Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats

Neurochemistry International

Volumn 66, Issue 1, 2014, Pages 27-32

  Chen, Lin ^a   Wei, Xinbing ^a   Hou, Yunfeng ^b   Liu, Xiaoqian ^a   Li, Senpeng ^a   Sun, Baozhu ^c   Liu, Xinyong ^d   Liu, Huiqing ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Ischemia reperfusion; PI3K Akt GSK3 pathway; Tetramethylpyrazine analogue CXC195

Indexed keywords

CASPASE 3; CXC 195; GLYCOGEN SYNTHASE KINASE 3BETA; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

APOPTOSIS; ISCHEMIA/REPERFUSION; PI3K/AKT/GSK3Β PATHWAY; TETRAMETHYLPYRAZINE ANALOGUE CXC195;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; GLYCOGEN SYNTHASE KINASE 3; MALE; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASE; PIPERAZINES; PYRAZINES; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84893467383     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.01.006     Document Type: Article

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