Synthesis and functional characterization of imbutamine analogs as histamine H3 and H4 receptor ligands

Archiv der Pharmazie

Volumn 347, Issue 2, 2014, Pages 77-88

  Geyer, Roland ^a   Kaske, Melanie ^a   Baumeister, Paul ^a   Buschauer, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Bioisosteres; H3 receptor; H4 receptor; Histamine; Imbutamine

Indexed keywords

2 (5 BROMO 6 OXOHEPTYL)ISOINDOLINE 1,3 DIONE; 2 [3 (2 METHYL 1H IMIDAZOL 4 YL)PROPYL]ISOINDOLINE 1,3 DIONE; 2 [4 (1H 1,2,3 TRIAZOL 5 YL)BUTYL]ISOINDOLINE 1,3 DIONE; 2 [4 (2 METHYL 1H IMIDAZOL 4 YL)BUTYL]ISOINDOLINE 1,3 DIONE; 2 [4 (5 METHYL 1H IMIDAZOL 4 YL)BUTYL]ISOINDOLINE 1,3 DIONE; 3 (2 METHYL 1H IMIDAZOL 4 YL)PROPAN 1 AMINE; 3 (3 AMINOPROPYLSULFANYL) 1H 1,2,4 TRIAZOL 5 AMINE; 4 (1H 1,2,3 TRIAZOL 5 YL)BUTAN 1 AMINE; 4 (2 METHYL 1H IMIDAZOL 4 YL)BUTAN 1 AMINE; 4 (5 METHYL 1H IMIDAZOL 4 YL)BUTAN 1 AMINE; 5 (4 AMINOBUTYL) 1H 1,2,4 TRIAZOL 3 AMINE; HISTAMINE AGONIST; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR AGONIST; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR AGONIST; MBUTAMINE DERIVATIVE; N 2 (2 AMINOETHYL) N 4 METHYLPYRIMIDINE 2,4 DIAMINE; N 2 (2 AMINOETHYL)PYRIMIDINE 2,4 DIAMINE; N 2 (3 AMINOETHYL)PYRIMIDINE 2,4 DIAMINE; N 3 (3 AMINOPROPYL) 1H 1,2,4 TRIAZOLE 3,5 DIAMINE; N 3 (4 AMINOBUTYL) 1H 1,2,4 TRIAZOLE 3,5 DIAMINE; N 4 (2 AMINOETHYL)PYRIMIDINE 2,4 DIAMINE; TERT BUTYL 3 (5 AMINO 1H 1,2,4 TRIAZOL 3 YLSULFANYL)PROPYLCARBAMATE; TERT BUTYL 3 [(CYANOIMINO)(PHENOXY)METHYLAMINO]PROPYLCARBAMATE; TERT BUTYL 3-(5 AMINO 1H 1,2,4 TRIAZOL 3 YLAMINO)PROPYLCARBAMATE; TERT BUTYL 4 (5 AMINO 1H 1,2,4 TRIAZOL 3 YLAMINO)BUTYLCARBAMATE; TERT BUTYL 4 [(CYANOIMINO)(PHENOXY)METHYLAMINO]BUTYLCARBAMATE; TERT BUTYL 5 [IMINO(METHYLSULFANYL)METHYLAMINO] 5 OXOPENTYLCARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CYCLIZATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSECT CELL; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

BIOISOSTERES; H3 RECEPTOR; H4 RECEPTOR; HISTAMINE; IMBUTAMINE;

ANIMALS; BUTYLAMINES; DRUG DESIGN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HISTAMINE; HISTAMINE AGONISTS; HUMANS; IMIDAZOLES; LIGANDS; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3; SF9 CELLS; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84893807003     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300316     Document Type: Article

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