Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive andcellular deficits in an Alzheimer's disease mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 44, 2010, Pages 19014-19019

  Zhang, Yongfang ^a   Kurup, Pradeep ^b   Xu, Jian ^b   Carty, Nikisha ^b   Fernandez, Stephanie M ^b   Nygaard, Haakon B ^c   Pittenger, Christopher ^c   Greengard, Paul ^d   Strittmatter, Stephen M ^c   Nairn, Angus C ^c   Lombroso, Paul J ^b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Glutamate receptor trafficking; Long term potentiation; Protein tyrosine phosphatase; Amyloid

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COGNITIVE DEFECT; CONFERENCE PAPER; CORPUS STRIATUM; ENZYME ACTIVITY; GENETIC MANIPULATION; GENETICS; INTERNALIZATION; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; TRANSGENICS;

ANIMALIA; MUS;

EID: 78650491806     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013543107     Document Type: Article

References (32)

1. Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101-112.
2. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297:353-356.
3. Venkitaramani DV, et al. (2007) Beta-amyloid modulation of synaptic transmission and plasticity. J Neurosci 27:11832-11837.
4. Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 192:106-113.
5. Mucke L, et al. (2000) High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation. JNeurosci 20:4050-4058.
6. Jacobsen JS, et al. (2006) Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 103:5161-5166.
7. Terry RD, et al. (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
8. Walsh DM, et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539.
9. Lacor PN, et al. (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27:796-807.
10. Shankar GM, et al. (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptordependent signaling pathway. J Neurosci 27:2866-2875.
11. Shankar GM, et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14:837-842.
12. Chapman PF, et al. (1999) Impaired synaptic plasticity and learning in aged amyloidprecursor protein transgenic mice. Nat Neurosci 2:271-276.
13. Oddo S, et al. (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron 39: 409-421.
14. Boulanger LM, et al. (1995) Cellular and molecular characterization of a brainenriched protein tyrosine phosphatase. J Neurosci 15:1532-1544.
15. Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD (2009) Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience 158:1446-1459.
16. Xu J, et al. (2009) Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. J Neurosci 29:9330-9343.
17. Snyder EM, et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8:1051-1058.
18. Pelkey KA, et al. (2002) Tyrosine phosphatase STEP is a tonic brake on induction oflong-term potentiation. Neuron 34:127-138.
19. Braithwaite SP, et al. (2006) Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP). Eur J Neurosci 23:2847-2856.
20. Nguyen TH, Liu J, Lombroso PJ (2002) Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. J Biol Chem 277:24274-24279.
21. Paul S, Nairn AC, Wang P, Lombroso PJ (2003) NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci 6: 34-42.
22. Braithwaite SP, Paul S, Nairn AC, Lombroso PJ (2006) Synaptic plasticity: One STEP at a time. Trends Neurosci 29:452-458.
23. Chin J, et al. (2005) Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 25:9694-9703.
24. Kurup P, et al. (2010) Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci 30: 5948-5957.
25. Venkitaramani DV, et al. (2009) Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse 63:69-81.
26. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45:675-688.
27. Carroll JC, et al. (2007) Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci 27:13357-13365.
28. Fernandez SM, et al. (2008) Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors. J Neurosci 28:8660-8667.
29. Hsiao K, et al. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102.
30. Satoh Y, et al. (2007) Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory.J Neurosci 27:10765-10776.
31. Grant SG, et al. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258:1903-1910.
32. Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (2009) Cellularprion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457:1128-1132.