Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis

Cell Death and Differentiation

Volumn 21, Issue 3, 2014, Pages 416-426

  De Poot, S A H ^a   Lai, K W ^a   Van Der Wal, L ^a   Plasman, K ^b,c   Van Damme, P ^b,c   Porter, A C ^d   Gevaert, K ^b,c   Bovenschen, N ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

apoptosis; cell cycle arrest; granzyme M; protease; topoisomerase II alpha

Indexed keywords

CASPASE; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; GRANZYME; TUMOR ANTIGEN;

ANIMAL; APOPTOSIS; CELL CYCLE CHECKPOINT; CELL DEATH; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; CYTOLOGY; ENZYMOLOGY; HELA CELL LINE; HUMAN; METABOLISM; NATURAL KILLER CELL; PHYSIOLOGY; TUMOR CELL CULTURE;

ANIMALS; ANTIGENS, NEOPLASM; APOPTOSIS; CASPASES; CELL CYCLE CHECKPOINTS; CELL DEATH; CERCOPITHECUS AETHIOPS; COS CELLS; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; GRANZYMES; HELA CELLS; HUMANS; KILLER CELLS, NATURAL; TUMOR CELLS, CULTURED;

EID: 84893838177     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.155     Document Type: Article

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