메뉴 건너뛰기




Volumn 119, Issue 5, 2006, Pages 858-865

Identification of α-tubulin as a granzyme B substrate during CTL-mediated apoptosis

Author keywords

Apoptosis; Cytotoxic lymphocyte; Tubulin

Indexed keywords

ALPHA TUBULIN; GRANZYME B;

EID: 33645220408     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02791     Document Type: Article
Times cited : (48)

References (50)
  • 1
    • 14244260622 scopus 로고    scopus 로고
    • Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B
    • Adrain, C., Murphy, B. M. and Martin, S. J. (2005). Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B. J. Biol. Chem. 280, 4663-4673.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4663-4673
    • Adrain, C.1    Murphy, B.M.2    Martin, S.J.3
  • 2
    • 0032516917 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B
    • Atkinson, E. A., Barry, M., Darmon, A. J., Shostak, I., Turner, P. C., Moyer, R. W. and Bleackley, R. C. (1998). Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B. J. Biol. Chem. 273, 21261-21266.
    • (1998) J. Biol. Chem. , vol.273 , pp. 21261-21266
    • Atkinson, E.A.1    Barry, M.2    Darmon, A.J.3    Shostak, I.4    Turner, P.C.5    Moyer, R.W.6    Bleackley, R.C.7
  • 3
    • 0036595397 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes: All roads lead to death
    • Barry, M. and Bleackley, R. C. (2002). Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2, 401-409.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 401-409
    • Barry, M.1    Bleackley, R.C.2
  • 4
    • 0034107096 scopus 로고    scopus 로고
    • Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid
    • Barry, M., Heibein, J. A., Pinkoski, M. J., Lee, S. F., Moyer, R. W., Green, D. R. and Bleackley, R. C. (2000). Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Mol. Cell. Biol. 20, 3781-3794.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3781-3794
    • Barry, M.1    Heibein, J.A.2    Pinkoski, M.J.3    Lee, S.F.4    Moyer, R.W.5    Green, D.R.6    Bleackley, R.C.7
  • 7
    • 0034671856 scopus 로고    scopus 로고
    • Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis
    • Browne, K. A., Johnstone, R. W., Jans, D. A. and Trapani, J. A. (2000). Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis. J. Biol. Chem. 275, 39262-39266.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39262-39266
    • Browne, K.A.1    Johnstone, R.W.2    Jans, D.A.3    Trapani, J.A.4
  • 8
    • 0033151922 scopus 로고    scopus 로고
    • Electrostatic reversal of serine proteinase substrate specificity
    • Caputo, A., Parrish, J. C., James, M. N., Powers, J. C. and Bleackley, R. C. (1999). Electrostatic reversal of serine proteinase substrate specificity. Proteins 35, 415-424.
    • (1999) Proteins , vol.35 , pp. 415-424
    • Caputo, A.1    Parrish, J.C.2    James, M.N.3    Powers, J.C.4    Bleackley, R.C.5
  • 9
    • 0025793801 scopus 로고
    • MAP-1 and MAP-2 binding sites at the C-terminus of beta-tubulin. Studies with synthetic tubulin peptides
    • Cross, D., Dominguez, J., Maccioni, R. B. and Avila, J. (1991). MAP-1 and MAP-2 binding sites at the C-terminus of beta-tubulin. Studies with synthetic tubulin peptides. Biochemistry 30, 4362-4366.
    • (1991) Biochemistry , vol.30 , pp. 4362-4366
    • Cross, D.1    Dominguez, J.2    Maccioni, R.B.3    Avila, J.4
  • 10
    • 0029099845 scopus 로고
    • Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
    • Darmon, A. J., Nicholson, D. W. and Bleackley, R. C. (1995). Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377, 446-448.
    • (1995) Nature , vol.377 , pp. 446-448
    • Darmon, A.J.1    Nicholson, D.W.2    Bleackley, R.C.3
  • 11
    • 0037133046 scopus 로고    scopus 로고
    • Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice
    • Duan, J. and Gorovsky, M. A. (2002). Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice. Curr. Biol. 12, 313-316.
    • (2002) Curr. Biol. , vol.12 , pp. 313-316
    • Duan, J.1    Gorovsky, M.A.2
  • 15
    • 0022308091 scopus 로고
    • Mechanism of lymphocyte-mediated cytotoxicity
    • Henkart, P. A. (1985). Mechanism of lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 3, 31-58.
    • (1985) Annu. Rev. Immunol. , vol.3 , pp. 31-58
    • Henkart, P.A.1
  • 19
    • 0029814394 scopus 로고    scopus 로고
    • Interaction of kinesin motor domains with alpha- and beta-tubulin subunits at a tau-independent binding site. Regulation by polyglutamylation
    • Larcher, J. C., Boucher, D., Lazereg, S., Gros, F. and Denoulet, P. (1996). Interaction of kinesin motor domains with alpha- and beta-tubulin subunits at a tau-independent binding site. Regulation by polyglutamylation. J. Biol. Chem. 271, 22117-22124.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22117-22124
    • Larcher, J.C.1    Boucher, D.2    Lazereg, S.3    Gros, F.4    Denoulet, P.5
  • 20
    • 0035811496 scopus 로고    scopus 로고
    • Endonuclease G is an apoptotic DNase when released from mitochondria
    • Li, L. Y., Luo, X. and Wang, X. (2001). Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412, 95-99.
    • (2001) Nature , vol.412 , pp. 95-99
    • Li, L.Y.1    Luo, X.2    Wang, X.3
  • 21
    • 0038725690 scopus 로고    scopus 로고
    • The ABCs of granule-mediated cytotoxicity: New weapons in the arsenal
    • Lieberman, J. (2003). The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat. Rev. Immunol. 3, 361-370.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 361-370
    • Lieberman, J.1
  • 24
    • 0027946007 scopus 로고
    • A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity
    • Lowin, B., Beermann, F., Schmidt, A. and Tschopp, J. (1994). A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA 91, 11571-11575.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11571-11575
    • Lowin, B.1    Beermann, F.2    Schmidt, A.3    Tschopp, J.4
  • 25
    • 0027207944 scopus 로고
    • Are tubulin isotypes functionally significant
    • Luduena, R. F. (1993). Are tubulin isotypes functionally significant. Mol. Biol. Cell 4, 445-457.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 445-457
    • Luduena, R.F.1
  • 26
    • 9344261615 scopus 로고    scopus 로고
    • The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism
    • Martin, S., Amarante-Mendes, G., Shi, L., Chuang, T., Casiano, C., O'Brien, G., Fitzgerald, P., Tan, E., Bokoch, G., Greenberg, A. et al. (1996). The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J. 15, 2407-2416.
    • (1996) EMBO J. , vol.15 , pp. 2407-2416
    • Martin, S.1    Amarante-Mendes, G.2    Shi, L.3    Chuang, T.4    Casiano, C.5    O'Brien, G.6    Fitzgerald, P.7    Tan, E.8    Bokoch, G.9    Greenberg, A.10
  • 27
    • 0021686169 scopus 로고
    • Dynamic instability of microtubule growth
    • Mitchison, T. and Kirschner, M. (1984). Dynamic instability of microtubule growth. Nature 312, 237-242.
    • (1984) Nature , vol.312 , pp. 237-242
    • Mitchison, T.1    Kirschner, M.2
  • 28
    • 0141996464 scopus 로고    scopus 로고
    • Microtubules, microtubule-interfering agents and apoptosis
    • Mollinedo, F. and Gajate, C. (2003). Microtubules, microtubule-interfering agents and apoptosis. Apoptosis 8, 413-450.
    • (2003) Apoptosis , vol.8 , pp. 413-450
    • Mollinedo, F.1    Gajate, C.2
  • 29
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata, S. and Golstein, P. (1995). The Fas death factor. Science 267, 1449-1456.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 30
    • 0032813799 scopus 로고    scopus 로고
    • Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells
    • Nguyen, H., Gruber, D. and Bulinski, J. (1999). Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells. J. Cell Sci. 112, 1813-1824.
    • (1999) J. Cell Sci. , vol.112 , pp. 1813-1824
    • Nguyen, H.1    Gruber, D.2    Bulinski, J.3
  • 31
    • 0032495513 scopus 로고    scopus 로고
    • Structure of the alpha beta tubulin dimer by electron crystallography
    • Nogales, E., Wolf, S. G. and Downing, K. H. (1998). Structure of the alpha beta tubulin dimer by electron crystallography. Nature 391, 199-203.
    • (1998) Nature , vol.391 , pp. 199-203
    • Nogales, E.1    Wolf, S.G.2    Downing, K.H.3
  • 32
    • 0023990198 scopus 로고
    • A survey of the alpha-tubulin gene family in chicken: Unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes
    • Pratt, L. F. and Cleveland, D. W. (1988). A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. EMBO J. 7, 931-940.
    • (1988) EMBO J. , vol.7 , pp. 931-940
    • Pratt, L.F.1    Cleveland, D.W.2
  • 34
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell, J. H. and Ley, T. J. (2002). Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20, 323-370.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 35
    • 17844365555 scopus 로고    scopus 로고
    • Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation
    • Sharif-Askari, E., Alam, A., Rheaume, E., Beresford, P. J., Scotto, C., Sharma, K., Lee, D., DeWolf, W. E., Nuttall, M. E., Lieberman, J. et al. (2001). Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J. 20, 3101-3113.
    • (2001) EMBO J. , vol.20 , pp. 3101-3113
    • Sharif-Askari, E.1    Alam, A.2    Rheaume, E.3    Beresford, P.J.4    Scotto, C.5    Sharma, K.6    Lee, D.7    DeWolf, W.E.8    Nuttall, M.E.9    Lieberman, J.10
  • 36
    • 0026532606 scopus 로고
    • A natural killer cell granule protein that induces DNA fragmentation and apoptosis
    • Shi, L., Kraut, R. P., Aebersold, R. and Greenberg, A. H. (1992). A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175, 553-566.
    • (1992) J. Exp. Med. , vol.175 , pp. 553-566
    • Shi, L.1    Kraut, R.P.2    Aebersold, R.3    Greenberg, A.H.4
  • 37
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • Stinchcombe, J. C., Bossi, G., Booth, S. and Griffiths, G. M. (2001). The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751-761.
    • (2001) Immunity , vol.15 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 39
    • 0034694091 scopus 로고    scopus 로고
    • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
    • Sutton, V. R., Davis, J. E., Cancilla, M., Johnstone, R. W., Ruefli, A. A., Sedelies, K., Browne, K. A. and Trapani, J. A. (2000). Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J. Exp. Med. 192, 1403-1414.
    • (2000) J. Exp. Med. , vol.192 , pp. 1403-1414
    • Sutton, V.R.1    Davis, J.E.2    Cancilla, M.3    Johnstone, R.W.4    Ruefli, A.A.5    Sedelies, K.6    Browne, K.A.7    Trapani, J.A.8
  • 40
    • 0037341354 scopus 로고    scopus 로고
    • Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors
    • Sutton, V. R., Wowk, M. E., Cancilla, M. and Trapani, J. A. (2003). Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity 18, 319-329.
    • (2003) Immunity , vol.18 , pp. 319-329
    • Sutton, V.R.1    Wowk, M.E.2    Cancilla, M.3    Trapani, J.A.4
  • 41
    • 0033673428 scopus 로고    scopus 로고
    • DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
    • Thomas, D. A., Du, C., Xu, M., Wang, X. and Ley, T. J. (2000). DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity 12, 621-632.
    • (2000) Immunity , vol.12 , pp. 621-632
    • Thomas, D.A.1    Du, C.2    Xu, M.3    Wang, X.4    Ley, T.J.5
  • 42
    • 0033588020 scopus 로고    scopus 로고
    • Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer
    • Tian, G., Bhamidipati, A., Cowan, N. J. and Lewis, S. A. (1999). Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J. Biol. Chem. 274, 24054-24058.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24054-24058
    • Tian, G.1    Bhamidipati, A.2    Cowan, N.J.3    Lewis, S.A.4
  • 43
    • 0141629530 scopus 로고    scopus 로고
    • Granzyme B: Pro-apoptotic, antiviral and antitumor functions
    • Trapani, J. A. and Sutton, V. R. (2003). Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr. Opin. Immunol. 15, 533-543.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 533-543
    • Trapani, J.A.1    Sutton, V.R.2
  • 44
    • 0032561352 scopus 로고    scopus 로고
    • Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
    • Trapani, J. A., Jans, D. A., Jans, P. J., Smyth, M. J., Browne, K. A. and Sutton, V. R. (1998). Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J. Biol. Chem. 273, 27934-27938.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27934-27938
    • Trapani, J.A.1    Jans, D.A.2    Jans, P.J.3    Smyth, M.J.4    Browne, K.A.5    Sutton, V.R.6
  • 46
    • 0022753748 scopus 로고
    • Six mouse alpha-tubulin mRNAs encode five distinct isotypes: Testis-specific expression of two sister genes
    • Villasante, A., Wang, D., Dobner, P., Dolph, P., Lewis, S. A. and Cowan, N. J. (1986). Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol. Cell. Biol. 6, 2409-2419.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 2409-2419
    • Villasante, A.1    Wang, D.2    Dobner, P.3    Dolph, P.4    Lewis, S.A.5    Cowan, N.J.6
  • 48
    • 0032724653 scopus 로고    scopus 로고
    • Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
    • Wolf, B. B., Schuler, M., Echeverri, F. and Green, D. R. (1999). Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation. J. Biol. Chem. 274, 30651-30656.
    • (1999) J. Biol. Chem. , vol.274 , pp. 30651-30656
    • Wolf, B.B.1    Schuler, M.2    Echeverri, F.3    Green, D.R.4
  • 50
    • 0022653477 scopus 로고
    • Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography
    • Yannelli, J. R., Sullivan, J. A., Mandell, G. L. and Engelhard, V. H. (1986). Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography. J. Immunol. 136, 377-382.
    • (1986) J. Immunol. , vol.136 , pp. 377-382
    • Yannelli, J.R.1    Sullivan, J.A.2    Mandell, G.L.3    Engelhard, V.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.