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Volumn 24, Issue 3, 1989, Pages 249-257

Non-basic histamine H1-antagonists. I. Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds

(10) Ife, Robert J a Catchpole, Keith W a Durant, Graham J a Robin Ganellin, C a Harvey, Carol A a Meeson, Malcolm L a Owen, David A A a Parsons, Michael E a Slingsby, Brian P a Theobald, Colin J a

a GLAXOSMITHKLINE (United Kingdom)

Author keywords

aminopyrimidones; antihistamines; CNS penetration; H1 antagonists; halopyridines; histamine; isocytosines

Indexed keywords

2 [3 (5 CHLORO 3 METHYL 2 PYRIDYLAMINO)PROPYLAMINO] 5 (6 METHYL 3 PYRIDYLMETHYL) 4 PYRIMIDINONE; 2 AMINO 4 PYRIMIDINONE DERIVATIVE; 5 (4,6 DIMETHYL 3 PYRIDYL) 2 [4 (3 METHOXY 2 PYRIDYL)BUTYLAMINO] 4 PYRIMIDINONE; CHLORPHENIRAMINE; HISTAMINE H1 RECEPTOR; ICOTIDINE; MEPYRAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN; BRONCHOSPASM; CAT; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0024358446 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/0223-5234(89)90006-8 Document Type: Article

Times cited : (13)

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