메뉴 건너뛰기




Volumn 8, Issue FEB, 2014, Pages

Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2

Author keywords

GABA; Intracellular chloride; KCC2; Neurons

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CARBACHOL; CHLORINE; CLATHRIN; CREATINE KINASE BB; EARLY GROWTH RESPONSE FACTOR; EARLY GROWTH RESPONSE FACTOR 4; FLUORESCENT DYE; FUROSEMIDE; GLUTAMIC ACID; GRAMICIDIN; GREEN FLUORESCENT PROTEIN; METABOTROPIC RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPILIN; NEURTURIN; OSR1 PROTEIN; PEPTIDES AND PROTEINS; POTASSIUM CHLORIDE COTRANSPORTER; POTASSIUM CHLORIDE COTRANSPORTER 2; PROTEIN KINASE C; PROTEIN KINASE WNK1; SEROTONIN 2A RECEPTOR; SOMATOMEDIN C; SPAK PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; ZINC ION;

EID: 84893632917     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00027     Document Type: Review
Times cited : (166)

References (210)
  • 1
    • 84862885026 scopus 로고    scopus 로고
    • Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain
    • doi: 10.1523/JNEUROSCI.6089-11.2012
    • Acton, B. A., Mahadevan, V., Mercado, A., Uvarov, P., Ding, Y., Pressey, J., et al. (2012). Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain. J. Neurosci. 32, 8746-8751. doi: 10.1523/JNEUROSCI.6089-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 8746-8751
    • Acton, B.A.1    Mahadevan, V.2    Mercado, A.3    Uvarov, P.4    Ding, Y.5    Pressey, J.6
  • 2
    • 0037383851 scopus 로고    scopus 로고
    • BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl-co-transporter KCC2
    • doi: 10.1242/dev.00351
    • Aguado, F., Carmona, M. A., Pozas, E., Aguiló, A., Martínez-Guijarro, F. J., Alcantara, S., et al. (2003). BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl-co-transporter KCC2. Development (Cambridge, England) 130, 1267-1280. doi: 10.1242/dev.00351
    • (2003) Development (Cambridge, England) , vol.130 , pp. 1267-1280
    • Aguado, F.1    Carmona, M.A.2    Pozas, E.3    Aguiló, A.4    Martínez-Guijarro, F.J.5    Alcantara, S.6
  • 3
    • 33646912707 scopus 로고    scopus 로고
    • Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
    • doi: 10.1523/JNEUROSCI.0319-06.2006
    • Akerman, C. J., and Cline, H. T. (2006). Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo. J. Neurosci. 26, 5117-5130. doi: 10.1523/JNEUROSCI.0319-06.2006
    • (2006) J. Neurosci , vol.26 , pp. 5117-5130
    • Akerman, C.J.1    Cline, H.T.2
  • 4
    • 73649106911 scopus 로고    scopus 로고
    • Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation
    • doi: 10.1074/jbc.M109.061275
    • Anthis, N. J., Haling, J. R., Oxley, C. L., Memo, M., Wegener, K. L., Lim, C. J., et al. (2009). Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J. Biol. Chem. 284, 36700-36710. doi: 10.1074/jbc.M109.061275
    • (2009) J. Biol. Chem , vol.284 , pp. 36700-36710
    • Anthis, N.J.1    Haling, J.R.2    Oxley, C.L.3    Memo, M.4    Wegener, K.L.5    Lim, C.J.6
  • 5
    • 84870482854 scopus 로고    scopus 로고
    • K+-Cl-cotransporter-2 KCC2 in chicken cardiomyocytes
    • doi: 10.1152/ajpcell.00274.2012
    • Antrobus, S. P., Lytle, C., and Payne, J. A. (2012). K+-Cl-cotransporter-2 KCC2 in chicken cardiomyocytes. Am. J. Physiol. Cell Physiol. 303, C1180-C1191. doi: 10.1152/ajpcell.00274.2012
    • (2012) Am. J. Physiol. Cell Physiol , vol.303
    • Antrobus, S.P.1    Lytle, C.2    Payne, J.A.3
  • 6
    • 77954750354 scopus 로고    scopus 로고
    • Simultaneous intracellular chloride and pH measurements using a GFP-based sensor
    • doi: 10.1038/nmeth.1471
    • Arosio, D., Ricci, F., Marchetti, L., Gualdani, R., Albertazzi, L., and Beltram, F. (2010). Simultaneous intracellular chloride and pH measurements using a GFP-based sensor. Nat. Methods 7, 516-518. doi: 10.1038/nmeth.1471
    • (2010) Nat. Methods , vol.7 , pp. 516-518
    • Arosio, D.1    Ricci, F.2    Marchetti, L.3    Gualdani, R.4    Albertazzi, L.5    Beltram, F.6
  • 7
    • 0038380527 scopus 로고    scopus 로고
    • Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem
    • Balakrishnan, V., Becker, M., Löhrke, S., Nothwang, H. G., Güresir, E., and Friauf, E. (2003). Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem. J. Neurosci. 23, 4134-4145.
    • (2003) J. Neurosci , vol.23 , pp. 4134-4145
    • Balakrishnan, V.1    Becker, M.2    Löhrke, S.3    Nothwang, H.G.4    Güresir, E.5    Friauf, E.6
  • 8
    • 54049099205 scopus 로고    scopus 로고
    • Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity
    • doi: 10.1113/jphysiol.2008.157024
    • Banke, T. G., and Gegelashvili, G. (2008). Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity. J. Physiol. 586, 4925-4934. doi: 10.1113/jphysiol.2008.157024
    • (2008) J. Physiol , vol.586 , pp. 4925-4934
    • Banke, T.G.1    Gegelashvili, G.2
  • 9
    • 80052523250 scopus 로고    scopus 로고
    • Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus
    • doi: 10.1111/j.1528-1167.2011.03247.x
    • Barmashenko, G., Hefft, S., Aertsen, A., Kirschstein, T., and Köhling, R. (2011). Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus. Epilepsia 52, 1570-1578. doi: 10.1111/j.1528-1167.2011.03247.x
    • (2011) Epilepsia , vol.52 , pp. 1570-1578
    • Barmashenko, G.1    Hefft, S.2    Aertsen, A.3    Kirschstein, T.4    Köhling, R.5
  • 10
    • 84875895073 scopus 로고    scopus 로고
    • Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride
    • doi: 10.3389/fnmol.2013.00011
    • Batti, L., Mukhtarov, M., Audero, E., Ivanov, A., Paolicelli, O., Zurborg, S., et al. (2013). Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride. Front. Mol. Neurosci. 6:11. doi: 10.3389/fnmol.2013.00011
    • (2013) Front. Mol. Neurosci , vol.6 , pp. 11
    • Batti, L.1    Mukhtarov, M.2    Audero, E.3    Ivanov, A.4    Paolicelli, O.5    Zurborg, S.6
  • 11
    • 79955575779 scopus 로고    scopus 로고
    • Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans
    • doi: 10.1038/emboj.2011.83
    • Bellemer, A., Hirata, T., Romero, M. F., and Koelle, M. R. (2011). Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans. EMBO J. 30, 1852-1863. doi: 10.1038/emboj.2011.83
    • (2011) EMBO J , vol.30 , pp. 1852-1863
    • Bellemer, A.1    Hirata, T.2    Romero, M.F.3    Koelle, M.R.4
  • 12
    • 0024430857 scopus 로고
    • Giant synaptic potentials in immature rat CA3 hippocampal neurones
    • Ben-Ari, Y., Cherubini, E., Corradetti, R., and Gaiarsa, J. L. (1989). Giant synaptic potentials in immature rat CA3 hippocampal neurones. J. Physiol. 416, 303-325.
    • (1989) J. Physiol , vol.416 , pp. 303-325
    • Ben-Ari, Y.1    Cherubini, E.2    Corradetti, R.3    Gaiarsa, J.L.4
  • 13
    • 35748954370 scopus 로고    scopus 로고
    • GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations
    • doi: 10.1152/physrev.00017.2006
    • Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., and Khazipov, R. (2007). GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations. Physiol. Rev. 87, 1215-1284. doi: 10.1152/physrev.00017.2006
    • (2007) Physiol. Rev , vol.87 , pp. 1215-1284
    • Ben-Ari, Y.1    Gaiarsa, J.-L.2    Tyzio, R.3    Khazipov, R.4
  • 14
    • 84866681617 scopus 로고    scopus 로고
    • The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
    • doi: 10.1177/1073858412438697
    • Ben-Ari, Y., Khalilov, I., Kahle, K. T., and Cherubini, E. (2012). The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. Neuroscientist 18, 467-486. doi: 10.1177/1073858412438697
    • (2012) Neuroscientist , vol.18 , pp. 467-486
    • Ben-Ari, Y.1    Khalilov, I.2    Kahle, K.T.3    Cherubini, E.4
  • 15
    • 33744940043 scopus 로고    scopus 로고
    • Identification of key functional domains in the C terminus of the K+-Cl-cotransporters
    • doi: 10.1074/jbc.M600015200
    • Bergeron, M. J., Gagnon, E., Caron, L., and Isenring, P. (2006). Identification of key functional domains in the C terminus of the K+-Cl-cotransporters. J. Biol. Chem. 281, 15959-15969. doi: 10.1074/jbc.M600015200
    • (2006) J. Biol. Chem , vol.281 , pp. 15959-15969
    • Bergeron, M.J.1    Gagnon, E.2    Caron, L.3    Isenring, P.4
  • 16
    • 82755182458 scopus 로고    scopus 로고
    • Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon
    • doi: 10.1101/pdb.prot066985
    • Berglund, K., Kuner, T., Feng, G., and Augustine, G. J. (2011). Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon. Cold Spring Harb. Protoc. 2011, 1492-1497. doi: 10.1101/pdb.prot066985
    • (2011) Cold Spring Harb. Protoc , vol.2011 , pp. 1492-1497
    • Berglund, K.1    Kuner, T.2    Feng, G.3    Augustine, G.J.4
  • 17
    • 44149098577 scopus 로고    scopus 로고
    • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon
    • doi: 10.1007/s11068-008-9019-6
    • Berglund, K., Schleich, W., Krieger, P., Loo, L. S., Wang, D., Cant, N. B., et al. (2006). Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. Brain Cell Biol. 35, 207-228. doi: 10.1007/s11068-008-9019-6
    • (2006) Brain Cell Biol , vol.35 , pp. 207-228
    • Berglund, K.1    Schleich, W.2    Krieger, P.3    Loo, L.S.4    Wang, D.5    Cant, N.B.6
  • 18
    • 62549109964 scopus 로고    scopus 로고
    • Cation-chloride cotransporters and neuronal function
    • doi: 10.1016/j.neuron.2009.03.003
    • Blaesse, P., Airaksinen, M. S., Rivera, C., and Kaila, K. (2009). Cation-chloride cotransporters and neuronal function. Neuron 61, 820-838. doi: 10.1016/j.neuron.2009.03.003
    • (2009) Neuron , vol.61 , pp. 820-838
    • Blaesse, P.1    Airaksinen, M.S.2    Rivera, C.3    Kaila, K.4
  • 19
    • 33749823040 scopus 로고    scopus 로고
    • Oligomerization of KCC2 correlates with development of inhibitory neurotransmission
    • doi: 10.1523/JNEUROSCI.3257-06.2006
    • Blaesse, P., Guillemin, I., Schindler, J., Schweizer, M., Delpire, E., Khiroug, L., et al. (2006). Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. J. Neurosci. 26, 10407-10419. doi: 10.1523/JNEUROSCI.3257-06.2006
    • (2006) J. Neurosci , vol.26 , pp. 10407-10419
    • Blaesse, P.1    Guillemin, I.2    Schindler, J.3    Schweizer, M.4    Delpire, E.5    Khiroug, L.6
  • 20
    • 64149128876 scopus 로고    scopus 로고
    • KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner
    • doi: 10.1016/j.neuron.2009.01.034
    • Bortone, D., and Polleux, F. (2009). KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron 62, 53-71. doi: 10.1016/j.neuron.2009.01.034
    • (2009) Neuron , vol.62 , pp. 53-71
    • Bortone, D.1    Polleux, F.2
  • 21
    • 84871982368 scopus 로고    scopus 로고
    • Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2
    • doi: 10.1073/pnas.1213680110
    • Bos, R., Sadlaoud, K., Boulenguez, P., Buttigieg, D., Liabeuf, S., Brocard, C., et al. (2013). Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2. Proc. Natl. Acad. Sci. U.S.A. 110, 348-353. doi: 10.1073/pnas.1213680110
    • (2013) Proc. Natl. Acad. Sci. U.S. A , vol.110 , pp. 348-353
    • Bos, R.1    Sadlaoud, K.2    Boulenguez, P.3    Buttigieg, D.4    Liabeuf, S.5    Brocard, C.6
  • 22
    • 77949275173 scopus 로고    scopus 로고
    • Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury
    • doi: 10.1038/nm.2107
    • Boulenguez, P., Liabeuf, S., Bos, R., Bras, H., Jean-xavier, C., Brocard, C., et al. (2010). Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nature Med. 16, 302-307. doi: 10.1038/nm.2107
    • (2010) Nature Med , vol.16 , pp. 302-307
    • Boulenguez, P.1    Liabeuf, S.2    Bos, R.3    Bras, H.4    Jean-xavier, C.5    Brocard, C.6
  • 23
    • 63849122971 scopus 로고    scopus 로고
    • The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset
    • doi: 10.1523/JNEUROSCI.5309-08.2009
    • Bragin, A., Azizyan, A., Almajano, J., and Engel, J. (2009). The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset. J. Neurosci. 29, 3660-3671. doi: 10.1523/JNEUROSCI.5309-08.2009
    • (2009) J. Neurosci , vol.29 , pp. 3660-3671
    • Bragin, A.1    Azizyan, A.2    Almajano, J.3    Engel, J.4
  • 24
    • 77955013423 scopus 로고    scopus 로고
    • Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity
    • doi: 10.3389/neuro.02.015.2009
    • Bregestovski, P., Waseem, T., and Mukhtarov, M. (2009). Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity. Front. Mol. Neurosci. 2:15. doi: 10.3389/neuro.02.015.2009
    • (2009) Front. Mol. Neurosci , vol.2 , pp. 15
    • Bregestovski, P.1    Waseem, T.2    Mukhtarov, M.3
  • 25
    • 28544442012 scopus 로고    scopus 로고
    • Age-dependent spontaneous hyperexcitability and impairment of GABAergic function in the hippocampus of mice lacking trkB
    • doi: 10.1093/cercor/bhi083
    • Carmona, M. A., Pozas, E., Martínez, A., Espinosa-Parrilla, J. F., Soriano, E., and Aguado, F. (2006). Age-dependent spontaneous hyperexcitability and impairment of GABAergic function in the hippocampus of mice lacking trkB. Cereb. Cortex 16, 47-63. doi: 10.1093/cercor/bhi083
    • (2006) Cereb. Cortex , vol.16 , pp. 47-63
    • Carmona, M.A.1    Pozas, E.2    Martínez, A.3    Espinosa-Parrilla, J.F.4    Soriano, E.5    Aguado, F.6
  • 26
    • 84875024575 scopus 로고    scopus 로고
    • High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells
    • doi: 10.1186/1471-2121-14-16
    • Carmosino, M., Rizzo, F., Torretta, S., Procino, G., and Svelto, M. (2013). High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells. BMC Cell Biol. 14:16. doi: 10.1186/1471-2121-14-16
    • (2013) BMC Cell Biol , vol.14 , pp. 16
    • Carmosino, M.1    Rizzo, F.2    Torretta, S.3    Procino, G.4    Svelto, M.5
  • 27
    • 0035834753 scopus 로고    scopus 로고
    • A dominant negative mutant of the KCC1 K-Cl cotransporter: Both N-and C-terminal cytoplasmic domains are required for K-Cl cotransport activity
    • doi: 10.1074/jbc.M107155200
    • Casula, S., Shmukler, B. E., Wilhelm, S., Stuart-Tilley, A. K., Su, W., Chernova, M. N., et al. (2001). A dominant negative mutant of the KCC1 K-Cl cotransporter: both N-and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J. Biol. Chem. 276, 41870-41878. doi: 10.1074/jbc.M107155200
    • (2001) J. Biol. Chem , vol.276 , pp. 41870-41878
    • Casula, S.1    Shmukler, B.E.2    Wilhelm, S.3    Stuart-Tilley, A.K.4    Su, W.5    Chernova, M.N.6
  • 29
    • 84856992916 scopus 로고    scopus 로고
    • Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
    • doi: 10.3389/fncel.2012.00005
    • Chamma, I., Chevy, Q., Poncer, J. C., and Lévi, S. (2012). Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission. Front. Cell. Neurosci. 6:5. doi: 10.3389/fncel.2012.00005
    • (2012) Front. Cell. Neurosci , vol.6 , pp. 5
    • Chamma, I.1    Chevy, Q.2    Poncer, J.C.3    Lévi, S.4
  • 30
    • 84884580889 scopus 로고    scopus 로고
    • Activity-dependent regulation of the K/Cl Transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons
    • doi: 10.1523/JNEUROSCI.5889-12.2013
    • Chamma, I., Heubl, M., Chevy, Q., Renner, M., Moutkine, I., Eugene, E., et al. (2013). Activity-dependent regulation of the K/Cl Transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J. Neurosci. 33, 15488-15503. doi: 10.1523/JNEUROSCI.5889-12.2013
    • (2013) J. Neurosci , vol.33 , pp. 15488-15503
    • Chamma, I.1    Heubl, M.2    Chevy, Q.3    Renner, M.4    Moutkine, I.5    Eugene, E.6
  • 31
    • 0023853114 scopus 로고
    • Renal brush-border chloride transport mechanisms characterized using a fluorescent indicator
    • Chen, P. Y., Illsley, N. P., and Verkman, A. S. (1988). Renal brush-border chloride transport mechanisms characterized using a fluorescent indicator. Am. J. Physiol. 254, F114-F120.
    • (1988) Am. J. Physiol , vol.254
    • Chen, P.Y.1    Illsley, N.P.2    Verkman, A.S.3
  • 32
    • 80052567863 scopus 로고    scopus 로고
    • Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor
    • doi: 10.1523/JNEUROSCI.2205-11.2011
    • Chorin, E., Vinograd, O., Fleidervish, I., Gilad, D., Herrmann, S., Sekler, I., et al. (2011). Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor. J. Neurosci. 31, 12916-12926. doi: 10.1523/JNEUROSCI.2205-11.2011
    • (2011) J. Neurosci , vol.31 , pp. 12916-12926
    • Chorin, E.1    Vinograd, O.2    Fleidervish, I.3    Gilad, D.4    Herrmann, S.5    Sekler, I.6
  • 33
    • 23744504648 scopus 로고    scopus 로고
    • Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses
    • doi: 10.1113/jphysiol.2005.089821
    • Chudotvorova, I., Ivanov, A., Rama, S., Hübner, C. A, Pellegrino, C., Ben-Ari, Y., et al. (2005). Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses. J. Physio. 566, 671-679. doi: 10.1113/jphysiol.2005.089821
    • (2005) J. Physio , vol.566 , pp. 671-679
    • Chudotvorova, I.1    Ivanov, A.2    Rama, S.3    Hübner, C.A.4    Pellegrino, C.5    Ben-Ari, Y.6
  • 34
    • 80052545981 scopus 로고    scopus 로고
    • Anomalous levels of Cl-transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex
    • doi: 10.1111/j.1528-1167.2011.03111.x
    • Conti, L., Palma, E., Roseti, C., Lauro, C., Cipriani, R., de Groot, M., et al. (2011). Anomalous levels of Cl-transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex. Epilepsia 52, 1635-1644. doi: 10.1111/j.1528-1167.2011.03111.x
    • (2011) Epilepsia , vol.52 , pp. 1635-1644
    • Conti, L.1    Palma, E.2    Roseti, C.3    Lauro, C.4    Cipriani, R.5    de Groot, M.6
  • 35
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • doi: 10.1038/nature04223
    • Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., et al. (2005). BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438, 1017-1021. doi: 10.1038/nature04223
    • (2005) Nature , vol.438 , pp. 1017-1021
    • Coull, J.A.M.1    Beggs, S.2    Boudreau, D.3    Boivin, D.4    Tsuda, M.5    Inoue, K.6
  • 36
    • 0042860080 scopus 로고    scopus 로고
    • Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    • doi: 10.1038/nature01868
    • Coull, J. A. M., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Sík, A., et al. (2003). Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424, 938-942. doi: 10.1038/nature01868
    • (2003) Nature , vol.424 , pp. 938-942
    • Coull, J.A.M.1    Boudreau, D.2    Bachand, K.3    Prescott, S.A.4    Nault, F.5    Sík, A.6
  • 37
    • 53549122751 scopus 로고    scopus 로고
    • The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury
    • doi: 10.1186/1744-8069-4-36
    • Cramer, S. W., Baggott, C., Cain, J., Tilghman, J., Allcock, B., Miranpuri, G., et al. (2008). The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury. Mol. Pain 4, 36. doi: 10.1186/1744-8069-4-36
    • (2008) Mol. Pain , vol.4 , pp. 36
    • Cramer, S.W.1    Baggott, C.2    Cain, J.3    Tilghman, J.4    Allcock, B.5    Miranpuri, G.6
  • 39
    • 84896691985 scopus 로고    scopus 로고
    • The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl-co-transporters
    • doi: 10.1042/BJ20131478. [Epub ahead of print]
    • De Los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., et al. (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl-co-transporters. Biochem. J. doi: 10.1042/BJ20131478. [Epub ahead of print].
    • (2014) Biochem. J
    • De Los Heros, P.1    Alessi, D.R.2    Gourlay, R.3    Campbell, D.G.4    Deak, M.5    McArtney, T.J.6
  • 40
    • 32444437942 scopus 로고    scopus 로고
    • WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
    • doi: 10.1073/pnas.0510947103
    • De Los Heros, P., Kahle, K. T., Rinehart, J., Bobadilla, N. A., Vázquez, N., San Cristobal, P., et al. (2006). WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc. Natl. Acad. Sci. U.S.A. 103, 1976-1981. doi: 10.1073/pnas.0510947103
    • (2006) Proc. Natl. Acad. Sci. U.S. A , vol.103 , pp. 1976-1981
    • De Los Heros, P.1    Kahle, K.T.2    Rinehart, J.3    Bobadilla, N.A.4    Vázquez, N.5    San Cristobal, P.6
  • 41
    • 80051673168 scopus 로고    scopus 로고
    • Spike-timing dependent plasticity beyond synapse-pre-and post-synaptic plasticity of intrinsic neuronal excitability
    • doi: 10.3389/fnsyn.2010.00021
    • Debanne, D., and Poo, M.-M. (2010). Spike-timing dependent plasticity beyond synapse-pre-and post-synaptic plasticity of intrinsic neuronal excitability. Front. Synaptic Neurosci. 2:21. doi: 10.3389/fnsyn.2010.00021
    • (2010) Front. Synaptic Neurosci , vol.2 , pp. 21
    • Debanne, D.1    Poo, M.-M.2
  • 42
    • 84863474697 scopus 로고    scopus 로고
    • Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe
    • doi: 10.1016/j.bmcl.2012.05.126
    • Delpire, E., Baranczak, A., Waterson, A. G., Kim, K., Kett, N., Morrison, R. D., et al. (2012). Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg. Med. Chem. Lett. 22, 4532-4535. doi: 10.1016/j.bmcl.2012.05.126
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , pp. 4532-4535
    • Delpire, E.1    Baranczak, A.2    Waterson, A.G.3    Kim, K.4    Kett, N.5    Morrison, R.D.6
  • 43
    • 62549111023 scopus 로고    scopus 로고
    • Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2
    • doi: 10.1073/pnas.0812756106
    • Delpire, E., Days, E., Lewis, L. M., Mi, D., Kim, K., Lindsley, C. W., et al. (2009). Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc. Natl. Acad. Sci. U.S.A. 106, 5383-5388. doi: 10.1073/pnas.0812756106
    • (2009) Proc. Natl. Acad. Sci. U.S. A , vol.106 , pp. 5383-5388
    • Delpire, E.1    Days, E.2    Lewis, L.M.3    Mi, D.4    Kim, K.5    Lindsley, C.W.6
  • 44
    • 38749087627 scopus 로고    scopus 로고
    • SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells
    • doi: 10.1042/BJ20071324
    • Delpire, E., and Gagnon, K. B. E. (2008). SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem. J. 409, 321-331. doi: 10.1042/BJ20071324
    • (2008) Biochem. J , vol.409 , pp. 321-331
    • Delpire, E.1    Gagnon, K.B.E.2
  • 45
    • 29544445660 scopus 로고    scopus 로고
    • Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    • doi: 10.1016/j.neuron.2005.10.035
    • Duebel, J., Haverkamp, S., Schleich, W., Feng, G., Augustine, G. J., Kuner, T., et al. (2006). Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon. Neuron 49, 81-94. doi: 10.1016/j.neuron.2005.10.035
    • (2006) Neuron , vol.49 , pp. 81-94
    • Duebel, J.1    Haverkamp, S.2    Schleich, W.3    Feng, G.4    Augustine, G.J.5    Kuner, T.6
  • 46
    • 30744467689 scopus 로고    scopus 로고
    • NKCC1 transporter facilitates seizures in the developing brain
    • doi: 10.1038/nm1301
    • Dzhala, V. I., Talos, D. M., Sdrulla, D. A., Brumback, A. C., Mathews, G. C., Benke, T. A., et al. (2005). NKCC1 transporter facilitates seizures in the developing brain. Nat. Med. 11, 1205-1213. doi: 10.1038/nm1301
    • (2005) Nat. Med , vol.11 , pp. 1205-1213
    • Dzhala, V.I.1    Talos, D.M.2    Sdrulla, D.A.3    Brumback, A.C.4    Mathews, G.C.5    Benke, T.A.6
  • 47
    • 84859597226 scopus 로고    scopus 로고
    • KCC2 transport activity requires the highly conserved L(675) in the C-terminal β 1 strand
    • doi: 10.1016/j.bbrc.2012.02.147
    • Döding, A., Hartmann, A.-M., Beyer, T., and Nothwang, H. G. (2012). KCC2 transport activity requires the highly conserved L(675) in the C-terminal β 1 strand. Biochem. Biophys. Res. Commun. 420, 492-497. doi: 10.1016/j.bbrc.2012.02.147
    • (2012) Biochem. Biophys. Res. Commun , vol.420 , pp. 492-497
    • Döding, A.1    Hartmann, A.-M.2    Beyer, T.3    Nothwang, H.G.4
  • 48
    • 0028964438 scopus 로고
    • Gramicidin-perforated patch recording: GABA response in mammalian neurones with intact intracellular chloride
    • Ebihara, S., Shirato, K., Harata, N., and Akaike, N. (1995). Gramicidin-perforated patch recording: GABA response in mammalian neurones with intact intracellular chloride. J. Physiol. 484(Pt 1), 77-86.
    • (1995) J. Physiol , vol.484 , Issue.PART 1 , pp. 77-86
    • Ebihara, S.1    Shirato, K.2    Harata, N.3    Akaike, N.4
  • 49
    • 84884829479 scopus 로고    scopus 로고
    • Microglia control neuronal network excitability via BDNF signalling
    • doi: 10.1155/2013/429815
    • Ferrini, F., and De Koninck, Y. (2013). Microglia control neuronal network excitability via BDNF signalling. Neural Plast. 2013, 429815. doi: 10.1155/2013/429815
    • (2013) Neural Plast , vol.2013 , pp. 429815
    • Ferrini, F.1    de Koninck, Y.2
  • 50
    • 28744450567 scopus 로고    scopus 로고
    • Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function
    • doi: 10.1016/j.neuron.2005.10.025
    • Fiumelli, H., Cancedda, L., and Poo, M. (2005). Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function. Neuron 48, 773-786. doi: 10.1016/j.neuron.2005.10.025
    • (2005) Neuron , vol.48 , pp. 773-786
    • Fiumelli, H.1    Cancedda, L.2    Poo, M.3
  • 51
    • 39149129333 scopus 로고    scopus 로고
    • Cotransporters, WNKs and hypertension: An update
    • doi: 10.1097/MNH.0b013e3282f5244e
    • Flatman, P. W. (2008). Cotransporters, WNKs and hypertension: an update. Curr. Opin. Nephrol. Hypertens. 17, 186-192. doi: 10.1097/MNH.0b013e3282f5244e
    • (2008) Curr. Opin. Nephrol. Hypertens , vol.17 , pp. 186-192
    • Flatman, P.W.1
  • 52
    • 57449086168 scopus 로고    scopus 로고
    • Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons
    • doi: 10.1111/j.1460-9568.2008.06528.x
    • Friauf, E., Wenz, M., Oberhofer, M., Nothwang, H. G., Balakrishnan, V., Knipper, M., et al. (2008). Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons. Eur. J. Neurosci. 28, 2371-2380. doi: 10.1111/j.1460-9568.2008.06528.x
    • (2008) Eur. J. Neurosci , vol.28 , pp. 2371-2380
    • Friauf, E.1    Wenz, M.2    Oberhofer, M.3    Nothwang, H.G.4    Balakrishnan, V.5    Knipper, M.6
  • 53
    • 84875516352 scopus 로고    scopus 로고
    • Improved method for efficient imaging of intracellular Cl(-) with Cl-Sensor using conventional fluorescence setup
    • doi: 10.3389/fnmol.2013.00007
    • Friedel, P., Bregestovski, P., and Medina, I. (2013). Improved method for efficient imaging of intracellular Cl(-) with Cl-Sensor using conventional fluorescence setup. Front. Mol. Neurosci. 6:7. doi: 10.3389/fnmol.2013.00007
    • (2013) Front. Mol. Neurosci , vol.6 , pp. 7
    • Friedel, P.1    Bregestovski, P.2    Medina, I.3
  • 54
    • 30644472724 scopus 로고    scopus 로고
    • Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter
    • doi: 10.1128/MCB.26.2.689-698.2006
    • Gagnon, K. B. E., England, R., and Delpire, E. (2006a). Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Mol. Cell. Biol. 26, 689-698. doi: 10.1128/MCB.26.2.689-698.2006
    • (2006) Mol. Cell. Biol , vol.26 , pp. 689-698
    • Gagnon, K.B.E.1    England, R.2    Delpire, E.3
  • 55
    • 30644458584 scopus 로고    scopus 로고
    • Volume sensitivity of cation-Cl-cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4
    • doi: 10.1152/ajpcell.00037.2005
    • Gagnon, K. B. E., England, R., and Delpire, E. (2006b). Volume sensitivity of cation-Cl-cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. Am. J. Physiol. Cell Physiol. 290, C134-C142. doi: 10.1152/ajpcell.00037.2005
    • (2006) Am. J. Physiol. Cell Physiol , vol.290
    • Gagnon, K.B.E.1    England, R.2    Delpire, E.3
  • 56
    • 84875943956 scopus 로고    scopus 로고
    • Physiology of SLC12 transporters: Lessons from inherited human genetic mutations and genetically engineered mouse knockouts
    • doi: 10.1152/ajpcell.00350.2012
    • Gagnon, K. B., and Delpire, E. (2013). Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts. Am. J. Physiol. Cell Physiol. 304, C693-C714. doi: 10.1152/ajpcell.00350.2012
    • (2013) Am. J. Physiol. Cell Physiol , vol.304
    • Gagnon, K.B.1    Delpire, E.2
  • 57
    • 84887500449 scopus 로고    scopus 로고
    • Chloride extrusion enhancers as novel therapeutics for neurological diseases
    • doi: 10.1038/nm.3356
    • Gagnon, M., Bergeron, M. J., Lavertu, G., Castonguay, A., Tripathy, S., Bonin, R. P., et al. (2013). Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat. Med. 19, 1524-1528. doi: 10.1038/nm.3356
    • (2013) Nat. Med , vol.19 , pp. 1524-1528
    • Gagnon, M.1    Bergeron, M.J.2    Lavertu, G.3    Castonguay, A.4    Tripathy, S.5    Bonin, R.P.6
  • 58
    • 2342604385 scopus 로고    scopus 로고
    • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: Effect of diazepam
    • doi: 10.1523/JNEUROSCI.0755-04.2004
    • Galeffi, F., Sah, R., Pond, B. B., George, A., and Schwartz-Bloom, R. D. (2004). Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. J. Neurosci. 24, 4478-4488. doi: 10.1523/JNEUROSCI.0755-04.2004
    • (2004) J. Neurosci , vol.24 , pp. 4478-4488
    • Galeffi, F.1    Sah, R.2    Pond, B.B.3    George, A.4    Schwartz-Bloom, R.D.5
  • 59
    • 84868103841 scopus 로고    scopus 로고
    • One-dimensional SDS gel electrophoresis of proteins
    • Chapter 10, Unit 10.1.1-44. doi: 10.1002/0471140864.ps1001s68
    • Gallagher, S. R. (2012). One-dimensional SDS gel electrophoresis of proteins. Curr. Protoc. Protein Sci. Chapter 10, Unit 10.1.1-44. doi: 10.1002/0471140864.ps1001s68
    • (2012) Curr. Protoc. Protein Sci
    • Gallagher, S.R.1
  • 60
    • 15544384004 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters
    • doi: 10.1152/physrev.00011.2004
    • Gamba, G. (2005). Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiol. Rev. 85, 423-493. doi: 10.1152/physrev.00011.2004
    • (2005) Physiol. Rev , vol.85 , pp. 423-493
    • Gamba, G.1
  • 61
    • 0028201013 scopus 로고
    • Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney
    • Gamba, G., Miyanoshita, A., Lombardi, M., Lytton, J., Lee, W. S., Hediger, M. A., et al. (1994). Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J. Biol. Chem. 269, 17713-17722.
    • (1994) J. Biol. Chem , vol.269 , pp. 17713-17722
    • Gamba, G.1    Miyanoshita, A.2    Lombardi, M.3    Lytton, J.4    Lee, W.S.5    Hediger, M.A.6
  • 62
    • 0035907025 scopus 로고    scopus 로고
    • GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition
    • doi: 10.1016/S0092-8674(01)00341-5
    • Ganguly, K., Schinder, A. F., Wong, S. T., and Poo, M. (2001). GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. Cell 105, 521-532. doi: 10.1016/S0092-8674(01)00341-5
    • (2001) Cell , vol.105 , pp. 521-532
    • Ganguly, K.1    Schinder, A.F.2    Wong, S.T.3    Poo, M.4
  • 63
    • 51149116784 scopus 로고    scopus 로고
    • The RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2
    • doi: 10.1159/000149781
    • Garbarini, N., and Delpire, E. (2008). The RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2. Cell. Physiol. Biochem. 22, 31-44. doi: 10.1159/000149781
    • (2008) Cell. Physiol. Biochem , vol.22 , pp. 31-44
    • Garbarini, N.1    Delpire, E.2
  • 64
    • 80053072877 scopus 로고    scopus 로고
    • The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines
    • doi: 10.1073/pnas.1107893108
    • Gauvain, G., Chamma, I., Chevy, Q., Cabezas, C., Irinopoulou, T., Bodrug, N., et al. (2011). The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 108, 15474-15479. doi: 10.1073/pnas.1107893108
    • (2011) Proc. Natl. Acad. Sci. U.S. A , vol.108 , pp. 15474-15479
    • Gauvain, G.1    Chamma, I.2    Chevy, Q.3    Cabezas, C.4    Irinopoulou, T.5    Bodrug, N.6
  • 65
    • 0019313077 scopus 로고
    • Electrically silent cotransport on Na+, K+ and Cl-in Ehrlich cells
    • doi: 10.1016/0005-2736(80)90446-0
    • Geck, P., Pietrzyk, C., Burckhardt, B. C., Pfeiffer, B., and Heinz, E. (1980). Electrically silent cotransport on Na+, K+ and Cl-in Ehrlich cells. Biochim. Biophys. Acta 600, 432-447. doi: 10.1016/0005-2736(80)90446-0
    • (1980) Biochim. Biophys. Acta , vol.600 , pp. 432-447
    • Geck, P.1    Pietrzyk, C.2    Burckhardt, B.C.3    Pfeiffer, B.4    Heinz, E.5
  • 66
    • 0030036478 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family
    • doi: 10.1074/jbc.271.27.16237
    • Gillen, C. M., Brill, S., Payne, J. A., and Forbush, B. (1996). Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J. Biol. Chem. 271, 16237-16244. doi: 10.1074/jbc.271.27.16237
    • (1996) J. Biol. Chem , vol.271 , pp. 16237-16244
    • Gillen, C.M.1    Brill, S.2    Payne, J.A.3    Forbush, B.4
  • 67
    • 84885095868 scopus 로고    scopus 로고
    • Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation
    • doi: 10.1523/JNEUROSCI.4616-11.2013
    • Grimley, J. S., Li, L., Wang, W., Wen, L., Beese, L. S., Hellinga, H. W., et al. (2013). Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. J. Neurosci. 33, 16297-16309. doi: 10.1523/JNEUROSCI.4616-11.2013
    • (2013) J. Neurosci , vol.33 , pp. 16297-16309
    • Grimley, J.S.1    Li, L.2    Wang, W.3    Wen, L.4    Beese, L.S.5    Hellinga, H.W.6
  • 68
    • 0028156602 scopus 로고
    • The Na-K-Cl cotransporters
    • Haas, M. (1994). The Na-K-Cl cotransporters. Am. J. Physiol. 267, C869-C885.
    • (1994) Am. J. Physiol , vol.267
    • Haas, M.1
  • 69
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders
    • doi: 10.1038/nrn2911
    • Hardingham, G. E., and Bading, H. (2010). Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696. doi: 10.1038/nrn2911
    • (2010) Nat. Rev. Neurosci , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 70
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • doi: 10.1038/nn835
    • Hardingham, G. E., Fukunaga, Y., and Bading, H. (2002). Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nature Neurosci. 5, 405-414. doi: 10.1038/nn835
    • (2002) Nature Neurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 71
    • 70349325892 scopus 로고    scopus 로고
    • Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1
    • doi: 10.1111/j.1471-4159.2009.06343.x
    • Hartmann, A.-M., Blaesse, P., Kranz, T., Wenz, M., Schindler, J., Kaila, K., et al. (2009). Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. J. Neurochem. 111, 321-331. doi: 10.1111/j.1471-4159.2009.06343.x
    • (2009) J. Neurochem , vol.111 , pp. 321-331
    • Hartmann, A.-M.1    Blaesse, P.2    Kranz, T.3    Wenz, M.4    Schindler, J.5    Kaila, K.6
  • 72
    • 77954928727 scopus 로고    scopus 로고
    • Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4
    • doi: 10.1074/jbc.M110.144063
    • Hartmann, A.-M., Wenz, M., Mercado, A., Störger, C., Mount, D. B., Friauf, E., et al. (2010). Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4. J. Biol. Chem. 285, 23994-24002. doi: 10.1074/jbc.M110.144063
    • (2010) J. Biol. Chem , vol.285 , pp. 23994-24002
    • Hartmann, A.-M.1    Wenz, M.2    Mercado, A.3    Störger, C.4    Mount, D.B.5    Friauf, E.6
  • 73
    • 33748279281 scopus 로고    scopus 로고
    • Mutations in the K+/Cl-cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila
    • doi: 10.1523/JNEUROSCI.4998-05.2006
    • Hekmat-Scafe, D. S., Lundy, M. Y., Ranga, R., and Tanouye, M. A. (2006). Mutations in the K+/Cl-cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. J. Neurosci. 26, 8943-8954. doi: 10.1523/JNEUROSCI.4998-05.2006
    • (2006) J. Neurosci , vol.26 , pp. 8943-8954
    • Hekmat-Scafe, D.S.1    Lundy, M.Y.2    Ranga, R.3    Tanouye, M.A.4
  • 74
    • 74249121339 scopus 로고    scopus 로고
    • Seizure sensitivity is ameliorated by targeted expression of K+-Cl-cotransporter function in the mushroom body of the Drosophila brain
    • doi: 10.1534/genetics.109.109074
    • Hekmat-Scafe, D. S., Mercado, A., Fajilan, A. A., Lee, A. W., Hsu, R., Mount, D. B., et al. (2010). Seizure sensitivity is ameliorated by targeted expression of K+-Cl-cotransporter function in the mushroom body of the Drosophila brain. Genetics 184, 171-183. doi: 10.1534/genetics.109.109074
    • (2010) Genetics , vol.184 , pp. 171-183
    • Hekmat-Scafe, D.S.1    Mercado, A.2    Fajilan, A.A.3    Lee, A.W.4    Hsu, R.5    Mount, D.B.6
  • 76
    • 77953769162 scopus 로고    scopus 로고
    • Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism
    • doi: 10.1111/j.1460-9568.2010.07258.x
    • Horn, Z., Ringstedt, T., Blaesse, P., Kaila, K., and Herlenius, E. (2010). Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur. J. Neurosci. 31, 2142-2155. doi: 10.1111/j.1460-9568.2010.07258.x
    • (2010) Eur. J. Neurosci , vol.31 , pp. 2142-2155
    • Horn, Z.1    Ringstedt, T.2    Blaesse, P.3    Kaila, K.4    Herlenius, E.5
  • 77
    • 34548612464 scopus 로고    scopus 로고
    • Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    • doi: 10.1523/JNEUROSCI.2761-07.2007
    • Huberfeld, G., Wittner, L., Clemenceau, S., Baulac, M., Kaila, K., Miles, R., et al. (2007). Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J. Neurosci. 27, 9866-9873. doi: 10.1523/JNEUROSCI.2761-07.2007
    • (2007) J. Neurosci , vol.27 , pp. 9866-9873
    • Huberfeld, G.1    Wittner, L.2    Clemenceau, S.3    Baulac, M.4    Kaila, K.5    Miles, R.6
  • 78
    • 0034990498 scopus 로고    scopus 로고
    • Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition
    • doi: 10.1016/S0896-6273(01)00297-5
    • Hübner, C. A., Stein, V., Hermans-Borgmeyer, I., Meyer, T., Ballanyi, K., and Jentsch, T. J. (2001). Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron 30, 515-524. doi: 10.1016/S0896-6273(01)00297-5
    • (2001) Neuron , vol.30 , pp. 515-524
    • Hübner, C.A.1    Stein, V.2    Hermans-Borgmeyer, I.3    Meyer, T.4    Ballanyi, K.5    Jentsch, T.J.6
  • 79
    • 9344231411 scopus 로고    scopus 로고
    • Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl-homeostasis in brainstem neurons
    • doi: 10.1523/JNEUROSCI.2909-04.2004
    • Ikeda, K., Onimaru, H., Yamada, J., Inoue, K., Ueno, S., Onaka, T., et al. (2004). Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl-homeostasis in brainstem neurons. J. Neurosci. 24, 10693-10701. doi: 10.1523/JNEUROSCI.2909-04.2004
    • (2004) J. Neurosci , vol.24 , pp. 10693-10701
    • Ikeda, K.1    Onimaru, H.2    Yamada, J.3    Inoue, K.4    Ueno, S.5    Onaka, T.6
  • 80
    • 84862275080 scopus 로고    scopus 로고
    • Taurine inhibits K+-Cl-cotransporter KCC2 to regulate embryonic Cl-homeostasis via with-no-lysine (WNK) protein kinase signaling pathway
    • doi: 10.1074/jbc.M111.319418
    • Inoue, K., Furukawa, T., Kumada, T., Yamada, J., Wang, T., Inoue, R., et al. (2012). Taurine inhibits K+-Cl-cotransporter KCC2 to regulate embryonic Cl-homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. J. Biol. Chem. 287, 20839-20850. doi: 10.1074/jbc.M111.319418
    • (2012) J. Biol. Chem , vol.287 , pp. 20839-20850
    • Inoue, K.1    Furukawa, T.2    Kumada, T.3    Yamada, J.4    Wang, T.5    Inoue, R.6
  • 81
    • 1842828884 scopus 로고    scopus 로고
    • Interaction of neuron-specific K+-Cl-cotransporter, KCC2, with brain-type creatine kinase
    • doi: 10.1016/S0014-5793(04)00328-X
    • Inoue, K., Ueno, S., and Fukuda, A. (2004). Interaction of neuron-specific K+-Cl-cotransporter, KCC2, with brain-type creatine kinase. FEBS Lett. 564, 131-135. doi: 10.1016/S0014-5793(04)00328-X
    • (2004) FEBS Lett , vol.564 , pp. 131-135
    • Inoue, K.1    Ueno, S.2    Fukuda, A.3
  • 82
    • 33644877145 scopus 로고    scopus 로고
    • Brain-type creatine kinase activates neuron-specific K+-Cl-co-transporter KCC2
    • doi: 10.1111/j.1471-4159.2005.03560.x
    • Inoue, K., Yamada, J., Ueno, S., and Fukuda, A. (2006). Brain-type creatine kinase activates neuron-specific K+-Cl-co-transporter KCC2. J. Neurochem. 96, 598-608. doi: 10.1111/j.1471-4159.2005.03560.x
    • (2006) J. Neurochem , vol.96 , pp. 598-608
    • Inoue, K.1    Yamada, J.2    Ueno, S.3    Fukuda, A.4
  • 83
    • 84874459209 scopus 로고    scopus 로고
    • Neto2 is a KCC2 interacting protein required for neuronal Cl-regulation in hippocampal neurons
    • doi: 10.1073/pnas.1212907110
    • Ivakine, E. A., Acton, B. A., Mahadevan, V., Ormond, J., Tang, M., Pressey, J. C., et al. (2013). Neto2 is a KCC2 interacting protein required for neuronal Cl-regulation in hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 110, 3561-3566. doi: 10.1073/pnas.1212907110
    • (2013) Proc. Natl. Acad. Sci. U.S. A , vol.110 , pp. 3561-3566
    • Ivakine, E.A.1    Acton, B.A.2    Mahadevan, V.3    Ormond, J.4    Tang, M.5    Pressey, J.C.6
  • 84
    • 33645837486 scopus 로고    scopus 로고
    • Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons
    • doi: 10.1113/jphysiol.2006.105510
    • Ivanov, A., Pellegrino, C., Rama, S., Dumalska, I., Salyha, Y., Ben-Ari, Y., et al. (2006). Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J. Physiol. 572, 789-798. doi: 10.1113/jphysiol.2006.105510
    • (2006) J. Physiol , vol.572 , pp. 789-798
    • Ivanov, A.1    Pellegrino, C.2    Rama, S.3    Dumalska, I.4    Salyha, Y.5    Ben-Ari, Y.6
  • 85
    • 77649152649 scopus 로고    scopus 로고
    • Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia
    • doi: 10.1161/STROKEAHA.109.570424
    • Jaenisch, N., Witte, O. W., and Frahm, C. (2010). Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia. Stroke 41, e151-e159. doi: 10.1161/STROKEAHA.109.570424
    • (2010) Stroke , vol.41
    • Jaenisch, N.1    Witte, O.W.2    Frahm, C.3
  • 86
    • 0033564407 scopus 로고    scopus 로고
    • A furosemide-sensitive K+-Cl-cotransporter counteracts intracellular Cl-accumulation and depletion in cultured rat midbrain neurons
    • Jarolimek, W., Lewen, A., and Misgeld, U. (1999). A furosemide-sensitive K+-Cl-cotransporter counteracts intracellular Cl-accumulation and depletion in cultured rat midbrain neurons. J. Neurosci. 19, 4695-4704.
    • (1999) J. Neurosci , vol.19 , pp. 4695-4704
    • Jarolimek, W.1    Lewen, A.2    Misgeld, U.3
  • 87
    • 0034052719 scopus 로고    scopus 로고
    • Mechanism and cellular applications of a green fluorescent protein-based halide sensor
    • doi: 10.1074/jbc.275.9.6047
    • Jayaraman, S., Haggie, P., Wachter, R. M., Remington, S. J., and Verkman, A. S. (2000). Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J. Biol. Chem. 275, 6047-6050. doi: 10.1074/jbc.275.9.6047
    • (2000) J. Biol. Chem , vol.275 , pp. 6047-6050
    • Jayaraman, S.1    Haggie, P.2    Wachter, R.M.3    Remington, S.J.4    Verkman, A.S.5
  • 88
    • 0034738962 scopus 로고    scopus 로고
    • SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
    • doi: 10.1038/sj.onc.1203784
    • Johnston, A. M., Naselli, G., Gonez, L. J., Martin, R. M., Harrison, L. C., and DeAizpurua, H. J. (2000). SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 19, 4290-4297. doi: 10.1038/sj.onc.1203784
    • (2000) Oncogene , vol.19 , pp. 4290-4297
    • Johnston, A.M.1    Naselli, G.2    Gonez, L.J.3    Martin, R.M.4    Harrison, L.C.5    DeAizpurua, H.J.6
  • 89
    • 84888874322 scopus 로고    scopus 로고
    • Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2
    • doi: 10.1016/j.tins.2013.08.006
    • Kahle, K. T., Deeb, T. Z., Puskarjov, M., Silayeva, L., Liang, B., Kaila, K., et al. (2013). Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends Neurosci. 36, 726-737. doi: 10.1016/j.tins.2013.08.006
    • (2013) Trends Neurosci , vol.36 , pp. 726-737
    • Kahle, K.T.1    Deeb, T.Z.2    Puskarjov, M.3    Silayeva, L.4    Liang, B.5    Kaila, K.6
  • 90
    • 78049295923 scopus 로고    scopus 로고
    • Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases
    • doi: 10.1016/j.bbadis.2010.07.009
    • Kahle, K. T., Rinehart, J., and Lifton, R. P. (2010). Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochim. Biophys. Acta 1802, 1150-1158. doi: 10.1016/j.bbadis.2010.07.009
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 1150-1158
    • Kahle, K.T.1    Rinehart, J.2    Lifton, R.P.3
  • 91
    • 28044473649 scopus 로고    scopus 로고
    • WNK3 modulates transport of Cl-in and out of cells: Implications for control of cell volume and neuronal excitability
    • doi: 10.1073/pnas.0508307102
    • Kahle, K. T., Rinehart, J., de Los Heros, P., Louvi, A., Meade, P., Vazquez, N., et al. (2005). WNK3 modulates transport of Cl-in and out of cells: implications for control of cell volume and neuronal excitability. Proc. Natl. Acad. Sci. U.S.A. 102, 16783-16788. doi: 10.1073/pnas.0508307102
    • (2005) Proc. Natl. Acad. Sci. U.S. A , vol.102 , pp. 16783-16788
    • Kahle, K.T.1    Rinehart, J.2    de Los Heros, P.3    Louvi, A.4    Meade, P.5    Vazquez, N.6
  • 92
    • 51849140945 scopus 로고    scopus 로고
    • Roles of the cation-chloride cotransporters in neurological disease
    • doi: 10.1038/ncpneuro0883
    • Kahle, K. T., Staley, K. J., Nahed, B. V., Gamba, G., Hebert, S. C., Lifton, R. P., et al. (2008). Roles of the cation-chloride cotransporters in neurological disease. Nat. Clin. Pract. Neurol. 4, 490-503. doi: 10.1038/ncpneuro0883
    • (2008) Nat. Clin. Pract. Neurol , vol.4 , pp. 490-503
    • Kahle, K.T.1    Staley, K.J.2    Nahed, B.V.3    Gamba, G.4    Hebert, S.C.5    Lifton, R.P.6
  • 93
    • 0024465190 scopus 로고
    • Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres
    • Kaila, K., Pasternack, M., Saarikoski, J., and Voipio, J. (1989). Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres. J. Physiol. 416, 161-181.
    • (1989) J. Physiol , vol.416 , pp. 161-181
    • Kaila, K.1    Pasternack, M.2    Saarikoski, J.3    Voipio, J.4
  • 94
    • 0035124822 scopus 로고    scopus 로고
    • Neuronal restrictive silencing element is found in the KCC2 gene: Molecular basis for KCC2-specific expression in neurons
    • Karadsheh, M. F., and Delpire, E. (2001). Neuronal restrictive silencing element is found in the KCC2 gene: molecular basis for KCC2-specific expression in neurons. J. Neurophysiol. 85, 995-997.
    • (2001) J. Neurophysiol , vol.85 , pp. 995-997
    • Karadsheh, M.F.1    Delpire, E.2
  • 95
    • 0035503062 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons
    • Kelsch, W., Hormuzdi, S., Straube, E., Lewen, A., Monyer, H., and Misgeld, U. (2001). Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons. J. Neurosci. 21, 8339-8347.
    • (2001) J. Neurosci , vol.21 , pp. 8339-8347
    • Kelsch, W.1    Hormuzdi, S.2    Straube, E.3    Lewen, A.4    Monyer, H.5    Misgeld, U.6
  • 96
    • 84857017249 scopus 로고    scopus 로고
    • Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus
    • doi: 10.3389/fncel.2011.00023
    • Khalilov, I., Chazal, G., Chudotvorova, I., Pellegrino, C., Corby, S., Ferrand, N., et al. (2011). Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus. Front. Cell. Neurosci. 5:23. doi: 10.3389/fncel.2011.00023
    • (2011) Front. Cell. Neurosci , vol.5 , pp. 23
    • Khalilov, I.1    Chazal, G.2    Chudotvorova, I.3    Pellegrino, C.4    Corby, S.5    Ferrand, N.6
  • 97
    • 77956600434 scopus 로고    scopus 로고
    • A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus
    • doi: 10.1523/JNEUROSCI.3154-10.2010
    • Khirug, S., Ahmad, F., Puskarjov, M., Afzalov, R., Kaila, K., and Blaesse, P. (2010). A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus. J. Neurosci. 30, 12028-12035. doi: 10.1523/JNEUROSCI.3154-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 12028-12035
    • Khirug, S.1    Ahmad, F.2    Puskarjov, M.3    Afzalov, R.4    Kaila, K.5    Blaesse, P.6
  • 98
    • 16244388582 scopus 로고    scopus 로고
    • Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices
    • doi: 10.1111/j.1460-9568.2005.03886.x
    • Khirug, S., Huttu, K., Ludwig, A., Smirnov, S., Voipio, J., Rivera, C., et al. (2005). Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices. Eur. J. Neurosci. 21, 899-904. doi: 10.1111/j.1460-9568.2005.03886.x
    • (2005) Eur. J. Neurosci , vol.21 , pp. 899-904
    • Khirug, S.1    Huttu, K.2    Ludwig, A.3    Smirnov, S.4    Voipio, J.5    Rivera, C.6
  • 99
    • 44649160758 scopus 로고    scopus 로고
    • GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
    • doi: 10.1523/JNEUROSCI.0908-08.2008
    • Khirug, S., Yamada, J., Afzalov, R., Voipio, J., Khiroug, L., and Kaila, K. (2008). GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J. Neurosci. 28, 4635-4639. doi: 10.1523/JNEUROSCI.0908-08.2008
    • (2008) J. Neurosci , vol.28 , pp. 4635-4639
    • Khirug, S.1    Yamada, J.2    Afzalov, R.3    Voipio, J.4    Khiroug, L.5    Kaila, K.6
  • 100
    • 84864453851 scopus 로고    scopus 로고
    • Two-photon chloride imaging using MQAE in vitro and in vivo
    • doi: 10.1101/pdb.prot070037
    • Kovalchuk, Y., and Garaschuk, O. (2012). Two-photon chloride imaging using MQAE in vitro and in vivo. Cold Spring Harb. Protoc. 2012, 778-785. doi: 10.1101/pdb.prot070037
    • (2012) Cold Spring Harb. Protoc , vol.2012 , pp. 778-785
    • Kovalchuk, Y.1    Garaschuk, O.2
  • 101
    • 0242573273 scopus 로고    scopus 로고
    • The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1
    • doi: 10.1016/S0896-6273(03)00645-7
    • Krapivinsky, G., Krapivinsky, L., Manasian, Y., Ivanov, A., Tyzio, R., Pellegrino, C., et al. (2003). The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 40, 775-784. doi: 10.1016/S0896-6273(03)00645-7
    • (2003) Neuron , vol.40 , pp. 775-784
    • Krapivinsky, G.1    Krapivinsky, L.2    Manasian, Y.3    Ivanov, A.4    Tyzio, R.5    Pellegrino, C.6
  • 102
    • 4143133173 scopus 로고    scopus 로고
    • SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation
    • doi: 10.1016/j.neuron.2004.08.003
    • Krapivinsky, G., Medina, I., Krapivinsky, L., Gapon, S., and Clapham, D. E. (2004). SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 43, 563-574. doi: 10.1016/j.neuron.2004.08.003
    • (2004) Neuron , vol.43 , pp. 563-574
    • Krapivinsky, G.1    Medina, I.2    Krapivinsky, L.3    Gapon, S.4    Clapham, D.E.5
  • 103
    • 0015143180 scopus 로고
    • The response of duck erythrocytes to nonhemolytic hypotonic media. Evidence for a volume-controlling mechanism
    • doi: 10.1085/jgp.58.4.372
    • Kregenow, F. M. (1971). The response of duck erythrocytes to nonhemolytic hypotonic media. Evidence for a volume-controlling mechanism. J. Gen. Physiol. 58, 372-395. doi: 10.1085/jgp.58.4.372
    • (1971) J. Gen. Physiol , vol.58 , pp. 372-395
    • Kregenow, F.M.1
  • 104
    • 77958471664 scopus 로고    scopus 로고
    • Activity-dependent dendritic secretion of brain-derived neurotrophic factor modulates synaptic plasticity
    • doi: 10.1111/j.1460-9568.2010.07378.x
    • Kuczewski, N., Porcher, C., and Gaiarsa, J.-L. (2010). Activity-dependent dendritic secretion of brain-derived neurotrophic factor modulates synaptic plasticity. Eur. J. Neurosci. 32, 1239-1244. doi: 10.1111/j.1460-9568.2010.07378.x
    • (2010) Eur. J. Neurosci , vol.32 , pp. 1239-1244
    • Kuczewski, N.1    Porcher, C.2    Gaiarsa, J.-L.3
  • 105
    • 49049111174 scopus 로고    scopus 로고
    • Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity
    • doi: 10.1523/JNEUROSCI.1673-08.2008
    • Kuczewski, N., Porcher, C., Ferrand, N., Fiorentino, H., Pellegrino, C., Kolarow, R., et al. (2008). Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity. J. Neurosci. 28, 7013-7023. doi: 10.1523/JNEUROSCI.1673-08.2008
    • (2008) J. Neurosci , vol.28 , pp. 7013-7023
    • Kuczewski, N.1    Porcher, C.2    Ferrand, N.3    Fiorentino, H.4    Pellegrino, C.5    Kolarow, R.6
  • 106
    • 0033724998 scopus 로고    scopus 로고
    • A genetically encoded ratiometric indicator for chloride: Capturing chloride transients in cultured hippocampal neurons
    • doi: 10.1016/S0896-6273(00)00056-8
    • Kuner, T., and Augustine, G. J. (2000). A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons. Neuron 27, 447-459. doi: 10.1016/S0896-6273(00)00056-8
    • (2000) Neuron , vol.27 , pp. 447-459
    • Kuner, T.1    Augustine, G.J.2
  • 107
    • 0028937180 scopus 로고
    • Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration
    • doi: 10.1016/0165-0270(94)00116-X
    • Kyrozis, A., and Reichling, D. B. (1995). Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration. J. Neurosci. Methods 57, 27-35. doi: 10.1016/0165-0270(94)00116-X
    • (1995) J. Neurosci. Methods , vol.57 , pp. 27-35
    • Kyrozis, A.1    Reichling, D.B.2
  • 108
    • 84858275137 scopus 로고    scopus 로고
    • KCC2a expression in a human fetal lens epithelial cell line
    • doi: 10.1159/000337611
    • Lauf, P. K., Di Fulvio, M., Srivastava, V., Sharma, N., and Adragna, N. C. (2012). KCC2a expression in a human fetal lens epithelial cell line. Cell. Physiol. Biochem. 29, 303-312. doi: 10.1159/000337611
    • (2012) Cell. Physiol. Biochem , vol.29 , pp. 303-312
    • Lauf, P.K.1    Di Fulvio, M.2    Srivastava, V.3    Sharma, N.4    Adragna, N.C.5
  • 109
    • 41549105808 scopus 로고    scopus 로고
    • Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells
    • doi: 10.1152/ajpcell.00375.2007
    • Lauf, P. K., Misri, S., Chimote, A. A., and Adragna, N. C. (2008). Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells. Am. J. Physiol. Cell Physiol. 294, C820-C832. doi: 10.1152/ajpcell.00375.2007
    • (2008) Am. J. Physiol. Cell Physiol , vol.294
    • Lauf, P.K.1    Misri, S.2    Chimote, A.A.3    Adragna, N.C.4
  • 110
    • 20444439280 scopus 로고    scopus 로고
    • KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses
    • doi: 10.1111/j.1460-9568.2005.04084.x
    • Lee, H., Chen, C. X.-Q., Liu, Y.-J., Aizenman, E., and Kandler, K. (2005). KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses. Eur. J. Neurosci. 21, 2593-2599. doi: 10.1111/j.1460-9568.2005.04084.x
    • (2005) Eur. J. Neurosci , vol.21 , pp. 2593-2599
    • Lee, H.1    Chen, C.X.-Q.2    Liu, Y.-J.3    Aizenman, E.4    Kandler, K.5
  • 111
    • 79960845291 scopus 로고    scopus 로고
    • NMDA receptor activity downregulates KCC2 resulting in depolarizing GABA(A) receptor-mediated currents
    • doi: 10.1038/nn.2806
    • Lee, H. H. C., Deeb, T. Z., Walker, J. A., Davies, P. A, and Moss, S. J. (2011). NMDA receptor activity downregulates KCC2 resulting in depolarizing GABA(A) receptor-mediated currents. Nat. Neurosci. 14, 736-743. doi: 10.1038/nn.2806
    • (2011) Nat. Neurosci , vol.14 , pp. 736-743
    • Lee, H.H.C.1    Deeb, T.Z.2    Walker, J.A.3    Davies, P.A.4    Moss, S.J.5
  • 112
    • 77955769549 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2
    • doi: 10.1016/j.mcn.2010.06.008
    • Lee, H. H. C., Jurd, R., and Moss, S. J. (2010). Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol. Cell. Neurosci. 45, 173-179. doi: 10.1016/j.mcn.2010.06.008
    • (2010) Mol. Cell. Neurosci , vol.45 , pp. 173-179
    • Lee, H.H.C.1    Jurd, R.2    Moss, S.J.3
  • 113
    • 35649026880 scopus 로고    scopus 로고
    • Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2
    • doi: 10.1074/jbc.M705053200
    • Lee, H. H. C., Walker, J. A., Williams, J. R., Goodier, R. J., Payne, J. A., and Moss, S. J. (2007). Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. J. Biol. Chem. 282, 29777-29784. doi: 10.1074/jbc.M705053200
    • (2007) J. Biol. Chem , vol.282 , pp. 29777-29784
    • Lee, H.H.C.1    Walker, J.A.2    Williams, J.R.3    Goodier, R.J.4    Payne, J.A.5    Moss, S.J.6
  • 114
    • 18644362663 scopus 로고    scopus 로고
    • GABA type-A activity controls its own developmental polarity switch in the maturing retina
    • doi: 10.1523/JNEUROSCI.0172-05.2005
    • Leitch, E., Coaker, J., Young, C., Mehta, V., and Sernagor, E. (2005). GABA type-A activity controls its own developmental polarity switch in the maturing retina. J. Neurosci. 25, 4801-4805. doi: 10.1523/JNEUROSCI.0172-05.2005
    • (2005) J. Neurosci , vol.25 , pp. 4801-4805
    • Leitch, E.1    Coaker, J.2    Young, C.3    Mehta, V.4    Sernagor, E.5
  • 115
    • 37049035922 scopus 로고    scopus 로고
    • KCC2 interacts with the dendritic cytoskeleton to promote spine development
    • doi: 10.1016/j.neuron.2007.10.039
    • Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., et al. (2007). KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron 56, 1019-1033. doi: 10.1016/j.neuron.2007.10.039
    • (2007) Neuron , vol.56 , pp. 1019-1033
    • Li, H.1    Khirug, S.2    Cai, C.3    Ludwig, A.4    Blaesse, P.5    Kolikova, J.6
  • 116
    • 0036924837 scopus 로고    scopus 로고
    • Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development
    • doi: 10.1046/j.1460-9568.2002.02419.x
    • Li, H., Tornberg, J., Kaila, K., Airaksinen, M. S., and Rivera, C. (2002). Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development. Eur. J. Neurosci. 16, 2358-2370. doi: 10.1046/j.1460-9568.2002.02419.x
    • (2002) Eur. J. Neurosci , vol.16 , pp. 2358-2370
    • Li, H.1    Tornberg, J.2    Kaila, K.3    Airaksinen, M.S.4    Rivera, C.5
  • 117
    • 74849118341 scopus 로고    scopus 로고
    • Lipid rafts as a membrane-organizing principle
    • doi: 10.1126/science.1174621
    • Lingwood, D., and Simons, K. (2010). Lipid rafts as a membrane-organizing principle. Science 327, 46-50. doi: 10.1126/science.1174621
    • (2010) Science , vol.327 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 118
    • 0033564808 scopus 로고    scopus 로고
    • Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains
    • doi: 10.1002/(SICI)1097-4695(19990615)39:4<558::AID-NEU9>3.0.CO;2-5
    • Lu, J., Karadsheh, M., and Delpire, E. (1999). Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains. J. Neurobiol. 39, 558-568. doi: 10.1002/(SICI)1097-4695(19990615)39:4<558::AID-NEU9>3.0.CO;2-5
    • (1999) J. Neurobiol , vol.39 , pp. 558-568
    • Lu, J.1    Karadsheh, M.2    Delpire, E.3
  • 119
    • 0347419242 scopus 로고    scopus 로고
    • Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission
    • doi: 10.1111/j.1460-9568.2003.03069.x
    • Ludwig, A., Li, H., Saarma, M., Kaila, K., and Rivera, C. (2003). Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission. Eur. J. Neurosci. 18, 3199-3206. doi: 10.1111/j.1460-9568.2003.03069.x
    • (2003) Eur. J. Neurosci , vol.18 , pp. 3199-3206
    • Ludwig, A.1    Li, H.2    Saarma, M.3    Kaila, K.4    Rivera, C.5
  • 121
    • 80053643920 scopus 로고    scopus 로고
    • Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons
    • doi: 10.1155/2011/641248
    • Ludwig, A., Uvarov, P., Pellegrino, C., Thomas-Crusells, J., Schuchmann, S., Saarma, M., et al. (2011a). Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons. Neural Plast. 2011, 1-8. doi: 10.1155/2011/641248
    • (2011) Neural Plast , vol.2011 , pp. 1-8
    • Ludwig, A.1    Uvarov, P.2    Pellegrino, C.3    Thomas-Crusells, J.4    Schuchmann, S.5    Saarma, M.6
  • 122
    • 78651473582 scopus 로고    scopus 로고
    • Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    • doi: 10.1523/JNEUROSCI.2006-10.2011
    • Ludwig, A., Uvarov, P., Soni, S., Thomas-Crusells, J., Airaksinen, M. S., and Rivera, C. (2011b). Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription. J. Neurosci. 31, 644-649. doi: 10.1523/JNEUROSCI.2006-10.2011
    • (2011) J. Neurosci , vol.31 , pp. 644-649
    • Ludwig, A.1    Uvarov, P.2    Soni, S.3    Thomas-Crusells, J.4    Airaksinen, M.S.5    Rivera, C.6
  • 123
    • 84875250685 scopus 로고    scopus 로고
    • Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments
    • doi: 10.1016/j.neuropharm.2012.05.045
    • Löscher, W., Puskarjov, M., and Kaila, K. (2013). Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments. Neuropharmacology 69, 62-74. doi: 10.1016/j.neuropharm.2012.05.045
    • (2013) Neuropharmacology , vol.69 , pp. 62-74
    • Löscher, W.1    Puskarjov, M.2    Kaila, K.3
  • 124
    • 84893589294 scopus 로고    scopus 로고
    • Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS
    • doi: 10.1002/cne.23510. Avilable online at
    • Markkanen, M., Karhunen, T., Llano, O., Ludwig, A., Rivera, C., Uvarov, P., et al. (2013). Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. J. Comp. Neurol. doi: 10.1002/cne.23510. Avilable online at:http://doi.wiley.com/10.1002/cne.23510
    • (2013) J. Comp. Neurol
    • Markkanen, M.1    Karhunen, T.2    Llano, O.3    Ludwig, A.4    Rivera, C.5    Uvarov, P.6
  • 125
    • 53049089883 scopus 로고    scopus 로고
    • Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2
    • doi: 10.1016/j.brainres.2008.08.007
    • Markkanen, M., Uvarov, P., and Airaksinen, M. S. (2008). Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2. Brain Res. 1236, 8-15. doi: 10.1016/j.brainres.2008.08.007
    • (2008) Brain Res , vol.1236 , pp. 8-15
    • Markkanen, M.1    Uvarov, P.2    Airaksinen, M.S.3
  • 126
    • 41049099330 scopus 로고    scopus 로고
    • Genetically encoded chloride indicator with improved sensitivity
    • doi: 10.1016/j.jneumeth.2007.12.016
    • Markova, O., Mukhtarov, M., Real, E., Jacob, Y., and Bregestovski, P. (2008). Genetically encoded chloride indicator with improved sensitivity. J. Neurosci. Methods 170, 67-76. doi: 10.1016/j.jneumeth.2007.12.016
    • (2008) J. Neurosci. Methods , vol.170 , pp. 67-76
    • Markova, O.1    Mukhtarov, M.2    Real, E.3    Jacob, Y.4    Bregestovski, P.5
  • 127
    • 70449623634 scopus 로고    scopus 로고
    • Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite
    • doi: 10.1523/JNEUROSCI.1863-09.2009
    • Matsuda, N., Lu, H., Fukata, Y., Noritake, J., Gao, H., Mukherjee, S., et al. (2009). Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J. Neurosci. 29, 14185-14198. doi: 10.1523/JNEUROSCI.1863-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 14185-14198
    • Matsuda, N.1    Lu, H.2    Fukata, Y.3    Noritake, J.4    Gao, H.5    Mukherjee, S.6
  • 129
    • 84878563368 scopus 로고    scopus 로고
    • Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse
    • doi: 10.1152/ajprenal.00288.2012
    • Mederle, K., Mutig, K., Paliege, A., Carota, I., Bachmann, S., Castrop, H., et al. (2013). Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse. Am. J. Physiol. Renal Physiol. 304, F1198-F1209. doi: 10.1152/ajprenal.00288.2012
    • (2013) Am. J. Physiol. Renal Physiol , vol.304
    • Mederle, K.1    Mutig, K.2    Paliege, A.3    Carota, I.4    Bachmann, S.5    Castrop, H.6
  • 130
    • 35148875095 scopus 로고    scopus 로고
    • Extrasynaptic NMDA receptors reshape gene ranks
    • doi: 10.1126/stke.3862007pe23
    • Medina, I. (2007). Extrasynaptic NMDA receptors reshape gene ranks. Signal Transduct. Knowledge Environ. 2007, pe23. doi: 10.1126/stke.3862007pe23
    • (2007) Signal Transduct. Knowledge Environ , vol.2007
    • Medina, I.1
  • 131
    • 36649001330 scopus 로고    scopus 로고
    • GABA neurotransmission and neural cation-chloride co-transporters: Actions beyond ion transport
    • doi: 10.1615/CritRevNeurobiol.v18.i1-2.110
    • Medina, I., and Chudotvorova, I. (2006). GABA neurotransmission and neural cation-chloride co-transporters: actions beyond ion transport. Crit. Rev. Neurobiol. 18, 105-112. doi: 10.1615/CritRevNeurobiol.v18.i1-2.110
    • (2006) Crit. Rev. Neurobiol , vol.18 , pp. 105-112
    • Medina, I.1    Chudotvorova, I.2
  • 132
    • 33644871505 scopus 로고    scopus 로고
    • A C-terminal domain in KCC2 confers constitutive K+-Cl-cotransport
    • doi: 10.1074/jbc.M509972200
    • Mercado, A., Broumand, V., Zandi-Nejad, K., Enck, A. H., and Mount, D. B. (2006). A C-terminal domain in KCC2 confers constitutive K+-Cl-cotransport. J. Biol. Chem. 281, 1016-1026. doi: 10.1074/jbc.M509972200
    • (2006) J. Biol. Chem , vol.281 , pp. 1016-1026
    • Mercado, A.1    Broumand, V.2    Zandi-Nejad, K.3    Enck, A.H.4    Mount, D.B.5
  • 133
    • 0034730622 scopus 로고    scopus 로고
    • Functional comparison of the K+-Cl-cotransporters KCC1 and KCC4
    • doi: 10.1074/jbc.M003112200
    • Mercado, A., Song, L., Vazquez, N., Mount, D. B., and Gamba, G. (2000). Functional comparison of the K+-Cl-cotransporters KCC1 and KCC4. J. Biol. Chem. 275, 30326-30334. doi: 10.1074/jbc.M003112200
    • (2000) J. Biol. Chem , vol.275 , pp. 30326-30334
    • Mercado, A.1    Song, L.2    Vazquez, N.3    Mount, D.B.4    Gamba, G.5
  • 134
    • 0034603704 scopus 로고    scopus 로고
    • The structural unit of the secretory Na+-K+-2Cl-cotransporter (NKCC1) is a homodimer
    • doi: 10.1021/bi992301v
    • Moore-Hoon, M. L., and Turner, R. J. (2000). The structural unit of the secretory Na+-K+-2Cl-cotransporter (NKCC1) is a homodimer. Biochemistry 39, 3718-3724. doi: 10.1021/bi992301v
    • (2000) Biochemistry , vol.39 , pp. 3718-3724
    • Moore-Hoon, M.L.1    Turner, R.J.2
  • 135
    • 0021262518 scopus 로고
    • Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro
    • Mueller, A. L., Taube, J. S., and Schwartzkroin, P. A. (1984). Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro. J. Neurosci. 4, 860-867.
    • (1984) J. Neurosci , vol.4 , pp. 860-867
    • Mueller, A.L.1    Taube, J.S.2    Schwartzkroin, P.A.3
  • 136
    • 84875887463 scopus 로고    scopus 로고
    • Calibration and functional analysis of three genetically encoded Cl(-)/pH sensors
    • doi: 10.3389/fnmol.2013.00009
    • Mukhtarov, M., Liguori, L., Waseem, T., Rocca, F., Buldakova, S., Arosio, D., et al. (2013). Calibration and functional analysis of three genetically encoded Cl(-)/pH sensors. Front. Mol. Neurosci. 6:9. doi: 10.3389/fnmol.2013.00009
    • (2013) Front. Mol. Neurosci , vol.6 , pp. 9
    • Mukhtarov, M.1    Liguori, L.2    Waseem, T.3    Rocca, F.4    Buldakova, S.5    Arosio, D.6
  • 137
    • 34247129585 scopus 로고    scopus 로고
    • Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsy
    • doi: 10.1111/j.1528-1167.2006.00954.x
    • Munakata, M., Watanabe, M., Otsuki, T., Nakama, H., Arima, K., Itoh, M., et al. (2007). Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsy. Epilepsia 48, 837-844. doi: 10.1111/j.1528-1167.2006.00954.x
    • (2007) Epilepsia , vol.48 , pp. 837-844
    • Munakata, M.1    Watanabe, M.2    Otsuki, T.3    Nakama, H.4    Arima, K.5    Itoh, M.6
  • 138
    • 0036618259 scopus 로고    scopus 로고
    • Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury
    • Nabekura, J., Ueno, T., Okabe, A., Furuta, A., Iwaki, T., Shimizu-okabe, C., et al. (2002). Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury. J. Neurosci. 22, 4412-4417.
    • (2002) J. Neurosci , vol.22 , pp. 4412-4417
    • Nabekura, J.1    Ueno, T.2    Okabe, A.3    Furuta, A.4    Iwaki, T.5    Shimizu-okabe, C.6
  • 139
    • 66349131378 scopus 로고    scopus 로고
    • Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus
    • doi: 10.1152/jn.90761.2008
    • Nardou, R., Ben-Ari, Y., and Khalilov, I. (2009). Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus. J. Neurophysiol. 101, 2878-2888. doi: 10.1152/jn.90761.2008
    • (2009) J. Neurophysiol , vol.101 , pp. 2878-2888
    • Nardou, R.1    Ben-Ari, Y.2    Khalilov, I.3
  • 140
    • 79953648268 scopus 로고    scopus 로고
    • Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital
    • doi: 10.1093/brain/awr041
    • Nardou, R., Yamamoto, S., Chazal, G., Bhar, A., Ferrand, N., Dulac, O., et al. (2011). Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital. Brain 134, 987-1002. doi: 10.1093/brain/awr041
    • (2011) Brain , vol.134 , pp. 987-1002
    • Nardou, R.1    Yamamoto, S.2    Chazal, G.3    Bhar, A.4    Ferrand, N.5    Dulac, O.6
  • 141
    • 33744832650 scopus 로고    scopus 로고
    • Anomalous levels of Cl-transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
    • doi: 10.1073/pnas.0602979103
    • Palma, E., Amici, M., Sobrero, F., Spinelli, G., Di Angelantonio, S., Ragozzino, D., et al. (2006). Anomalous levels of Cl-transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proc. Natl. Acad. Sci. U.S.A. 103, 8465-8468. doi: 10.1073/pnas.0602979103
    • (2006) Proc. Natl. Acad. Sci. U.S. A , vol.103 , pp. 8465-8468
    • Palma, E.1    Amici, M.2    Sobrero, F.3    Spinelli, G.4    Di Angelantonio, S.5    Ragozzino, D.6
  • 142
    • 46549087720 scopus 로고    scopus 로고
    • Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia
    • doi: 10.1016/j.neuroscience.2008.03.072
    • Papp, E., Rivera, C., Kaila, K., and Freund, T. F. (2008). Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia. Neuroscience 154, 677-689. doi: 10.1016/j.neuroscience.2008.03.072
    • (2008) Neuroscience , vol.154 , pp. 677-689
    • Papp, E.1    Rivera, C.2    Kaila, K.3    Freund, T.F.4
  • 143
    • 34548107626 scopus 로고    scopus 로고
    • Regions in the cytosolic C-terminus of the secretory Na(+)-K(+)-2Cl(-) cotransporter NKCC1 are required for its homodimerization
    • doi: 10.1021/bi700881a
    • Parvin, M. N., Gerelsaikhan, T., and Turner, R. J. (2007). Regions in the cytosolic C-terminus of the secretory Na(+)-K(+)-2Cl(-) cotransporter NKCC1 are required for its homodimerization. Biochemistry 46, 9630-9637. doi: 10.1021/bi700881a
    • (2007) Biochemistry , vol.46 , pp. 9630-9637
    • Parvin, M.N.1    Gerelsaikhan, T.2    Turner, R.J.3
  • 144
    • 0030658056 scopus 로고    scopus 로고
    • Functional characterization of the neuronal-specific K-Cl cotransporter: Implications for [K+]o regulation
    • Payne, J. A. (1997). Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. Am. J. Phys. 273, C1516-C1525.
    • (1997) Am. J. Phys , vol.273
    • Payne, J.A.1
  • 145
    • 0030059455 scopus 로고    scopus 로고
    • Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform
    • doi: 10.1074/jbc.271.27.16245
    • Payne, J. A., Stevenson, T. J., and Donaldson, L. F. (1996). Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J. Biol. Chem. 271, 16245-16252. doi: 10.1074/jbc.271.27.16245
    • (1996) J. Biol. Chem , vol.271 , pp. 16245-16252
    • Payne, J.A.1    Stevenson, T.J.2    Donaldson, L.F.3
  • 146
    • 41449101925 scopus 로고    scopus 로고
    • Intramolecular and intermolecular fluorescence resonance energy transfer in fluorescent protein-tagged Na-K-Cl cotransporter (NKCC1): Sensitivity to regulatory conformational change and cell volume
    • doi: 10.1074/jbc.M708194200
    • Pedersen, M., Carmosino, M., and Forbush, B. (2008). Intramolecular and intermolecular fluorescence resonance energy transfer in fluorescent protein-tagged Na-K-Cl cotransporter (NKCC1): sensitivity to regulatory conformational change and cell volume. J. Biol. Chem. 283, 2663-2674. doi: 10.1074/jbc.M708194200
    • (2008) J. Biol. Chem , vol.283 , pp. 2663-2674
    • Pedersen, M.1    Carmosino, M.2    Forbush, B.3
  • 147
    • 79955944363 scopus 로고    scopus 로고
    • Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival
    • doi: 10.1113/jphysiol.2010.203703
    • Pellegrino, C., Gubkina, O., Schaefer, M., Becq, H., Ludwig, A., Mukhtarov, M., et al. (2011). Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival. J. Physiol. 589, 2475-2496. doi: 10.1113/jphysiol.2010.203703
    • (2011) J. Physiol , vol.589 , pp. 2475-2496
    • Pellegrino, C.1    Gubkina, O.2    Schaefer, M.3    Becq, H.4    Ludwig, A.5    Mukhtarov, M.6
  • 148
    • 84865017910 scopus 로고    scopus 로고
    • Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
    • doi: 10.1523/JNEUROSCI.6265-11.2012
    • Puskarjov, M., Ahmad, F., Kaila, K., and Blaesse, P. (2012). Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. J. Neurosci 32, 11356-11364. doi: 10.1523/JNEUROSCI.6265-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 11356-11364
    • Puskarjov, M.1    Ahmad, F.2    Kaila, K.3    Blaesse, P.4
  • 149
    • 77953459148 scopus 로고    scopus 로고
    • Role of the WNK-activated SPAK kinase in regulating blood pressure
    • doi: 10.1002/emmm.200900058
    • Rafiqi, F. H., Zuber, A. M., Glover, M., Richardson, C., Fleming, S., Jovanović, S., et al. (2010). Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol. Med. 2, 63-75. doi: 10.1002/emmm.200900058
    • (2010) EMBO Mol. Med , vol.2 , pp. 63-75
    • Rafiqi, F.H.1    Zuber, A.M.2    Glover, M.3    Richardson, C.4    Fleming, S.5    Jovanović, S.6
  • 150
    • 84888194352 scopus 로고    scopus 로고
    • A genetically-encoded chloride and pH sensor for dissociating ion dynamics in the nervous system
    • doi: 10.3389/fncel.2013.00202
    • Raimondo, J. V., Joyce, B., Kay, L., Schlagheck, T., Newey, S. E., Srinivas, S., et al. (2013). A genetically-encoded chloride and pH sensor for dissociating ion dynamics in the nervous system. Front. Cell. Neurosci. 7:202. doi: 10.3389/fncel.2013.00202
    • (2013) Front. Cell. Neurosci , vol.7 , pp. 202
    • Raimondo, J.V.1    Joyce, B.2    Kay, L.3    Schlagheck, T.4    Newey, S.E.5    Srinivas, S.6
  • 151
    • 39549097528 scopus 로고    scopus 로고
    • Neurogenic role of the depolarizing chloride gradient revealed by global overexpression of KCC2 from the onset of development
    • doi: 10.1523/JNEUROSCI.3791-07.2008
    • Reynolds, A., Brustein, E., Liao, M., Mercado, A., Babilonia, E., Mount, D. B., et al. (2008). Neurogenic role of the depolarizing chloride gradient revealed by global overexpression of KCC2 from the onset of development. J. Neurosci. 28, 1588-1597. doi: 10.1523/JNEUROSCI.3791-07.2008
    • (2008) J. Neurosci , vol.28 , pp. 1588-1597
    • Reynolds, A.1    Brustein, E.2    Liao, M.3    Mercado, A.4    Babilonia, E.5    Mount, D.B.6
  • 152
    • 68149100251 scopus 로고    scopus 로고
    • Sites of regulated phosphorylation that control K-Cl cotransporter activity
    • doi: 10.1016/j.cell.2009.05.031
    • Rinehart, J., Maksimova, Y. D., Tanis, J. E., Stone, K. L., Caleb, A., Zhang, J., et al. (2009). Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell 138, 525-536. doi: 10.1016/j.cell.2009.05.031
    • (2009) Cell , vol.138 , pp. 525-536
    • Rinehart, J.1    Maksimova, Y.D.2    Tanis, J.E.3    Stone, K.L.4    Caleb, A.5    Zhang, J.6
  • 153
    • 80051937272 scopus 로고    scopus 로고
    • WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
    • doi: 10.1074/jbc.M111.222893
    • Rinehart, J., Vázquez, N., Kahle, K. T., Hodson, C. A., Ring, A. M., Gulcicek, E. E., et al. (2011). WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J. Biol. Chem. 286, 30171-30180. doi: 10.1074/jbc.M111.222893
    • (2011) J. Biol. Chem , vol.286 , pp. 30171-30180
    • Rinehart, J.1    Vázquez, N.2    Kahle, K.T.3    Hodson, C.A.4    Ring, A.M.5    Gulcicek, E.E.6
  • 154
    • 0037049553 scopus 로고    scopus 로고
    • BDNF-induced TrkB activation down-regulates the K+-Cl-cotransporter KCC2 and impairs neuronal Cl-extrusion
    • doi: 10.1083/jcb.200209011
    • Rivera, C., Li, H., Thomas-Crusells, J., Lahtinen, H., Viitanen, T., Nanobashvili, A., et al. (2002). BDNF-induced TrkB activation down-regulates the K+-Cl-cotransporter KCC2 and impairs neuronal Cl-extrusion. J. Cell Biol. 159, 747-752. doi: 10.1083/jcb.200209011
    • (2002) J. Cell Biol , vol.159 , pp. 747-752
    • Rivera, C.1    Li, H.2    Thomas-Crusells, J.3    Lahtinen, H.4    Viitanen, T.5    Nanobashvili, A.6
  • 155
    • 0033590541 scopus 로고    scopus 로고
    • The K+/Cl-co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    • doi: 10.1038/16697
    • Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., et al. (1999). The K+/Cl-co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397, 251-255. doi: 10.1038/16697
    • (1999) Nature , vol.397 , pp. 251-255
    • Rivera, C.1    Voipio, J.2    Payne, J.A.3    Ruusuvuori, E.4    Lahtinen, H.5    Lamsa, K.6
  • 156
    • 2442707888 scopus 로고    scopus 로고
    • Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2
    • doi: 10.1523/JNEUROSCI.5265-03.2004
    • Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipilä, S., et al. (2004). Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J. Neurosci. 24, 4683-4691. doi: 10.1523/JNEUROSCI.5265-03.2004
    • (2004) J. Neurosci , vol.24 , pp. 4683-4691
    • Rivera, C.1    Voipio, J.2    Thomas-Crusells, J.3    Li, H.4    Emri, Z.5    Sipilä, S.6
  • 157
    • 0033968208 scopus 로고    scopus 로고
    • Sodium-potassium-chloride cotransport
    • doi: 10.1016/B978-0-12-374373-2.00027-3
    • Russell, J. M. (2000). Sodium-potassium-chloride cotransport. Physiol. Rev. 80, 211-276. doi: 10.1016/B978-0-12-374373-2.00027-3
    • (2000) Physiol. Rev , vol.80 , pp. 211-276
    • Russell, J.M.1
  • 158
    • 0017103272 scopus 로고
    • Role of choloride transport in regulation of intracellular pH
    • doi: 10.1038/264073a0
    • Russell, J. M., and Boron, W. F. (1976). Role of choloride transport in regulation of intracellular pH. Nature 264, 73-74. doi: 10.1038/264073a0
    • (1976) Nature , vol.264 , pp. 73-74
    • Russell, J.M.1    Boron, W.F.2
  • 159
    • 84861202732 scopus 로고    scopus 로고
    • SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro
    • doi: 10.1016/j.neuroscience.2012.03.001
    • Saadi, R. A., He, K., Hartnett, K. A., Kandler, K., Hershfinkel, M., and Aizenman, E. (2012). SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro. Neuroscience 210, 38-46. doi: 10.1016/j.neuroscience.2012.03.001
    • (2012) Neuroscience , vol.210 , pp. 38-46
    • Saadi, R.A.1    He, K.2    Hartnett, K.A.3    Kandler, K.4    Hershfinkel, M.5    Aizenman, E.6
  • 160
    • 0347931720 scopus 로고    scopus 로고
    • Experience-dependent changes in intracellular Cl-regulation in developing auditory neurons
    • doi: 10.1016/j.neures.2003.10.011
    • Shibata, S., Kakazu, Y., Okabe, A., Fukuda, A., and Nabekura, J. (2004). Experience-dependent changes in intracellular Cl-regulation in developing auditory neurons. Neurosci. Res. 48, 211-220. doi: 10.1016/j.neures.2003.10.011
    • (2004) Neurosci. Res , vol.48 , pp. 211-220
    • Shibata, S.1    Kakazu, Y.2    Okabe, A.3    Fukuda, A.4    Nabekura, J.5
  • 161
    • 79251629725 scopus 로고    scopus 로고
    • KCC2 was downregulated in small neurons localized in epileptogenic human focal cortical dysplasia
    • doi: 10.1016/j.eplepsyres.2010.12.008
    • Shimizu-Okabe, C., Tanaka, M., Matsuda, K., Mihara, T., Okabe, A., Sato, K., et al. (2011). KCC2 was downregulated in small neurons localized in epileptogenic human focal cortical dysplasia. Epilepsy Res. 93, 177-184. doi: 10.1016/j.eplepsyres.2010.12.008
    • (2011) Epilepsy Res , vol.93 , pp. 177-184
    • Shimizu-Okabe, C.1    Tanaka, M.2    Matsuda, K.3    Mihara, T.4    Okabe, A.5    Sato, K.6
  • 162
    • 84876084384 scopus 로고    scopus 로고
    • Interplay between thyroxin, BDNF and GABA in injured neurons
    • doi: 10.1016/j.neuroscience.2012.12.007
    • Shulga, A., and Rivera, C. (2013). Interplay between thyroxin, BDNF and GABA in injured neurons. Neuroscience 239, 241-252. doi: 10.1016/j.neuroscience.2012.12.007
    • (2013) Neuroscience , vol.239 , pp. 241-252
    • Shulga, A.1    Rivera, C.2
  • 163
    • 70350749277 scopus 로고    scopus 로고
    • Thyroxin regulates BDNF expression to promote survival of injured neurons
    • doi: 10.1016/j.mcn.2009.09.002
    • Shulga, A., Blaesse, A., Kysenius, K., Huttunen, H. J., Tanhuanpää, K., Saarma, M., et al. (2009). Thyroxin regulates BDNF expression to promote survival of injured neurons. Mol. Cell. Neurosci. 42, 408-418. doi: 10.1016/j.mcn.2009.09.002
    • (2009) Mol. Cell. Neurosci , vol.42 , pp. 408-418
    • Shulga, A.1    Blaesse, A.2    Kysenius, K.3    Huttunen, H.J.4    Tanhuanpää, K.5    Saarma, M.6
  • 164
    • 84856646357 scopus 로고    scopus 로고
    • The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons
    • doi: 10.1523/JNEUROSCI.3282-11.2012
    • Shulga, A., Magalhaes, A. C., Autio, H., Plantman, S., di Lieto, A., Nykjaer, A., et al. (2012). The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J. Neurosci. 32, 1757-1770. doi: 10.1523/JNEUROSCI.3282-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 1757-1770
    • Shulga, A.1    Magalhaes, A.C.2    Autio, H.3    Plantman, S.4    di Lieto, A.5    Nykjaer, A.6
  • 165
    • 49049093088 scopus 로고    scopus 로고
    • Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons
    • doi: 10.1523/JNEUROSCI.5268-07.2008
    • Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., et al. (2008). Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J. Neurosci. 28, 6996-7005. doi: 10.1523/JNEUROSCI.5268-07.2008
    • (2008) J. Neurosci , vol.28 , pp. 6996-7005
    • Shulga, A.1    Thomas-Crusells, J.2    Sigl, T.3    Blaesse, A.4    Mestres, P.5    Meyer, M.6
  • 166
    • 34547121995 scopus 로고    scopus 로고
    • Homooligomeric and heterooligomeric associations between K+-Cl-cotransporter isoforms and between K+-Cl-and Na+-K+-Cl-cotransporters
    • doi: 10.1074/jbc.M607811200
    • Simard, C. F., Bergeron, M. J., Frenette-Cotton, R., Carpentier, G. A., Pelchat, M.-E., Caron, L., et al. (2007). Homooligomeric and heterooligomeric associations between K+-Cl-cotransporter isoforms and between K+-Cl-and Na+-K+-Cl-cotransporters. J. Biol. Chem. 282, 18083-18093. doi: 10.1074/jbc.M607811200
    • (2007) J. Biol. Chem , vol.282 , pp. 18083-18093
    • Simard, C.F.1    Bergeron, M.J.2    Frenette-Cotton, R.3    Carpentier, G.A.4    Pelchat, M.-E.5    Caron, L.6
  • 167
    • 4644347264 scopus 로고    scopus 로고
    • Self-interacting domains in the C terminus of a cation-Cl-cotransporter described for the first time
    • doi: 10.1074/jbc.M406458200
    • Simard, C. F., Brunet, G. M., Daigle, N. D., Montminy, V., Caron, L., and Isenring, P. (2004). Self-interacting domains in the C terminus of a cation-Cl-cotransporter described for the first time. J. Biol. Chem. 279, 40769-40777. doi: 10.1074/jbc.M406458200
    • (2004) J. Biol. Chem , vol.279 , pp. 40769-40777
    • Simard, C.F.1    Brunet, G.M.2    Daigle, N.D.3    Montminy, V.4    Caron, L.5    Isenring, P.6
  • 168
    • 0037198951 scopus 로고    scopus 로고
    • Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter
    • doi: 10.1016/S0169-328X(02)00190-0
    • Song, L., Mercado, A., Vázquez, N., Xie, Q., Desai, R., George, A. L., et al. (2002). Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Brain Res. 103, 91-105. doi: 10.1016/S0169-328X(02)00190-0
    • (2002) Brain Res , vol.103 , pp. 91-105
    • Song, L.1    Mercado, A.2    Vázquez, N.3    Xie, Q.4    Desai, R.5    George, A.L.6
  • 169
    • 0344667759 scopus 로고    scopus 로고
    • Dimeric architecture of the human bumetanide-sensitive Na-K-Cl Co-transporter
    • doi: 10.1097/01.ASN.0000097370.29737.5B
    • Starremans, P. G. J. F., Kersten, F. F. J., Van Den Heuvel, L. P. W. J., Knoers, N. V. A. M., and Bindels, R. J. M. (2003). Dimeric architecture of the human bumetanide-sensitive Na-K-Cl Co-transporter. J. Am. Soc. Nephrol. 14, 3039-3046. doi: 10.1097/01.ASN.0000097370.29737.5B
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. 3039-3046
    • Starremans, P.G.J.F.1    Kersten, F.F.J.2    van den Heuvel, L.P.W.J.3    Knoers, N.V.A.M.4    Bindels, R.J.M.5
  • 170
    • 0348042110 scopus 로고    scopus 로고
    • Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride
    • doi: 10.1002/cne.10983
    • Stein, V., Hermans-Borgmeyer, I., Jentsch, T. J., and Hübner, C. A (2004). Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride. J. Comp. Neurol. 468, 57-64. doi: 10.1002/cne.10983
    • (2004) J. Comp. Neurol , vol.468 , pp. 57-64
    • Stein, V.1    Hermans-Borgmeyer, I.2    Jentsch, T.J.3    Hübner, C.A.4
  • 171
    • 0033826061 scopus 로고    scopus 로고
    • Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue
    • Strange, K., Singer, T. D., Morrison, R., and Delpire, E. (2000). Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue. Am. J. Physiol. Cell Physiol. 279, C860-C867.
    • (2000) Am. J. Physiol. Cell Physiol , vol.279
    • Strange, K.1    Singer, T.D.2    Morrison, R.3    Delpire, E.4
  • 172
    • 84859181212 scopus 로고    scopus 로고
    • Intracellular chloride concentration influences the GABAA receptor subunit composition
    • doi: 10.1038/ncomms1744
    • Succol, F., Fiumelli, H., Benfenati, F., Cancedda, L., and Barberis, A. (2012). Intracellular chloride concentration influences the GABAA receptor subunit composition. Nature Commun. 3, 738. doi: 10.1038/ncomms1744
    • (2012) Nature Commun , vol.3 , pp. 738
    • Succol, F.1    Fiumelli, H.2    Benfenati, F.3    Cancedda, L.4    Barberis, A.5
  • 173
    • 84863411653 scopus 로고    scopus 로고
    • Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia
    • doi: 10.1002/ana.22696
    • Talos, D. M., Sun, H., Kosaras, B., Joseph, A., Folkerth, R. D., Poduri, A., et al. (2012). Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia. Ann. Neurol. 71, 539-551. doi: 10.1002/ana.22696
    • (2012) Ann. Neurol , vol.71 , pp. 539-551
    • Talos, D.M.1    Sun, H.2    Kosaras, B.3    Joseph, A.4    Folkerth, R.D.5    Poduri, A.6
  • 174
    • 0033045705 scopus 로고    scopus 로고
    • Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3
    • doi: 10.1007/s100380050121
    • Tamari, M., Daigo, Y., and Nakamura, Y. (1999). Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. J. Hum. Genet. 44, 116-120. doi: 10.1007/s100380050121
    • (1999) J. Hum. Genet , vol.44 , pp. 116-120
    • Tamari, M.1    Daigo, Y.2    Nakamura, Y.3
  • 175
    • 84870856640 scopus 로고    scopus 로고
    • Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors
    • doi: 10.1371/journal.pone.0051433
    • Tang, M., Ivakine, E., Mahadevan, V., Salter, M. W., and McInnes, R. R. (2012). Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors. PLoS ONE 7:e51433. doi: 10.1371/journal.pone.0051433
    • (2012) PLoS ONE , vol.7
    • Tang, M.1    Ivakine, E.2    Mahadevan, V.3    Salter, M.W.4    McInnes, R.R.5
  • 176
    • 68849127731 scopus 로고    scopus 로고
    • The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans
    • doi: 10.1523/JNEUROSCI.1989-09.2009
    • Tanis, J. E., Bellemer, A., Moresco, J. J., Forbush, B., and Koelle, M. R. (2009). The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. J. Neurosci. 29, 9943-9954. doi: 10.1523/JNEUROSCI.1989-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 9943-9954
    • Tanis, J.E.1    Bellemer, A.2    Moresco, J.J.3    Forbush, B.4    Koelle, M.R.5
  • 177
    • 84055219428 scopus 로고    scopus 로고
    • SPAK/OSR1 regulate NKCC1 and WNK activity: Analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
    • doi: 10.1042/BJ20111879
    • Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y., et al. (2012). SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. Biochem. J. 441, 325-337. doi: 10.1042/BJ20111879
    • (2012) Biochem. J , vol.441 , pp. 325-337
    • Thastrup, J.O.1    Rafiqi, F.H.2    Vitari, A.C.3    Pozo-Guisado, E.4    Deak, M.5    Mehellou, Y.6
  • 178
    • 0041474565 scopus 로고    scopus 로고
    • Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons
    • doi: 10.1113/jphysiol.2003.041863
    • Titz, S., Hans, M., Kelsch, W., Lewen, A., Swandulla, D., and Misgeld, U. (2003). Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons. J. Physiol. 550, 719-730. doi: 10.1113/jphysiol.2003.041863
    • (2003) J. Physiol , vol.550 , pp. 719-730
    • Titz, S.1    Hans, M.2    Kelsch, W.3    Lewen, A.4    Swandulla, D.5    Misgeld, U.6
  • 179
    • 33644945566 scopus 로고    scopus 로고
    • Intracellular acidification in neurons induced by ammonium depends on KCC2 function
    • doi: 10.1111/j.1460-9568.2005.04583.x
    • Titz, S., Hormuzdi, S., Lewen, A., Monyer, H., and Misgeld, U. (2006). Intracellular acidification in neurons induced by ammonium depends on KCC2 function. Eur. J. Neurosci. 23, 454-464. doi: 10.1111/j.1460-9568.2005.04583.x
    • (2006) Eur. J. Neurosci , vol.23 , pp. 454-464
    • Titz, S.1    Hormuzdi, S.2    Lewen, A.3    Monyer, H.4    Misgeld, U.5
  • 180
    • 0037342017 scopus 로고    scopus 로고
    • 2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons
    • doi: 10.1152/jn.00721.2002
    • 2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons. J. Neurophysiol. 89, 1353-1362. doi: 10.1152/jn.00721.2002
    • (2003) J. Neurophysiol , vol.89 , pp. 1353-1362
    • Toyoda, H.1    Ohno, K.2    Yamada, J.3    Ikeda, M.4    Okabe, A.5    Sato, K.6
  • 181
    • 33845685603 scopus 로고    scopus 로고
    • Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery
    • doi: 10.1126/science.1133212
    • Tyzio, R., Cossart, R., Khalilov, I., Minlebaev, M., Hübner, C. A., Represa, A., et al. (2006). Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science 314, 1788-1792. doi: 10.1126/science.1133212
    • (2006) Science , vol.314 , pp. 1788-1792
    • Tyzio, R.1    Cossart, R.2    Khalilov, I.3    Minlebaev, M.4    Hübner, C.A.5    Represa, A.6
  • 182
    • 0242425689 scopus 로고    scopus 로고
    • Membrane potential of CA3 hippocampal pyramidal cells during postnatal development
    • doi: 10.1152/jn.00172.2003
    • Tyzio, R., Ivanov, A., Bernard, C., Holmes, G. L., Ben-Ari, Y., and Khazipov, R. (2003). Membrane potential of CA3 hippocampal pyramidal cells during postnatal development. J. Neurophysiol. 90, 2964-2972. doi: 10.1152/jn.00172.2003
    • (2003) J. Neurophysiol , vol.90 , pp. 2964-2972
    • Tyzio, R.1    Ivanov, A.2    Bernard, C.3    Holmes, G.L.4    Ben-Ari, Y.5    Khazipov, R.6
  • 183
    • 44649084334 scopus 로고    scopus 로고
    • Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus
    • doi: 10.1111/j.1460-9568.2008.06234.x
    • Tyzio, R., Minlebaev, M., Rheims, S., Ivanov, A., Jorquera, I., Holmes, G. L., et al. (2008). Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus. Eur. J. Neurosci. 27, 2515-2528. doi: 10.1111/j.1460-9568.2008.06234.x
    • (2008) Eur. J. Neurosci , vol.27 , pp. 2515-2528
    • Tyzio, R.1    Minlebaev, M.2    Rheims, S.3    Ivanov, A.4    Jorquera, I.5    Holmes, G.L.6
  • 185
    • 35648999986 scopus 로고    scopus 로고
    • A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    • doi: 10.1074/jbc.M705095200
    • Uvarov, P., Ludwig, A., Markkanen, M., Pruunsild, P., Kaila, K., Delpire, E., et al. (2007). A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J. Biol. Chem. 282, 30570-30576. doi: 10.1074/jbc.M705095200
    • (2007) J. Biol. Chem , vol.282 , pp. 30570-30576
    • Uvarov, P.1    Ludwig, A.2    Markkanen, M.3    Pruunsild, P.4    Kaila, K.5    Delpire, E.6
  • 186
    • 33845904119 scopus 로고    scopus 로고
    • Upregulation of the neuron-specific K+/Cl-cotransporter expression by transcription factor early growth response 4
    • doi: 10.1523/JNEUROSCI.4731-06.2006
    • Uvarov, P., Ludwig, A., Markkanen, M., Rivera, C., and Airaksinen, M. S. (2006). Upregulation of the neuron-specific K+/Cl-cotransporter expression by transcription factor early growth response 4. J. Neurosci. 26, 13463-13473. doi: 10.1523/JNEUROSCI.4731-06.2006
    • (2006) J. Neurosci , vol.26 , pp. 13463-13473
    • Uvarov, P.1    Ludwig, A.2    Markkanen, M.3    Rivera, C.4    Airaksinen, M.S.5
  • 187
    • 67649397774 scopus 로고    scopus 로고
    • Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    • doi: 10.1074/jbc.M807366200
    • Uvarov, P., Ludwig, A., Markkanen, M., Soni, S., Hübner, C. A., Rivera, C., et al. (2009). Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J. Biol. Chem. 284, 13696-13704. doi: 10.1074/jbc.M807366200
    • (2009) J. Biol. Chem , vol.284 , pp. 13696-13704
    • Uvarov, P.1    Ludwig, A.2    Markkanen, M.3    Soni, S.4    Hübner, C.A.5    Rivera, C.6
  • 188
    • 28244440522 scopus 로고    scopus 로고
    • Neuronal K+/Cl-co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene
    • doi: 10.1111/j.1471-4159.2005.03434.x
    • Uvarov, P., Pruunsild, P., Timmusk, T., and Airaksinen, M. S. (2005). Neuronal K+/Cl-co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene. J. Neurochem. 95, 1144-1155. doi: 10.1111/j.1471-4159.2005.03434.x
    • (2005) J. Neurochem , vol.95 , pp. 1144-1155
    • Uvarov, P.1    Pruunsild, P.2    Timmusk, T.3    Airaksinen, M.S.4
  • 189
    • 0033539088 scopus 로고    scopus 로고
    • Sensitivity of the yellow variant of green fluorescent protein to halides and nitrate
    • doi: 10.1016/S0960-9822(99)80408-4
    • Wachter, R. M., and Remington, S. J. (1999). Sensitivity of the yellow variant of green fluorescent protein to halides and nitrate. Curr. Biol. 9, R628-R629. doi: 10.1016/S0960-9822(99)80408-4
    • (1999) Curr. Biol , vol.9
    • Wachter, R.M.1    Remington, S.J.2
  • 190
    • 33847155572 scopus 로고    scopus 로고
    • Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation
    • doi: 10.1523/JNEUROSCI.3104-06.2007
    • Wake, H., Watanabe, M., Moorhouse, A. J., Kanematsu, T., Horibe, S., Matsukawa, N., et al. (2007). Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J. Neurosci. 27, 1642-1650. doi: 10.1523/JNEUROSCI.3104-06.2007
    • (2007) J. Neurosci , vol.27 , pp. 1642-1650
    • Wake, H.1    Watanabe, M.2    Moorhouse, A.J.3    Kanematsu, T.4    Horibe, S.5    Matsukawa, N.6
  • 191
    • 64049117335 scopus 로고    scopus 로고
    • X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter
    • doi: 10.1016/j.str.2009.02.009
    • Warmuth, S., Zimmermann, I., and Dutzler, R. (2009). X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter. Structure 17, 538-546. doi: 10.1016/j.str.2009.02.009
    • (2009) Structure , vol.17 , pp. 538-546
    • Warmuth, S.1    Zimmermann, I.2    Dutzler, R.3
  • 192
    • 77957688441 scopus 로고    scopus 로고
    • Genetically encoded Cl-Sensor as a tool for monitoring of Cl-dependent processes in small neuronal compartments
    • doi: 10.1016/j.jneumeth.2010.08.002
    • Waseem, T., Mukhtarov, M., Buldakova, S., Medina, I., and Bregestovski, P. (2010). Genetically encoded Cl-Sensor as a tool for monitoring of Cl-dependent processes in small neuronal compartments. J. Neurosci. Methods 193, 14-23. doi: 10.1016/j.jneumeth.2010.08.002
    • (2010) J. Neurosci. Methods , vol.193 , pp. 14-23
    • Waseem, T.1    Mukhtarov, M.2    Buldakova, S.3    Medina, I.4    Bregestovski, P.5
  • 193
    • 70350437221 scopus 로고    scopus 로고
    • Clustering of neuronal K+-Cl-cotransporters in lipid rafts by tyrosine phosphorylation
    • doi: 10.1074/jbc.M109.043620
    • Watanabe, M., Wake, H., Moorhouse, A. J., and Nabekura, J. (2009). Clustering of neuronal K+-Cl-cotransporters in lipid rafts by tyrosine phosphorylation. J. Biol. Chem. 284, 27980-27988. doi: 10.1074/jbc.M109.043620
    • (2009) J. Biol. Chem , vol.284 , pp. 27980-27988
    • Watanabe, M.1    Wake, H.2    Moorhouse, A.J.3    Nabekura, J.4
  • 194
    • 81255177596 scopus 로고    scopus 로고
    • The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism
    • doi: 10.1113/jphysiol.2011.214635
    • Wei, W.-C., Akerman, C. J., Newey, S. E., Pan, J., Clinch, N. W. V., Jacob, Y., et al. (2011). The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism. J. Physiol. 589, 5349-5359. doi: 10.1113/jphysiol.2011.214635
    • (2011) J. Physiol , vol.589 , pp. 5349-5359
    • Wei, W.-C.1    Akerman, C.J.2    Newey, S.E.3    Pan, J.4    Clinch, N.W.V.5    Jacob, Y.6
  • 195
    • 62349110653 scopus 로고    scopus 로고
    • CIP1 is an activator of the K+-Cl-cotransporter KCC2
    • doi: 10.1016/j.bbrc.2009.02.057
    • Wenz, M., Hartmann, A.-M., Friauf, E., and Nothwang, H. G. (2009). CIP1 is an activator of the K+-Cl-cotransporter KCC2. Biochem. Biophys. Res. Commun. 381, 388-392. doi: 10.1016/j.bbrc.2009.02.057
    • (2009) Biochem. Biophys. Res. Commun , vol.381 , pp. 388-392
    • Wenz, M.1    Hartmann, A.-M.2    Friauf, E.3    Nothwang, H.G.4
  • 196
    • 0025032271 scopus 로고
    • Development and biological applications of chloride-sensitive fluorescent indicators
    • Verkman, A. S. (1990). Development and biological applications of chloride-sensitive fluorescent indicators. Am. J. Physiol. 259, C375-C388.
    • (1990) Am. J. Physiol , vol.259
    • Verkman, A.S.1
  • 197
    • 84880302658 scopus 로고    scopus 로고
    • Thyroid hormone-dependent development of early cortical networks: Temporal specificity and the contribution of trkB and mTOR pathways
    • doi: 10.3389/fncel.2013.00121
    • Westerholz, S., de Lima, A. D., and Voigt, T. (2013). Thyroid hormone-dependent development of early cortical networks: temporal specificity and the contribution of trkB and mTOR pathways. Front. Cell. Neurosci. 7:121. doi: 10.3389/fncel.2013.00121
    • (2013) Front. Cell. Neurosci , vol.7 , pp. 121
    • Westerholz, S.1    de Lima, A.D.2    Voigt, T.3
  • 198
    • 4544295660 scopus 로고    scopus 로고
    • Cation transport by the neuronal K(+)-Cl(-) cotransporter KCC2: Thermodynamics and kinetics of alternate transport modes
    • doi: 10.1152/ajpcell.00005.2004
    • Williams, J. R., and Payne, J. A. (2004). Cation transport by the neuronal K(+)-Cl(-) cotransporter KCC2: thermodynamics and kinetics of alternate transport modes. Am. J. Physiol. Cell Physiol. 287, C919-C931. doi: 10.1152/ajpcell.00005.2004
    • (2004) Am. J. Physiol. Cell Physiol , vol.287
    • Williams, J.R.1    Payne, J.A.2
  • 199
    • 0036227728 scopus 로고    scopus 로고
    • Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene
    • doi: 10.1002/hipo.10014
    • Woo, N.-S., Lu, J., England, R., McClellan, R., Dufour, S., Mount, D. B., et al. (2002). Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus 12, 258-268. doi: 10.1002/hipo.10014
    • (2002) Hippocampus , vol.12 , pp. 258-268
    • Woo, N.-S.1    Lu, J.2    England, R.3    McClellan, R.4    Dufour, S.5    Mount, D.B.6
  • 200
    • 0042028516 scopus 로고    scopus 로고
    • Coincident pre-and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl-transporter activity
    • doi: 10.1016/S0896-6273(03)00507-5
    • Woodin, M. A., Ganguly, K., and Poo, M. (2003). Coincident pre-and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl-transporter activity. Neuron 39, 807-820. doi: 10.1016/S0896-6273(03)00507-5
    • (2003) Neuron , vol.39 , pp. 807-820
    • Woodin, M.A.1    Ganguly, K.2    Poo, M.3
  • 201
    • 84875422106 scopus 로고    scopus 로고
    • WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade
    • doi: 10.1074/jbc.M113.451575
    • Xie, J., Yoon, J., Yang, S.-S., Lin, S.-H., and Huang, C.-L. (2013). WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J. Biol. Chem. 288, 8566-8574. doi: 10.1074/jbc.M113.451575
    • (2013) J. Biol. Chem , vol.288 , pp. 8566-8574
    • Xie, J.1    Yoon, J.2    Yang, S.-S.3    Lin, S.-H.4    Huang, C.-L.5
  • 202
    • 0028343934 scopus 로고
    • Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter
    • doi: 10.1073/pnas.91.6.2201
    • Xu, J. C., Lytle, C., Zhu, T. T., Payne, J. A., Benz, E., and Forbush, B. (1994). Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter. Proc. Natl. Acad. Sci. U.S.A. 91, 2201-2205. doi: 10.1073/pnas.91.6.2201
    • (1994) Proc. Natl. Acad. Sci. U.S. A , vol.91 , pp. 2201-2205
    • Xu, J.C.1    Lytle, C.2    Zhu, T.T.3    Payne, J.A.4    Benz, E.5    Forbush, B.6
  • 203
    • 78149310726 scopus 로고    scopus 로고
    • SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction
    • doi: 10.1681/ASN.2009121295
    • Yang, S.-S., Lo, Y.-F., Wu, C.-C., Lin, S.-W., Yeh, C.-J., Chu, P., et al. (2010). SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J. Am. Soc. Nephrol. 21, 1868-1877. doi: 10.1681/ASN.2009121295
    • (2010) J. Am. Soc. Nephrol , vol.21 , pp. 1868-1877
    • Yang, S.-S.1    Lo, Y.-F.2    Wu, C.-C.3    Lin, S.-W.4    Yeh, C.-J.5    Chu, P.6
  • 204
    • 70949101850 scopus 로고    scopus 로고
    • Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride
    • doi: 10.1523/JNEUROSCI.2934-09.2009
    • Yeo, M., Berglund, K., Augustine, G., and Liedtke, W. (2009). Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. J. Neurosci. 29, 14652-14662. doi: 10.1523/JNEUROSCI.2934-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 14652-14662
    • Yeo, M.1    Berglund, K.2    Augustine, G.3    Liedtke, W.4
  • 205
    • 33845970213 scopus 로고    scopus 로고
    • Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
    • doi: 10.1083/jcb.200605093
    • Zagórska, A., Pozo-Guisado, E., Boudeau, J., Vitari, A. C., Rafiqi, F. H., Thastrup, J., et al. (2007). Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J. Cell Biol. 176, 89-100. doi: 10.1083/jcb.200605093
    • (2007) J. Cell Biol , vol.176 , pp. 89-100
    • Zagórska, A.1    Pozo-Guisado, E.2    Boudeau, J.3    Vitari, A.C.4    Rafiqi, F.H.5    Thastrup, J.6
  • 206
    • 77949413218 scopus 로고    scopus 로고
    • A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators
    • doi: 10.1177/1087057109355708
    • Zhang, D., Gopalakrishnan, S. M., Freiberg, G., and Surowy, C. S. (2010). A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J. Biomol. Screen. 15, 177-184. doi: 10.1177/1087057109355708
    • (2010) J. Biomol. Screen , vol.15 , pp. 177-184
    • Zhang, D.1    Gopalakrishnan, S.M.2    Freiberg, G.3    Surowy, C.S.4
  • 207
    • 84884695851 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl-cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation
    • doi: 10.1124/mol.113.086496
    • Zhang, Z., Wang, X., Wang, W., Lu, Y.-G., and Pan, Z. Z. (2013). Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl-cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation. Mol. Pharmacol. 84, 511-520. doi: 10.1124/mol.113.086496
    • (2013) Mol. Pharmacol , vol.84 , pp. 511-520
    • Zhang, Z.1    Wang, X.2    Wang, W.3    Lu, Y.-G.4    Pan, Z.Z.5
  • 208
    • 49549103079 scopus 로고    scopus 로고
    • Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis
    • doi: 10.1016/j.cellsig.2008.06.011
    • Zhao, B., Wong, A. Y. C., Murshid, A., Bowie, D., Presley, J. F., and Bedford, F. K. (2008). Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis. Cell. Signal. 20, 1769-1779. doi: 10.1016/j.cellsig.2008.06.011
    • (2008) Cell. Signal , vol.20 , pp. 1769-1779
    • Zhao, B.1    Wong, A.Y.C.2    Murshid, A.3    Bowie, D.4    Presley, J.F.5    Bedford, F.K.6
  • 209
    • 14144253198 scopus 로고    scopus 로고
    • Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride
    • doi: 10.1152/jn.00616.2004
    • Zhu, L., Lovinger, D., and Delpire, E. (2005). Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride. J. Neurophysiol. 93, 1557-1568. doi: 10.1152/jn.00616.2004
    • (2005) J. Neurophysiol , vol.93 , pp. 1557-1568
    • Zhu, L.1    Lovinger, D.2    Delpire, E.3
  • 210
    • 42749090883 scopus 로고    scopus 로고
    • NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus
    • doi: 10.1016/j.eplepsyres.2008.02.005
    • Zhu, L., Polley, N., Mathews, G. C., and Delpire, E. (2008). NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus. Epilepsy Res. 79, 201-212. doi: 10.1016/j.eplepsyres.2008.02.005
    • (2008) Epilepsy Res , vol.79 , pp. 201-212
    • Zhu, L.1    Polley, N.2    Mathews, G.C.3    Delpire, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.