A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

Cell Death and Disease

Volumn 2, Issue 12, 2011, Pages

  Nguyen, D ^a   Alavi, M V ^b   Kim, K Y ^c   Kang, T ^a   Scott, R T ^c   Noh, Y H ^a   Lindsey, J D ^a   Wissinger, B ^d   Ellisman, M H ^c   Weinreb, R N ^a   Perkins, G A ^c   Ju, W K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Glutamate excitotoxicity; Mitochondrial fragmentation; NMDA receptors; OPA1 mutation; Oxidative stress; Retinal ganglion cells

Indexed keywords

GLUTAMIC ACID; MANGANESE SUPEROXIDE DISMUTASE; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; OPTIC ATROPHY TYPE 1 PROTEIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL XL; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPA1 PROTEIN (GTPASE), MOUSE; PROTEIN BCL X; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT OPTIC ATROPHY; CELL ACTIVATION; CONTROLLED STUDY; ELECTRON TOMOGRAPHY; EXCITOTOXICITY; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MACROGLIA; MICROGLIA; MITOCHONDRION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OPTIC NERVE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINA GANGLION CELL; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; CYTOLOGY; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PHOSPHORYLATION;

MUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; CELL LINE; GLUTAMIC ACID; GTP PHOSPHOHYDROLASES; MICE; MITOCHONDRIA; MUTATION; OPTIC ATROPHY, AUTOSOMAL DOMINANT; OXIDATIVE STRESS; PHOSPHORYLATION; RECEPTORS, N-METHYL-D-ASPARTATE; RETINAL GANGLION CELLS; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 84862974980     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.117     Document Type: Article

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