Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro

Apoptosis

Volumn 18, Issue 2, 2013, Pages 135-149

  Zhang, Feng ^a   Kong, De Song ^a   Zhang, Zi Li ^a   Lei, Na ^a   Zhu, Xiao Jing ^a   Zhang, Xiao Ping ^a   Chen, Li ^a   Lu, Yin ^a   Zheng, Shi Zhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Extracellular signal regulated kinase; Hepatic fibrosis; Hepatic stellate cell; Mitochondrial apoptosis; p53; Tetramethylpyrazine

Indexed keywords

CASPASE; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN P21; PROTEIN P27; PROTEIN P53; TETRAMETHYLPYRAZINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; G1 PHASE CELL CYCLE CHECKPOINT; HEMATOPOIETIC STEM CELL; HYDROGEN BOND; IN VITRO STUDY; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; APOPTOSIS; CASPASES; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G1 PHASE CELL CYCLE CHECKPOINTS; HEPATIC STELLATE CELLS; HEPATOCYTES; LIVER CIRRHOSIS; MALE; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; PYRAZINES; RATS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84877153476     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0791-5     Document Type: Article

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