One. 2011;6:1-12.
45. Chaudhary P, Ahmed F, Sharma SC. MK801: a neuroprotectant in rat hypertensive eyes. Brain Res. 1998;792:154-158.
46. Qu J, Kaufman Y, Washington I. Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci. 2009;50:1814-1818.