Analysis of fyn function in hemostasis and αllbβ3-integrin signaling

Journal of Cell Science

Volumn 121, Issue 10, 2008, Pages 1641-1648

  Reddy, Kumar B ^a   Smith, Dawn M ^a   Plow, Edward F ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

llb 3; Integrin; Src family kinases

Indexed keywords

ALPHAIIB BETA3 INTEGRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLUTATHIONE TRANSFERASE; INTEGRIN; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; THROMBIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BLEEDING; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FOCAL ADHESION; GENE MUTATION; HEMOSTASIS; HUMAN; HUMAN CELL; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BLEEDING TIME; BLOOD PLATELETS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; HEMOSTASIS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEIN PP60(V-SRC); PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTO-ONCOGENE PROTEINS C-FYN; SIGNAL TRANSDUCTION;

MUS;

EID: 46249134182     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.014076     Document Type: Article

References (56)

1. Appleby, M. W., Gross, J. A., Cooke, M. P., Levin, S. D., Qian, X. and Perlmutter, R. M. (1992). Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70, 751-763.
2. Arias-Salgado, E. G., Lizano, S., Sarkar, S., Brugge, J. S., Ginsberg, M. H. and Shattil, S. J. (2003), Src kinase activation by direct interaction with the integrin {beta} cytoplasmic domain. Proc. Natl. Acad. Sci. USA 100, 13298-13302.
3. Arias-Salgado, E. G., Lizano, S., Shattil, S. J. and Ginsberg, M. H. (2005). Specification of the direction of adhesive signaling by the integrin {beta} cytoplasmic domain. J. Biol. Chem. 280, 29699-29707.
4. Barry, S. T., Flinn, H. M., Humphries, M. J., Critchley, D. R. and Ridley, A. J. (1997). Requirement for Rho in integrin signalling. Cell Adhes. Commun. 4, 387-398.
5. Bennett, J. S. and Vilaire, G. (1979). Exposure of platelet fibrinogen receptors by ADP and epinephrine. J. Clin. Invest. 64, 1393-1401.
6. Bergmeier, W., Schulte, V., Brockhoff, G., Bier, U., Zirngibl, H. A. and Nieswandt, B. (2002). Flow cytometric detection of activated mouse integrin αIIbβ3 with a novel monoclonal antibody. Cytometry 48, 80-86.
7. Berrier, A. L., Martinez, R., Bokoch, G. M. and LaFlamme, S. E. (2002). The integrin {beta} tail is required and sufficient to regulate adhesion signaling to Rac1. J. Cell Sci. 115, 4285-4291.
8. Bertoni, A., Tadokoro, S., Eto, K., Pampori, N., Parise, L. V., White, G. C. and Shattil, S. J. (2002). Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J. Biol. Chem. 277, 25715-25721.
9. Brickell, P. M. (1992). The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. Crit. Rev. Oncog. 3, 401-446.
10. Buensuceso, C. S., Arias-Salgado, E. G. and Shattil, S. J. (2004). Protein-protein interactions in platelet alphaIIbbeta3 signaling. Semin. Thromb. Hemost. 30, 427-439.
11. Calderwood, D., Zent, R., Grant, R., Rees, D., Hynes, R. and Ginsberg, M. (1999). The talin head domain binds to integrin b cytoplasmic tails and regulates integrin activation. J Biol. Chem. 274, 28071-28074.
12. 3-mediated activation of nuclear factor-κB. J. Biol. Chem. 280, 12145-12151.
13. Du, X., Saido, T. C., Tsubuki, S., Indig, F. E., Williams, M. J. and Ginsberg, M. H. (1995). Calpain cleavage of the cytoplasmic domain of the integrin β3 subunit. J. Biol. Chem. 270, 26146-26151.
14. Eto, K., Takizawa, H., Takaki, S., Nishikü, H., Oda, A. and Nakauchi, H. (2007). The cytokine signaling inhibitor Lnk promotes αIIbβ3 integrin outside-in signaling through β3-tyrosine phosphorylation in platelets. Blood 110.
15. Ferrell, J. E., Jr and Martin, G. S. (1989). Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc. Natl. Acad. Sci. USA 86, 2234-2238.
16. Folts, J. (1991), An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis. Circulation 83, IV3-IV14.
17. Fox, J. E. B. and Phillips, D. R. (1993). Stimulus-induced activation of the calcium-dependent protease within platelets. Cell Motility 3, 579-598.
18. Fox, J. E. B., Taylor, R. G., Taffarel, M., Boyles, J. K. and Goll, D. E. (1993). Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa. J. Cell Biol. 120, 1501-1507.
19. Frangioni, J. V., Oda, A., Smith, M., Salzman, E. W. and Neel, B. G. (1993). Calpain catalyzed cleavage and subcelluiar relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J 12, 4843-4856.
20. Ginsberg, M. H., Partridge, A. and Shattil, S. J. (2005). Integrin regulation. Curr. Opin. Cell Biol. 17, 509-516.
21. Golden, A., Brugge, J. S. and Shattil, S. J. (1990). Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J. Cell Biol. 111, 3117-3127.
22. Hoover-Plow, J., Shchurin, A., Hart, E., Sha, J., Hill, A., Singer, J. and Nadeau, J. (2006). Genetic background determines response to hemostasis and thrombosis. BMC Blood Disord. 6, 6.
23. Hynes, R. O. (1992). Integrins: versatility, modulation, and signaling cell adhesion. Cell 69, 11-25.
24. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
25. King, W., Mattaliano, M., Chan, T., Tsichlis, P. and Brugge, J. (1997). Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen- activated protein kinase pathway activation. Mol. Cell. Biol. 17, 4406-4419.
26. Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. and Soriano, P. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18, 2459-2471.
27. Kumar, C. S., James, I. E., Wong, A., Mwangi, V., Feild, J. A., Nuthulaganti, P., Connor, J. R., Eichman, C., Ali, F., Hwang, S. M. et al. (1997). Cloning and characterization of a novel integrin beta3 subunit. J. Biol. Chem. 272, 16390-16397.
28. Lam. S.. Plow, E., D'Souza, S., Cheresh, D., Frelinger, A., 3rd and Ginsberg, M. (1989). Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. J. Biol. Chem. 264, 3742-3749.
29. Laudanna, C., Campbell, J. J. and Butcher, E. C. (1996). Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271, 981-983.
30. Law, D. A., DeGuzman, F. R., Heiser, P., Ministri-Madrid, K., Killeen, N. and Phillips, D. R. (1999). Integrin cytoplasmic tyrosine motif is required for outside-in [alpha]IIb[beta]3 signalling and platelet function. Nature 401, 808-811.
31. Liddington, R. C. and Ginsberg, M. H. (2002). Integrin activation takes shape. J. Cell Biol. 158, 833-839.
32. FAK in platelets. J Cell Biol. 119, 905-912.
33. Liu, S., Calderwood, D. and Ginsberg, M. (2000). Integrin cytoplasmic domain-binding proteins. J. Cell Sci. 113, 3563-3571.
34. Lyman, S., Gilmore, A., Burridge, K., Gidwitz, S. and White, G. (1997). Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. J. Biol. Chem. 272, 22538-22547.
35. Ma, Y.-Q., Qin, J. and Plow, E. F. (2007). Platelet integrin aIIbβ3: activation mechanisms. J. Thromb. Haemost. 5, 1345-1352.
36. Marguerie, G. A., Plow, E. F. and Edgington, T. S. (1979). Human platelets possess an inducible and saturable receptor specific for fibrinogen. J. Biol. Chem. 254, 5357-5363.
37. Melford, S. K., Turner, M., Briddon, S. J., Tybulewicz, V. L. J. and Watson, S. P. (1997). Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide. J. Biol. Chem. 272, 27539-27542.
38. Nitabach, M. N., Llamas, D. A., Araneda, R. C., Intile, J. L., Thompson, I. J., Zhou, Y. I. and Holmes T. C. (2001) A mechanism for combinatorial regulation of electrical activity: potassium channel subunits capable of functioning as Src homology 3- dependent adaptors. Proc. Natl. Acad. Sci. USA 98, 705-710.
39. Obergfell, A., Eto, K., Mocsai, A., Buensuceso, C., Moores, S. L., Brugge, J. S., Lowell, C. A. and Shattil, S. J. (2002). Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J. Cell Biol. 157, 265-275.
40. O'Toole, T. E., Ylanne, J. and Culley, B. M. (1995). Regulation of integrin affinity states through an NPXY motif in the β subunit cytoplasmic domain. J. Biol. Chem. 270, 8553-8558.
41. Pestina, T. I., Stenberg, P. E., Druker, B. J., Steward, S. A., Hutson, N. K., Barrie, R. J. and Jackson, C. W. (1997). Identification of the Src family kinases, Lck and Fgr in platelets: their tyrosine phosphorylation status and subcellular distribution compared with other Src family members. Arterioscler Thromb. Vasc. Biol. 17, 3278-3285.
42. Phillips, D. R., Prasad, K. S., Manganello, J., Bao, M. and Nannizzi-Alaimo, L. (2001). Integrin tyrosine phosphorylation in platelet signaling. Curr. Opin. Cell Biol. 13, 546-554.
43. Price, L. S., Leng, J., Schwartz, M. A. and Bokoch, G. M. (1998). Activation of Rac and Cdc42 by integrin mediates cell spreading. Mol. Biol. Cell 9, 1863-1871.
44. Reddy, K. B., Gascard, P., Price, M. G., Negrescu, E. and Fox, J. E. B. (1998). Identification of an interaction between the M-band Protein skelemin and beta integrin subunits. J. Biol. Chem. 273, 35039-35047.
45. Renshaw, M. W., Toksoz, D. and Schwartz, M. A. (1996). Involvement of the small GTPase Rho in integrin-mediated activation of mitogen-activated protein kinase. J. Biol. Chem. 271, 21691-21694.
46. 3 integrin cytoplasmic domain tyrosine residues 747 and 759 in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling. J. Biol. Chem. 273, 12623-12632.
47. Schaller, M. D., Otey, C. A., Hildebrand, J. D. and Parsons, J. T. (1995). Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains. J. Cell Biol. 130, 1181-1187.
48. Shattil, S. J., Hoxie, J. A., Cunningham, M. and Brass, L. F. (1985). Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J. Biol. Chem. 260, 11107-11114.
49. Stein, P. L., Lee, H.-M., Rich, S. and Soriano, P. (1992). pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70, 741-750.
50. Stein, P. L., Vogel, H. and Soriano, P. (1994). Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 8, 1999-2007.
51. Stenberg, P. E., Pestina, T. I., Barrie, R. J. and Jackson, C. W. (1997). The Src family kinases, Fgr, Fyn, Lck, and Lyn, colocalize with coated membranes in platelets. Blood 89, 2384-2393.
52. Stenberg, P. E., Barrie, R. J., Pestina, T. I., Steward, S. A., Arnold, J. T., Murti, A. K., Hutson, N. K. and Jackson, C. W. (1998). Prolonged bleeding time with defective platelet filopodia formation in the Wistar Furth rat. Blood 91, 1599-1608.
53. van Kuppevelt, T. H., Languino, L. R., Gailit, J. O., Suzuki, S. and Ruoslahti, E. (1989). An alternative cytoplasmic domain of the integrin beta 3 subunit. Proc. Natl. Acad. Sci. USA 86, 5415-5418.
54. Vinogradova, O., Velyvis, A., Velyviene, A., Hu, B., Haas, T., Plow, E. and Qin, J. (2002). A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell 110, 587-597.
55. Wary, K. K., Mariotti, A., Zurzolo, C. and Giancotti, F. G. (1998). A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94, 625-634.
56. Ylanne, J., Huuskonen, J., O'Toole, T. E., Ginsberg, M. H., Virtanen, I. and Gahmberg, C. G. (1995). Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. J. Biol. Chem. 270, 9550-9557.