Cellular and molecular interactions of mesenchymal stem cells in innate immunity

Immunology and Cell Biology

Volumn 91, Issue 1, 2013, Pages 27-31

  Maria Spaggiari, Grazia ^a   Moretta, Lorenzo ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

Author keywords

dendritic cells; immumodulation; macrophages; mesenchymal stem cells; natural killer cells

Indexed keywords

CD14 ANTIGEN; CD34 ANTIGEN; GAMMA INTERFERON;

CELL INTERACTION; CELL PROLIFERATION; DENDRITE; HUMAN; INNATE IMMUNITY; MACROPHAGE; MESENCHYMAL STEM CELL; MOLECULAR INTERACTION; MONOCYTE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; TISSUE REGENERATION;

ACUTE DISEASE; ANIMALS; AUTOIMMUNE DISEASES; CELL COMMUNICATION; CELL PROLIFERATION; DENDRITIC CELLS; GRAFT VS HOST DISEASE; HUMANS; IMMUNITY, INNATE; INFLAMMATION; KILLER CELLS, NATURAL; MACROPHAGES; MESENCHYMAL STROMAL CELLS; REGENERATIVE MEDICINE; TISSUE THERAPY;

EID: 84872159367     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2012.62     Document Type: Review

References (41)

1. Tolar J, Le Blanc K, Keating A, Blazar BR. Concise review: Hitting the right spot with mesenchymal stromal cells. Stem Cells 2010; 28: 1446-1455.
2. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99: 3838-3843. (Pubitemid 34534559)
3. Jiang X-X, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005; 105: 4120-4126. (Pubitemid 40656164)
4. Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 2006; 177: 2080-2087. (Pubitemid 44200965)
5. Spaggiari GM, Abdelrazik H, Becchetti F, Moretta L. Mesenchymal stem cells inhibit dendritic cell maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2. Blood 2009; 113: 6576-6583.
6. Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005; 105: 2214-2219. (Pubitemid 40731815)
7. Cutler AJ, Limbani V, Girdlestone J, Navarrete CV. Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation. J Immunol 2010; 185: 6617-6623.
8. Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol 2009; 37: 1445-1453.
9. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-969.
10. Trinchieri G. Biology of natural killer cells. Adv Immunol 1989; 47: 187-376. (Pubitemid 20010960)
11. Biron CA. Activation and function of natural killer cell responses during viral infections. Curr Opin Immunol 1997; 9: 24-34. (Pubitemid 27098860)
12. Moretta A, Bottino C, Vitale M, Pende D, Biassoni R, Mingari MC et al. Receptors for HLA-class I molecules in human natural killer cells. Annu Rev Immunol 1996; 14: 619-648. (Pubitemid 26130196)
13. Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 2001; 19: 197-223. (Pubitemid 32368034)
14. Moretta A. Natural killer cells and dendritic cells: Rendezvous in abused tissues. Nat Rev Immunol 2002; 2: 957-965.
15. Ferlazzo G, Tsang ML, Moretta L, Melioli G, Steinman RM, Munz C. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med 2002; 195: 343-351. (Pubitemid 34461492)
16. Moretta L, Ferlazzo G, Bottino C, Vitale M, Pende D, Mingari MC et al. Effector and regulatory events during natural killer-dendritic cell interactions. Immunol Rev 2006; 214: 219-228. (Pubitemid 44707913)
17. Agaugué S, Marcenaro E, Ferranti B, Moretta L, Moretta A. Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells. Blood 2008; 11: 1776-1783.
18. Dale DC, Boxer L, Liles WC. The phagocytes: Neutrophils and monocytes. Blood 2008; 112: 935-945.
19. Locatelli F, Pende D, Maccario R, Mingari MC, Moretta A, Moretta L. Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: How NK cells make the difference. Clin Immunol 2009; 133: 171-178.
20. Le Blanc K, Frassoni F, Ball LM, Locatelli F, Roelofs H, Lewis I et al. Mesenchymal stem cells for treatment of steroid-resistant severe, acute graft-versus-host disease: A phase II study. Lancet 2008; 371: 1579-1586. (Pubitemid 351626841)
21. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295: 2097-2100. (Pubitemid 34229476)
22. Sotiropoulou PA, Perez SA, Gritzapis AD, Baxevanis CN, Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells 2006; 24: 74-85.
23. Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 2006; 107: 1484-1490. (Pubitemid 43242385)
24. Moretta A, Marcenaro E, Sivori S, Della Chiesa M, Vitale M, Moretta L. Early liaisons between cells of the innate immune system in inflamed peripheral tissues. Trends Immunol 2005; 26: 668-675. (Pubitemid 41628200)
25. Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit natural killer cell proliferation, cytotoxicity and cytokine production: Role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 2008; 111: 1327-1333. (Pubitemid 351213419)
26. Moretta L, Bottino C, Pende D, Castriconi R, Mingari MC, Moretta A. Surface NK receptors and their ligands on tumor cells. Semin Immunol 2006; 18: 151-158. (Pubitemid 43817561)
27. Selmani Z, Naji A, Zidi I, Favier B, Gaiffe E, Obert L et al. Human leucocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T-lymphocyte and NK function and to induce CD4 +CD25highFOXP3+ regulatory T cells. Stem Cells 2008; 26: 212-222.
28. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Diloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenasemediated tryptophan degradation. Blood 2004; 103: 4619-4621. (Pubitemid 38745993)
29. Krampera M, Cosmi L, Angeli R, Pasini A, Liotta F, Andreini A et al. Role for interferongamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006; 24: 386-398. (Pubitemid 44464808)
30. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune responses. Blood 2005; 105: 1815-1822. (Pubitemid 40223708)
31. Banas RA, Trumpower C, Bentlejewski C, Marshall V, Sing G, Zeevi A. Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells. Hum Immunol 2008; 69: 321-328.
32. Poggi A, Prevosto C, Massaro AM, Negrini S, Urbani S, Pierri I et al. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: Role of NKp30 and NKG2D receptors. J Immunol 2005; 175: 6352-6360. (Pubitemid 41598875)
33. Gotherstrom C, Lundqvist A, Duprez IR, Childs R, Berg L, Le Blanc K. Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways. Cytotherapy 2011; 13: 269-278.
34. Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003; 31: 890-896. (Pubitemid 37211373)
35. Li Y-P, Paczesny S, Lauret E, Poirault S, Bordigoni P, Mekhloufi F et al. Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway. J Immunol 2008; 180: 1598-1608.
36. Aldinucci A, Rizzetto L, Pieri L, Nosi D, Romagnoli P, Biagioli T et al. Inhibition of immune synapse by altered dendritic cell actin distribution: A new pathway of mesenchymal stem cell immune regulation. J Immunol 2010; 185: 5102-5110.
37. Bassi Ê J, de Almeida DC, Moraes-Vieira PM, Câmara NO. Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells. Stem Cell Rev and Rep 2012; 8: 329-342.
38. Zhang QZ, Su WR, Shi SH, Wilder-Smith P, Xiang AP, Wong A et al. Human gingivaderived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing. Stem Cells 2010; 28: 1856-1868.
39. François M, Romieu-Mourez R, Li M, Galipeau J. Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther 2012; 20: 187-195.
40. Krampera M. Mesenchymal stromal cell "licensing": A multistep process. Leukemia 2011; 25: 1408-1414.
41. Wang D, Chen K, Du WT, Han ZB, Ren H, Chi Y et al. CD14+ monocytes promote the immunosuppressive effect of human umbilical cord matrix stem cells. Exp Cell Res 2010; 316: 2414-2423.