Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B

Journal of Biological Chemistry

Volumn 279, Issue 52, 2004, Pages 54275-54282

  Mahrus, Sami ^a   Kisiel, Walter ^b   Craik, Charles S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; ESTERS; GENETIC ENGINEERING; SUBSTRATES;

COUMARIN SUBSTRATES; NATURAL KILLER CELLS; SERINE PROTEASE;

ENZYMES;

4 NITROANILINE; ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; COUMARIN; ESTER; GRANZYME A; GRANZYME B; GRANZYME M; PROTEINASE INHIBITOR; PROTEINASE INHIBITOR 9; RECOMBINANT ENZYME; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CYTOTOXIC LYMPHOCYTE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROLYSIS; NATURAL KILLER CELL; PRIORITY JOURNAL;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; BINDING SITES; COUMARINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GRANZYMES; HUMANS; HYDROLYSIS; LEUCINE; MOLECULAR SEQUENCE DATA; NORLEUCINE; PEPTIDE LIBRARY; PROLINE; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERPINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 11144234552     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411482200     Document Type: Article

References (34)

1. Smyth, M. J., O'Connor, M. D., Trapani, J. A., Kershaw, M. H., and Brinkworth, R. I. (1996) J. Immunol. 156, 4174-4181
2. Russell, J. H., and Ley, T. J. (2002) Annu. Rev. Immunol. 20, 323-370
3. Tak, P. P., Spaeny-Dekking, L., Kraan, M. C., Breedveld, F. C., Froelich, C. J., and Hack, C. E. (1999) Clin. Exp. Immunol. 116, 366-370
4. Beresford, P. J., Kam, C. M., Powers, J. C., and Lieberman, J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9285-9290
5. Wilharm, E., Parry, M. A., Friebel, R., Tschesche, H., Matschiner, G., Sommerhoff, C. P., and Jenne, D. E. (1999) J. Biol. Chem. 274, 27331-27337
6. Poe, M., Blake, J. T., Boulton, D. A., Gammon, M., Sigal, N. H., Wu, J. K., and Zweerink, H. J. (1991) J. Biol. Chem. 266, 98-103
7. Edwards, K. M., Kam, C. M., Powers, J. C., and Trapani, J. A. (1999) J. Biol. Chem. 274, 30468-30473
8. Sayers, T. J., Brooks, A. D., Ward, J. M., Hoshino, T., Bere, W. E., Wiegand, G. W., Kelly, J. M., Smyth, M. J., and Kelley, J. M. (2001) J. Immunol. 166, 765-771
9. Shi, L., Kam, C. M., Powers, J. C., Aebersold, R., and Greenberg, A. H. (1992) J. Exp. Med. 176, 1521-1529
10. Woodard, S. L., Jackson, D. S., Abuelyaman, A. S., Powers, J. C., Winkler, U., and Hudig, D. (1994) J. Immunol. 153, 5016-5025
11. Kelly, J. M., Waterhouse, N. J., Cretney, E., Browne, K. A., Ellis, S., Trapani, J. A., and Smyth, M. J. (2004) J. Biol. Chem. 279, 22236-22242
12. Harris, J. L., Backes, B. J., Leonetti, F., Mahrus, S., Ellman, J. A., and Craik, C. S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7754-7759
13. Potempa, J., Korzus, E., and Travis, J. (1994) J. Biol. Chem. 269, 15957-15960
14. Dahlen, J. R., Foster, D. C., and Kisiel, W. (1999) Biachim. Biophys. Acta 1451, 233-241
15. Bell, J. K., Goetz, D. H., Mahrus, S., Harris, J. L., Fletterick, R. J., and Craik, C. S. (2003) Nat. Struct. Biol. 10, 527-534
16. Sprecher, C. A., Morgenstern, K. A., Mathewes, S., Dahlen, J. R., Schrader, S. K., Foster, D. C., and Kisiel, W. (1995) J. Biol. Chem. 270, 29854-29861
17. Armand, R. R., Dahlen, J. R., Sprecher, C. A., De Dreu, P., Foster, D. C., Mankovich, J. A., Talanian, R. V., Kisiel, W., and Giegel, D. A. (1999) Biochem. J. 342, 655-665
18. Dauber, D. S., Ziermann, R., Parkin, N., Maly, D. J., Mahrus, S., Harris, J. L., Ellman, J. A., Petropoulos, C., and Craik, C. S. (2002) J. Virol. 76, 1359-1368
19. Morrison, J. F. (1982) Trends Biochem. Sci. 7, 102-105
20. Smyth, M. J., Sayers, T. J., Wiltrout, T., Powers, J. C., and Trapani, J. A. (1993) J. Immunol. 151, 6195-6205
21. Smyth, M. J., Wiltrout, T., Trapani, J. A., Ottaway, K. S., Sowder, R., Henderson, L. E., Kam, C. M., Powers, J. C., Young, H. A., and Sayers, T. J. (1992) J. Biol. Chem. 267, 24418-24425
22. Kelly, J. M., O'Connor, M. D., Hulett, M. D., Thia, K. Y., and Smyth, M. J. (1996) Immunogenetics 44, 340-350
23. Silverman, G. A., Bird, P. I., Carrell, R. W., Church, F. C., Coughlin, P. B., Gettins, P. G., Irving, J. A., Lomas, D. A., Luke, C. J., Moyer, R. W., Pemberton, P. A., Remold-O'Donnell, E., Salvesen, G. S., Travis, J., and Whisstock, J. C. (2001) J. Biol. Chem. 276, 33293-33296
24. Casciola-Rosen, L., Andrade, F., Ulanet, D., Wong, W. B., and Rosen, A. (1999) J. Exp. Med. 190, 815-826
25. Sun, J., Bird, C. H., Button, V., McDonald, L., Coughlin, P. B., De Jong, T. A., Trapani, J. A., and Bird, P. I. (1996) J. Biol. Chem. 271, 27802-27809
26. Hedstrom, L., Szilagyi, L., and Rutter, W. J. (1992) Science 255, 1249-1253
27. Harris, J. L., Peterson, E. P., Hudig, D., Thornberry, N. A., and Craik, C. S. (1998) J. Biol. Chem. 273, 27364-27373
28. Owen, C. A., and Campbell, E. J. (1999) J. Leukocyte Biol. 65, 137-150
29. Volanakis, J. E., and Narayana, S. V. (1996) Protein Sci. 5, 553-564
30. Medema, J. P., de Jong, J., Peltenburg, L. T., Verdegaal, E. M., Gorter, A., Bres, S. A., Franken, K. L., Hahne, M., Albar, J. P., Melief, C. J., and Offringa, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 11515-11520
31. Djie, M. Z., Stone, S. R., and Le Bonniec, B. F. (1997) J. Biol. Chem. 272, 16268-16273
32. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
33. Sun, J., Whisstock, J. C., Harriott, P., Walker, B., Novak, A., Thompson, P. E., Smith, A. I., and Bird, P. I. (2001) J. Biol. Chem. 276, 15177-15184
34. Schechter, I., and Berger, A. (1968) Biochem. Biophys. Res. Commun. 32, 898-902