Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1029-1032

  Krawczyk, B ^a   Fabianowska Majewska, Krystyna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Cladribine; Decitabine; Fludarabine; PTEN and APC methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADENINE DERIVATIVE; APC PROTEIN; BETA DEXTRO ARABINOFURANOSYL 2 FLUOROADENINE; BRCA1 PROTEIN; CLADRIBINE; ESTROGEN RECEPTOR ALPHA; NUCLEOSIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN K 562; CELL STRAIN MCF 7; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA SYNTHESIS INHIBITION; DRUG EFFECT; ERYTHROLEUKEMIA CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

AZACITIDINE; BREAST NEOPLASMS; CADHERINS; CELL LINE, TUMOR; CLADRIBINE; DNA METHYLATION; ESTROGEN RECEPTOR ALPHA; GENES, APC; GENES, BRCA1; HUMANS; K562 CELLS; NUCLEOSIDES; PROMOTER REGIONS (GENETICS); PTEN PHOSPHOHYDROLASE; VIDARABINE;

EID: 33750444968     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600890764     Document Type: Article

References (8)

1. Pettitt, A.R. Mechanism of action of purine analogues in chronic lymphocytic leukaemia. Br. J. Haematol. 2003, 121, 692-702.
2. Wyczechowska, D.; Fabianowska-Majewska, K. The effects of cladribine and fludarabine on DNA methylation in K562 cells. Biochem. Pharmacol. 2003, 65, 219-225.
3. Widschwendter, M.; Jones, P.A. DNA methylation and breast carcinogenesis. Oncogene 2002, 21, 5462-5482.
4. Yamada, K.M.; Araki, M. Tumor suppressor PTEN, modulator of cell signaling, growth migration and apoptosis. J. Cell Science 2001, 114, 2375-2382.
5. Goss, K.H.; Groden, J. Biology of the adenomatous polyposis coli tumor suppressor. J. Cli. Oncol. 2000, 18, 1967-1979.
6. Garcia, J.M.; Silva, J.; Pena, C.; Garcia, V.; Rodriguez, R.; Cruz, M.A.; Cantos, B.; Provencio, M.; Espana, P.; Bonilla, F. Promoter methylation of the PTEN gene is a common molecular change in breast cancer. Genes Chromosomes Cancer 2004, 41, 117-124.
7. Virmani, A.K.; Rathi, A.; Sathyanarayana, U.G.; Padar, A.; Huang, C.X.; Cunningham, H.T.; Farinas, A.J.; Milchgrub, S.; Euhus, D.M.; Gilcrease, M.; Herman, J.; Minna, J.D.; Gazdar, A.F. Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas. Int. J. Cancer Res. 2001, 7, 1998-2004.
8. Iwase, H.; Omoto, Y.; Iwata, H.; Toyama, T.; Hara, Y.; Ando, Y.; Ito, Y.; Fuji, Y.; Kobayashi, S. DNA methylation analysis at distal and proximal promoter regions of the oestrogen receptor gene in breast cancers. Brit. J. Cancer 1999, 80, 1982-1986.