Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions

PLoS Genetics

Volumn 6, Issue 10, 2010, Pages 1-13

  Hirota, Kouji ^a   Sonoda, Eiichiro ^a   Kawamoto, Takuo ^a   Motegi, Akira ^a   Masutani, Chikahide ^b   Hanaoka, Fumio ^b,f   Szüts, Dávid ^c   Iwai, Shigenori ^b   Sale, Julian E ^d   Lehmann, Alan ^e   Takeda, Shunichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e UNIVERSITY OF SUSSEX   (United Kingdom)

^f GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CAFFEINE; CISPLATIN; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE H; DNA DIRECTED DNA POLYMERASE ZETA; MESYLIC ACID; METHYLMETHANE SULFONATE; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE ZETA; MESYLIC ACID METHYL ESTER;

ANIMAL CELL; ARTICLE; CANCER SUSCEPTIBILITY; CELL STRAIN; CHICKEN; CONTROLLED STUDY; DNA DAMAGE; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE INTERACTION; GENE LOSS; GENETIC VARIABILITY; GENOMIC INSTABILITY; GENOTOXICITY; IONIZING RADIATION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PHENOTYPE; SENSITIVITY ANALYSIS; SISTER CHROMATID EXCHANGE; ULTRAVIOLET RADIATION; XERODERMA PIGMENTOSUM; ANIMAL; BIOLOGICAL MODEL; CELL PROLIFERATION; CELL STRAIN HEK293; DNA REPAIR; DOSE RESPONSE; DRUG EFFECT; GENE REPRESSION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; RADIATION EXPOSURE; RADIATION RESPONSE; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

AVES;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; CHICKENS; CISPLATIN; DNA DAMAGE; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEK293 CELLS; HUMANS; METHYL METHANESULFONATE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPRESSION, GENETIC; ULTRAVIOLET RAYS;

EID: 78449261906     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001151     Document Type: Article

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