Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes

Leukemia

Volumn 16, Issue 5, 2002, Pages 785-790

  Tauro, S ^a   Hepburn, M D ^a   Peddie, C M ^a,b   Bowen, D T ^a   Pippard, M J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Apoptosis; Contact; Stroma; TNF

Indexed keywords

CYTOKINE; FAS ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; TUMOR NECROSIS FACTOR ALPHA;

AGED; APOPTOSIS; ARTICLE; BONE MARROW DISEASE; CELL ADHESION; CELL CONTACT; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKEMIA CELL LINE; MACROPHAGE; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STANDARDIZATION; STROMA; SUPERNATANT;

EID: 0036113574     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402440     Document Type: Article

References (16)

1. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
2. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
3. Regulatory role of hematopoietic growth factors in abnormal localization of immature precursors (ALIP) formation in myelodysplastic syndrome
4. Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes
5. Functional studies of bone marrow haemopoietic and stromal cells in the myelodysplastic syndrome (MDS)
6. Reduced growth of normal myeloid progenitors on MDS stroma is unrelated to confluence
7. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro
8. Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: A parental line requiring granulocyte-macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin
9. Localisation of granulocyte macrophage colony-stimulating factor in human long-term bone marrow cultures. Biological and immunocytochemical characterisation
10. Interleukin-3 is produced by normal stroma in long-term bone marrow cultures
11. Modification of human long-term bone marrow cultures: Establishment of a functional stromal microenvironment devoid of myeloid progenitors
12. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis
13. Increased apoptosis in aplastic anemia bone marrow progenitor cells: Possible pathophysiologic significance
14. Establishment of stromal cell line from an MDS RA patient which induced an apoptotic change in haemopoietic and leukaemic cells in vitro
15. Apoptosis in tumor necrosis factor-α dependent monocyte mediated leukemic cell death. A functional, morphological and flowcytometric analysis
16. Cellular and cytokine dependent monocyte-mediated leukemic cell death: Modulation by interferon-gamma and tumor necrosis factor-alpha