Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Li, Yapeng ^a   Zhu, Wei ^a   Tao, Jianping ^a   Xin, Ping ^a   Liu, Mingya ^a   Li, Jingbo ^a   Wei, Meng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 12; FASUDIL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; JANUS KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HEART INFARCTION SIZE; HEART PROTECTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 12; CHROMONES; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; JANUS KINASE 2; MALE; MORPHOLINES; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 84868282994     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048115     Document Type: Article

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