Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K

Free Radical Biology and Medicine

Volumn 51, Issue 3, 2011, Pages 641-657

  Yang, Juan Cheng ^a   Lu, Mei Chin ^b,c   Lee, Chia Lin ^d,e   Chen, Guan Yu ^e   Lin, Yan Yu ^a   Chang, Fang Rong ^a,f   Wu, Yang Chang ^d,e  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^c NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Breast cancer; Caspase independent cell death; Free radicals; PARP 1; ROS

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; DITERPENE; GELOMULIDE K; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE MU; GLUTATHIONE TRANSFERASE OMEGA; GLUTATHIONE TRANSFERASE P1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PACLITAXEL; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DITERPENES; DRUG SYNERGISM; EPOXY COMPOUNDS; FEMALE; HUMANS; LACTONES; MICE; MICE, NUDE; OXIDATIVE STRESS; PACLITAXEL; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTIONAL ACTIVATION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79960004073     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.05.012     Document Type: Article

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