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Volumn 36, Issue 12, 2013, Pages 726-737

Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POTASSIUM CHLORIDE COTRANSPORTER; POTASSIUM CHLORIDE COTRANSPORTER KCC2 PROTEIN; PROTEIN KINASE C; SERINE; SEROTONIN 2A RECEPTOR; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

EID: 84888874322     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2013.08.006     Document Type: Review
Times cited : (171)

References (115)
  • 1
    • 34247893682 scopus 로고    scopus 로고
    • The cellular, molecular and ionic basis of GABAA receptor signalling
    • Farrant M., Kaila K. The cellular, molecular and ionic basis of GABAA receptor signalling. Prog. Brain Res. 2007, 160:59-87.
    • (2007) Prog. Brain Res. , vol.160 , pp. 59-87
    • Farrant, M.1    Kaila, K.2
  • 2
    • 0028173658 scopus 로고
    • Ionic basis of GABAA receptor channel function in the nervous system
    • Kaila K. Ionic basis of GABAA receptor channel function in the nervous system. Prog. Neurobiol. 1994, 42:489-537.
    • (1994) Prog. Neurobiol. , vol.42 , pp. 489-537
    • Kaila, K.1
  • 3
    • 0024604819 scopus 로고
    • Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro
    • Thompson S.M., Gähwiler B.H. Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. J. Neurophysiol. 1989, 61:501-511.
    • (1989) J. Neurophysiol. , vol.61 , pp. 501-511
    • Thompson, S.M.1    Gähwiler, B.H.2
  • 4
    • 42349109493 scopus 로고    scopus 로고
    • GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
    • Jacob T.C., et al. GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat. Rev. Neurosci. 2008, 9:331-343.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 331-343
    • Jacob, T.C.1
  • 5
    • 23944507074 scopus 로고    scopus 로고
    • Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus
    • Naylor D.E., et al. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J. Neurosci. 2005, 25:7724-7733.
    • (2005) J. Neurosci. , vol.25 , pp. 7724-7733
    • Naylor, D.E.1
  • 6
    • 38349004774 scopus 로고    scopus 로고
    • Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus
    • Terunuma M., et al. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J. Neurosci. 2008, 28:376-384.
    • (2008) J. Neurosci. , vol.28 , pp. 376-384
    • Terunuma, M.1
  • 7
    • 40449122488 scopus 로고    scopus 로고
    • Subunit-specific trafficking of GABA(A) receptors during status epilepticus
    • Goodkin H.P., et al. Subunit-specific trafficking of GABA(A) receptors during status epilepticus. J. Neurosci. 2008, 28:2527-2538.
    • (2008) J. Neurosci. , vol.28 , pp. 2527-2538
    • Goodkin, H.P.1
  • 8
    • 62549109964 scopus 로고    scopus 로고
    • Cation-chloride cotransporters and neuronal function
    • Blaesse P., et al. Cation-chloride cotransporters and neuronal function. Neuron 2009, 61:820-838.
    • (2009) Neuron , vol.61 , pp. 820-838
    • Blaesse, P.1
  • 9
    • 84866681617 scopus 로고    scopus 로고
    • The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
    • Ben-Ari Y., et al. The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. Neuroscientist 2012, 18:467-486.
    • (2012) Neuroscientist , vol.18 , pp. 467-486
    • Ben-Ari, Y.1
  • 10
    • 0033590541 scopus 로고    scopus 로고
    • The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    • Rivera C., et al. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 1999, 397:251-255.
    • (1999) Nature , vol.397 , pp. 251-255
    • Rivera, C.1
  • 11
    • 35748954370 scopus 로고    scopus 로고
    • GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations
    • Ben-Ari Y., et al. GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations. Physiol. Rev. 2007, 87:1215-1284.
    • (2007) Physiol. Rev. , vol.87 , pp. 1215-1284
    • Ben-Ari, Y.1
  • 12
    • 3242683426 scopus 로고    scopus 로고
    • Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1
    • Yamada J., et al. Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1. J. Physiol. 2004, 557:829-841.
    • (2004) J. Physiol. , vol.557 , pp. 829-841
    • Yamada, J.1
  • 13
    • 44649084334 scopus 로고    scopus 로고
    • Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus
    • Tyzio R., et al. Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus. Eur. J. Neurosci. 2008, 27:2515-2528.
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 2515-2528
    • Tyzio, R.1
  • 14
    • 79958743627 scopus 로고    scopus 로고
    • The depolarizing action of GABA controls early network activity in the developing hippocampus
    • Cherubini E., et al. The depolarizing action of GABA controls early network activity in the developing hippocampus. Mol. Neurobiol. 2011, 43:97-106.
    • (2011) Mol. Neurobiol. , vol.43 , pp. 97-106
    • Cherubini, E.1
  • 15
    • 64149128876 scopus 로고    scopus 로고
    • KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner
    • Bortone D., Polleux F. KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron 2009, 62:53-71.
    • (2009) Neuron , vol.62 , pp. 53-71
    • Bortone, D.1    Polleux, F.2
  • 16
    • 18644384781 scopus 로고    scopus 로고
    • Trophic actions of GABA on neuronal development
    • Represa A., Ben-Ari Y. Trophic actions of GABA on neuronal development. Trends Neurosci. 2005, 28:278-283.
    • (2005) Trends Neurosci. , vol.28 , pp. 278-283
    • Represa, A.1    Ben-Ari, Y.2
  • 17
    • 0036717789 scopus 로고    scopus 로고
    • Is there more to GABA than synaptic inhibiton?
    • Owens D.F., Kriegstein A.R. Is there more to GABA than synaptic inhibiton?. Nat. Rev. Neurosci. 2002, 3:715-727.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 715-727
    • Owens, D.F.1    Kriegstein, A.R.2
  • 18
    • 34447635854 scopus 로고    scopus 로고
    • Refining the roles of GABAergic signaling during neural circuit formation
    • Akerman C.J., Cline H.T. Refining the roles of GABAergic signaling during neural circuit formation. Trends Neurosci. 2007, 30:382-389.
    • (2007) Trends Neurosci. , vol.30 , pp. 382-389
    • Akerman, C.J.1    Cline, H.T.2
  • 19
    • 0036719162 scopus 로고    scopus 로고
    • Excitatory actions of GABA during development: the nature of the nurture
    • Ben-Ari Y. Excitatory actions of GABA during development: the nature of the nurture. Nat. Rev. Neurosci. 2002, 3:728-739.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 728-739
    • Ben-Ari, Y.1
  • 20
    • 0029996819 scopus 로고    scopus 로고
    • Role of chloride-homeostasis in the inhibitory control of neuronal network oscillators
    • Jarolimek W., et al. Role of chloride-homeostasis in the inhibitory control of neuronal network oscillators. J. Neurophysiol. 1996, 75:2654-2657.
    • (1996) J. Neurophysiol. , vol.75 , pp. 2654-2657
    • Jarolimek, W.1
  • 21
    • 42749090883 scopus 로고    scopus 로고
    • NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus
    • Zhu L., et al. NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus. Epilepsy Res. 2008, 79:201-212.
    • (2008) Epilepsy Res. , vol.79 , pp. 201-212
    • Zhu, L.1
  • 22
    • 84881318076 scopus 로고    scopus 로고
    • Disrupted Cl homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states
    • Deeb T.Z., et al. Disrupted Cl homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. Eur. J. Neurosci. 2013, 38:2453-2467.
    • (2013) Eur. J. Neurosci. , vol.38 , pp. 2453-2467
    • Deeb, T.Z.1
  • 23
    • 68849127731 scopus 로고    scopus 로고
    • The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans
    • Tanis J.E., et al. The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. J. Neurosci. 2009, 29:9943-9954.
    • (2009) J. Neurosci. , vol.29 , pp. 9943-9954
    • Tanis, J.E.1
  • 24
    • 33748279281 scopus 로고    scopus 로고
    • Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila
    • Hekmat-Scafe D.S., et al. Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. J. Neurosci. 2006, 26:8943-8954.
    • (2006) J. Neurosci. , vol.26 , pp. 8943-8954
    • Hekmat-Scafe, D.S.1
  • 25
    • 74249121339 scopus 로고    scopus 로고
    • Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain
    • Hekmat-Scafe D.S., et al. Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain. Genetics 2010, 184:171-183.
    • (2010) Genetics , vol.184 , pp. 171-183
    • Hekmat-Scafe, D.S.1
  • 26
    • 0034990498 scopus 로고    scopus 로고
    • Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition
    • Hübner C.A., et al. Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron 2001, 30:515-524.
    • (2001) Neuron , vol.30 , pp. 515-524
    • Hübner, C.A.1
  • 27
    • 17144422426 scopus 로고    scopus 로고
    • Behavioural phenotypes of hypomorphic KCC2-deficient mice
    • Tornberg J., et al. Behavioural phenotypes of hypomorphic KCC2-deficient mice. Eur. J. Neurosci. 2005, 21:1327-1337.
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 1327-1337
    • Tornberg, J.1
  • 28
    • 0036227728 scopus 로고    scopus 로고
    • Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene
    • Woo N.S., et al. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus 2002, 12:258-268.
    • (2002) Hippocampus , vol.12 , pp. 258-268
    • Woo, N.S.1
  • 29
    • 51849140945 scopus 로고    scopus 로고
    • Roles of the cation-chloride cotransporters in neurological disease
    • Kahle K.T., et al. Roles of the cation-chloride cotransporters in neurological disease. Nat. Clin. Pract. Neurol. 2008, 4:490-503.
    • (2008) Nat. Clin. Pract. Neurol. , vol.4 , pp. 490-503
    • Kahle, K.T.1
  • 30
    • 79960109333 scopus 로고    scopus 로고
    • Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
    • Song I., et al. Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons. Nat. Commun. 2011, 2:376.
    • (2011) Nat. Commun. , vol.2 , pp. 376
    • Song, I.1
  • 31
    • 0033119147 scopus 로고    scopus 로고
    • Noninvasive measurements of the membrane potential and GABAergic action in hippocampal interneurons
    • Verheugen J.A., et al. Noninvasive measurements of the membrane potential and GABAergic action in hippocampal interneurons. J. Neurosci. 1999, 19:2546-2555.
    • (1999) J. Neurosci. , vol.19 , pp. 2546-2555
    • Verheugen, J.A.1
  • 32
    • 0026056571 scopus 로고
    • Excitatory synaptic responses mediated by GABAA receptors in the hippocampus
    • Michelson H.B., Wong R.K. Excitatory synaptic responses mediated by GABAA receptors in the hippocampus. Science 1991, 253:1420-1423.
    • (1991) Science , vol.253 , pp. 1420-1423
    • Michelson, H.B.1    Wong, R.K.2
  • 33
    • 84855645201 scopus 로고    scopus 로고
    • GABA is excitatory in adult vasopressinergic neuroendocrine cells
    • Haam J., et al. GABA is excitatory in adult vasopressinergic neuroendocrine cells. J. Neurosci. 2012, 32:572-582.
    • (2012) J. Neurosci. , vol.32 , pp. 572-582
    • Haam, J.1
  • 34
    • 36549004502 scopus 로고    scopus 로고
    • Inhibition and brain work
    • Buzsaki G., et al. Inhibition and brain work. Neuron 2007, 56:771-783.
    • (2007) Neuron , vol.56 , pp. 771-783
    • Buzsaki, G.1
  • 35
    • 79960845291 scopus 로고    scopus 로고
    • NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents
    • Lee H.H., et al. NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat. Neurosci. 2011, 14:736-743.
    • (2011) Nat. Neurosci. , vol.14 , pp. 736-743
    • Lee, H.H.1
  • 36
    • 84875279904 scopus 로고    scopus 로고
    • Chloride homeostasis and GABA signaling in temporal lobe epilepsy
    • Oxford University Press, J.L. Noebels (Ed.)
    • Miles R., et al. Chloride homeostasis and GABA signaling in temporal lobe epilepsy. Jasper's Basic Mechanisms of the Epilepsies 2012, 219-226. Oxford University Press. 4th edn. J.L. Noebels (Ed.).
    • (2012) Jasper's Basic Mechanisms of the Epilepsies , pp. 219-226
    • Miles, R.1
  • 37
    • 84875250685 scopus 로고    scopus 로고
    • Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments
    • Löscher W., et al. Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments. Neuropharmacology 2013, 69:62-74.
    • (2013) Neuropharmacology , vol.69 , pp. 62-74
    • Löscher, W.1
  • 38
    • 84873730342 scopus 로고    scopus 로고
    • Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?
    • Pavlov I., et al. Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?. J. Physiol. 2013, 591:765-774.
    • (2013) J. Physiol. , vol.591 , pp. 765-774
    • Pavlov, I.1
  • 39
    • 63449096743 scopus 로고    scopus 로고
    • Chloride regulation in the pain pathway
    • Price T.J., et al. Chloride regulation in the pain pathway. Brain Res. Rev. 2009, 60:149-170.
    • (2009) Brain Res. Rev. , vol.60 , pp. 149-170
    • Price, T.J.1
  • 40
    • 84876891236 scopus 로고    scopus 로고
    • Treating pathological pain: is KCC2 the key to the gate?
    • Doyon N., et al. Treating pathological pain: is KCC2 the key to the gate?. Expert Rev. Neurother. 2013, 13:469-471.
    • (2013) Expert Rev. Neurother. , vol.13 , pp. 469-471
    • Doyon, N.1
  • 41
    • 79956045271 scopus 로고    scopus 로고
    • Differential GABAergic disinhibition during the development of painful peripheral neuropathy
    • Janssen S.P., et al. Differential GABAergic disinhibition during the development of painful peripheral neuropathy. Neuroscience 2011, 184:183-194.
    • (2011) Neuroscience , vol.184 , pp. 183-194
    • Janssen, S.P.1
  • 42
    • 0037384485 scopus 로고    scopus 로고
    • Cation-chloride co-transporters in neuronal communication, development and trauma
    • Payne J.A., et al. Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci. 2003, 26:199-206.
    • (2003) Trends Neurosci. , vol.26 , pp. 199-206
    • Payne, J.A.1
  • 43
    • 33751104238 scopus 로고    scopus 로고
    • Brain injury impairs dentate gyrus inhibitory efficacy
    • Bonislawski D.P., et al. Brain injury impairs dentate gyrus inhibitory efficacy. Neurobiol. Dis. 2007, 25:163-169.
    • (2007) Neurobiol. Dis. , vol.25 , pp. 163-169
    • Bonislawski, D.P.1
  • 44
    • 49049093088 scopus 로고    scopus 로고
    • Posttraumatic GABAA-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons
    • Shulga A., et al. Posttraumatic GABAA-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J. Neurosci. 2008, 28:6996-7005.
    • (2008) J. Neurosci. , vol.28 , pp. 6996-7005
    • Shulga, A.1
  • 45
    • 15544364485 scopus 로고    scopus 로고
    • Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex
    • Jin X., et al. Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J. Neurophysiol. 2005, 93:2117-2126.
    • (2005) J. Neurophysiol. , vol.93 , pp. 2117-2126
    • Jin, X.1
  • 46
    • 34548612464 scopus 로고    scopus 로고
    • Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    • Huberfeld G., et al. Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J. Neurosci. 2007, 27:9866-9873.
    • (2007) J. Neurosci. , vol.27 , pp. 9866-9873
    • Huberfeld, G.1
  • 47
    • 38449107212 scopus 로고    scopus 로고
    • Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy
    • Pathak H.R., et al. Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J. Neurosci. 2007, 27:14012-14022.
    • (2007) J. Neurosci. , vol.27 , pp. 14012-14022
    • Pathak, H.R.1
  • 48
    • 0037049553 scopus 로고    scopus 로고
    • BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
    • Rivera C., et al. BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J. Cell Biol. 2002, 159:747-752.
    • (2002) J. Cell Biol. , vol.159 , pp. 747-752
    • Rivera, C.1
  • 49
    • 39549110817 scopus 로고    scopus 로고
    • Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABAA receptors
    • Galanopoulou A.S. Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABAA receptors. J. Neurosci. 2008, 28:1557-1567.
    • (2008) J. Neurosci. , vol.28 , pp. 1557-1567
    • Galanopoulou, A.S.1
  • 50
    • 84865017910 scopus 로고    scopus 로고
    • Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
    • Puskarjov M., et al. Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. J. Neurosci. 2012, 32:11356-11364.
    • (2012) J. Neurosci. , vol.32 , pp. 11356-11364
    • Puskarjov, M.1
  • 51
    • 84866900940 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain
    • Zhou H.Y., et al. N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain. J. Biol. Chem. 2012, 287:33853-33864.
    • (2012) J. Biol. Chem. , vol.287 , pp. 33853-33864
    • Zhou, H.Y.1
  • 52
    • 77956600434 scopus 로고    scopus 로고
    • A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus
    • Khirug S., et al. A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus. J. Neurosci. 2010, 30:12028-12035.
    • (2010) J. Neurosci. , vol.30 , pp. 12028-12035
    • Khirug, S.1
  • 53
    • 79953648268 scopus 로고    scopus 로고
    • Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital
    • Nardou R., et al. Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital. Brain 2011, 134:987-1002.
    • (2011) Brain , vol.134 , pp. 987-1002
    • Nardou, R.1
  • 54
    • 80051937272 scopus 로고    scopus 로고
    • WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
    • Rinehart J., et al. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J. Biol. Chem. 2011, 286:30171-30180.
    • (2011) J. Biol. Chem. , vol.286 , pp. 30171-30180
    • Rinehart, J.1
  • 55
    • 32444437942 scopus 로고    scopus 로고
    • WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
    • de los Heros P., et al. WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:1976-1981.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 1976-1981
    • de los Heros, P.1
  • 56
    • 68149100251 scopus 로고    scopus 로고
    • Sites of regulated phosphorylation that control K-Cl cotransporter activity
    • Rinehart J., et al. Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell 2009, 138:525-536.
    • (2009) Cell , vol.138 , pp. 525-536
    • Rinehart, J.1
  • 57
    • 28044473649 scopus 로고    scopus 로고
    • WNK3 modulates of Cl- transport in and out of cells: implications for control of cell volume and neuronal excitability
    • Kahle K.T., et al. WNK3 modulates of Cl- transport in and out of cells: implications for control of cell volume and neuronal excitability. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:16783-16788.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 16783-16788
    • Kahle, K.T.1
  • 58
    • 35649026880 scopus 로고    scopus 로고
    • Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2
    • Lee H.H.C., et al. Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. J. Biol. Chem. 2007, 282:29777-29784.
    • (2007) J. Biol. Chem. , vol.282 , pp. 29777-29784
    • Lee, H.H.C.1
  • 59
    • 33847155572 scopus 로고    scopus 로고
    • Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation
    • Wake H., et al. Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J. Neurosci. 2007, 27:1642-1650.
    • (2007) J. Neurosci. , vol.27 , pp. 1642-1650
    • Wake, H.1
  • 60
    • 70350437221 scopus 로고    scopus 로고
    • Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation
    • Watanabe M., et al. Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. J. Biol. Chem. 2009, 284:27980-27988.
    • (2009) J. Biol. Chem. , vol.284 , pp. 27980-27988
    • Watanabe, M.1
  • 61
    • 77955769549 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2
    • Lee H.H., et al. Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol. Cell. Neurosci. 2010, 45:173-179.
    • (2010) Mol. Cell. Neurosci. , vol.45 , pp. 173-179
    • Lee, H.H.1
  • 62
    • 33749440293 scopus 로고    scopus 로고
    • WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters
    • Kahle K.T., et al. WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. Physiology 2006, 21:326-335.
    • (2006) Physiology , vol.21 , pp. 326-335
    • Kahle, K.T.1
  • 63
    • 84856646357 scopus 로고    scopus 로고
    • The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons
    • Shulga A., et al. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J. Neurosci. 2012, 32:1757-1770.
    • (2012) J. Neurosci. , vol.32 , pp. 1757-1770
    • Shulga, A.1
  • 64
    • 84856992916 scopus 로고    scopus 로고
    • Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
    • Chamma I., et al. Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission. Front. Cell. Neurosci. 2012, 6:5.
    • (2012) Front. Cell. Neurosci. , vol.6 , pp. 5
    • Chamma, I.1
  • 65
    • 2442707888 scopus 로고    scopus 로고
    • Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2
    • Rivera C., et al. Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J. Neurosci. 2004, 24:4683-4691.
    • (2004) J. Neurosci. , vol.24 , pp. 4683-4691
    • Rivera, C.1
  • 66
    • 54049099205 scopus 로고    scopus 로고
    • Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity
    • Banke T.G., Gegelashvili G. Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity. J. Physiol. 2008, 586:4925-4934.
    • (2008) J. Physiol. , vol.586 , pp. 4925-4934
    • Banke, T.G.1    Gegelashvili, G.2
  • 67
    • 83455179222 scopus 로고    scopus 로고
    • Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors
    • Sarkar J., et al. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J. Neurosci. 2011, 31:18198-18210.
    • (2011) J. Neurosci. , vol.31 , pp. 18198-18210
    • Sarkar, J.1
  • 68
    • 63649151672 scopus 로고    scopus 로고
    • Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis
    • Hewitt S.A., et al. Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis. Nat. Neurosci. 2009, 12:438-443.
    • (2009) Nat. Neurosci. , vol.12 , pp. 438-443
    • Hewitt, S.A.1
  • 69
    • 84869121865 scopus 로고    scopus 로고
    • Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders?
    • Kanner A.M. Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders?. Lancet Neurol. 2012, 11:1093-1102.
    • (2012) Lancet Neurol. , vol.11 , pp. 1093-1102
    • Kanner, A.M.1
  • 70
    • 84875236129 scopus 로고    scopus 로고
    • Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy
    • Maguire J., Salpekar J.A. Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy. Epilepsy Behav. 2013, 26:352-362.
    • (2013) Epilepsy Behav. , vol.26 , pp. 352-362
    • Maguire, J.1    Salpekar, J.A.2
  • 71
    • 84876006492 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism
    • Tyagarajan S.K., et al. Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J. Biol. Chem. 2013, 288:9634-9647.
    • (2013) J. Biol. Chem. , vol.288 , pp. 9634-9647
    • Tyagarajan, S.K.1
  • 72
    • 0036242552 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain
    • Nicolas G., et al. Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain. Mol. Cell. Biol. 2002, 22:3527-3536.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 3527-3536
    • Nicolas, G.1
  • 73
    • 38849124293 scopus 로고    scopus 로고
    • Post-activation depression of soleus stretch reflexes in healthy and spastic humans
    • Grey M.J., et al. Post-activation depression of soleus stretch reflexes in healthy and spastic humans. Exp. Brain Res. 2008, 185:189-197.
    • (2008) Exp. Brain Res. , vol.185 , pp. 189-197
    • Grey, M.J.1
  • 74
    • 84871982368 scopus 로고    scopus 로고
    • Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2
    • Bos R., et al. Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:348-353.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 348-353
    • Bos, R.1
  • 75
    • 0036924837 scopus 로고    scopus 로고
    • Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development
    • Li H., et al. Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development. Eur. J. Neurosci. 2002, 16:2358-2370.
    • (2002) Eur. J. Neurosci. , vol.16 , pp. 2358-2370
    • Li, H.1
  • 76
    • 0348042110 scopus 로고    scopus 로고
    • Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride
    • Stein V., et al. Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride. J. Comp. Neurol. 2004, 468:57-64.
    • (2004) J. Comp. Neurol. , vol.468 , pp. 57-64
    • Stein, V.1
  • 77
    • 62549111023 scopus 로고    scopus 로고
    • Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2
    • Delpire E., et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:5383-5388.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 5383-5388
    • Delpire, E.1
  • 78
    • 84888871303 scopus 로고    scopus 로고
    • Probe Reports from the NIH Molecular Libraries Program, National Center for Biotechnology Information
    • Lindsley,C. et al. (2010) Discovery of a Highly Selective KCC2 Antagonist, Probe Reports from the NIH Molecular Libraries Program, National Center for Biotechnology Information.
    • (2010) Discovery of a Highly Selective KCC2 Antagonist
    • Lindsley, C.1
  • 79
    • 84863474697 scopus 로고    scopus 로고
    • Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe
    • Delpire E., et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg. Med. Chem. Lett. 2012, 22:4532-4535.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 4532-4535
    • Delpire, E.1
  • 80
    • 78049295923 scopus 로고    scopus 로고
    • Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases
    • Kahle K.T., et al. Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochim. Biophys. Acta 2010, 1802:1150-1158.
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 1150-1158
    • Kahle, K.T.1
  • 81
    • 84862275080 scopus 로고    scopus 로고
    • Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway
    • Inoue K., et al. Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. J. Biol. Chem. 2012, 287:20839-20850.
    • (2012) J. Biol. Chem. , vol.287 , pp. 20839-20850
    • Inoue, K.1
  • 82
    • 35648999986 scopus 로고    scopus 로고
    • A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    • Uvarov P., et al. A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J. Biol. Chem. 2007, 282:30570-30576.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30570-30576
    • Uvarov, P.1
  • 83
    • 67649397774 scopus 로고    scopus 로고
    • Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    • Uvarov P., et al. Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J. Biol. Chem. 2009, 284:13696-13704.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13696-13704
    • Uvarov, P.1
  • 84
    • 80054993342 scopus 로고    scopus 로고
    • Spatio-temporal transcriptome of the human brain
    • Kang H.J., et al. Spatio-temporal transcriptome of the human brain. Nature 2011, 478:483-489.
    • (2011) Nature , vol.478 , pp. 483-489
    • Kang, H.J.1
  • 85
    • 84055219428 scopus 로고    scopus 로고
    • SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
    • Thastrup J.O., et al. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. Biochem. J. 2012, 441:325-337.
    • (2012) Biochem. J. , vol.441 , pp. 325-337
    • Thastrup, J.O.1
  • 86
    • 84874382806 scopus 로고    scopus 로고
    • Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues
    • Shekarabi M., et al. Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues. PLoS ONE 2013, 8:e57807.
    • (2013) PLoS ONE , vol.8
    • Shekarabi, M.1
  • 87
    • 46749127782 scopus 로고    scopus 로고
    • Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II
    • Shekarabi M., et al. Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II. J. Clin. Invest. 2008, 118:2496-2505.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2496-2505
    • Shekarabi, M.1
  • 88
    • 84873496357 scopus 로고    scopus 로고
    • WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio)
    • Bercier V., et al. WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio). PLoS Genet. 2013, 9:e1003124.
    • (2013) PLoS Genet. , vol.9
    • Bercier, V.1
  • 89
    • 36148992525 scopus 로고    scopus 로고
    • WNKs: protein kinases with a unique kinase domain
    • Huang C.L., et al. WNKs: protein kinases with a unique kinase domain. Exp. Mol. Med. 2007, 39:565-573.
    • (2007) Exp. Mol. Med. , vol.39 , pp. 565-573
    • Huang, C.L.1
  • 90
    • 84862885026 scopus 로고    scopus 로고
    • Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain
    • Acton B.A., et al. Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain. J. Neurosci. 2012, 32:8746-8751.
    • (2012) J. Neurosci. , vol.32 , pp. 8746-8751
    • Acton, B.A.1
  • 91
    • 0035503062 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons
    • Kelsch W., et al. Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons. J. Neurosci. 2001, 21:8339-8347.
    • (2001) J. Neurosci. , vol.21 , pp. 8339-8347
    • Kelsch, W.1
  • 92
    • 16244388582 scopus 로고    scopus 로고
    • Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices
    • Khirug S., et al. Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices. Eur. J. Neurosci. 2005, 21:899-904.
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 899-904
    • Khirug, S.1
  • 93
    • 0038380527 scopus 로고    scopus 로고
    • Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem
    • Balakrishnan V., et al. Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem. J. Neurosci. 2003, 23:4134-4145.
    • (2003) J. Neurosci. , vol.23 , pp. 4134-4145
    • Balakrishnan, V.1
  • 94
    • 33749823040 scopus 로고    scopus 로고
    • Oligomerization of KCC2 correlates with development of inhibitory neurotransmission
    • Blaesse P., et al. Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. J. Neurosci. 2006, 26:10407-10419.
    • (2006) J. Neurosci. , vol.26 , pp. 10407-10419
    • Blaesse, P.1
  • 95
    • 23144443153 scopus 로고    scopus 로고
    • Expression and developmental regulation of the K+-Cl- cotransporter KCC2 in the cochlear nucleus
    • Vale C., et al. Expression and developmental regulation of the K+-Cl- cotransporter KCC2 in the cochlear nucleus. Hear. Res. 2005, 206:107-115.
    • (2005) Hear. Res. , vol.206 , pp. 107-115
    • Vale, C.1
  • 96
    • 70349325892 scopus 로고    scopus 로고
    • Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1
    • Hartmann A.M., et al. Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. J. Neurochem. 2009, 111:321-331.
    • (2009) J. Neurochem. , vol.111 , pp. 321-331
    • Hartmann, A.M.1
  • 97
    • 84873207255 scopus 로고    scopus 로고
    • Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures
    • Deeb T.Z., et al. Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures. Epilepsia 2012, 53(Suppl. 9):79-88.
    • (2012) Epilepsia , vol.53 , Issue.SUPPL. 9 , pp. 79-88
    • Deeb, T.Z.1
  • 98
    • 33744940043 scopus 로고    scopus 로고
    • Identification of key functional domains in the C terminus of the K+-Cl- cotransporters
    • Bergeron M.J., et al. Identification of key functional domains in the C terminus of the K+-Cl- cotransporters. J. Biol. Chem. 2006, 281:15959-15969.
    • (2006) J. Biol. Chem. , vol.281 , pp. 15959-15969
    • Bergeron, M.J.1
  • 99
    • 0034554915 scopus 로고    scopus 로고
    • Cation-chloride cotransporters in neuronal communication
    • Delpire E. Cation-chloride cotransporters in neuronal communication. News Physiol. Sci. 2000, 15:309-312.
    • (2000) News Physiol. Sci. , vol.15 , pp. 309-312
    • Delpire, E.1
  • 100
    • 0030059455 scopus 로고    scopus 로고
    • Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform
    • Payne J.A., et al. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J. Biol. Chem. 1996, 271:16245-16252.
    • (1996) J. Biol. Chem. , vol.271 , pp. 16245-16252
    • Payne, J.A.1
  • 101
    • 44649160758 scopus 로고    scopus 로고
    • GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
    • Khirug S., et al. GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J. Neurosci. 2008, 28:4635-4639.
    • (2008) J. Neurosci. , vol.28 , pp. 4635-4639
    • Khirug, S.1
  • 102
    • 84888785760 scopus 로고    scopus 로고
    • Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII
    • Rivera C., et al. Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J. Physiol. 2005, 564:953.
    • (2005) J. Physiol. , vol.564 , pp. 953
    • Rivera, C.1
  • 103
    • 84872377074 scopus 로고    scopus 로고
    • Short-term ionic plasticity at GABAergic synapses
    • Raimondo J.V., et al. Short-term ionic plasticity at GABAergic synapses. Front. Synaptic Neurosci. 2012, 4:5.
    • (2012) Front. Synaptic Neurosci. , vol.4 , pp. 5
    • Raimondo, J.V.1
  • 104
    • 8644288484 scopus 로고    scopus 로고
    • Regulation of K-Cl cotransport: from function to genes
    • Adragna N.C., et al. Regulation of K-Cl cotransport: from function to genes. J. Membr. Biol. 2004, 201:109-137.
    • (2004) J. Membr. Biol. , vol.201 , pp. 109-137
    • Adragna, N.C.1
  • 105
    • 26844532768 scopus 로고    scopus 로고
    • The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
    • Vitari A.C., et al. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem. J. 2005, 391:17-24.
    • (2005) Biochem. J. , vol.391 , pp. 17-24
    • Vitari, A.C.1
  • 106
    • 33745530924 scopus 로고    scopus 로고
    • Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1
    • Vitari A.C., et al. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem. J. 2006, 397:223-231.
    • (2006) Biochem. J. , vol.397 , pp. 223-231
    • Vitari, A.C.1
  • 107
    • 33845970213 scopus 로고    scopus 로고
    • Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
    • Zagorska A., et al. Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J. Cell Biol. 2007, 176:89-100.
    • (2007) J. Cell Biol. , vol.176 , pp. 89-100
    • Zagorska, A.1
  • 108
    • 0019222931 scopus 로고
    • Chloride-activated passive potassium transport in human erythrocytes
    • Dunham P.B., et al. Chloride-activated passive potassium transport in human erythrocytes. Proc. Natl. Acad. Sci. U.S.A. 1980, 77:1711-1715.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 1711-1715
    • Dunham, P.B.1
  • 109
    • 0018884541 scopus 로고
    • A chloride dependent K+ flux induced by N-ethylmaleimide in genetically low K+ sheep and goat erythrocytes
    • Lauf P.K., Theg B.E. A chloride dependent K+ flux induced by N-ethylmaleimide in genetically low K+ sheep and goat erythrocytes. Biochem. Biophys. Res. Commun. 1980, 92:1422-1428.
    • (1980) Biochem. Biophys. Res. Commun. , vol.92 , pp. 1422-1428
    • Lauf, P.K.1    Theg, B.E.2
  • 110
    • 0015143180 scopus 로고
    • The response of duck erythrocytes to nonhemolytic hypotonic media. Evidence for a volume-controlling mechanism
    • Kregenow F.M. The response of duck erythrocytes to nonhemolytic hypotonic media. Evidence for a volume-controlling mechanism. J. Gen. Physiol. 1971, 58:372-395.
    • (1971) J. Gen. Physiol. , vol.58 , pp. 372-395
    • Kregenow, F.M.1
  • 111
    • 0030255731 scopus 로고    scopus 로고
    • The role of swelling-induced anion channels during neuronal volume regulation
    • Basavappa S., Ellory J.C. The role of swelling-induced anion channels during neuronal volume regulation. Mol. Neurobiol. 1996, 13:137-153.
    • (1996) Mol. Neurobiol. , vol.13 , pp. 137-153
    • Basavappa, S.1    Ellory, J.C.2
  • 112
    • 84885754029 scopus 로고    scopus 로고
    • Physiological roles of auquaporin-4 in brain
    • Nagelhus E.A., Ottersen O.P. Physiological roles of auquaporin-4 in brain. Physiol Rev. 2013, 10.1152/physrev.00011.2013.
    • (2013) Physiol Rev.
    • Nagelhus, E.A.1    Ottersen, O.P.2
  • 113
    • 0030658056 scopus 로고    scopus 로고
    • Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+](o) regulation
    • Payne J.A. Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+](o) regulation. Am. J. Physiol. 1997, 42:C1516-C1525.
    • (1997) Am. J. Physiol. , vol.42
    • Payne, J.A.1
  • 114
    • 33644871505 scopus 로고    scopus 로고
    • A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport
    • Mercado A., et al. A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport. J. Biol. Chem. 2006, 281:1016-1026.
    • (2006) J. Biol. Chem. , vol.281 , pp. 1016-1026
    • Mercado, A.1
  • 115
    • 0037198951 scopus 로고    scopus 로고
    • Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter
    • Song L.Y., et al. Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Mol. Brain Res. 2002, 103:91-105.
    • (2002) Mol. Brain Res. , vol.103 , pp. 91-105
    • Song, L.Y.1


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