All human granzymes target hnRNP K that is essential for tumor cell viability

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22854-22864

  Van Domselaar, Robert ^a   Quadir, Razi ^a   Van Der Made, Astrid M ^a   Broekhuizen, Roel ^a   Bovenschen, Niels ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACID REGION; APOPTOTIC PATHWAYS; CASPASE ACTIVATION; CASPASE-INDEPENDENT; CELL-CELL CONTACT; CELLULAR CYTOTOXICITY; CYTOTOXIC; LIVING TUMORS; NUCLEAR RIBONUCLEOPROTEIN; PERFORIN; PHYSIOLOGICAL CONDITION; PORE-FORMING PROTEINS; PROTEIN EXPRESSIONS; REACTIVE OXYGEN SPECIES; SERINE PROTEASE; SUBSTRATE SPECIFICITY; TUMOR CELLS; VIRUS-INFECTED CELLS;

AMINO ACIDS; CELL DEATH; CYTOTOXICITY; ENZYME ACTIVITY; GRANULATION; PROTEINS; RNA; TUMORS; VIRUSES;

SUBSTRATES;

AMINO ACID; CASPASE; DNA BINDING PROTEIN; GRANZYME; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; REACTIVE OXYGEN METABOLITE; RNA; RNA BINDING PROTEIN;

APOPTOSIS; ARTICLE; CELL CONTACT; CELL DEATH; CELL DENSITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PURIFICATION; ENZYME SUBSTRATE; GENE SILENCING; HUMAN; HUMAN CELL; LYMPHOKINE ACTIVATED KILLER CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; TUMOR CELL;

CASPASE 3; CASPASE 7; CELL DEATH; CELL SURVIVAL; GRANZYMES; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN K; HUMANS; JURKAT CELLS; K562 CELLS; NEOPLASMS; RIBONUCLEASES; RNA, NEOPLASM; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84863329244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.365692     Document Type: Article

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