Mesenchymal stem cells in immune-mediated bone marrow failure syndromes

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Kastrinaki, Maria Christina ^a   Pavlaki, Konstantia ^a   Batsali, Aristea K ^a   Kouvidi, Elisavet ^a   Mavroudi, Irene ^a   Pontikoglou, Charalampos ^a   Papadaki, Helen A ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

APLASTIC ANEMIA; CELL DIFFERENTIATION; CYTOLOGY; HUMAN; IMMUNOLOGY; MESENCHYMAL STROMA CELL; METABOLISM; MYELODYSPLASTIC SYNDROME; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; REVIEW;

ANEMIA, APLASTIC; CELL DIFFERENTIATION; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; MESENCHYMAL STROMAL CELLS; MYELODYSPLASTIC SYNDROMES; NEUTROPENIA;

EID: 84893748157     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/265608     Document Type: Review

References (111)

1. Ellis S. L., Nilsson S. K., The location and cellular composition of the hemopoietic stem cell niche. Cytotherapy 2012 14 2 135 143 2-s2.0-84855880098 10.3109/14653249.2011.630729
2. Cook D., Genever P., Regulation of mesenchymal stem cell differentiation. Advances in Experimental Medicine and Biology 2013 786 213 229 10.1007/978-94-007-6621-1-12
3. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells. Science 1999 284 5411 143 147 2-s2.0-0033515827 10.1126/science.284.5411.143 (Pubitemid 29282067)
4. Pontikoglou C., Delorme B., Charbord P., Human bone marrow native mesenchymal stem cells. Regenerative Medicine 2008 3 5 731 741 2-s2.0-55949095378 10.2217/17460751.3.5.731
5. Frenette P. S., Pinho S., Lucas D., Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine. Annual Review of Immunology 2013 31 285 316 10.1146/annurev-immunol- 032712-095919
6. Thanabalasundaram G., Arumalla N., Tailor H. D., Khan W. S., Regulation of differentiation of mesenchymal stem cells into musculoskeletal cells. Current Stem Cell Research and Therapy 2012 7 2 95 102 2-s2.0-84857778921 10.2174/157488812799218974
7. Woodbury D., Schwarz E. J., Prockop D. J., Adult rat and human bone marrow stromal cells differentiate into neurons. Journal of Neuroscience Research 2000 61 364 370 (Pubitemid 30620221)
8. Zhang L., Ye J. S., Decot V., Research on stem cells as candidates to be differentiated into hepatocytes. Bio-Medical Materials and Engineering 2012 22 105 111
9. Friedenstein A. J., Gorskaja U. F., Kulagina N. N., Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Experimental Hematology 1976 4 5 267 274 2-s2.0-0017119380
10. Huang G. T., Gronthos S., Shi S., Critical reviews in oral biology & medicine: mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in Regenerative Medicine. Journal of Dental Research 2009 88 9 792 806 2-s2.0-70349510607 10.1177/0022034509340867
11. Lin C. S., Lin G., Lue T. F., Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants. Stem Cells and Development 2012 21 15 2770 2778 10.1089/scd.2012.0176
12. Sabatini F., Petecchia L., Tavian M., De Villeroché V. J., Rossi G. A., Brouty-Boyé D., Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Laboratory Investigation 2005 85 8 962 971 2-s2.0-27144487780 10.1038/labinvest.3700300 (Pubitemid 41486421)
13. Karahuseyinoglu S., Cinar O., Kilic E., Kara F., Akay G. G., Demiralp D. Ö., Tukun A., Uckan D., Can A., Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells 2007 25 2 319 331 2-s2.0-33846923121 10.1634/stemcells.2006-0286 (Pubitemid 46232786)
14. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F. C., Krause D. S., Deans R. J., Keating A., Prockop D. J., Horwitz E. M., Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006 8 4 315 317 2-s2.0-33747713246 10.1080/14653240600855905 (Pubitemid 44269669)
15. Battula V. L., Treml S., Bareiss P. M., Gieseke F., Roelofs H., De Zwart P., Müller I., Schewe B., Skutella T., Fibbe W. E., Kanz L., Bühring H., Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Haematologica 2009 94 2 173 184 2-s2.0-59449093151 10.3324/haematol.13740
16. Hatzfeld A., Eid P., Peiffer I., Li M. L., Barbet R., Oostendorp R. A. J., Haydont V., Monier M.-N., Milon L., Fortunel N., Charbord P., Tovey M., Hatzfeld J., A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon α / β Leukemia 2007 21 4 714 724 2-s2.0-33947393200 10.1038/sj.leu.2404589 (Pubitemid 46444555)
17. Sugiyama T., Kohara H., Noda M., Nagasawa T., Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006 25 6 977 988 2-s2.0-33845445939 10.1016/j.immuni.2006.10.016 (Pubitemid 44894948)
18. Calvi L. M., Adams G. B., Weibrecht K. W., Weber J. M., Olson D. P., Knight M. C., Martin R. P., Schipani E., Divieti P., Bringhurst F. R., Milner L. A., Kronenberg H. M., Scadden D. T., Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003 425 6960 841 846 2-s2.0-0242268524 10.1038/nature02040 (Pubitemid 37351468)
19. Sacchetti B., Funari A., Michienzi S., Di Cesare S., Piersanti S., Saggio I., Tagliafico E., Ferrari S., Robey P. G., Riminucci M., Bianco P., Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007 131 2 324 336 2-s2.0-35348921682 10.1016/j.cell.2007.08.025 (Pubitemid 47592917)
20. Mayack S. R., Wagers A. J., Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood 2008 112 3 519 531 2-s2.0-50949111817 10.1182/blood-2008-01-133710
21. Chitteti B. R., Cheng Y., Poteat B., Rodriguez-Rodriguez S., Goebel W. S., Carlesso N., Kacena M. A., Srour E. F., Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function. Blood 2010 115 16 3239 3248 2-s2.0-77951455778 10.1182/blood-2009-09-246173
22. Naveiras O., Nardi V., Wenzel P. L., Hauschka P. V., Fahey F., Daley G. Q., Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 2009 460 7252 259 263 2-s2.0-67650504733 10.1038/nature08099
23. Omatsu Y., Sugiyama T., Kohara H., Kondoh G., Fujii N., Kohno K., Nagasawa T., The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity 2010 33 3 387 399 2-s2.0-77957020167 10.1016/j.immuni.2010.08.017
24. Tzeng Y. S., Li H., Kang Y. L., Chen W., Cheng W., Lai D., Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood 2011 117 2 429 439 2-s2.0-78751559016 10.1182/blood-2010-01-266833
25. Méndez-Ferrer S., Michurina T. V., Ferraro F., Mazloom A. R., MacArthur B. D., Lira S. A., Scadden D. T., Mag'Ayan A., Enikolopov G. N., Frenette P. S., Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010 466 7308 829 834 2-s2.0-77955646193 10.1038/nature09262
26. Sharma M., Afrin F., Satija N., Tripathi R. P., Gangenahalli G. U., Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow. Stem Cells and Development 2011 20 6 933 946 2-s2.0-79957833180 10.1089/scd.2010.0263
27. Chabanon A., Desterke C., Rodenburger E., Clay D., Guerton B., Boutin L., Bennaceur-Griscelli A., Pierre-Louis O., Uzan G., Abecassis L., Bourgeade M., Lataillade J., Le Bousse-Kerdilès M., A cross-talk between stromal cell-derived factor-1 and transforming growth factor- β controls the quiescence/cycling switch of CD34+ progenitors through FoxO3 and mammalian target of rapamycin. Stem Cells 2008 26 12 3150 3161 2-s2.0-58049192716 10.1634/stemcells.2008-0219
28. Lataillade J. J., Clay D., Dupuy C., Rigal S., Jasmin C., Bourin P., Le Bousse-Kerdilès M., Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival. Blood 2000 95 3 756 768 2-s2.0-0034141444 (Pubitemid 30062693)
29. Lataillade J. J., Clay D., Bourin P., Hérodin F., Dupuy C., Jasmin C., Le Bousse-Kerdilès M., Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism. Blood 2002 99 4 1117 1129 2-s2.0-0037082510 10.1182/blood.V99.4.1117 (Pubitemid 34547062)
30. Flores-Figueroa E., Varma S., Montgomery K., Distinctive contact between CD34+ hematopoietic progenitors and CXCL12+ CD271+ mesenchymal stromal cells in benign and myelodysplastic bone marrow. Laboratory Investigation 2012 92 1330 1341 10.1038/labinvest.2012.93
31. Dazzi F., Ramasamy R., Glennie S., Jones S. P., Roberts I., The role of mesenchymal stem cells in haemopoiesis. Blood Reviews 2006 20 3 161 171 2-s2.0-33646015065 10.1016/j.blre.2005.11.002
32. Kemp K. C., Hows J., Donaldson C., Bone marrow-derived mesenchymal stem cells. Leukemia and Lymphoma 2005 46 11 1531 1544 2-s2.0-28244440913 10.1080/10428190500215076 (Pubitemid 41700985)
33. da Silva Meirelles L., Fontes A. M., Covas D. T., Caplan A. I., Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine and Growth Factor Reviews 2009 20 5-6 419 427 2-s2.0-70849103924 10.1016/j.cytogfr.2009.10.002
34. von Bahr L., Sundberg B., Lönnies L., Sander B., Karbach H., Hägglund H., Ljungman P., Gustafsson B., Karlsson H., Le Blanc K., Ringdén O., Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biology of Blood and Marrow Transplantation 2012 18 4 557 564 2-s2.0-84858080480 10.1016/j.bbmt.2011. 07.023
35. Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P. D., Matteucci P., Grisanti S., Gianni A. M., Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002 99 10 3838 3843 2-s2.0-0037093058 10.1182/blood.V99.10.3838 (Pubitemid 34534559)
36. Asari S., Itakura S., Ferreri K., Liu C., Kuroda Y., Kandeel F., Mullen Y., Mesenchymal stem cells suppress B-cell terminal differentiation. Experimental Hematology 2009 37 5 604 615 2-s2.0-64249129065 10.1016/j.exphem.2009.01.005
37. Corcione A., Benvenuto F., Ferretti E., Giunti D., Cappiello V., Cazzanti F., Risso M., Gualandi F., Mancardi G. L., Pistoia V., Uccelli A., Human mesenchymal stem cells modulate B-cell functions. Blood 2006 107 1 367 372 2-s2.0-30144440925 10.1182/blood-2005-07-2657 (Pubitemid 43053565)
38. Spaggiari G. M., Moretta L., Cellular and molecular interactions of mesenchymal stem cells in innate immunity. Immunology & Cell Biology 2013 91 27 31
39. Luz-Crawford P., Kurte M., Bravo-Alegria J., Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem Cell Research & Therapy 2013 4 65
40. Chabannes D., Hill M., Merieau E., Rossignol J., Brion R., Soulillou J. P., Anegon I., Cuturi M. C., A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood 2007 110 10 3691 3694 2-s2.0-36349017810 10.1182/blood-2007-02-075481 (Pubitemid 350159638)
41. Jones B. J., Brooke G., Atkinson K., McTaggart S. J., Immunosuppression by placental indoleamine 2,3-dioxygenase: a role for mesenchymal stem cells. Placenta 2007 28 11-12 1174 1181 2-s2.0-35348823105 10.1016/j.placenta.2007.07. 001 (Pubitemid 47570911)
42. Sato K., Ozaki K., Oh I., Meguro A., Hatanaka K., Nagai T., Muroi K., Ozawa K., Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 2007 109 1 228 234 2-s2.0-33846006154 10.1182/blood-2006-02-002246 (Pubitemid 46053063)
43. Selmani Z., Naji A., Zidi I., Favier B., Gaiffe E., Obert L., Borg C., Saas P., Tiberghien P., Rouas-Freiss N., Carosella E. D., Deschaseaux F., Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+ CD25highFOXP3+ regulatory T cells. Stem Cells 2008 26 1 212 222 2-s2.0-38349053355 10.1634/stemcells.2007-0554
44. Waterman R. S., Tomchuck S. L., Henkle S. L., Betancourt A. M., A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. PLoS ONE 2010 5 4 2-s2.0-77956420421 10.1371/journal.pone.0010088 e10088
45. Chan J. L., Tang K. C., Patel A. P., Bonilla L. M., Pierobon N., Ponzio N. M., Rameshwar P., Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon- γ Blood 2006 107 12 4817 4824 2-s2.0-33745076513 10.1182/blood-2006-01-0057 (Pubitemid 43882633)
46. Krampera M., Cosmi L., Angeli R., Pasini A., Liotta F., Andreini A., Santarlasci V., Mazzinghi B., Pizzolo G., Vinante F., Romagnani P., Maggi E., Romagnani S., Annunziato F., Role for interferon- γ in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006 24 2 386 398 2-s2.0-33746889097 10.1634/stemcells.2005-0008 (Pubitemid 44464808)
47. Prasanna S. J., Gopalakrishnan D., Shankar S. R., Vasandan A. B., Pro-inflammatory cytokines, IFN γ and TNF α influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS ONE 2010 5 2 2-s2.0-77949308137 10.1371/journal.pone. 0009016 e9016
48. Campo E., Swerdlow S. H., Harris N. L., Pileri S., Stein H., Jaffe E. S., The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 2011 117 19 5019 5032 2-s2.0-79955961315 10.1182/blood-2011-01-293050
49. Greenberg P., Cox C., LeBeau M. M., Fenaux P., Morel P., Sanz G., Sanz M., Vallespi T., Hamblin T., Oscier D., Ohyashiki K., Toyama K., Aul C., Mufti G., Bennett J., International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997 89 6 2079 2088 2-s2.0-0030897009 (Pubitemid 27132124)
50. Beris P., Georgiou G., Overview of myelodysplastic syndromes. Seminars in Hematology 2012 49 4 287 294 10.1053/j.seminhematol.2012.07.002
51. Khan H., Vale C., Bhagat T., Role of DNA methylation in the pathogenesis and treatment of myelodysplastic syndromes. Seminars in Hematology 2013 50 1 16 37 10.1053/j.seminhematol.2013.01.001
52. Nimer S. D., Myelodysplastic syndromes. Blood 2008 111 10 4841 4851 2-s2.0-46749151451 10.1182/blood-2007-08-078139
53. Nolte F., Hofmann W., Myelodysplastic syndromes: molecular pathogenesis and genomic changes. Annals of Hematology 2008 87 10 777 795 2-s2.0-50849085449 10.1007/s00277-008-0502-z
54. Tiu R., Gondek L., O'Keefe C., Maciejewski J. P., Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes. Leukemia 2007 21 8 1648 1657 2-s2.0-34447627193 10.1038/sj.leu.2404757 (Pubitemid 47086755)
55. Fozza C., Longinotti M., The role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers. Leukemia Research 2013 37 2 201 203 10.1016/j.leukres.2012.11.007
56. Tauro S., Hepburn M. D., Peddie C. M., Bowen D. T., Pippard M. J., Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes. Leukemia 2002 16 5 785 790 2-s2.0-0036113574 10.1038/sj.leu.2402440 (Pubitemid 34537549)
57. Aizawa S., Nakano M., Iwase O., Yaguchi M., Hiramoto M., Hoshi H., Nabeshima R., Shima D., Handa H., Toyama K., Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leukemia Research 1999 23 3 239 246 2-s2.0-0032941565 10.1016/S0145-2126(98)00163-5 (Pubitemid 29083379)
58. Raaijmakers M. H., Mukherjee S., Guo S., Zhang S., Kobayashi T., Schoonmaker J. A., Ebert B. L., Al-Shahrour F., Hasserjian R. P., Scadden E. O., Aung Z., Matza M., Merkenschlager M., Lin C., Rommens J. M., Scadden D. T., Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010 464 7290 852 857 2-s2.0-77950862042 10.1038/nature08851
59. Walkley C. R., Olsen G. H., Dworkin S., Fabb S. A., Swann J., McArthur G., Westmoreland S. V., Chambon P., Scadden D. T., Purton L. E., A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor γ deficiency. Cell 2007 129 6 1097 1110 2-s2.0-34250331610 10.1016/j.cell.2007.05.014 (Pubitemid 46908696)
60. Flores-Figueroa E., Arana-Trejo R. M., Gutiérrez-Espíndola G., Pérez-Cabrera A., Mayani H., Mesenchymal stem cells in myelodysplastic syndromes: phenotypic and cytogenetic characterization. Leukemia Research 2005 29 2 215 224 2-s2.0-10644247684 10.1016/j.leukres.2004.06.011 (Pubitemid 39647516)
61. Flores-Figueroa E., Montesinos J. J., Flores-Guzmán P., Gutiérrez-Espíndola G., Arana-Trejo R. M., Castillo-Medina S., Pérez-Cabrera A., Hernández-Estévez E., Arriaga L., Mayani H., Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells. Leukemia Research 2008 32 9 1407 1416 2-s2.0-43049156408 10.1016/j.leukres.2008.02.013
62. Klaus M., Stavroulaki E., Kastrinaki M., Fragioudaki P., Giannikou K., Psyllaki M., Pontikoglou C., Tsoukatou D., Mamalaki C., Papadaki H. A., Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes. Stem Cells and Development 2010 19 7 1043 1054 2-s2.0-77954928083 10.1089/scd.2009.0286
63. Campioni D., Moretti S., Ferrari L., Punturieri M., Castoldi G. L., Lanza F., Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment. Haematologica 2006 91 3 364 368 2-s2.0-33645392228
64. Campioni D., Rizzo R., Stignani M., Melchiorri L., Ferrari L., Moretti S., Russo A., Bagnara G. P., Bonsi L., Alviano F., Lanzoni G., Cuneo A., Baricordi O. R., Lanza F., A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. Cytometry B 2009 76 3 225 230 2-s2.0-66949138068 10.1002/cyto.b.20461
65. Lopez-Villar O., Garcia J. L., Sanchez-Guijo F. M., Robledo C., Villaron E. M., Hernández-Campo P., Lopez-Holgado N., Diez-Campelo M., Barbado M. V., Perez-Simon J. A., Hernández-Rivas J. M., San-Miguel J. F., del Cañizo M.-C., Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q- syndrome. Leukemia 2009 23 4 664 672 2-s2.0-64849104318 10.1038/leu.2008.361
66. Geyh S., Oz S., Cadeddu R. P., Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells. Leukemia 2013 27 1841 1851 10.1038/leu.2013.193
67. Zhao Z. G., Xu W., Yu H. P., Fang B., Wu S., Li F., Li W., Li Q., Chen Z., Zou P., Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes. Cancer Letters 2012 317 2 136 143 2-s2.0-84856600396 10.1016/j.canlet.2011.08.030
68. Aanei C. M., Eloae F. Z., Flandrin-Gresta P., Tavernier E., Carasevici E., Guyotat D., Campos L., Focal adhesion protein abnormalities in myelodysplastic mesenchymal stromal cells. Experimental Cell Research 2011 317 18 2616 2629 2-s2.0-80053562733 10.1016/j.yexcr.2011.08.007
69. Yüksel M. K., Topçuolu P., Kurdal M., Ilhan O., The clonogenic potential of hematopoietic stem cells and mesenchymal stromal cells in various hematologic diseases: a pilot study. Cytotherapy 2010 12 1 38 44 2-s2.0-75449083192 10.3109/14653240903313958
70. Varga G., Kiss J., Várkonyi J., Vas V., Farkas P., Pálóczi K., Uher F., Inappropriate Notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplasia syndromes. Pathology and Oncology Research 2007 13 4 311 319 2-s2.0-39649091183 (Pubitemid 351287312)
71. Aanei C. M., Flandrin P., Eloae F. Z., Intrinsic growth deficiencies of mesenchymal stromal cells in myelodysplastic syndromes. Stem Cells and Development 2012 21 10 1604 1615 10.1089/scd.2011.0390
72. Zhao Z., Wang Z., Li Q., The different immunoregulatory functions of mesenchymal stem cells in patients with low-risk or high-risk myelodysplastic syndromes. PLoS ONE 2012 7 9 e45675
73. Marcondes A. M., Bair S., Rabinovitch P. S., Gooley T., Deeg H. J., Risques R., No telomere shortening in marrow stroma from patients with MDS. Annals of Hematology 2009 88 7 623 628 2-s2.0-67349197819 10.1007/s00277-008- 0649-7
74. Delorme B., Ringe J., Pontikoglou C., Gaillard J., Langonné A., Sensebé L., Noël D., Jorgensen C., Häupl T., Charbord P., Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity. Stem Cells 2009 27 5 1142 1151 2-s2.0-66149168688 10.1002/stem.34
75. Ramakrishnan A., Awaya N., Bryant E., Torok-Storb B., The stromal component of the marrow microenvironment is not derived from the malignant clone in MDS. Blood 2006 108 2 772 773 2-s2.0-33745963171 10.1182/blood-2006-02- 001479 (Pubitemid 44061386)
76. Soenen-Cornu V., Tourino C., Bonnet M., Guillier M., Flamant S., Kotb R., Bernheim A., Bourhis J., Preudhomme C., Fenaux P., Turhan A. G., Mesenchymal cells generated from patients with myelodysplastic syndromes are devoid of chromosomal clonal markers and support short- and long-term hematopoiesis in vitro. Oncogene 2005 24 15 2441 2448 2-s2.0-20944442426 10.1038/sj.onc.1208405 (Pubitemid 40593035)
77. Blau O., Baldus C. D., Hofmann W., Thiel G., Nolte F., Burmeister T., Türkmen S., Benlasfer O., Schümann E., Sindram A., Molkentin M., Mundlos S., Keilholz U., Thiel E., Blau I. W., Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts. Blood 2011 118 20 5583 5592 2-s2.0-81555196340 10.1182/blood-2011-03-343467
78. Blau O., Hofmann W., Baldus C. D., Thiel G., Serbent V., Schümann E., Thiel E., Blau I. W., Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia. Experimental Hematology 2007 35 2 221 229 2-s2.0-33846386176 10.1016/j.exphem.2006.10.012 (Pubitemid 46135819)
79. Han Q., Sun Z., Liu L., Chen B., Cao Y., Li K., Zhao R. C., Impairment in immuno-modulatory function of Flk1+CD31-CD34- MSCs from MDS-RA patients. Leukemia Research 2007 31 11 1469 1478 2-s2.0-35548960969 10.1016/j.leukres. 2006.12.016 (Pubitemid 350010962)
80. Wang Z., Tang X., Xu W., The different immunoregulatory functions on dendritic cells between mesenchymal stem cells derived from bone marrow of patients with low-risk or high-risk myelodysplastic syndromes. PLoS ONE 2013 8 3 e57470
81. Zhi-Gang Z., Wei-Ming L., Zhi-Chao C., Yong Y., Ping Z., Immunosuppressive properties of mesenchymal stem cells derived from bone marrow of patient with hematological malignant diseases. Leukemia and Lymphoma 2008 49 11 2187 2195 2-s2.0-57049184148 10.1080/10428190802455875
82. Santamaria C., Muntion S., Roson B., Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients. Haematologica 2012 97 8 1218 1224 10.3324/haematol.2011.054437
83. Guinan E. C., Diagnosis and management of aplastic anemia. Hematology 2011 2011 76 81 2-s2.0-84859387843
84. Li J. P., Zheng C. L., Han Z. C., Abnormal immunity and stem/progenitor cells in acquired aplastic anemia. Critical Reviews in Oncology/Hematology 2010 75 2 79 93 2-s2.0-77955049033 10.1016/j.critrevonc.2009.12.001
85. Giannakoulas N. C., Karakantza M., Theodorou G. L., Pagoni M., Galanopoulos A., Kakagianni T., Kouraklis-Symeonidis A., Matsouka P., Maniatis A., Zoumbos N. C., Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anaemia patients. British Journal of Haematology 2004 124 1 97 105 2-s2.0-9144270491 10.1046/j.1365-2141.2003.04729.x (Pubitemid 38021629)
86. Kook H., Zeng W., Guibin C., Kirby M., Young N. S., Maciejewski J. P., Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia. Experimental Hematology 2001 29 11 1270 1277 2-s2.0-0034765667 10.1016/S0301-472X(01)00736-6 (Pubitemid 33033303)
87. Zonghong S., Meifeng T., Huaquan W., Limin X., Jun W., Rong F., Hong L., Yuhong W., Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia. International Journal of Hematology 2011 93 2 156 162 2-s2.0-79952250762 10.1007/s12185-010-0761-z
88. Solomou E. E., Rezvani K., Mielke S., Malide D., Keyvanfar K., Visconte V., Kajigaya S., Barrett A. J., Young N. S., Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood 2007 110 5 1603 1606 2-s2.0-34548848237 10.1182/blood-2007-01-066258 (Pubitemid 47443977)
89. Dubey S., Shukla P., Nityanand S., Expression of interferon- γ and tumor necrosis factor- α in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia. Annals of Hematology 2005 84 9 572 577 2-s2.0-23944473434 10.1007/s00277-005-1022-8 (Pubitemid 41194543)
90. Sloand E., Kim S., Maciejewski J. P., Tisdale J., Follmann D., Young N. S., Intracellular interferon- γ in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood 2002 100 4 1185 1191 2-s2.0-0037103384 10.1182/blood-2002-01-0035 (Pubitemid 34864270)
91. Zeng W., Miyazato A., Chen G., Kajigaya S., Young N. S., Maciejewski J. P., Interferon- γ -induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles. Blood 2006 107 1 167 175 2-s2.0-30144446015 10.1182/blood-2005-05-1884 (Pubitemid 43053539)
92. Zoumbos N. C., Gascon P., Djeu J. Y., Young N. S., Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proceedings of the National Academy of Sciences of the United States of America 1985 82 1 188 192 2-s2.0-1842402749 (Pubitemid 15168240)
93. Rizzo S., Scopes J., Elebute M. O., Papadaki H. A., Gordon-Smith E. C., Gibson F. M., Stem cell defect in aplastic anemia: reduced long term culture-initiating cells (LTC-IC) in CD34+ cells isolated from aplastic anemia patient bone marrow. Hematology Journal 2002 3 5 230 236 2-s2.0-0036430336 10.1038/sj.thj.6200187 (Pubitemid 35331382)
94. Matsui W. H., Brodsky R. A., Smith B. D., Borowitz M. J., Jones R. J., Quantitative analysis of bone marrow CD34 cells in aplastic anemia and hypoplastic myelodysplastic syndromes. Leukemia 2006 20 3 458 462 2-s2.0-33644505823 10.1038/sj.leu.2404119 (Pubitemid 43291744)
95. Scopes J., Bagnara M., Gordon-Smith E. C., Ball S. E., Gibson F. M., Haemopoietic progenitor cells are reduced in aplastic anaemia. British Journal of Haematology 1994 86 2 427 430 2-s2.0-0028246610 (Pubitemid 24199023)
96. Timeus F., Crescenzio N., Doria A., Foglia L., Linari A., Giaccone M., Pastore G., Di Montezemolo L. C., Ramenghi U., Saracco P., Flow cytometric evaluation of circulating CD34+ cell counts and apoptotic rate in children with acquired aplastic anemia and myelodysplasia. Experimental Hematology 2005 33 5 597 604 2-s2.0-20944446075 10.1016/j.exphem.2005.02.005 (Pubitemid 40592177)
97. Killick S. B., Cox C. V., Marsh J. C. W., Gordon-Smith E. C., Gibson F. M., Mechanisms of bone marrow progenitor cell apoptosis in aplastic anaemia and the effect of anti-thymocyte globulin: examination of the role of the Fas-Fas-L interaction. British Journal of Haematology 2000 111 4 1164 1169 2-s2.0-0034487601 10.1046/j.1365-2141.2000.02485.x (Pubitemid 32104934)
98. Risitano A. M., Kook H., Zeng W., Chen G., Young N. S., Maciejewski J. P., Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V β CDR3 spectratyping and flow cytometry. Blood 2002 100 1 178 183 2-s2.0-0036660175 10.1182/blood-2002- 01-0236 (Pubitemid 35177445)
99. Zeng W., Maciejewski J. P., Chen G., Young N. S., Limited heterogeneity of T cell receptor BV usage in aplastic anemia. Journal of Clinical Investigation 2001 108 5 765 773 2-s2.0-0034793917 10.1172/JCI200112687 (Pubitemid 32906206)
100. Zoumbos N. C., Gascon P., Djeu J. Y., Circulating activated suppressor T lymphocytes in aplastic anemia. New England Journal of Medicine 1985 312 5 257 265 2-s2.0-0022006029 (Pubitemid 15199363)
101. Luther-Wyrsch A., Nissen C., Wodnar-Filipowicz A., Intracellular Fas ligand is elevated in T lymphocytes in severe aplastic anaemia. British Journal of Haematology 2001 114 4 884 890 2-s2.0-0034791955 10.1046/j.1365-2141.2001. 03026.x (Pubitemid 32953750)
102. Maciejewski J. P., Selleri C., Sato T., Anderson S., Young N. S., Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia. British Journal of Haematology 1995 91 1 245 252 2-s2.0-0029048258
103. Bacigalupo A., Valle M., Podestà M., Pitto A., Zocchi E., De Flora A., Pozzi S., Luchetti S., Frassoni F., Van Lint M. T., Piaggio G., T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia. Experimental Hematology 2005 33 7 819 827 2-s2.0-20444491475 10.1016/j.exphem.2005.05.006 (Pubitemid 40826596)
104. Xu Y., Takahashi Y., Wang Y., Hama A., Nishio N., Muramatsu H., Tanaka M., Yoshida N., Villalobos I. B., Yagasaki H., Kojima S., Downregulation of GATA-2 and overexpression of adipogenic gene-PPAR γ in mesenchymal stem cells from patients with aplastic anemia. Experimental Hematology 2009 37 12 1393 1399 2-s2.0-70449380277 10.1016/j.exphem.2009.09.005
105. Li J., Yang S., Lu S., Differential gene expression profile associated with the abnormality of bone marrow mesenchymal stem cells in aplastic anemia. PLoS ONE 2012 7 11 e47764
106. Chao Y., Peng C., Harn H., Chan C., Wu K., Poor potential of proliferation and differentiation in bone marrow mesenchymal stem cells derived from children with severe aplastic anemia. Annals of Hematology 2010 89 7 715 723 2-s2.0-77953042879 10.1007/s00277-009-0892-6
107. Shipounova I. N., Petrova T. V., Svinareva D. A., Momotuk K. S., Mikhailova E. A., Drize N. I., Alterations in hematopoietic microenvironment in patients with aplastic anemia. Clinical and Translational Science 2009 2 1 67 74 2-s2.0-77955069832 10.1111/j.1752-8062.2008.00074.x
108. Xu Y., Takahashi Y., Yoshimi A., Tanaka M., Yagasaki H., Kojima S., Immunosuppressive activity of mesenchymal stem cells is not decreased in children with aplastic anemia. International Journal of Hematology 2009 89 1 126 127 2-s2.0-67349198516 10.1007/s12185-008-0237-6
109. Papadaki H. A., Palmblad J., Eliopoulos G. D., Non-immune chronic idiopathic neutropenia of adult: an overview. European Journal of Haematology 2001 67 1 35 44 2-s2.0-0034887423 10.1034/j.1600-0609.2001.00473.x (Pubitemid 32769812)
110. Papadaki H. A., Eliopoulos A. G., Kosteas T., Gemetzi C., Damianaki A., Koutala H., Bux J., Eliopoulos G. D., Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood 2003 101 7 2591 2600 2-s2.0-0038107361 10.1182/blood-2002-09-2898 (Pubitemid 36857618)
111. Stavroulaki E., Kastrinaki M., Pontikoglou C., Eliopoulos D., Damianaki A., Mavroudi I., Pyrovolaki K., Katonis P., Papadaki H. A., Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor- β 1. Stem Cells and Development 2011 20 8 1309 1318 2-s2.0-80051526117 10.1089/scd.2010.0425