Ligustrazine Derivatives. Part 4: Design, Synthesis, and Biological Evaluation of Novel Ligustrazine-based Stilbene Derivatives as Potential Cardiovascular Agents

Chemical Biology and Drug Design

Volumn 79, Issue 5, 2012, Pages 731-739

  Deng, Lijuan ^a,b   Guo, Xiuli ^a   Zhai, Li ^a   Song, Yuning ^a   Chen, Hongfei ^a   Zhan, Peng ^a   Wu, Jingde ^a   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b Pingxiang People's Hospital   (China)

Author keywords

Cardiovascular activity; Ligustrazine; Stilbene derivatives; Synthesis

Indexed keywords

2 (2 CHLOROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2 CYANOSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2 FLUOROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2 FURYL) VINYL 3,5,6 TRIMETHYLPYRAZINE; 2 (2 HYDROXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2 METHYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2 THIENYL) VINYL 3,5,6 TRIMETHYLPYRAZINE; 2 (2,3 DIMETHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2,3,4 TRIMETHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2,4 DIMETHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (2,5 DIMETHOXYSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3 CHLOROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3 CYANOSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3 HYDROXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3 METHOXYL 2 HYDROXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3 METHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3 METHYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3,4 DIMETHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (3,4,5 TRIMETHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (4 FLUOROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (4 METHOXYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (4 METHYLSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 (4 NITROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 2 [2 (3,5,6 TRIMETHYLPYRAZINYL) VINYL 3,5,6 TRIMETHYL]PYRAZINE; 2,3,5 TRIMETHYL 6 4 PHENYLBUTA 1,3 DIENYL)PYRAZINE; 2,3,5 TRIMETHYL 6 STYRYLPYRAZINE; CARDIOVASCULAR AGENT; RESVERATROL; STILBENE DERIVATIVE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CELL PROTECTION; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENDOTHELIUM CELL; EVALUATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CARDIOVASCULAR AGENTS; DRUG DESIGN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; OXIDATIVE STRESS; PYRAZINES; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862808833     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01332.x     Document Type: Article

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