-
1
-
-
0007595762
-
Synthesis and biological evaluations of certain 2-halo-2′-substituted derivatives of 9-β-D-arabinofuranosyladenine
-
Secrist, J A., III, Shortnacy, A. T , and Montgomery, J A. Synthesis and biological evaluations of certain 2-halo-2′-substituted derivatives of 9-β-D-arabinofuranosyladenine. J Med Chem., 31: 405-410, 1988
-
(1988)
J Med Chem
, vol.31
, pp. 405-410
-
-
Secrist III, J.A.1
Shortnacy, A.T.2
Montgomery, J.A.3
-
2
-
-
0026533461
-
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabinofluoro-2′ deoxadenosine
-
Carson, D. A., Wasson, D B , Esparza, L M., Carrera, C. J., Kipps, T. J., and Cottam, H B Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabinofluoro-2′ deoxadenosine. Proc. Natl. Acad. Sci USA, 89. 2970-2974, 1992.
-
(1992)
Proc. Natl. Acad. Sci USA
, vol.89
, pp. 2970-2974
-
-
Carson, D.A.1
Wasson, D.B.2
Esparza, L.M.3
Carrera, C.J.4
Kipps, T.J.5
Cottam, H.B.6
-
3
-
-
0013515937
-
Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
-
Waud, W. R. Schmid, S. M., Harrison, S D., Jr., Secrist, J. A., III, and Montgomery, J. A. Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine Proc. Am Assoc Cancer Res., 33 545, 1992.
-
(1992)
Proc. Am Assoc Cancer Res.
, vol.33
, pp. 545
-
-
Waud, W.R.1
Schmid, S.M.2
Harrison Jr., S.D.3
Secrist III, J.A.4
Montgomery, J.A.5
-
4
-
-
0026565544
-
Synthesis and biologic activity of 2′-fiuoro-2-halo derivatives of 9-β-D-arabinofuranosyladenine
-
Montgomery, J A , Shortnacy-Power, A. T., Clayton, S D , Riordan, J. M., and Secrist, J. A., III. Synthesis and biologic activity of 2′-fiuoro-2-halo derivatives of 9-β-D-arabinofuranosyladenine. J. Med. Chem., 35. 397-401, 1992
-
(1992)
J. Med. Chem.
, vol.35
, pp. 397-401
-
-
Montgomery, J.A.1
Shortnacy-Power, A.T.2
Clayton, S.D.3
Riordan, J.M.4
Secrist III, J.A.5
-
5
-
-
0014930807
-
Calf intestine adenosine deaminase. Substrate specificity
-
Simon, L. N., Bauer, R. J , Tolman, R L., and Robins, R K. Calf intestine adenosine deaminase. Substrate specificity. Biochemistry, 9: 573-577, 1970
-
(1970)
Biochemistry
, vol.9
, pp. 573-577
-
-
Simon, L.N.1
Bauer, R.J.2
Tolman, R.L.3
Robins, R.K.4
-
6
-
-
0023261751
-
Phosphorolytic cleavage of 2-fluoroadenine from 9-β-D-arabinofuranosyl-2-fluoroadenine by Escherichia coli
-
Huang, P , and Plunkett, W. Phosphorolytic cleavage of 2-fluoroadenine from 9-β-D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. Biochem. Pharmacol , 36: 2945-2950, 1987.
-
(1987)
Biochem. Pharmacol
, vol.36
, pp. 2945-2950
-
-
Huang, P.1
Plunkett, W.2
-
7
-
-
0028886682
-
Kinetics of 2-chloro-2′-deoxyadenosine and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine in isolated perfused rat liver
-
Albertioni, F., Hassan, M., Sillerring, J., and Liliemark, J. Kinetics of 2-chloro-2′-deoxyadenosine and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine in isolated perfused rat liver Eur. J. Drug Metab Pharmacokinet., 20. 225-232, 1995.
-
(1995)
Eur. J. Drug Metab Pharmacokinet.
, vol.20
, pp. 225-232
-
-
Albertioni, F.1
Hassan, M.2
Sillerring, J.3
Liliemark, J.4
-
8
-
-
0028314452
-
Pharmacokinetics of the anticancer agent 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosy-1)adenine in rats
-
Qian, M , Wang, X., Shanmuganathan, K., Chu, C. K., and Gallo, J. M. Pharmacokinetics of the anticancer agent 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosy-1)adenine in rats. Cancer Chemother. Pharmacol., 33: 484-488, 1994.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.33
, pp. 484-488
-
-
Qian, M.1
Wang, X.2
Shanmuganathan, K.3
Chu, C.K.4
Gallo, J.M.5
-
9
-
-
0004913242
-
Membrane transport of 2-chloro-2′-deoxyadenosine and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine is required for cytotoxicity
-
King, K M., and Cass, C E Membrane transport of 2-chloro-2′-deoxyadenosine and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine is required for cytotoxicity Proc. Am Assn. Cancer Res., 35: 577, 1994.
-
(1994)
Proc. Am Assn. Cancer Res.
, vol.35
, pp. 577
-
-
King, K.M.1
Cass, C.E.2
-
10
-
-
0025811415
-
Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate
-
Parker, W B., Shaddix, C. C., Chang, C. H., White, E L , Rose, L. M., Brockman, R. W , Shortnacy, A. T., Montgomery, J. A., Secrist, J. A., III, and Bennett, L. L., Jr. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate. Cancer Res., 51 2386-2394, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 2386-2394
-
-
Parker, W.B.1
Shaddix, C.C.2
Chang, C.H.3
White, E.L.4
Rose, L.M.5
Brockman, R.W.6
Shortnacy, A.T.7
Montgomery, J.A.8
Secrist III, J.A.9
Bennett Jr., L.L.10
-
11
-
-
0029053894
-
Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine in human lymphoblastoid cells
-
Xie, C , and Plunkett, W Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine in human lymphoblastoid cells. Cancer Res , 55. 2847-2852, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 2847-2852
-
-
Xie, C.1
Plunkett, W.2
-
13
-
-
0023925454
-
Interactions between deoxyribonucleotide and DNA synthesis
-
Reichard, P Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev Biochem , 57: 349-374, 1988
-
(1988)
Annu. Rev Biochem
, vol.57
, pp. 349-374
-
-
Reichard, P.1
-
14
-
-
3042910622
-
Inhibition of DNA synthesis in CCRF-CEM cells by 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
-
Xie, C., and Plunkett, W. Inhibition of DNA synthesis in CCRF-CEM cells by 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine Proc Am Assn Cancer Res., 33: 512, 1992.
-
(1992)
Proc Am Assn Cancer Res
, vol.33
, pp. 512
-
-
Xie, C.1
Plunkett, W.2
-
15
-
-
3042915727
-
A simple one flask synthesis of nucleoside 5′-triphosphates from unprotected nucleosides via nucleoside 5′-cyclotriphosphates
-
K S Bruzik and W J. Stec (eds ), Biophosphates and Their Analogues: Synthesis, Structure, Metabolism and Activity. Amsterdam: Elsevier Science Publishers B. V.
-
Ludwig, J A simple one flask synthesis of nucleoside 5′-triphosphates from unprotected nucleosides via nucleoside 5′-cyclotriphosphates. In. K S Bruzik and W J. Stec (eds ), Biophosphates and Their Analogues: Synthesis, Structure, Metabolism and Activity. Proceedings of the 2nd International Symposium on Phosphorus Chemistry Directed Towards Biology, pp. 201-204 Amsterdam: Elsevier Science Publishers B. V., 1987
-
(1987)
Proceedings of the 2nd International Symposium on Phosphorus Chemistry Directed Towards Biology
, pp. 201-204
-
-
Ludwig, J.1
-
16
-
-
0025130572
-
Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine: A mechanism for cytotoxicity
-
Huang, P , Chubb, S., and Plunkett, W. Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine: a mechanism for cytotoxicity J Biol Chem , 265: 16617-16625, 1990.
-
(1990)
J Biol Chem
, vol.265
, pp. 16617-16625
-
-
Huang, P.1
Chubb, S.2
Plunkett, W.3
-
17
-
-
0025049372
-
Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine
-
Heinemann, V , Xu, Y-Z., Chubb, S., Sen, A., Hertel, L. W., Grindey, G. B., and Plunkett, W Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol Pharmacol , 38: 567-572, 1990.
-
(1990)
Mol Pharmacol
, vol.38
, pp. 567-572
-
-
Heinemann, V.1
Xu, Y.-Z.2
Chubb, S.3
Sen, A.4
Hertel, L.W.5
Grindey, G.B.6
Plunkett, W.7
-
18
-
-
0024402491
-
Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers
-
Sherman, P., and Fyfe, J A. Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers Anal. Biochem., 180: 222-226, 1989
-
(1989)
Anal. Biochem.
, vol.180
, pp. 222-226
-
-
Sherman, P.1
Fyfe, J.A.2
-
19
-
-
0017681196
-
DNA sequencing with chain-terminating inhibitors
-
Sanger, F , Nicklen, S , and Coulson, A. R DNA sequencing with chain-terminating inhibitors Proc. Natl. Acad. Sci USA, 74: 5463-5467, 1977
-
(1977)
Proc. Natl. Acad. Sci USA
, vol.74
, pp. 5463-5467
-
-
Sanger, F.1
Nicklen, S.2
Coulson, A.R.3
-
20
-
-
0025950771
-
The mechanism of DNA polymerase α inhibition by aphidicolin
-
Sheaff, R., Ilsley, D., and Kuchta, R The mechanism of DNA polymerase α inhibition by aphidicolin. Biochemistry, 30. 8590-8597, 1991
-
(1991)
Biochemistry
, vol.30
, pp. 8590-8597
-
-
Sheaff, R.1
Ilsley, D.2
Kuchta, R.3
-
21
-
-
0020541188
-
Ribonucleotide reductase - A radical enzyme
-
Washington DC
-
Reichard, P , and Eherenberg, A Ribonucleotide reductase - a radical enzyme. Science (Washington DC), 221: 514-519, 1983.
-
(1983)
Science
, vol.221
, pp. 514-519
-
-
Reichard, P.1
Eherenberg, A.2
-
23
-
-
0025788158
-
Synthesis of DNA by DNA polymerase ε in vitro
-
Lee, S-H., Pan, Z-Q., Kwong, A. D , Burgers, P. M. J., and Hurwitz, J. Synthesis of DNA by DNA polymerase ε in vitro. J. Biol. Chem., 266. 22707-22717, 1991
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 22707-22717
-
-
Lee, S.-H.1
Pan, Z.-Q.2
Kwong, A.D.3
Burgers, P.M.J.4
Hurwitz, J.5
-
24
-
-
0026098470
-
Properties of DNA polymerases δ and ε, and their roles in eukaryotic DNA replication
-
Bambara, R A , and Jessee, C. B Properties of DNA polymerases δ and ε, and their roles in eukaryotic DNA replication Biochim. Biophys. Acta, 1088: 11-24, 1991
-
(1991)
Biochim. Biophys. Acta
, vol.1088
, pp. 11-24
-
-
Bambara, R.A.1
Jessee, C.B.2
-
26
-
-
0021133987
-
Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis
-
Eriksson, S., Graslund, A , Skog, S , Thelander, L , and Tribukait, B. Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis. J. Biol Chem., 259 11695-11700, 1984.
-
(1984)
J. Biol Chem.
, vol.259
, pp. 11695-11700
-
-
Eriksson, S.1
Graslund, A.2
Skog, S.3
Thelander, L.4
Tribukait, B.5
-
27
-
-
0028952497
-
Functional compartmentation of dCTP pools. Preferential utilization of salvaged deoxycytidine for DNA repair in human lymphoblasts
-
Xu, Y-Z., Huang, P , and Plunkett, W Functional compartmentation of dCTP pools. Preferential utilization of salvaged deoxycytidine for DNA repair in human lymphoblasts. J. Biol Chem , 270: 631-637, 1995
-
(1995)
J. Biol Chem
, vol.270
, pp. 631-637
-
-
Xu, Y.-Z.1
Huang, P.2
Plunkett, W.3
-
28
-
-
0024787036
-
Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells
-
Griffig, J , Koob, R., and Blakley, R L. Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells. Cancer Res., 49: 6923-6928, 1989.
-
(1989)
Cancer Res.
, vol.49
, pp. 6923-6928
-
-
Griffig, J.1
Koob, R.2
Blakley, R.L.3
-
29
-
-
0025890427
-
Metabolism and action of purine nucleoside analogs
-
Plunkett, W., and Saunders, P P. Metabolism and action of purine nucleoside analogs Pharmacol. Ther , 49: 239-268, 1991.
-
(1991)
Pharmacol. Ther
, vol.49
, pp. 239-268
-
-
Plunkett, W.1
Saunders, P.P.2
-
30
-
-
0025737572
-
2′-Deoxy-2′-difluorodeoxycytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates, potent mechanism-based inhibitors of ribonucleotide reductase
-
Baker, C. H., Banzon, J , Bollinger, J. M , Stubbe, J., Samano, V., Robins, M. J., Lippert, B., Jarvi, E , and Resvick, R. 2′-Deoxy-2′-difluorodeoxycytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates, potent mechanism-based inhibitors of ribonucleotide reductase. J. Med. Chem., 34: 1879-1884, 1991.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1879-1884
-
-
Baker, C.H.1
Banzon, J.2
Bollinger, J.M.3
Stubbe, J.4
Samano, V.5
Robins, M.J.6
Lippert, B.7
Jarvi, E.8
Resvick, R.9
-
31
-
-
0027200169
-
Long-term follow-up of patients with chrome lymphocytic leukemia treated with fludarabine as a single agent
-
Keating, M. J , O'Brien, S , Kantarjian, H., Plunkett, W., Estey, E., Koller, C., Beran, M , and Freireich, E J Long-term follow-up of patients with chrome lymphocytic leukemia treated with fludarabine as a single agent Blood. 81 2878-2884, 1993
-
(1993)
Blood
, vol.81
, pp. 2878-2884
-
-
Keating, M.J.1
O'Brien, S.2
Kantarjian, H.3
Plunkett, W.4
Estey, E.5
Koller, C.6
Beran, M.7
Freireich, E.J.8
-
32
-
-
0029118503
-
Purine nucleoside analogs: Emerging roles in indolent lymphoproliferative disorders
-
Tallman, M. S., and Hakimian, D. Purine nucleoside analogs: emerging roles in indolent lymphoproliferative disorders. Blood. 86: 2463-2474, 1995
-
(1995)
Blood
, vol.86
, pp. 2463-2474
-
-
Tallman, M.S.1
Hakimian, D.2
-
33
-
-
0028219970
-
2-Chlorodeoxyadenosine a newer purine analog active in the treatment of indolent lymphoid malignancies
-
Saven, A , and Piro, L. D 2-Chlorodeoxyadenosine a newer purine analog active in the treatment of indolent lymphoid malignancies. Ann Intern. Med., 120: 784-791. 1994.
-
(1994)
Ann Intern. Med.
, vol.120
, pp. 784-791
-
-
Saven, A.1
Piro, L.D.2
-
34
-
-
0028022127
-
Gemcitabine: Current status of phase I and phase II trials
-
Kaye, S. B Gemcitabine: current status of phase I and phase II trials. J. Clin Oncol., 12: 1527-1531, 1994.
-
(1994)
J. Clin Oncol.
, vol.12
, pp. 1527-1531
-
-
Kaye, S.B.1
-
35
-
-
0027436016
-
Fludarabine pharmacokinetics, mechanisms of action, and rationales for combination therapies
-
Plunkett, W , Gandhi, V., Huang, P., Robertson, L. E , Yang, L-Y, Gregoire, V , Estey, E., and Keating, M. J. Fludarabine pharmacokinetics, mechanisms of action, and rationales for combination therapies Semin Oncol , 20 (Suppl.7): 2-12, 1993
-
(1993)
Semin Oncol
, vol.20
, Issue.7 SUPPL.
, pp. 2-12
-
-
Plunkett, W.1
Gandhi, V.2
Huang, P.3
Robertson, L.E.4
Yang, L.-Y.5
Gregoire, V.6
Estey, E.7
Keating, M.J.8
-
36
-
-
0028799108
-
Gemcitabine: Metabolism, mechanisms of action, and self-potentiation
-
Plunkett, W , Huang, P , Xu, Y-Z, Heinemann, V., Grunewald, R., and Gandhi, V Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin Oncol., 22 (Suppl. 11): 3-10, 1995
-
(1995)
Semin Oncol.
, vol.22
, Issue.11 SUPPL.
, pp. 3-10
-
-
Plunkett, W.1
Huang, P.2
Xu, Y.-Z.3
Heinemann, V.4
Grunewald, R.5
Gandhi, V.6
-
37
-
-
0000243802
-
Pharmacokinetics of arabinosylcytosine
-
Plunkett, W., and Gandhi, V. Pharmacokinetics of arabinosylcytosine. J. Infus Chemother., 2: 169-176, 1992
-
(1992)
J. Infus Chemother.
, vol.2
, pp. 169-176
-
-
Plunkett, W.1
Gandhi, V.2
-
38
-
-
0025295958
-
Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
-
Gandhi, V., and Plunkett, W. Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides Cancer Res., 50: 3675-3680, 1990
-
(1990)
Cancer Res.
, vol.50
, pp. 3675-3680
-
-
Gandhi, V.1
Plunkett, W.2
-
39
-
-
0027450455
-
Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy
-
Gandhi, V , Estey, E , Keating, M. J , and Plunkett, W Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy. J. Clin. Oncol., 11. 116-124, 1993
-
(1993)
J. Clin. Oncol.
, vol.11
, pp. 116-124
-
-
Gandhi, V.1
Estey, E.2
Keating, M.J.3
Plunkett, W.4
-
40
-
-
0030042611
-
Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: Pharmacokinetic, pharmacodynamic, and molecular interactions
-
Gandhi, V., Estey, E , Keating, M. J., Chucrallah, A., and Plunkett, W Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions. Blood, 87: 256-264, 1996.
-
(1996)
Blood
, vol.87
, pp. 256-264
-
-
Gandhi, V.1
Estey, E.2
Keating, M.J.3
Chucrallah, A.4
Plunkett, W.5
-
41
-
-
0029019181
-
Arabinosyl-2-fluoroaderine augments cisplatin cytotoxicity and inhibits cisplatin-DNA cross-link repair
-
Yang, L-Y., Li, L , Keating, M J , and Plunkett, W. Arabinosyl-2-fluoroaderine augments cisplatin cytotoxicity and inhibits cisplatin-DNA cross-link repair. Mol Pharmacol , 47. 1072-1079, 1995.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 1072-1079
-
-
Yang, L.-Y.1
Li, L.2
Keating, M.J.3
Plunkett, W.4
-
42
-
-
0027976379
-
Potentiation of radiation-induced regrowth delay in murine tumors by fludarabine
-
Gregoire, V., Hunter, N., Milas, L., Brock, W. A., Plunkett, W., and Hittelman, W. N Potentiation of radiation-induced regrowth delay in murine tumors by fludarabine Cancer Res , 54: 468-474, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 468-474
-
-
Gregoire, V.1
Hunter, N.2
Milas, L.3
Brock, W.A.4
Plunkett, W.5
Hittelman, W.N.6
-
43
-
-
0028240063
-
Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells
-
Shewach, D. S., Hahn, T. M., Chang, E., Hertel, L. W., and Lawrence, T. S. Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res., 54: 3218-3223, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 3218-3223
-
-
Shewach, D.S.1
Hahn, T.M.2
Chang, E.3
Hertel, L.W.4
Lawrence, T.S.5
|