Promoter hypermethylation of the cyclin-dependent kinase inhibitor (CDKI) gene p21WAF1/CIP1/SDI1 is rare in various lymphomas and carcinomas [2]

Blood

Volumn 103, Issue 2, 2004, Pages 743-746

  Ying, Jianming ^b   Srivastava, Gopesh ^b   Gao, Zifen ^b   Zhang, Xiaohua ^b   Murray, Paul ^b   Ambinder, Richard ^b   Tao, Qian ^a  

^a Johns Hopkins Singapore   (Singapore)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P21;

CARCINOMA; CONTROLLED STUDY; CPG ISLAND; EXON; GENE SEQUENCE; HUMAN; HUMAN CELL; LETTER; LYMPHOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; RAJI CELL; RESTRICTION MAPPING; SEQUENCE ANALYSIS; TUMOR CELL LINE;

EID: 0942298594     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-08-2896     Document Type: Letter

References (11)

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2. Roman-Gomez J, Castillejo JA, Jimenez A, et al. 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood. 2002;99:2291-2296.
3. Shen L, Kondo Y, Issa JP, Garcia-Manero G. Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia. Blood. 2002;100:3432-3433.
4. Kikuchi T, Toyota M, Itoh F, et al. Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors. Oncogene. 2002;21:2741-2749.
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8. Shin JY, Kim HS, Park J, Park JB, Lee JY. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. Cancer Res. 2000;60:262-265.
9. Go JH. Methylation analysis of cyclin-dependent kinase inhibitor genes in primary gastrointestinal lymphomas. Mod Pathol. 2003;16:752-755.
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11. Richon VM, Sandhoff TW, Rifkind RA, Marks PA. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci U S A. 2000;97:10014-10019.