Mechanism of tetramethylpyrazine analogue CXC195 inhibition of hydrogen peroxide-induced apoptosis in human endothelial cells

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 3, 2010, Pages 432-438

  Ou, Yang ^a   Dong, Xue ^a   Liu, Xin Yong ^a   Cheng, Xian Chao ^a   Cheng, Yan Na ^a   Yu, Lu Gang ^b   Guo, Xiu Li ^a  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Apoptosis; Extracellular signal regulated kinase 1 2; Human endothelial cell; Hydrogen peroxide; Mitochondrial membrane; Potential; Tetramethylpyrazine analogue CXC195

Indexed keywords

CALCIUM; CASPASE 3; CXC 195; FLUNARIZINE; FURA 2 ACETOXYMETHYL ESTER; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PIPERAZINE DERIVATIVE; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RHODAMINE 123; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG; ANTIOXIDANT; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PYRAZINE DERIVATIVE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL NUCLEUS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG INHIBITION; DRUG SYNTHESIS; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLUOROMETRY; HUMAN; HUMAN CELL; INCUBATION TIME; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAINING; UMBILICAL VEIN; CELL LINE; CHEMISTRY; DRUG EFFECTS; LIGUSTICUM; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; PHYTOTHERAPY; SYNTHESIS;

ANTIOXIDANTS; APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE; DOWN-REGULATION; DRUGS, CHINESE HERBAL; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; LIGUSTICUM; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; PHOSPHORYLATION; PHYTOTHERAPY; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZINES; TUMOR SUPPRESSOR PROTEIN P53; UMBILICAL VEINS;

EID: 77649221493     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.432     Document Type: Article

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