메뉴 건너뛰기




Volumn 9, Issue , 2012, Pages

Post-ischemic estradiol treatment reduced glial response and triggers distinct cortical and hippocampal signaling in a rat model of cerebral ischemia

Author keywords

Akt; Brain; Estradiol; Estrogen; Focal ischemia; Immunohistochemistry; MCAO; Neuroprotection; Rat; Stroke; Western blot

Indexed keywords

BETA CATENIN; CELL MARKER; ESTRADIOL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3; IBA1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 84864809822     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-157     Document Type: Article
Times cited : (63)

References (77)
  • 2
    • 78049425264 scopus 로고    scopus 로고
    • P120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia
    • 10.1002/jnr.22511, 20936696
    • Céspedes-Rubio A, Jurado FW, Cardona-Gómez GP. p120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia. J Neurosci Res 2010, 88:3621-3634. 10.1002/jnr.22511, 20936696.
    • (2010) J Neurosci Res , vol.88 , pp. 3621-3634
    • Céspedes-Rubio, A.1    Jurado, F.W.2    Cardona-Gómez, G.P.3
  • 3
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • 10.1016/S0166-2236(99)01401-0, 10441299
    • Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999, 22:391-397. 10.1016/S0166-2236(99)01401-0, 10441299.
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 4
    • 0041659304 scopus 로고    scopus 로고
    • Animal models of stroke: do they have value for discovering neuroprotective agents?
    • 10.1016/S0165-6147(03)00192-5, 12915049
    • Richard Green A, Odergren T, Ashwood T. Animal models of stroke: do they have value for discovering neuroprotective agents?. Trends Pharmacol Sci 2003, 24:402-408. 10.1016/S0165-6147(03)00192-5, 12915049.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 402-408
    • Richard Green, A.1    Odergren, T.2    Ashwood, T.3
  • 5
    • 33845547792 scopus 로고    scopus 로고
    • Pathophysiology and therapy of experimental stroke
    • Hossmann K-A. Pathophysiology and therapy of experimental stroke. Cel Mol Neurobiol 2006, 26:1055-1081.
    • (2006) Cel Mol Neurobiol , vol.26 , pp. 1055-1081
    • Hossmann, K.-A.1
  • 6
    • 19544376505 scopus 로고    scopus 로고
    • Inflammation in areas of remote changes following focal brain lesion
    • 10.1016/j.pneurobio.2005.03.004, 15925027
    • Block F, Dihné M, Loos M. Inflammation in areas of remote changes following focal brain lesion. Prog Neurobiol 2005, 75:342-365. 10.1016/j.pneurobio.2005.03.004, 15925027.
    • (2005) Prog Neurobiol , vol.75 , pp. 342-365
    • Block, F.1    Dihné, M.2    Loos, M.3
  • 7
    • 34247150317 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications
    • 10.1016/j.steroids.2007.02.003, 2048656, 17379265
    • Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan MM. Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications. Steroids 2007, 72:381-405. 10.1016/j.steroids.2007.02.003, 2048656, 17379265.
    • (2007) Steroids , vol.72 , pp. 381-405
    • Brann, D.W.1    Dhandapani, K.2    Wakade, C.3    Mahesh, V.B.4    Khan, M.M.5
  • 8
    • 47749128919 scopus 로고    scopus 로고
    • Pathways to ischemic neuronal cell death:are sex differences relevant?
    • Lang J, McCullough L. Pathways to ischemic neuronal cell death:are sex differences relevant?. J Transl Med 2008, 223:6-33.
    • (2008) J Transl Med , vol.223 , pp. 6-33
    • Lang, J.1    McCullough, L.2
  • 9
    • 38349127387 scopus 로고    scopus 로고
    • Stroke and the female brain
    • Bushnell C. Stroke and the female brain. Nat Clin Pract Neurol 2008, 4:22-33.
    • (2008) Nat Clin Pract Neurol , vol.4 , pp. 22-33
    • Bushnell, C.1
  • 10
    • 33746191796 scopus 로고    scopus 로고
    • Neuroprotection by ovarian hormones in animal models of neurological disease
    • Hoffman GE MI, Zup SL. Neuroprotection by ovarian hormones in animal models of neurological disease. Endocrine 2006, 29:14.
    • (2006) Endocrine , vol.29 , pp. 14
    • Hoffman GE, M.I.1    Zup, S.L.2
  • 11
    • 0031984050 scopus 로고    scopus 로고
    • Gender-linked brain injury in experimental stroke
    • 10.1161/01.STR.29.1.159, 9445346
    • Alkayed N, Harukuni I, Kimes A, London E, Traystman R, Hurn P. Gender-linked brain injury in experimental stroke. Stroke 1998, 29:159-165. 10.1161/01.STR.29.1.159, 9445346.
    • (1998) Stroke , vol.29 , pp. 159-165
    • Alkayed, N.1    Harukuni, I.2    Kimes, A.3    London, E.4    Traystman, R.5    Hurn, P.6
  • 13
    • 0031904678 scopus 로고    scopus 로고
    • Estrogen-mediated neuroprotection after experimental stroke in male rats
    • 1666-1670, 10.1161/01.STR.29.8.1666, 9707210
    • Toung TJK, Traystman RJ, Hurn PD. Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 1998, 29:1666-1670. 1666-1670, 10.1161/01.STR.29.8.1666, 9707210.
    • (1998) Stroke , vol.29 , pp. 1666-1670
    • Toung, T.J.K.1    Traystman, R.J.2    Hurn, P.D.3
  • 14
    • 0033178294 scopus 로고    scopus 로고
    • Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors
    • Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 1999, 19:6385-6393.
    • (1999) J Neurosci , vol.19 , pp. 6385-6393
    • Dubal, D.B.1    Shughrue, P.J.2    Wilson, M.E.3    Merchenthaler, I.4    Wise, P.M.5
  • 15
    • 0035118001 scopus 로고    scopus 로고
    • Neuroprotective effects of estradiol in middle-aged female rats
    • 10.1210/en.142.1.43, 11145565
    • Dubal DB, Wise PM. Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology 2001, 142:43-48. 10.1210/en.142.1.43, 11145565.
    • (2001) Endocrinology , vol.142 , pp. 43-48
    • Dubal, D.B.1    Wise, P.M.2
  • 16
    • 33645993568 scopus 로고    scopus 로고
    • Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation
    • 10.1016/j.neulet.2005.12.060, 16423457
    • Won CK, Ji HH, Koh PO. Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 2006, 398:39-43. 10.1016/j.neulet.2005.12.060, 16423457.
    • (2006) Neurosci Lett , vol.398 , pp. 39-43
    • Won, C.K.1    Ji, H.H.2    Koh, P.O.3
  • 17
    • 0038268485 scopus 로고    scopus 로고
    • Estrogen and ischemic neuroprotection: an integrated view
    • McCullough L, Hurn P. Estrogen and ischemic neuroprotection: an integrated view. Trends Endocrin Metab 2003, 14:228-235.
    • (2003) Trends Endocrin Metab , vol.14 , pp. 228-235
    • McCullough, L.1    Hurn, P.2
  • 18
    • 33845960245 scopus 로고    scopus 로고
    • Estradiol prevents the injury-induced decrease of 90 ribosomal S6 kinase (p90RSK) and Bad phosphorylation
    • 10.1016/j.neulet.2006.10.060, 17196335
    • Koh PO. Estradiol prevents the injury-induced decrease of 90 ribosomal S6 kinase (p90RSK) and Bad phosphorylation. Neurosci Lett 2007, 412:68-72. 10.1016/j.neulet.2006.10.060, 17196335.
    • (2007) Neurosci Lett , vol.412 , pp. 68-72
    • Koh, P.O.1
  • 19
    • 33746316421 scopus 로고    scopus 로고
    • Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3[beta] phosphorylation
    • 10.1016/j.neulet.2006.06.020, 16815634
    • Koh PO, Won CK, Cho JH. Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3[beta] phosphorylation. Neurosci Lett 2006, 404:303-308. 10.1016/j.neulet.2006.06.020, 16815634.
    • (2006) Neurosci Lett , vol.404 , pp. 303-308
    • Koh, P.O.1    Won, C.K.2    Cho, J.H.3
  • 20
    • 0034018107 scopus 로고    scopus 로고
    • Estradiol exerts neuroprotective effects when administered after ischemic insult
    • 10.1161/01.STR.31.3.745, 10700514
    • Yang S-H, Shi J, Day AL, Simpkins JW. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke 2000, 31:745-750. 10.1161/01.STR.31.3.745, 10700514.
    • (2000) Stroke , vol.31 , pp. 745-750
    • Yang, S.-H.1    Shi, J.2    Day, A.L.3    Simpkins, J.W.4
  • 21
    • 14644435096 scopus 로고    scopus 로고
    • Detrimental effects of 17[beta]-oestradiol after permanent middle cerebral artery occlusion
    • 10.1038/sj.jcbfm.9600031, 15647739
    • Bingham D, Macrae IM, Carswell HV. Detrimental effects of 17[beta]-oestradiol after permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 2005, 25:414-420. 10.1038/sj.jcbfm.9600031, 15647739.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 414-420
    • Bingham, D.1    Macrae, I.M.2    Carswell, H.V.3
  • 22
    • 33747151044 scopus 로고    scopus 로고
    • 17[beta]-Estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function
    • 10.1016/j.nbd.2006.04.009, 16759876
    • Farr TD, Carswell HVO, Gallagher L, Condon B, Fagan AJ, Mullin J, Macrae IM. 17[beta]-Estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function. Neurobiol Dis 2006, 23:552-562. 10.1016/j.nbd.2006.04.009, 16759876.
    • (2006) Neurobiol Dis , vol.23 , pp. 552-562
    • Farr, T.D.1    Carswell, H.V.O.2    Gallagher, L.3    Condon, B.4    Fagan, A.J.5    Mullin, J.6    Macrae, I.M.7
  • 23
    • 0035666912 scopus 로고    scopus 로고
    • Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection
    • 10.1016/S0165-0173(01)00137-0, 11744097
    • Cardona-Gómez GP, Mendez P, DonCarlos LL, Azcoitia I, Garcia-Segura LM. Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection. Brain Res Rev 2001, 37:320-334. 10.1016/S0165-0173(01)00137-0, 11744097.
    • (2001) Brain Res Rev , vol.37 , pp. 320-334
    • Cardona-Gómez, G.P.1    Mendez, P.2    DonCarlos, L.L.3    Azcoitia, I.4    Garcia-Segura, L.M.5
  • 24
    • 0037430850 scopus 로고    scopus 로고
    • Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain
    • 10.1016/S0169-328X(03)00088-3, 12670715
    • Mendez P, Azcoitia I, Garcia-Segura LM. Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Mol Brain Res 2003, 112:170-176. 10.1016/S0169-328X(03)00088-3, 12670715.
    • (2003) Mol Brain Res , vol.112 , pp. 170-176
    • Mendez, P.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 26
    • 65249123993 scopus 로고    scopus 로고
    • Estradiol activates beta-Catenin dependent transcription in neurons
    • 10.1371/journal.pone.0005153, 2664482, 19360103
    • Varea O, Garrido JJ, Dopazo A, Mendez P, Garcia-Segura LM, Wandosell F. Estradiol activates beta-Catenin dependent transcription in neurons. PLoS ONE 2009, 4:e5153. 10.1371/journal.pone.0005153, 2664482, 19360103.
    • (2009) PLoS ONE , vol.4
    • Varea, O.1    Garrido, J.J.2    Dopazo, A.3    Mendez, P.4    Garcia-Segura, L.M.5    Wandosell, F.6
  • 28
    • 33751331389 scopus 로고    scopus 로고
    • Activation of the Akt//GSK3[beta] signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats
    • 10.1038/sj.jcbfm.9600303, 16538228
    • Endo H, Nito C, Kamada H, Nishi T, Chan PH. Activation of the Akt//GSK3[beta] signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. J Cereb Blood Flow Metab 2006, 26:1479-1489. 10.1038/sj.jcbfm.9600303, 16538228.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1479-1489
    • Endo, H.1    Nito, C.2    Kamada, H.3    Nishi, T.4    Chan, P.H.5
  • 29
    • 79959201790 scopus 로고    scopus 로고
    • The Akt/GSK-3[beta] pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats
    • 10.1016/j.bbrc.2011.05.095, 21624354
    • Sun B, Chen L, Wei X, Xiang Y, Liu X, Zhang X. The Akt/GSK-3[beta] pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. Biochem Biophys Res Comm 2011, 409:808-813. 10.1016/j.bbrc.2011.05.095, 21624354.
    • (2011) Biochem Biophys Res Comm , vol.409 , pp. 808-813
    • Sun, B.1    Chen, L.2    Wei, X.3    Xiang, Y.4    Liu, X.5    Zhang, X.6
  • 30
    • 0035194849 scopus 로고    scopus 로고
    • Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice
    • Noshita N, Lewen A, Sugawara T, Chan PH. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 2001, 21:1442-1450.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1442-1450
    • Noshita, N.1    Lewen, A.2    Sugawara, T.3    Chan, P.H.4
  • 32
    • 0034785791 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases and cerebral ischemia
    • 10.1385/MN:23:1:01, 11642541
    • Nozaki K, Nishimura M, Hashimoto N. Mitogen-activated protein kinases and cerebral ischemia. Mol Neurobiol 2001, 23:1-19. 10.1385/MN:23:1:01, 11642541.
    • (2001) Mol Neurobiol , vol.23 , pp. 1-19
    • Nozaki, K.1    Nishimura, M.2    Hashimoto, N.3
  • 33
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathway
    • Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993, 268:14553-14556.
    • (1993) J Biol Chem , vol.268 , pp. 14553-14556
    • Davis, R.J.1
  • 35
    • 0033843407 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain
    • 10.1097/00004647-200009000-00007, 10994854
    • Wu D-C, Ye W, Che X-M, Yang G-Y. Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain. J Cereb Blood Flow Metab 2000, 20:1320-1330. 10.1097/00004647-200009000-00007, 10994854.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1320-1330
    • Wu, D.-C.1    Ye, W.2    Che, X.-M.3    Yang, G.-Y.4
  • 36
    • 0034646936 scopus 로고    scopus 로고
    • Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat
    • 10.1016/S0169-328X(00)00043-7, 10814833
    • Irving EA, Barone FC, Reith AD, Hadingham SJ, Parsons AA. Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. Mol Brain Res 2000, 77:65-75. 10.1016/S0169-328X(00)00043-7, 10814833.
    • (2000) Mol Brain Res , vol.77 , pp. 65-75
    • Irving, E.A.1    Barone, F.C.2    Reith, A.D.3    Hadingham, S.J.4    Parsons, A.A.5
  • 38
    • 0036908754 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases in experimental cerebral ischemia
    • 10.1034/j.1600-0404.2002.01313.x, 12460137
    • Lennmyr F, Karlsson S, Gerwins P, Ata KA, Terént A. Activation of mitogen-activated protein kinases in experimental cerebral ischemia. Acta Neurol Scand 2002, 106:333-340. 10.1034/j.1600-0404.2002.01313.x, 12460137.
    • (2002) Acta Neurol Scand , vol.106 , pp. 333-340
    • Lennmyr, F.1    Karlsson, S.2    Gerwins, P.3    Ata, K.A.4    Terént, A.5
  • 39
    • 77953608972 scopus 로고    scopus 로고
    • JNK inhibition and inflammation after cerebral ischemia
    • 10.1016/j.bbi.2009.11.001, 19903520
    • Benakis C, Bonny C, Hirt L. JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun 2010, 24:800-811. 10.1016/j.bbi.2009.11.001, 19903520.
    • (2010) Brain Behav Immun , vol.24 , pp. 800-811
    • Benakis, C.1    Bonny, C.2    Hirt, L.3
  • 40
    • 0033524740 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
    • Shimoke K, Yamagishi S, Yamada M, Ikeuchi T, Hatanaka H. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain Res Dev Brain Res 1999, 112:245-253.
    • (1999) Brain Res Dev Brain Res , vol.112 , pp. 245-253
    • Shimoke, K.1    Yamagishi, S.2    Yamada, M.3    Ikeuchi, T.4    Hatanaka, H.5
  • 41
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • Longa EZWP, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:8.
    • (1989) Stroke , vol.20 , pp. 8
    • Longa, E.Z.W.P.1    Carlson, S.2    Cummins, R.3
  • 42
    • 23644456682 scopus 로고    scopus 로고
    • Long-term protective effect of atorvastatin in permanent focal cerebral ischemia
    • 10.1016/j.brainres.2005.06.004, 16023089
    • Yrjänheikki J, Koistinaho J, Kettunen M, Kauppinen RA, Appel K, Hüll M, Fiebich BL. Long-term protective effect of atorvastatin in permanent focal cerebral ischemia. Brain Res 2005, 1052:174-179. 10.1016/j.brainres.2005.06.004, 16023089.
    • (2005) Brain Res , vol.1052 , pp. 174-179
    • Yrjänheikki, J.1    Koistinaho, J.2    Kettunen, M.3    Kauppinen, R.A.4    Appel, K.5    Hüll, M.6    Fiebich, B.L.7
  • 44
    • 0029880252 scopus 로고    scopus 로고
    • Differential cellular response after glutamate analog hippocampal damage
    • 10.1002/(SICI)1097-4547(19960515)44:4<397::AID-JNR11>3.0.CO;2-#, 8739159
    • Araujo M, Wandosell F. Differential cellular response after glutamate analog hippocampal damage. J Neurosci Res 1996, 44:397-409. 10.1002/(SICI)1097-4547(19960515)44:4<397::AID-JNR11>3.0.CO;2-#, 8739159.
    • (1996) J Neurosci Res , vol.44 , pp. 397-409
    • Araujo, M.1    Wandosell, F.2
  • 45
    • 0034193219 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons
    • 10.1002/(SICI)1097-4547(20000501)60:3<321::AID-JNR6>3.0.CO;2-T, 10797534
    • Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 2000, 60:321-327. 10.1002/(SICI)1097-4547(20000501)60:3<321::AID-JNR6>3.0.CO;2-T, 10797534.
    • (2000) J Neurosci Res , vol.60 , pp. 321-327
    • Honda, K.1    Sawada, H.2    Kihara, T.3    Urushitani, M.4    Nakamizo, T.5    Akaike, A.6    Shimohama, S.7
  • 46
    • 79959261693 scopus 로고    scopus 로고
    • Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3
    • Mines MA, Beurel E, Jope RS. Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3. International Journal of Alzheimer's Disease 2011, 2011:861072.
    • (2011) International Journal of Alzheimer's Disease , vol.2011 , pp. 861072
    • Mines, M.A.1    Beurel, E.2    Jope, R.S.3
  • 47
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Ann Rev Cell Dev Biol 2004, 20:781-810.
    • (2004) Ann Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 48
    • 79953278853 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion model in rodents: methods and potential fitfalls
    • 3035178, 21331357
    • Liu F, McCullough LD. Middle cerebral artery occlusion model in rodents: methods and potential fitfalls. J Biomed Biotechnol 2011, 2011:464701. 3035178, 21331357.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 464701
    • Liu, F.1    McCullough, L.D.2
  • 49
    • 41749111752 scopus 로고    scopus 로고
    • Estradiol attenuates the focal cerebral ischemic injury through mTOR/p70S6 kinase signaling pathway
    • 10.1016/j.neulet.2008.02.061, 18378082
    • Koh P-O, Cho J-H, Won C-K, Lee H-J, Sung J-H, Kim M-O. Estradiol attenuates the focal cerebral ischemic injury through mTOR/p70S6 kinase signaling pathway. Neurosci Lett 2008, 436:62-66. 10.1016/j.neulet.2008.02.061, 18378082.
    • (2008) Neurosci Lett , vol.436 , pp. 62-66
    • Koh, P.-O.1    Cho, J.-H.2    Won, C.-K.3    Lee, H.-J.4    Sung, J.-H.5    Kim, M.-O.6
  • 50
    • 36649022397 scopus 로고    scopus 로고
    • Inflammation in ischemic brain injury: timing is important
    • 10.1615/CritRevNeurobiol.v18.i1-2.150, 17725517
    • Kriz J. Inflammation in ischemic brain injury: timing is important. Crit Rev Neurobiol 2006, 18(1-2):145-157. 10.1615/CritRevNeurobiol.v18.i1-2.150, 17725517.
    • (2006) Crit Rev Neurobiol , vol.18 , Issue.1-2 , pp. 145-157
    • Kriz, J.1
  • 51
    • 0027104247 scopus 로고
    • CNS glial scar tissue: a source of molecules which inhibit central neurite outgrowth
    • Bovolenta P, Wandosell F, Nieto-Sampedro M. CNS glial scar tissue: a source of molecules which inhibit central neurite outgrowth. Prog Brain Res 1992, 94:367-379.
    • (1992) Prog Brain Res , vol.94 , pp. 367-379
    • Bovolenta, P.1    Wandosell, F.2    Nieto-Sampedro, M.3
  • 52
    • 0027287253 scopus 로고
    • Characterization of a neurite outgrowth inhibitor expressed after CNS injury
    • 10.1111/j.1460-9568.1993.tb00512.x, 8261122
    • Bovolenta P, Wandosell F, Nieto-Sampedro M. Characterization of a neurite outgrowth inhibitor expressed after CNS injury. Eur J Neurosci 1993, 5:454-465. 10.1111/j.1460-9568.1993.tb00512.x, 8261122.
    • (1993) Eur J Neurosci , vol.5 , pp. 454-465
    • Bovolenta, P.1    Wandosell, F.2    Nieto-Sampedro, M.3
  • 55
    • 70849085134 scopus 로고    scopus 로고
    • Central nervous system regeneration inhibitors and their intracellular substrates
    • 10.1007/s12035-009-8083-y, 19763907
    • Nash M, Pribiag H, Fournier AE, Jacobson C. Central nervous system regeneration inhibitors and their intracellular substrates. Mol Neurobiol 2009, 40:224-235. 10.1007/s12035-009-8083-y, 19763907.
    • (2009) Mol Neurobiol , vol.40 , pp. 224-235
    • Nash, M.1    Pribiag, H.2    Fournier, A.E.3    Jacobson, C.4
  • 56
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • 10.1016/j.jneuroim.2006.11.014, 1868538, 17188755
    • Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke. J Neuroimmunol 2007, 184:53-68. 10.1016/j.jneuroim.2006.11.014, 1868538, 17188755.
    • (2007) J Neuroimmunol , vol.184 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 57
    • 84055197913 scopus 로고    scopus 로고
    • Selective Oestrogen receptor modulators decrease the inflammatory response of glial cells
    • 10.1111/j.1365-2826.2011.02156.x, 21564348
    • Arevalo MA, Diz-Chaves Y, Santos-Galindo M, Bellini MJ, Garcia-Segura LM. Selective Oestrogen receptor modulators decrease the inflammatory response of glial cells. J Neuroendocrinol 2012, 24:183-190. 10.1111/j.1365-2826.2011.02156.x, 21564348.
    • (2012) J Neuroendocrinol , vol.24 , pp. 183-190
    • Arevalo, M.A.1    Diz-Chaves, Y.2    Santos-Galindo, M.3    Bellini, M.J.4    Garcia-Segura, L.M.5
  • 58
    • 70350322693 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones
    • 10.1210/en.2009-0352, 19797123
    • Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernia O, Carrero P, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology 2009, 150:5010-5015. 10.1210/en.2009-0352, 19797123.
    • (2009) Endocrinology , vol.150 , pp. 5010-5015
    • Barreto, G.1    Santos-Galindo, M.2    Diz-Chaves, Y.3    Pernia, O.4    Carrero, P.5    Azcoitia, I.6    Garcia-Segura, L.M.7
  • 59
    • 41249090606 scopus 로고    scopus 로고
    • Effect of 17beta-estradiol on functional outcome, release of cytokines, astrocyte reactivity and inflammatory spreading after spinal cord injury in male rats
    • Ritz MF, Hausmann ON. Effect of 17beta-estradiol on functional outcome, release of cytokines, astrocyte reactivity and inflammatory spreading after spinal cord injury in male rats. Brain Res 2008, 1203:177-188.
    • (2008) Brain Res , vol.1203 , pp. 177-188
    • Ritz, M.F.1    Hausmann, O.N.2
  • 60
    • 41949104261 scopus 로고    scopus 로고
    • Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    • 10.1016/j.jneuroim.2008.01.006, 2394738, 18328572
    • Lewis DK, Johnson AB, Stohlgren S, Harms A, Sohrabji F. Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats. J Neuroimmunol 2008, 195:47-59. 10.1016/j.jneuroim.2008.01.006, 2394738, 18328572.
    • (2008) J Neuroimmunol , vol.195 , pp. 47-59
    • Lewis, D.K.1    Johnson, A.B.2    Stohlgren, S.3    Harms, A.4    Sohrabji, F.5
  • 61
    • 79960559114 scopus 로고    scopus 로고
    • Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats
    • 10.1186/1742-2094-8-82, 3161870, 21774811
    • Sarvari M, Hrabovszky E, Kallo I, Solymosi N, Toth K, Liko I, Szeles J, Maho S, Molnar B, Liposits Z. Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats. J Neuroinflammation 2011, 8:82. 10.1186/1742-2094-8-82, 3161870, 21774811.
    • (2011) J Neuroinflammation , vol.8 , pp. 82
    • Sarvari, M.1    Hrabovszky, E.2    Kallo, I.3    Solymosi, N.4    Toth, K.5    Liko, I.6    Szeles, J.7    Maho, S.8    Molnar, B.9    Liposits, Z.10
  • 62
    • 79960840961 scopus 로고    scopus 로고
    • Guo Ca, Fang T, Chen Z: GSK-3[beta] inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury
    • 10.1016/j.bbrc.2011.06.117, 21723251
    • Zhou X, Zhou J, Li X. Guo Ca, Fang T, Chen Z: GSK-3[beta] inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury. Biochem Biophys Res Commun 2011, 411:271-275. 10.1016/j.bbrc.2011.06.117, 21723251.
    • (2011) Biochem Biophys Res Commun , vol.411 , pp. 271-275
    • Zhou, X.1    Zhou, J.2    Li, X.3
  • 63
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signalling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits
    • Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits. Biochimica et Biophysica Acta (BBA) 2005, 1754:253-262.
    • (2005) Biochimica et Biophysica Acta (BBA) , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 64
    • 0030273118 scopus 로고    scopus 로고
    • Ischemia-induced neuronal apoptosis
    • 10.1016/S0959-4388(96)80101-2, 8937832
    • Choi DW. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996, 6:667-672. 10.1016/S0959-4388(96)80101-2, 8937832.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 667-672
    • Choi, D.W.1
  • 65
    • 0030884358 scopus 로고    scopus 로고
    • Apoptosis and protein expression after focal cerebral ischemia in rat
    • 10.1016/S0006-8993(97)00524-6, 9313903
    • Li Y, Chopp M, Powers C, Jiang N. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Res 1997, 765:301-312. 10.1016/S0006-8993(97)00524-6, 9313903.
    • (1997) Brain Res , vol.765 , pp. 301-312
    • Li, Y.1    Chopp, M.2    Powers, C.3    Jiang, N.4
  • 66
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • 10.1074/jbc.273.32.19929, 9685326
    • Pap M, Cooper GM. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 1998, 273:19929-19932. 10.1074/jbc.273.32.19929, 9685326.
    • (1998) J Biol Chem , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 67
    • 67650095053 scopus 로고    scopus 로고
    • Prevention of glutamate accumulation and upregulation of phospho-Akt may account for neuroprotection afforded by bergamot essential oil against brain injury induced by focal cerebral ischemia in rat
    • Amantea D, Fratto V, Maida S, Rotiroti D, Ragusa S, Nappi G, Bagetta G, Corasaniti MT, Bagetta G. Prevention of glutamate accumulation and upregulation of phospho-Akt may account for neuroprotection afforded by bergamot essential oil against brain injury induced by focal cerebral ischemia in rat. Int Rev Neurobiol 2009, 85:389-405.
    • (2009) Int Rev Neurobiol , vol.85 , pp. 389-405
    • Amantea, D.1    Fratto, V.2    Maida, S.3    Rotiroti, D.4    Ragusa, S.5    Nappi, G.6    Bagetta, G.7    Corasaniti, M.T.8    Bagetta, G.9
  • 68
    • 0037189059 scopus 로고    scopus 로고
    • Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice
    • 10.1016/S0006-8993(02)02474-5, 12031847
    • Shibata M, Yamawaki T, Sasaki T, Hattori H, Hamada J, Fukuuchi Y, Okano H, Miura M. Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice. Brain Res 2002, 942:1-10. 10.1016/S0006-8993(02)02474-5, 12031847.
    • (2002) Brain Res , vol.942 , pp. 1-10
    • Shibata, M.1    Yamawaki, T.2    Sasaki, T.3    Hattori, H.4    Hamada, J.5    Fukuuchi, Y.6    Okano, H.7    Miura, M.8
  • 69
    • 0032886308 scopus 로고    scopus 로고
    • Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain
    • 10.1016/S0304-3940(99)00676-X, 10530516
    • Kitagawa H, Warita H, Sasaki C, Ri Zhang W, Sakai K, Shiro Y, Mitsumoto Y, Mori T, Abe K. Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain. Neurosci Lett 1999, 274:45-48. 10.1016/S0304-3940(99)00676-X, 10530516.
    • (1999) Neurosci Lett , vol.274 , pp. 45-48
    • Kitagawa, H.1    Warita, H.2    Sasaki, C.3    Ri Zhang, W.4    Sakai, K.5    Shiro, Y.6    Mitsumoto, Y.7    Mori, T.8    Abe, K.9
  • 70
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • 10.1016/0092-8674(95)90534-0, 7774014
    • Franke TF, Yang S-I, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995, 81:727-736. 10.1016/0092-8674(95)90534-0, 7774014.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.-I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 71
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex
    • 10.1126/science.1106148, 15718470
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex. Science 2005, 307:1098-1101. 10.1126/science.1106148, 15718470.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 72
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • 10.1016/j.cell.2006.08.033, 16962653
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006, 127:125-137. 10.1016/j.cell.2006.08.033, 16962653.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huang, Q.7    Qin, J.8    Su, B.9
  • 73
    • 80052873360 scopus 로고    scopus 로고
    • The functions of mTOR in ischemic diseases
    • 10.5483/BMBRep.2011.44.8.506, 21871173
    • Hwang SK, Kim HH. The functions of mTOR in ischemic diseases. BMB Rep 2011, 44:506-511. 10.5483/BMBRep.2011.44.8.506, 21871173.
    • (2011) BMB Rep , vol.44 , pp. 506-511
    • Hwang, S.K.1    Kim, H.H.2
  • 74
    • 1642375658 scopus 로고    scopus 로고
    • Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus
    • 10.1016/j.mcn.2003.10.008, 15033165
    • Cardona-Gomez P, Perez M, Avila J, Garcia-Segura LM, Wandosell F. Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Mol Cell Neurosci 2004, 25:363-373. 10.1016/j.mcn.2003.10.008, 15033165.
    • (2004) Mol Cell Neurosci , vol.25 , pp. 363-373
    • Cardona-Gomez, P.1    Perez, M.2    Avila, J.3    Garcia-Segura, L.M.4    Wandosell, F.5
  • 75
    • 69949167076 scopus 로고    scopus 로고
    • Involvement of Akt in neurite outgrowth
    • 10.1007/s00018-009-0057-8, 19504044
    • Read D, Gorman A. Involvement of Akt in neurite outgrowth. Cell Mol Life Sci 2009, 66:2975-2984. 10.1007/s00018-009-0057-8, 19504044.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2975-2984
    • Read, D.1    Gorman, A.2
  • 76
    • 77349112413 scopus 로고    scopus 로고
    • Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway
    • Liu C, Wu J, Xu K, Cai F, Gu J, Ma L, Chen J. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochemistry 2010, 112:1500-1512.
    • (2010) J Neurochemistry , vol.112 , pp. 1500-1512
    • Liu, C.1    Wu, J.2    Xu, K.3    Cai, F.4    Gu, J.5    Ma, L.6    Chen, J.7
  • 77
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • 10.1093/emboj/20.1.27, 140191, 11226152
    • Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 2001, 20:27-39. 10.1093/emboj/20.1.27, 140191, 11226152.
    • (2001) EMBO J , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.