Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2-derived neurons and astrocytes: Protective effects of coenzyme Q10

Journal of Neuroscience Research

Volumn 72, Issue 6, 2003, Pages 691-703

  Sandhu, Jagdeep K ^a   Pandey, Siyaram ^a,b   Ribecco Lutkiewicz, Maria ^a   Monette, Robert ^a   Borowy Borowski, Henryk ^a   Walker, P Roy ^a   Sikorska, Marianna ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF WINDSOR   (Canada)

Author keywords

ATP; Coenzyme Q10; Glutamate transporters; NMDA receptors; Reactive oxygen species

Indexed keywords

GLUTAMATE TRANSPORTER; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REACTIVE OXYGEN METABOLITE; UBIDECARENONE;

ARTICLE; ASTROCYTE; CELL HYPOXIA; CELL INTERACTION; ENERGY; HUMAN; HUMAN CELL; MITOCHONDRIAL ENERGY TRANSFER; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL;

ASTROCYTES; CELL DEATH; CELLS, CULTURED; CYTOPROTECTION; GLUTAMIC ACID; HUMANS; NEURONS; TUMOR CELLS, CULTURED; UBIQUINONE;

EID: 0038320062     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10579     Document Type: Article

References (51)

1. Anderson CM, Swanson RA. 2000. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32:1-14.
2. Andrews PW. 1984. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 103:285-293.
3. Atlante A, Calissano P, Bobba A, Giannattasio S, Marra E, Passarella S. 2001. Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett 497:1-5.
4. Baker KA, Hong M, Sadi D, Mendez I. 2000. Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease. Exp Neurol 162:350-360.
5. Beal MF. 1999. Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. Biofactors 9:261-266.
6. Beal MF, Matthews RT. 1997. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Mol Aspects Med 18(Suppl):169-179.
7. Beal MF, Matthews RT, Tieleman A, Shults CW. 1998. Co enzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res 783:109-114.
8. Bliss TV, Collingridge GL. 1993. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
9. Borlongan CV, Tajima Y, Trojanowski JQ, Lee VM, Sanberg PR. 1998. Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp Neurol 149:310-321.
10. Borowy-Borowski H, Sikorska M, Walker PR. 2000. Water-soluble composition of bioactive lipophilic compounds. US Patent No. 6,045,826.
11. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
12. Chabrier PE, Demerle-Pallardy C, Auguet M. 1999. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell Mol Life Sci 55:1029-1035.
13. Duchen MR. 2000. Mitochondria and calcium: from cell signaling to cell death. J Physiol 529 1:57-68.
14. Ducrocq C, Blanchard B, Pignatelli B, Ohshima H. 1999. Peroxynitrite: an endogenous oxidizing and nitrating agent. Cell Mol Life Sci 55:1068-1077.
15. Facchinetti F, Dawson VL, Dawson TM. 1998. Free radicals as mediators of neuronal injury. Cell Mol Neurobiol 18:667-682.
16. Graves S, Sikorska M, Borowy-Borowski H, Ho RJ, Bui T, Woodhouse C. 1998. Analysis of coenzyme Q10 content in human plasma and other biological samples. Methods Mol Biol 108:353-365.
17. Hartley RS, Trojanowski JQ, Lee VM. 1999. Differential effects of spinal cord gray and white matter on process outgrowth from grafted human NTEKA2 neurons (NT2N, hNT). J Comp Neurol 415:404-418.
18. Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D, Sauermann G, Schreiner V, Stab F, Steckel F. 1999. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors 9:371-378.
19. Ihara Y, Namba R, Kuroda S, Sato T, Shirabe T. 1989. Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. J Neurol Sci 90:263-271.
20. Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Gebel J, Jannetta P, DeCesare S, Elder EM, McGrogan M, Reitman MA, Bynum L. 2000. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55:565-569.
21. Lipton SA, Rosenberg PA. 1994. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622.
22. Malenka RC, Nicoll RA. 1993. NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms. Trends Neurosci 16:521-527.
23. Mattson MP, Rychlik B, You JS, Sisken JE. 1991. Sensitivity of cultured human embryonic cerebral cortical neurons to excitatory amino acid-induced calcium influx and neurotoxicity. Brain Res 542:97-106.
24. Meldrum BS. 1998. The glutamate synapse as a therapeutical target: perspectives for the future. Prog Brain Res 116:441-458.
25. Michaelis EK. 1998. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 54:369-415.
26. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH. 1992. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256:1217-1221.
27. Muir JK, Raghupathi R, Saatman KE, Wilson CA, Lee VM, Trojanowski JQ, Philips MF, McIntosh TK. 1999. Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain. J Neurotrauma 16:403-414.
28. Munir M, Lu L, McGonigle P. 1995. Excitotoxic cell death and delayed rescue in human neurons derived from NT2 cells. J Neurosci 15:7847-7860.
29. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. 1989. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2:1547-1558.
30. North WG, Fay MJ, Du J, Cleary M, Gallagher JD, McCann FV. 1997. Presence of functional NMDA receptors in a human neuroblastoma cell line. Mol Chem Neuropathol 30:77-94.
31. Novelli A, Reilly JA, Lysko PG, Henneberry RC. 1988. Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res 451:205-212.
32. Patel M, Day BJ, Crapo JD, Fridovich I, McNamara JO. 1996. Requirement for superoxide in excitotoxic cell death. Neuron 16:345-355.
33. Pereira C, Santos MS, Oliveira C. 1998. Metabolic inhibition increases glutamate susceptibility on a PC12 cell line. J Neurosci Res 51:360-370.
34. Pleasure SJ, Lee VM. 1993. NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J Neurosci Res 35:585-602.
35. Reiter RJ. 1998. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 56:359-384.
36. Rootwelt T, Dunn M, Yudkoff M, Itoh T, Almaas R, Pleasure D. 1998. Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non NMDA glutamate receptors. J Neurochem 71:1544-1553.
37. Rosenberg PA, Aizenman E. 1989. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci Lett 103:162-168.
38. Said SI, Pakbaz H, Berisha HI, Raza S. 2000. NMDA receptor activation: critical role in oxidant tissue injury. Free Radic Biol Med 28:1300-1302.
39. Sandhu JK, Sikorska M, Walker PR. 2002. Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells. J Neurosci Res 68:604-614.
40. Schubert D, Piasecki D. 2001. Oxidative glutamate toxicity can be a component of the excitotoxicity cascade. J Neurosci 21:7455-7462.
41. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M. 2002. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 59:1541-1550.
42. Singh RB, Wander GS, Rastogi A, Shukla PK, Mittal A, Sharma JP, Mehrotra SK, Kapoor R, Chopra RK. 1998. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther 12:347-353.
43. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, lwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K. 1997. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276:1699-1702.
44. Tomasetti M, Littarru GP, Stocker R, Alleva R. 1999. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Radic Biol Med 27:1027-1032.
45. Trotti D, Danbolt NC, Volterra A. 1998. Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? Trends Pharmacol Sci 19:328-334.
46. Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt NC, Volterra A. 1996. Peroxynitrite inhibits glutamate transporter subtypes. J Biol Chem 271:5976-5979.
47. Urushitani M, Nakamizo T, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S. 2001. N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. J Neurosci Res 63:377-387.
48. Volterra A, Trotti D, Tromba C, Floridi S, Racagni G. 1994. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci 14:2924-2932.
49. Walker PR, Leblanc J, Carson C, Ribecco M, Sikorska M. 1999. Neither caspase-3 nor DNA fragmentation factor is required for high molecular weight DNA degradation in apoptosis. Ann N Y Acad Sci 887:48-59.
50. Younkin DP, Tang CM, Hardy M, Reddy UR, Shi QY, Pleasure SJ, Lee VM, Pleasure D. 1993. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc Natl Acad Sci USA 90:2174-2178.
51. Zhou M, Diwu Z, Panchuk-Voloshina N, Haugland RP. 1997. A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem 253:162-168.