Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers

British Journal of Cancer

Volumn 85, Issue 1, 2001, Pages 69-73

  Jin, Z ^a   Tamura, G ^a   Tsuchiya, T ^a   Sakata, K ^a   Kashiwaba, M ^b   Osakabe, M ^a   Motoyama, T ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

APC; Breast cancer; Hypermethylation; Methylation specific PCR

Indexed keywords

BETA CATENIN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER STAGING; COLON POLYPOSIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE DISRUPTION; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ADULT; ALLELES; BETA CATENIN; BREAST NEOPLASMS; CPG ISLANDS; CYTOSKELETAL PROTEINS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENES, APC; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATORS;

EID: 0035816342     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1853     Document Type: Article

References (36)

1. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas
2. No evidence for mutations in the α-and β-catenin genes in human gastric and breast carcinomas
3. High sensitivity mapping of methylated cytosines
4. Compartment switching of WNT-2 expression in human breast tumors
5. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
6. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
7. Low frequency of p16/CDKN2A methylation in sporadic melanoma: Comparative approaches for methylation analysis of primary tumors
8. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
9. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 β
10. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
11. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
12. Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma
13. Reduced expression of APC and DCC gene protein in breast cancer
14. CpG-island methylation in aging and cancer
15. Cancer epigenetics comes of age
16. Involvement of adenomatous polyposis coli (APC)/β-catenin signalling in human breast cancer
17. Aberrations of the APC gene in primary breast carcinoma
18. Lessons from hereditary colorectal cancer
19. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma
20. Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
21. β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
22. CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site
23. Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas
24. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
25. Axin, an inhibitor of the Wnt signalling pathway, interacts with β-catenin, GSK-3 β and APC and reduces the β-catenin level
26. Frequent somatic mutations of the β-catenin gene in intestinal-type gastric cancer
27. Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells
28. Association of the APC gene product with β-catenin
29. Stabilization of β-catenin by genetic defects in melanoma cell lines
30. APC truncation and increased β-catenin levels in a human breast cancer cell line
31. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
32. Association of the APC tumor suppressor protein with catenins
33. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas
34. Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer
35. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia