Intracellular acidification in neurons induced by ammonium depends on KCC2 function

European Journal of Neuroscience

Volumn 23, Issue 2, 2006, Pages 454-464

  Titz, Stefan ^a   Hormuzdi, Sheriar ^a   Lewen, Andrea ^a   Monyer, Hannah ^a   Misgeld, Ulrich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Development; GABA; NKCC1; Rat cultured neurons; Synaptic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID; AMMONIA; AMMONIUM CHLORIDE; BARIUM ION; BUMETANIDE; CALCIUM ION; CHLORIDE ION; COMPLEMENTARY DNA; COTRANSPORTER; FUROSEMIDE; POTASSIUM ION; SODIUM ION;

ACIDIFICATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL CULTURE; CONTROLLED STUDY; EMBRYO; FEMALE; GLIA CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN;

ANIMALS; BUMETANIDE; CALCIUM; CALCIUM CHANNEL AGONISTS; CELLS, CULTURED; DIAGNOSTIC IMAGING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO; FEMALE; FUROSEMIDE; GAMMA-AMINOBUTYRIC ACID; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SPACE; MESENCEPHALON; NEUROGLIA; NEURONS; POTASSIUM CHLORIDE; PREGNANCY; PYRROLES; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; SODIUM POTASSIUM CHLORIDE SYMPORTER INHIBITORS; SYMPORTERS; TIME FACTORS; TRANSFECTION;

EID: 33644945566     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04583.x     Document Type: Article

References (42)

1. Aickin CC. Deisz RA. Lux HD. 1982 Ammonium action on post-synaptic inhibition in crayfish neurones: implications for the mechanism of chloride extrusion JPhysiol(Lond) 329 319 339
2. + transport mechanisms in medullary thick ascending limb cells AmJPhysiol Cell Physiol 267 C1607 C1615
3. Baird GS. Zacharias DA. Tsien RY. 2000 Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral ProcNatl AcadSciUSA 97 11984 11989
4. - cotransporters AmJPhysiolRenal Physiol 285 F68 F78
5. 3, and metabolic inhibitors JGenPhysiol 67 91 112
6. Cabantchik ZI. Greger R. 1992 Chemical probes for anion transporters of mammalian cell membranes AmJPhysiolCell Physiol 262 C803 C827
7. Felipo V. Butterworth RF. 2002 Neurobiology of ammonia ProgNeurobiol 67 259 279
8. Gillen CM. Forbush B. III. 1999 Functional interaction of the K-Cl cotransporter (KCC1) with the Na-K-Cl cotransporter in HEK-293 cells AmJPhysiolCell Physiol 276 C328 C336
9. Haas M. Forbush B. 1998 The Na-K-Cl cotransporters JBioenergBiomembr 30 161 172
10. Hamberger A. Lindroth P. Nystrom B. 1982 Regulation of glutamate biosynthesis and release in vitro by low levels of ammonium ions Brain Res 237 339 350
11. Hübner CA. Lorke DE. Hermans-Borgmeyer I. 2001 Expression of the Na-K-2Cl-cotransporter NKCC1 during mouse development MechDev 102 267 269
12. Irie T. Hara M. Yasukura T. Minamino M. Omori K. Matsuda H. Inoue K. Inagaki C. 1998 Chloride concentration in cultured hippocampal neurons increases during long-term exposure to ammonia through enhanced expression of an anion exchanger Brain Res 806 246 256
13. - accumulation and depletion in cultured rat midbrain neurons JNeurosci 19 4695 4704
14. Jarolimek W. Misgeld U. 1992 On the inhibitory actions of baclofen and γ-aminobutyric acid in rat ventral midbrain culture JPhysiol(Lond) 451 419 443
15. Kelsch W. Hormuzdi S. Straube E. Lewen A. Monyer H. Misgeld U. 2001 Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons JNeurosci 21 8339 8347
16. Khirug S. Huttu K. Ludwig A. Smirnov S. Voipio J. Rivera C. Kaila K. Khiroug L. 2005 Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices EurJNeurosci 21 899 904
17. - cotransporter JMembrBiol 94 279 284
18. +-ATPase JNeurochem 63 2172 2178
19. 2+ channel activator, FPL 64176, in GH3 cells MolPharmacol 42 666 670
20. Lee H. Chen CX. Liu YJ. Aizenman E. Kandler K. 2005 KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses EurJNeurosci 21 2593 2599
21. + uptake in cultured rat brain neurons JNeurophysiol 90 2785 2790
22. + in glial cells of bee retina JGenPhysiol 116 125 141
23. Marcaggi P. Coles JA. 2001 Ammonium in nervous tissue: transport across cell membranes, fluxes from neurons to glial cells, and role in signalling ProgNeurobiol 64 157 183
24. Monfort P. Kosenko E. Erceg S. Canales JJ. Felipo V. 2002 Molecular mechanism of acute ammonia toxicity: role of NMDA receptors NeurochemInt 41 95 102
25. Nagaraja TN. Brookes N. 1998 Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes AmJPhysiolCell Physiol 274 C883 C891
26. O'Callaghan JFX. Jarolimek W. Lewen A. Misgeld U. 1996 (-)-Baclofen-induced and constitutively active inwardly rectifying potassium conductances in cultured rat midbrain neurons Pflügers Arch 433 49 57
27. o regulation AmJPhysiolCell Physiol 273 C1516 C1525
28. Payne JA. Rivera C. Voipio J. Kaila K. 2003 Cation-chloride co-transporters in neuronal communication, development and trauma Trends Neurosci 26 199 206
29. Post RL. Jolly PC. 1957 The linkage of sodium, potassium, and ammonium active transport across the human erythrocyte membrane BiochimBiophysActa 25 118 128
30. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation Nature 397 251 255
31. Roos A. Boron WF. 1981 Intracellular pH PhysiolRev 61 296 435
32. Russell JM. 2000 Sodium-potassium-chloride cotransport PhysiolRev 80 211 276
33. Stein V. Hermans-Borgmeyer I. Jentsch TJ. Hübner CA. 2004 Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride JCompNeurol 468 57 64
34. Strange K. Singer TD. Morrison R. Delpire E. 2000 Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue AmJPhysiolCell Physiol 279 C860 C867
35. Sugimoto H. Koehler RC. Wilson DA. Brusilow SW. Traystman RJ. 1997 Methionine sulfoximine, a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia JCerebBlood Flow Metab 17 44 49
36. Swain M. Butterworth RF. Blei AT. 1992 Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats Hepatology 15 449 453
37. A response in dissociated rat cortical neurons NeurosciLett 151 51 54
38. Thomas JA. Buchsbaum RN. Zimniak A. Racker E. 1979 Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ Biochemistry 18 2210 2218
39. Titz S. Hans M. Kelsch W. Lewen A. Swandulla D. Misgeld U. 2003 Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons JPhysiol(Lond) 550 719 730
40. Williams JR. Payne JA. 2004 Cation transport by the neuronal K-Cl cotransporter, KCC2: thermodynamics and kinetics of alternate transport modes AmJPhysiolCell Physiol 287 C919 C931
41. Williams JR. Sharp JW. Kumari VG. Wilson M. Payne JA. 1999 The neuron-specific K-Cl cotransporter, KCC2. Antibody development and initial characterization of the protein JBiolChem 274 12656 12664
42. - cotransporter in rat brain during development and its localization in mature astrocytes Brain Res 911 43 55