Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells

European Journal of Pharmacology

Volumn 723, Issue 1, 2014, Pages 276-287

  Lubecka Pietruszewska, Katarzyna ^a   Kaufman Szymczyk, Agnieszka ^a   Stefanska, Barbara ^b,c   Cebula Obrzut, Barbara ^a   Smolewski, Piotr ^a   Fabianowska Majewska, Krystyna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b PURDUE UNIVERSITY   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Breast cancer; Clofarabine; Epigenetic therapy; Promoter methylation; Tumour suppressor genes

Indexed keywords

BREAST CANCER; CLOFARABINE; EPIGENETIC THERAPY; PROMOTER METHYLATION; TUMOUR SUPPRESSOR GENES;

ADENINE NUCLEOTIDES; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; ARABINONUCLEOSIDES; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; PROMOTER REGIONS, GENETIC; PTEN PHOSPHOHYDROLASE; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84893753036     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.11.021     Document Type: Article

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