Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats

Neurochemistry International

Volumn 48, Issue 3, 2006, Pages 166-176

  Kao, Tsung Kuei ^a,c   Ou, Yen Chuan ^b   Kuo, Jong Song ^b   Chen, Wen Yin ^b   Liao, Su Lan ^b   Wu, Ching Wen ^b   Chen, Chun Jung ^b   Ling, Nai Nu ^b   Zhang, Yong Hong ^c   Peng, Wen Huang ^d  

^a TAJEN INSTITUTE OF TECHNOLOGY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase; Cerebral ischemia reperfusion; Inflammation; Neuroprotection; Tetramethylpyrazine

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; TETRAMETHYLPYRAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CELL ACTIVATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; INFLAMMATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN ISCHEMIA; IMMUNOHISTOCHEMISTRY; MALE; NEUROPROTECTIVE AGENTS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; LIGUSTICUM WALLICHII;

EID: 30544445874     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.10.008     Document Type: Article

References (46)

1. S. Adachi, A.R. Cross, B.M. Babior, and R.A. Gottlieb Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis J. Biol. Chem. 272 1997 21878 21882
2. A.E. Baird, A. Benfield, G. Schlaug, B. Siewert, K.O. Lovblad, R.R. Edelman, and S. Warach Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging Ann. Neurol. 41 1997 581 589
3. C.M. Carthy, B. Yanagawa, H. Luo, D.J. Granville, D. Yang, P. Cheung, C. Cheung, M. Esfandiarei, C.M. Rudin, C.B. Thompson, D.W.C. Hunt, and B.M. McManus Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection Virology 313 2003 147 157
4. C.J. Chen, and S.L. Liao Neurotrophic and neurotoxic effects of zinc on neonatal cortical neurons Neurochem. Int. 42 2003 471 479
5. C.J. Chen, S.L. Liao, W.Y. Chen, J.S. Hong, and J.S. Kuo Cerebral ischemia/reperfusion injury in rat brain: effects of naloxone Neuroreport 12 2001 1245 1249
6. S. Cho, D. Liu, C. Gonzales, M.M. Zaleska, and A. Wood Temporal assessment of caspase activation in experimental models of focal and global ischemia Brain Res. 982 2003 146 155
7. W.M. Clark, and J.A. Zivin Antileukocyte adhesion therapy: preclinical trials and combination therapy Neurology 49 1997 S32 S38
8. X.Z. Dai, and R.J. Bache Coronary and systemic haemodynamic effect of tetramethylpyrazine in the dog J. Cardiovasc. Pharmacol. 7 1985 841 849
9. B.A. Eldadah, and A.I. Faden Caspase pathways, neuronal apoptosis, and CNS injury J. Neurotrauma 17 2000 811 829
10. M.G. Feng, G.H. Feng, and Q.G. Zhou Effects of methylhesperidin on coronary, renal and cerebral circulation in dogs Acta Pharmacol. Sin. 9 1988 548 550 (original in Chinese)
11. J.H. Garcia, K.F. Liu, and K.L. Ho Neuronal necrosis after middle cerebral arterial occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex Stroke 26 1995 636 642
12. R.J. Hamm, B.R. Pike, D.M. O'Dell, B.G. Lyeth, and L.W. Jenkins The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury J. Neurotrauma 11 1994 187 196
13. W.K. Ho, H.L. Wen, and C.M. Lee Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils Stroke 20 1989 96 99
14. J. Honkaniemi, S.M. Massa, M. Breckinridge, and F.R. Sharp Global ischemia induces apoptosis-associated genes in hippocampus Mol. Brain Res. 42 1996 79 88
15. Y.S. Hwang, C.Y. Shin, Y. Huh, and J.H. Ryu Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats Life Sci. 71 2002 2105 2117
16. S. Itagaki, P.L. McGeer, H. Akiyama, S. Zhu, and D. Selkoe Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease J. Neuroimmunol. 24 1989 173 182
17. G.G. Jeohn, L.Y. Hong, B. Wilson, P. Hudson, and J.H. Hong Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuro/glia cultures J. Neuroimmunol. 85 1998 1 10
18. J.S. Kim, M. Chopp, and S.C. Gautam High dose methylprednisolone therapy reduces expression of JE/MCP-1 mRNA and macrophage accumulation in the ischemic rat brain J. Neurol. Sci. 128 1995 28 35
19. K. Kitagawa, M. Matsumoto, M. Niinobe, K. Mikoshiba, R. Hata, H. Ueda, N. Handa, R. Fukunaga, Y. Isaka, and K. Kimura Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage - immunohistochemical investigation of dendritic damage Neuroscience 31 1989 401 411
20. G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci. 19 1996 312 318
21. J.M. Lee, M.C. Grabb, G.J. Zipfel, and D.W. Choi Brain tissue responses to ischemia J. Clin. Invest. 106 2000 723 731
22. P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489
23. Y. Li, N. Chopp, N. Jiang, F. Yao, and C. Zaloga Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat J. Cerebr. Blood Flow Metab. 15 1995 389 397
24. S.L. Liao, T.K. Kao, W.Y. Chen, Y.S. Lin, S.Y. Chen, S.L. Raung, C.W. Wu, H.C. Lu, and C.J. Chen Tetramethylpyrazine reduces ischemic brain injury in rats Neurosci. Lett. 372 2004 40 45
25. S.L. Liao, Y.Y. Chen, S.L. Raung, J.S. Kuo, and C.J. Chen Association of immune responses and ischemic brain infarction in rat Neuroreport 12 2001 1943 1947
26. M.D. Linnik, R.H. Zobrist, and M.D. Hatfield Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats Stroke 24 1993 2002 2008
27. J. Lister Ethologically based animal models of anxiety disorders Pharmacol. Therap. 46 1990 321 340
28. C.S. Lu, M.H. Yin, Y.H. Huang, C. Pao, and C.F. Sung Radix salviae miltiorrhizae and Rhizoma ligustici wallichii in coronary heart disease Chin. Med. J. 4 1978 43 46
29. P.L. McGeer, S. Itagaki, B.E. Boyes, and E.G. McGeer Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brain Neurology 38 1988 1285 1291
30. J.E. Merrill, Y. Koyanagi, J. Zack, L. Thomas, F. Martin, and J.S. Chen Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1 J. Virol. 66 1992 2217 2225
31. L. Minghetti, and G. Levi Microglia as an effector cells in brain damage and repair: focus on prostanoids and nitric oxide Prog. Neurobiol. 54 1998 99 125
32. T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, and J. Yuan Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β Nature 403 2000 98 103
33. D.W. Nicholson, and N.A. Thornberry Caspases: killer proteases Trends Biochem. Sci. 22 1997 299 306
34. J.B. Phillips, A.J. Williams, J. Adams, P.J. Elliott, and F.C. Tortella Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia Stroke 31 2000 1686 1693
35. Y.W. Ruan, G.Y. Ling, J.L. Zhang, and Z.C. Xu Apoptosis in the rat striatum after transient forebrain ischemia and the effects of ischemic severity Brain Res. 982 2003 228 240
36. S. Satoh, T. Kobayashi, A. Hitomi, I. Ikegaki, Y. Suzuki, M. Shibuya, J. Yoshida, and T. Asano Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction Jpn. J. Pharmacol. 80 1999 41 48
37. Y.H. Shih, S.L. Wu, W.F. Chiou, H.H. Ku, T.L. Ko, and Y.S. Fu Protective effects of tetramethylpyrazine on kainite-induced excitotoxicity in hippocampal culture Neuroreport 13 2002 515 519
38. R.V. Talanian, X. Yang, J. Turbov, P. Seth, T. Ghayur, C.A. Casiano, K. Orth, and C.J. Froelich Granule-mediated killing: pathways for granzyme B-initiated apoptosis J. Exp. Med. 186 1997 1323 1331
39. R.S. Tuttle, L. Marmelstein, T. Trad, S. Reddy, and T. Radley In vitro uterine response to tetramethylpyrazine, the active constituent of chung chong (a traditional Chinese medicine) Am. J. Obstet. Gynecol. 161 1989 1319 1323
40. C.C. Wu, M.H. Liao, S.J. Chen, and M.H. Yen Tetramethylpyrazine prevents inducible NO synthase expression and improves survival in rodent models of endotoxic shock N. S. Arch. Pharmacol. 360 1999 435 444
41. S. Yamagami, M. Tamura, M. Hayashi, N. Endo, H. Tanabe, Y. Katsuura, and K. Komoriya Differential production of MCP-1 and cytokine-induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats J. Leukocyte Biol. 65 1999 744 749
42. E. Yang, J. Zha, J. Jockel, L.H. Boise, C.B. Thompson, and S.J. Korsmeyer Bad, a heterodimeric partner for Bcl-xL and Bcl-2. Displaces Bax and promotes cell death Cell 80 1995 285 291
43. J. Yrjanheikki, T. Tikka, R. Keinanen, G. Goldsteins, P.H. Chan, and J. Koistinaho A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc. Natl. Acad. Sci. U.S.A. 96 1999 13496 13500
44. Z. Zhang, T. Wei, J. Hou, G. Li, S. Yu, and W. Xin Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid Eur. J. Pharmacol. 467 2003 41 47
45. Z. Zhang, T. Wei, J. Hou, G. Li, S. Yu, and W. Xin Tetramethylpyrazine scavengers superoxide anion and decreases nitric oxide production in human polymorphnuclear leukocytes Life Sci. 72 2003 2465 2472
46. H. Zhao, F. Zhuang, J.F. Stoltz, and X. Wang Comparative studies of LFA-1/ICAM-1 interaction by micropipette and flow chamber techniques Biorheology 40 2003 179 187