메뉴 건너뛰기




Volumn 92, Issue 9, 2012, Pages 1330-1341

Distinctive contact between CD34+ hematopoietic progenitors and CXCL12+ CD271+ mesenchymal stromal cells in benign and myelodysplastic bone marrow

Author keywords

bone marrow; CD271; CXCL12; mesenchymal stromal cell; microenvironment; myelodysplastic syndrome

Indexed keywords

CD146 ANTIGEN; NESTIN; PARAFFIN; STROMAL CELL DERIVED FACTOR 1;

EID: 84865635864     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.93     Document Type: Article
Times cited : (71)

References (53)
  • 1
    • 79959810834 scopus 로고    scopus 로고
    • Control of hematopoietic stem cells by the bone marrow stromal niche: The role of reticular cells
    • Nagasawa T, Omatsu Y, Sugiyama T. Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells. Trends Immunol 2011;32:315-320.
    • (2011) Trends Immunol , vol.32 , pp. 315-320
    • Nagasawa, T.1    Omatsu, Y.2    Sugiyama, T.3
  • 4
    • 34247512663 scopus 로고    scopus 로고
    • WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. International Agency for Research on Cancer: Lyon, France
    • Swerdlow S. International Agency for Research on Cancer: World Health Organization. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. International Agency for Research on Cancer: Lyon, France, 2008.
    • (2008) International Agency for Research on Cancer: World Health Organization
    • Swerdlow, S.1
  • 5
    • 33344478513 scopus 로고    scopus 로고
    • Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
    • DOI 10.1182/blood-2005-06-2211
    • Muguruma Y, Yahata T, Miyatake H, et al. Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 2006;107:1878-1887. (Pubitemid 43289366)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1878-1887
    • Muguruma, Y.1    Yahata, T.2    Miyatake, H.3    Sato, T.4    Uno, T.5    Itoh, J.6    Kato, S.7    Ito, M.8    Hotta, T.9    Ando, K.10
  • 6
    • 33847657159 scopus 로고    scopus 로고
    • 1-integrin-dependent mechanism
    • DOI 10.1634/stemcells.2006-0513
    • Gottschling S, Saffrich R, Seckinger A, et al. Human mesenchymal stromal cells regulate initial self-renewing divisions of hematopoietic progenitor cells by a beta1-integrin-dependent mechanism. Stem Cells 2007;25:798-806. (Pubitemid 46354240)
    • (2007) Stem Cells , vol.25 , Issue.3 , pp. 798-806
    • Gottschling, S.1    Saffrich, R.2    Seckinger, A.3    Krause, U.4    Horsch, K.5    Miesala, K.6    Ho, A.D.7
  • 7
    • 33646526915 scopus 로고    scopus 로고
    • Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells
    • Van Overstraeten-Schlögel N, Beguin Y, Gothot A. Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells. Eur J Haematol 2006;76:488-493.
    • (2006) Eur J Haematol , vol.76 , pp. 488-493
    • Van Overstraeten-Schlögel, N.1    Beguin, Y.2    Gothot, A.3
  • 9
    • 79956344963 scopus 로고    scopus 로고
    • Bone and the hematopoietic niche: A tale of two stem cells
    • Bianco P. Bone and the hematopoietic niche: a tale of two stem cells. Blood 2011;117:5281-5288.
    • (2011) Blood , vol.117 , pp. 5281-5288
    • Bianco, P.1
  • 10
    • 77954323523 scopus 로고    scopus 로고
    • Current therapeutic approaches for patients with myelodysplastic syndromes
    • Greenberg PL. Current therapeutic approaches for patients with myelodysplastic syndromes. Br J Haematol 2010;150:131-143.
    • (2010) Br J Haematol , vol.150 , pp. 131-143
    • Greenberg, P.L.1
  • 11
    • 0034766727 scopus 로고    scopus 로고
    • Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes
    • Tauro S, Hepburn MD, Bowen DT, et al. Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes. Haematologica 2001;86:1038-1045. (Pubitemid 33031869)
    • (2001) Haematologica , vol.86 , Issue.10 , pp. 1038-1045
    • Tauro, S.1    Hepburn, M.D.2    Bowen, D.T.3    Pippard, M.J.4
  • 12
    • 0036236034 scopus 로고    scopus 로고
    • In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndrome
    • DOI 10.1016/S0145-2126(01)00193-X, PII S014521260100193X
    • Flores-Figueroa E, Gutierrez-Espindola G, Montesinos JJ, et al. In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndrome. Leuk Res 2002;26:677-686. (Pubitemid 34465704)
    • (2002) Leukemia Research , vol.26 , Issue.7 , pp. 677-686
    • Flores-Figueroa, E.1    Gutierrez-Espindola, G.2    Montesinos, J.J.3    Arana-Trejo, R.M.4    Mayani, H.5
  • 14
    • 0027499588 scopus 로고
    • MDS-macrophage derived inhibitory activity on meylopoiesis of MDS abdominal clones
    • Ohmori S, Ohmori M, Yamagishi M, et al. MDS-macrophage derived inhibitory activity on myelopoiesis of MDS abnormal clones. Br J Haematol 1993;83:388-391. (Pubitemid 23080007)
    • (1993) British Journal of Haematology , vol.83 , Issue.3 , pp. 388-391
    • Ohmori, S.1    Ohmori, M.2    Yamagishi, M.3    Okuma, M.4
  • 15
    • 10644247684 scopus 로고    scopus 로고
    • Mesenchymal stem cells in myelodysplastic syndromes: Phenotypic and cytogenetic characterization
    • DOI 10.1016/j.leukres.2004.06.011, PII S0145212604002437
    • Flores-Figueroa E, Arana-Trejo RM, Gutierrez-Espindola G, et al. Mesenchymal stem cells in myelodysplastic syndromes: phenotypic and cytogenetic characterization. Leuk Res 2005;29:215-224. (Pubitemid 39647516)
    • (2005) Leukemia Research , vol.29 , Issue.2 , pp. 215-224
    • Flores-Figueroa, E.1    Arana-Trejo, R.M.2    Gutierrez-Espindola, G.3    Perez-Cabrera, A.4    Mayani, H.5
  • 16
    • 33846386176 scopus 로고    scopus 로고
    • Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia
    • DOI 10.1016/j.exphem.2006.10.012, PII S0301472X06006606
    • Blau O, Hofmann WK, Baldus CD, et al. Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia. Exp Hematol 2007;35:221-229. (Pubitemid 46135819)
    • (2007) Experimental Hematology , vol.35 , Issue.2 , pp. 221-229
    • Blau, O.1    Hofmann, W.-K.2    Baldus, C.D.3    Thiel, G.4    Serbent, V.5    Schumann, E.6    Thiel, E.7    Blau, I.W.8
  • 17
    • 64849104318 scopus 로고    scopus 로고
    • Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q-syndrome
    • Lopez-Villar O, Garcia JL, Sanchez-Guijo FM, et al. Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q-syndrome. Leukemia 2009;23:664-672.
    • (2009) Leukemia , vol.23 , pp. 664-672
    • Lopez-Villar, O.1    Garcia, J.L.2    Sanchez-Guijo, F.M.3
  • 18
    • 81555196340 scopus 로고    scopus 로고
    • Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts
    • Blau O, Baldus CD, Hofmann W-K, et al. Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts. Blood 2011;118:5583-5592.
    • (2011) Blood , vol.118 , pp. 5583-5592
    • Blau, O.1    Baldus, C.D.2    Hofmann, W.-K.3
  • 19
    • 77950862042 scopus 로고    scopus 로고
    • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    • Raaijmakers MH, Mukherjee S, Guo S, et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010;464:852-857.
    • (2010) Nature , vol.464 , pp. 852-857
    • Raaijmakers, M.H.1    Mukherjee, S.2    Guo, S.3
  • 20
    • 0036322290 scopus 로고    scopus 로고
    • Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies
    • DOI 10.1016/S0301-472X(02)00812-3, PII S0301472X02008123
    • Quirici N, Soligo D, Bossolasco P, et al. Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp Hematol 2002;30:783-791. (Pubitemid 34835685)
    • (2002) Experimental Hematology , vol.30 , Issue.7 , pp. 783-791
    • Quirici, N.1    Soligo, D.2    Bossolasco, P.3    Servida, F.4    Lumini, C.5    Deliliers, G.L.6
  • 21
    • 39449133645 scopus 로고    scopus 로고
    • Alkaline phosphatase, glutathione-S-transferase-P, and cofilin-1 distinguish multipotent mesenchymal stromal cell lines derived from the bone marrow versus peripheral blood
    • DOI 10.1089/scd.2007.0159
    • Conrad C, Zeindl-Eberhart E, Moosmann S, et al. Alkaline phosphatase, glutathione-S-transferase-P, and cofilin-1 distinguish multipotent mesenchymal stromal cell lines derived from the bone marrow versus peripheral blood. Stem Cells Dev 2008;17:23-27. (Pubitemid 351271618)
    • (2008) Stem Cells and Development , vol.17 , Issue.1 , pp. 23-27
    • Conrad, C.1    Zeindl-Eberhart, E.2    Moosmann, S.3    Nelson, P.J.4    Bruns, C.J.5    Huss, R.6
  • 22
    • 0018732719 scopus 로고
    • Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors
    • DOI 10.1084/jem.150.4.919
    • Westen H, Bainton DF. Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors. J Exp Med 1979;150:919-937. (Pubitemid 10227339)
    • (1979) Journal of Experimental Medicine , vol.150 , Issue.4 , pp. 919-937
    • Westen, H.1    Bainton, D.P.2
  • 23
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • Mendez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829-834.
    • (2010) Nature , vol.466 , pp. 829-834
    • Mendez-Ferrer, S.1    Michurina, T.V.2    Ferraro, F.3
  • 25
    • 77957020167 scopus 로고    scopus 로고
    • The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche
    • Omatsu Y, Sugiyama T, Kohara H, et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity 2010;33:387-399.
    • (2010) Immunity , vol.33 , pp. 387-399
    • Omatsu, Y.1    Sugiyama, T.2    Kohara, H.3
  • 26
    • 0027503426 scopus 로고
    • Bone marrow stroma in humans: Anti-nerve growth factor receptor antibodies selectively stain reticular cells in vivo and in vitro
    • Cattoretti G, Schiro R, Orazi A, et al. Bone marrow stroma in humans: anti-nerve growth factor receptor antibodies selectively stain reticular cells in vivo and in vitro. Blood 1993;81:1726-1738. (Pubitemid 23101584)
    • (1993) Blood , vol.81 , Issue.7 , pp. 1726-1738
    • Cattoretti, G.1    Schiro, R.2    Orazi, A.3    Soligo, D.4    Colombo, M.P.5
  • 27
    • 79957833180 scopus 로고    scopus 로고
    • Stromal-derived factor-1/CXCR4 signaling: Indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow
    • Sharma M, Afrin F, Satija N, et al. Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow. Stem Cells Dev 2011;20:933-946.
    • (2011) Stem Cells Dev , vol.20 , pp. 933-946
    • Sharma, M.1    Afrin, F.2    Satija, N.3
  • 28
    • 2342473250 scopus 로고    scopus 로고
    • + progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma [8]
    • DOI 10.1038/sj.leu.2403301
    • Matsuda M, Morita Y, Hanamoto H, et al. CD34+ progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma. Leukemia 2004;18:1038-1040. (Pubitemid 38714636)
    • (2004) Leukemia , vol.18 , Issue.5 , pp. 1038-1040
    • Matsuda, M.1    Morita, Y.2    Hanamoto, H.3    Tatsumi, Y.4    Maeda, Y.5    Kanamaru, A.6
  • 29
    • 84869223485 scopus 로고    scopus 로고
    • The biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome
    • Yang R, Pu J, Guo J, et al. The biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome. Med Oncol 2011.
    • (2011) Med Oncol
    • Yang, R.1    Pu, J.2    Guo, J.3
  • 30
    • 0027245821 scopus 로고
    • The bone marrow trephine biopsy: A review of normal histology
    • Brown DC, Gatter KC. The bone marrow trephine biopsy: a review of normal histology. Histopathology 1993;22:411-422. (Pubitemid 23168581)
    • (1993) Histopathology , vol.22 , Issue.5 , pp. 411-422
    • Brown, D.C.1    Gatter, K.C.2
  • 31
    • 0013812517 scopus 로고
    • The structure of bone marrow. Functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia: An electron microscopic study
    • Weiss L. The structure of bone marrow. Functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia: an electron microscopic study. J Morphol 1965;117:467-537.
    • (1965) J Morphol , vol.117 , pp. 467-537
    • Weiss, L.1
  • 32
    • 0023276009 scopus 로고
    • Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study
    • DOI 10.1016/8756-3282(87)90015-9
    • Burkhardt R, Kettner G, Böhm W, et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 1987;8:157-164. (Pubitemid 17111858)
    • (1987) Bone , vol.8 , Issue.3 , pp. 157-164
    • Burkhardt, R.1    Kettner, G.2    Bohm, W.3
  • 33
    • 0026508990 scopus 로고
    • Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: An immunomorphometric study on trephine biopsies of the bone marrow
    • Thiele J, Rompcik V, Wagner S, et al. Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: an immunomorphometric study on trephine biopsies of the bone marrow. Br J Haematol 1992;80:227-234.
    • (1992) Br J Haematol , vol.80 , pp. 227-234
    • Thiele, J.1    Rompcik, V.2    Wagner, S.3
  • 34
    • 0035691851 scopus 로고    scopus 로고
    • Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM)
    • Baschong W, Suetterlin R, Laeng RH. Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM). J Histochem Cytochem 2001;49:1565-1572.
    • (2001) J Histochem Cytochem , vol.49 , pp. 1565-1572
    • Baschong, W.1    Suetterlin, R.2    Laeng, R.H.3
  • 35
    • 36048945922 scopus 로고    scopus 로고
    • ImageJ for microscopy
    • Collins TJ. ImageJ for microscopy. BioTechniques 2007;43(1 Suppl):25-30.
    • (2007) BioTechniques , vol.43 , Issue.1 SUPPL. , pp. 25-30
    • Collins, T.J.1
  • 36
    • 0026514341 scopus 로고
    • Primary hyperparathyroidism: Iliac crest trabecular bone volume, structure, remodeling, and balance evaluated by histomorphometric methods
    • Christiansen P, Steiniche T, Vesterby A, et al. Primary hyperparathyroidism: iliac crest trabecular bone volume, structure, remodeling, and balance evaluated by histomorphometric methods. Bone 1992;13:41-49.
    • (1992) Bone , vol.13 , pp. 41-49
    • Christiansen, P.1    Steiniche, T.2    Vesterby, A.3
  • 37
    • 0028971850 scopus 로고
    • Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies
    • Caneva L, Soligo D, Cattoretti G, et al. Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. Blood Cells Mol Dis 1995;21:73-85.
    • (1995) Blood Cells Mol Dis , vol.21 , pp. 73-85
    • Caneva, L.1    Soligo, D.2    Cattoretti, G.3
  • 38
    • 79955944297 scopus 로고    scopus 로고
    • CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization
    • Tormin A, Li O, Brune JC, et al. CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization. Blood 2011;117:5067-5077.
    • (2011) Blood , vol.117 , pp. 5067-5077
    • Tormin, A.1    Li, O.2    Brune, J.C.3
  • 39
    • 84856506096 scopus 로고    scopus 로고
    • The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging
    • Maijenburg MW, Kleijer M, Vermeul K, et al. The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging. Haematologica 2011;97:179-183.
    • (2011) Haematologica , vol.97 , pp. 179-183
    • Maijenburg, M.W.1    Kleijer, M.2    Vermeul, K.3
  • 42
    • 80054035544 scopus 로고    scopus 로고
    • Diabetes impairs hematopoietic stem cell mobilization by altering niche function
    • Ferraro F, Lymperi S, Méndez-Ferrer S, et al. Diabetes impairs hematopoietic stem cell mobilization by altering niche function. Sci Transl Med 2011;3(104):104ra101.
    • (2011) Sci Transl Med , vol.3 , Issue.104
    • Ferraro, F.1    Lymperi, S.2    Méndez-Ferrer, S.3
  • 44
    • 59449093151 scopus 로고    scopus 로고
    • Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
    • Battula VL, Treml S, Bareiss PM, et al. Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Haematologica 2009;94:173-184.
    • (2009) Haematologica , vol.94 , pp. 173-184
    • Battula, V.L.1    Treml, S.2    Bareiss, P.M.3
  • 45
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
    • DOI 10.1016/j.immuni.2006.10.016, PII S1074761306005152
    • Sugiyama T, Kohara H, Noda M, et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-988. (Pubitemid 44894948)
    • (2006) Immunity , vol.25 , Issue.6 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3    Nagasawa, T.4
  • 46
    • 68149149784 scopus 로고    scopus 로고
    • What is the true nature of the osteoblastic hematopoietic stem cell niche?
    • Askmyr M, Sims NA, Martin TJ, et al. What is the true nature of the osteoblastic hematopoietic stem cell niche? Trends Endocrinol Metab 2009;20:303-309.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 303-309
    • Askmyr, M.1    Sims, N.A.2    Martin, T.J.3
  • 47
    • 84865624478 scopus 로고    scopus 로고
    • Native CD271(+) multipotential stromal cells (MSCs) have a transcript profile indicative of multiple fates with prominent osteogenic and wnt pathway signalling activity
    • Churchman SM, Ponchel F, Boxall SA, et al. Native CD271(+) multipotential stromal cells (MSCs) have a transcript profile indicative of multiple fates with prominent osteogenic and Wnt pathway signalling activity. Arthritis Rheum 2012, Available at http://www.ncbi.nlm.nih.gov/pubmed/22378497.
    • (2012) Arthritis Rheum
    • Churchman, S.M.1    Ponchel, F.2    Boxall, S.A.3
  • 49
    • 0037082510 scopus 로고    scopus 로고
    • + cells: Evidence for an autocrine/paracrine mechanism
    • DOI 10.1182/blood.V99.4.1117
    • Lataillade J-J, Clay D, Bourin P, et al. Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism. Blood 2002;99:1117-1129. (Pubitemid 34547062)
    • (2002) Blood , vol.99 , Issue.4 , pp. 1117-1129
    • Lataillade, J.-J.1    Clay, D.2    Bourin, P.3    Herodin, F.4    Dupuy, C.5    Jasmin, C.6    Le Bousse-Kerdiles, M.-C.7
  • 50
    • 58049192716 scopus 로고    scopus 로고
    • A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin
    • Chabanon A, Desterke C, Rodenburger E, et al. A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin. Stem Cells 2008;26:3150-3161.
    • (2008) Stem Cells , vol.26 , pp. 3150-3161
    • Chabanon, A.1    Desterke, C.2    Rodenburger, E.3
  • 51
    • 38049144636 scopus 로고    scopus 로고
    • Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell derived factor-1 induced migration of CD34+ cells from patients with myelodysplasia
    • Fuhler GM, Drayer AL, Olthof SGM, et al. Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell derived factor-1 induced migration of CD34+ cells from patients with myelodysplasia. Blood 2008;111:359-368.
    • (2008) Blood , vol.111 , pp. 359-368
    • Fuhler, G.M.1    Drayer, A.L.2    Olthof, S.G.M.3
  • 52
    • 69849104865 scopus 로고    scopus 로고
    • The leukemic stem cell niche: Current concepts and therapeutic opportunities
    • Lane SW, Scadden DT, Gilliland DG. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 2009;114: 1150-1157.
    • (2009) Blood , vol.114 , pp. 1150-1157
    • Lane, S.W.1    Scadden, D.T.2    Gilliland, D.G.3
  • 53
    • 0037440124 scopus 로고    scopus 로고
    • Additional prognostic value of bone marrow histology in patients subclassified according to the International Prognostic Scoring System for myelodysplastic syndromes
    • DOI 10.1200/JCO.2003.04.182
    • Verburgh E, Achten R, Maes B, et al. Additional prognostic value of bone marrow histology in patients subclassified according to the International Prognostic Scoring System for myelodysplastic syndromes. J Clin Oncol 2003;21:273-282. (Pubitemid 46606156)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.2 , pp. 273-282
    • Verburgh, E.1    Achten, R.2    Maes, B.3    Hagemeijer, A.4    Boogaerts, M.5    De Wolf-Peeters, C.6    Verhoef, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.