Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS

Oncology Letters

Volumn 3, Issue 5, 2012, Pages 1159-1165

  Yang, Li Jing ^a   Chen, Yan ^a   He, Jing ^a   Yi, Sha ^a   Wen, Lu ^a   Zhao, Shuai ^a   Cui, Guo Hui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Gambogic acid; Multiple myeloma; Reactive oxygen species; SIRT1

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; GAMBOGIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL AGING; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MULTIPLE MYELOMA; NEUROPROTECTION; PROTEIN EXPRESSION;

EID: 84863243034     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.634     Document Type: Article

References (39)

1. Kasenda B, Ruckert A, Farthmann J, et al: Management of multiple myeloma in pregnancy: strategies for a rare challenge. Clin Lymphoma Myeloma Leuk 11: 190-197, 2011.
2. Siegel DS, Vij R and Jakubowiak AJ: Clinical roundtable monograph. Emerging treatment options for relapsed and refractory multiple myeloma. Clin Adv Hematol Oncol 9: 1-15, 2011.
3. Gu H, Rao S, Zhao J, et al: Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. J Cancer Res Clin Oncol 135: 1777-1782, 2009.
4. Xu X, Liu Y, Wang L, et al: Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells. Int J Dermatol 48: 186-192, 2009.
5. Cui G, Shu W, Wu Q and Chen Y: Effect of Gambogic acid on the regulation of hERG channel in K562 cells in vitro. J Huazhong Univ Sci Technolog Med Sci 29: 540-545, 2009.
6. Wang Y, Chen Y, Chen Z, Wu Q, Ke WJ and Wu QL: Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells. Acta Pharmacol Sin 29: 349-354, 2008.
7. Rong JJ, Hu R, Song XM, et al: Gambogic acid triggers DNA damage signaling that induces p53/p21 (Waf1/CIP1) activation through the ATR-Chk1 pathway. Cancer Lett 296: 55-64, 2010.
8. Nanduri J, Wang N, Bergson P, Yuan G, Ficker E and Prabhakar NR: Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. Biochem Biophys Res Commun 373: 309-314, 2008.
9. Liu B, Chen Y and St Clair DK: ROS and p53: a versatile partnership. Free Radic Biol Med 44: 1529-1535, 2008.
10. Azad N, Iyer A, Vallyathan V, et al: Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation. Ann NY Acad Sci 1203: 1-6, 2010.
11. Borutaite V and Brown GC: Caspases are reversibly inactivated by hydrogen peroxide. FEBS Lett 500: 114-118, 2001.
12. Chen YC, Shen SC and Tsai SH: Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. Biochim Biophys Acta 1743: 291-304, 2005.
13. Nie F, Zhang X, Qi Q, et al: Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells. Toxicology 260: 60-67, 2009.
14. Scherz-Shouval R and Elazar Z: Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 36: 30-38, 2011.
15. Bokoch GM: Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins. Curr Opin Cell Biol 6: 212-218, 1994.
16. Sundaresan M, Yu ZX, Ferrans VJ, et al: Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J 318 (Pt 2): 379-382, 1996.
17. Terada LS: Specificity in reactive oxidant signaling: think globally, act locally. J Cell Biol 174: 615-623, 2006.
18. Jones DP: Redefining oxidative stress. Antioxid Redox Signal 8: 1865-1879, 2006.
19. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84, 2007.
20. Chen Y, Jungsuwadee P, Vore M, Butterfield DA and St Clair DK: Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol Interv 7: 147-156, 2007.
21. Smith BC, Hallows WC and Denu JM: Mechanisms and molecular probes of sirtuins. Chem Biol 15: 1002-1013, 2008.
22. Luo J, Nikolaev AY, Imai S, et al: Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148, 2001.
23. Zeng R, He J, Peng J, et al: The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion. Ann Hematol 91: 407-417, 2012.
24. Olmos Y, Brosens JJ and Lam EW: Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer. Drug Resist Updat 14: 35-44, 2011.
25. Chauhan D, Bandi M, Singh AV, et al: Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br J Haematol 155: 588-598, 2011.
26. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347, 1994.
27. Prasad S, Pandey MK, Yadav VR and Aggarwal BB: Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer Prev Res (Phila) 4: 1084-1094, 2011.
28. Degterev A, Boyce M and Yuan J: A decade of caspases. Oncogene 22: 8543-8567, 2003.
29. Salvesen GS and Abrams JM: Caspase activation stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene 23: 2774-2784, 2004.
30. Circu ML and Aw TY: Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48: 749-762, 2010.
31. Slee EA, Harte MT, Kluck RM, et al: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144: 281-292, 1999.
32. Fraga MF, Agrelo R and Esteller M: Cross-talk between aging and cancer: the epigenetic language. Ann NY Acad Sci 1100: 60-74, 2007.
33. Fraga MF and Esteller M: Epigenetics and aging: the targets and the marks. Trends Genet 23: 413-418, 2007.
34. Hida Y, Kubo Y, Murao K and Arase S: Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res 299: 103-106, 2007.
35. Lim CS: Human SIRT1: a potential biomarker for tumorigenesis? Cell Biol Int 31: 636-637, 2007.
36. Chu F, Chou PM, Zheng X, Mirkin BL and Rebbaa A: Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. Cancer Res 65: 10183-10187, 2005.
37. Matsushita N, Takami Y, Kimura M, et al: Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 10: 321-332, 2005.
38. Brunet A, Sweeney LB, Sturgill JF, et al: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015, 2004.
39. Zhao G, Cui J, Zhang JG, et al: SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. Gene Ther 18: 920-928, 2011.