On-line near infrared bioreactor monitoring of cell density and concentrations of glucose and lactate during insect cell cultivation

Journal of Biotechnology

Volumn 173, Issue 1, 2014, Pages 106-111

  Qiu, Jiang ^a   Arnold, Mark A ^b   Murhammer, David W ^a  

^a IA United States   (United States)

^b E11 SSH   (United States)

Author keywords

Bioreactor monitoring; Cell culture; Near infrared spectroscopy (NIR); On line bioprocess monitoring; Process analytical technology (PAT)

Indexed keywords

ABSORBANCE SPECTRUM; BIOREACTOR MONITORING; CULTIVATION PROCESS; NEAR INFRARED SPECTRA; NEAR-INFRARED MEASUREMENTS; ON-LINE BIOPROCESS MONITORING; PARTIAL LEAST SQUARES CALIBRATIONS; PROCESS ANALYTICAL TECHNOLOGY;

BIOCONVERSION; BIOREACTORS; CALIBRATION; CELL CULTURE; GLUCOSE; INFRARED DEVICES; LEAST SQUARES APPROXIMATIONS; NEAR INFRARED SPECTROSCOPY; REGRESSION ANALYSIS;

CELLS;

GLUCOSE; LACTIC ACID; MICROSPHERE; POLYSTYRENE;

ANIMAL CELL; ARTICLE; CALIBRATION; CELL DENSITY; CULTURE MEDIUM; GLUCOSE BLOOD LEVEL; INSECT CELL CULTURE; LIGHT SCATTERING; NEAR INFRARED SPECTROSCOPY; NONHUMAN; ONLINE MONITORING; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; REACTOR MONITORING; SIGNAL NOISE RATIO; TRICHOPLUSIA NI;

BIOREACTOR MONITORING; CELL CULTURE; NEAR INFRARED SPECTROSCOPY (NIR); ON-LINE BIOPROCESS MONITORING; PROCESS ANALYTICAL TECHNOLOGY (PAT);

ANIMALS; BIOREACTORS; CALIBRATION; CELL COUNT; CELL CULTURE TECHNIQUES; CELL LINE; CULTURE MEDIA; GLUCOSE; INSECTS; LACTIC ACID; REGRESSION ANALYSIS; SPECTROSCOPY, NEAR-INFRARED;

EID: 84893383641     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.01.009     Document Type: Article

References (40)

1. Akhnoukh R., Kretzmer G., Schügerl K. On-line monitoring and control of the cultivation of Spodoptera frugiperda Sf9 insect cells and -galactosidase production by Autographa californica virus vector. Enzyme Microb. Technol. 1996, 18:220-228.
2. Arnold S.A., Gaensakoo R., Harvey L.M., McNeil B. Use of at-line and in-situ near-infrared spectroscopy to monitor biomass in an industrial fed-batch Escherichia coli process. Biotechnol. Bioeng. 2002, 80:405-413.
3. ASTM Standard Practices for Infrared, Multivariate, Quantitative Analysis 1995, ASTM, West Conshohocken, PA.
4. Bédard C., Jolicoeur M., Jardin B., Tom R., Perret S., Kamen A. Insect cell density in bioreactor cultures can be estimated from on-line measurements of optical density. Biotechnol. Tech. 1994, 8:605-610.
5. Burmeister J.J., Arnold M.A. Accuracy of the YSI stat plus analyzer for glucose and lactate. Anal. Lett. 1995, 28:581-592.
6. Cervera A.E., Petersen N., Lantz A.E., Larsen A., Gernaey K.V. Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation. Biotechnol. Prog. 2009, 25:1561-1581.
7. Chico E., Jäger V. Perfusion culture of baculovirus-infected BTI-Tn-5B1-4 insect cells: a method to restore cell-specific β-trace glycoprotein productivity at high cell density. Biotechnol. Bioeng. 2000, 70:574-586.
8. Chung H., Arnold M.A., Rhiel M., Murhammer D.W. Simultaneous measurements of glucose, glutamine, ammonia, lactate, and glutamate in aqueous solutions by near-infrared spectroscopy. Appl. Spectrosc. 1996, 50:270-276.
9. Crowley J., Arnold S.A., Wood N., Harvey L.M., McNeil B. Monitoring a high cell density recombinant Pichia pastoris fed-batch bioprocess using transmission and reflectance near infrared spectroscopy. Enzyme Microb. Technol. 2005, 36:621-628.
10. Ding Q., Small G.W., Arnold M.A. Evaluation of data pretreatment and model building methods for the determination of glucose from near-infrared single-beam spectra. Appl. Spectrosc. 1999, 53:402-414.
11. Donaldson M., Wood H.A., Kulakosky P.C., Shuler M.L. Glycosylation of a recombinant protein in the Tn5B1-4 insect cell line: influence of ammonia, time of harvest, temperature, and dissolved oxygen. Biotechnol. Bioeng. 1999, 63:255-262.
12. Ducommun P., Bolzonella I., Rhiel M., Pugeaud P., von Stockar U., Marison I.W. On-line determination of animal cell concentration. Biotechnol. Bioeng. 2001, 72:515-522.
13. Egidio V., Sinelli N., Giovanelli G., Moles A., Casiraghi E. NIR and MIR spectroscopy as rapid methods to monitor red wine fermentation. Eur. Food Res. Technol. 2010, 230:947-955.
14. Finn B., Harvey L.M., McNeil B. Near-infrared spectroscopic monitoring of biomass, glucose, ethanol and protein content in a high cell density baker's yeast fed-batch bioprocess. Yeast 2006, 23:507-517.
15. Ge Z., Cavinato A.G., Callis J.B. Noninvasive spectroscopy for monitoring cell density in a fermentation process. Anal. Chem. 1994, 66:1354-1362.
16. Green C.E., Wiencek J.M., Arnold M.A. Multivariate calibration models for lysozyme from near-infrared transmission spectra in scattering solutions of monodisperse microspheres. Anal. Chem. 2002, 74(14):3392-3399.
17. Hall J.W., McNeil B., Rollins M.J., Draper I., Thompson B.G., Macaloney G. Near-infrared spectroscopic determination of acetate, ammonium, biomass, and glycerol in an industrial Escherichia coli fermentation. Appl. Spectrosc. 1996, 50:102-108.
18. Hoffmann F., Schmidt M., Rinas U. Simple technique for simultaneous on-line estimation of biomass and acetate from base consumption and conductivity measurements in high-cell density cultures of Escherichia coli. Biotechnol. Bioeng. 2000, 70:358-361.
19. Lewis C.B., McNichols R.J., Gowda A., Coté G.L. Investigation of near-infrared spectroscopy for periodic determination of glucose in cell culture media in situ. Appl. Spectrosc. 2000, 54:1453-1457.
20. Lu G., Zhou X., Arnold M.A., Small G.W. Multivariate calibration models based on the direct analysis of near-infrared single-beam spectra. Appl. Spectrosc. 1997, 51:1330-1339.
21. Macaloney G., Hall J.W., Rollins M.J., Draper I., Thompson B.G., McNeil B. Monitoring biomass and glycerol in an Escherichia coli fermentation using near-infrared spectroscopy. Biotechnol. Tech. 1994, 8:281-286.
22. McShane M.J., Coté G.L. Near-infrared spectroscopy for determination of glucose, lactate, and ammonia in cell culture media. Appl. Spectrosc. 1998, 52:1073-1078.
23. Mitchell-Logean C., Murhammer D.W. Bioreactor headspace purging reduces dissolved carbon dioxide accumulation in insect cell cultures and enhances cell growth. Biotechnol. Prog. 1997, 13:875-877.
24. Petersen N., Ödman P., Padrell A.E.C., Stocks S., Lantz A.E., Gernaey K.V. In situ near infrared spectroscopy for analyte-specific monitoring of glucose and ammonium in Streptomyces coelicolor fermentations. Biotechnol. Prog. 2010, 26:263-271.
25. Qiu J., Huang M., Hang H., Han C., Ye Q., Zhang S. Simultaneous quantitative analysis of sorbitol and sorbose in the fermentation broth with Fourier transform infrared spectroscopy. Appl. Spectrosc. 2001, 55:794-798.
26. Rhiel M., Cohen M.B., Murhammer D.W., Arnold M.A. Nondestructive near-infrared spectroscopic measurement of multiple analytes in undiluted samples of serum-based cell culture media. Biotechnol. Bioeng. 2002, 77:73-82.
27. Riley M.R., Arnold M.A., Murhammer D.W., Walls E.L., DelaCruz N. Adaptive calibration scheme for quantification of nutrients and byproducts in insect cell bioreactors by near-infrared spectroscopy. Biotechnol. Prog. 1998, 14:527-533.
28. Riley M.R., Rhiel M., Zhou X., Arnold M.A., Murhammer D.W. Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy. Biotechnol. Bioeng. 1997, 55:11-15.
29. Rodrigues L.O., Cardoso J.P., Menezes J.C. Applying near-infrared spectroscopy in downstream processing: one calibration for multiple clarification processes of fermentation media. Biotechnol. Prog. 2008, 24:432-435.
30. Saarinen M.A., Murhammer D.W. The response of virally infected insect cells to dissolved oxygen concentration: recombinant protein production and oxidative damage. Biotechnol. Bioeng. 2003, 81:106-114.
31. Saarinen M.A., Troutner K.A., Gladden S.G., Mitchell-Logean C.M., Murhammer D.W. Recombinant protein synthesis in Trichoplusia ni BTI-Tn-5B1-4 insect cell aggregates. Biotechnol. Bioeng. 1999, 63:612-617.
32. Sandor M., Rüdinger F., Bienert R., Grimm C., Solle D., Scheper T. Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations. J. Biotechnol. 2013.
33. Vaccari G., Dosi E., Campi A.L., González-Varay R.A., Matteuzzi D., Mantovani G. A near-infrared spectroscopy technique for the control of fermentation processes: an application to lactic acid fermentation. Biotechnol. Bioeng. 1994, 43:913-917.
34. Vaidyanathan S., Macaloney G., Harvey L.M., McNeil B. Assessment of the structure and predictive ability of models developed for monitoring key analytes in a submerged fungal bioprocess using near-infrared spectroscopy. Appl. Spectrosc. 2001, 55:444-453.
35. Yamane Y., Mikami T., Higashida K., Kakizono T., Nishio N. Estimation of the concentrations of cells, astaxanthin and glucose in a culture of Phaffia rhodozyma by near infrared reflectance spectroscopy. Biotechnol. Tech. 1996, 10:529-534.
36. Yano T., Aimi T., Nakano Y., Tamai M. Prediction of the concentration of ethanol and acetic acid in the culture broth of a rice vinegar fermentation using near-infrared spectroscopy. J. Ferment. Bioeng. 1997, 84:461-465.
37. Yano T., Harata M. Prediction of the concentration of several constituents in a mouse-mouse hybridoma culture by near-infrared spectroscopy. J. Ferment. Bioeng. 1994, 77:659-662.
38. Yeung K.S.Y., Hoare M., Thornhill N.F., Williams T., Vaghjiani J.D. Near-infrared spectroscopy for bioprocess monitoring and control. Biotechnol. Bioeng. 1999, 63:684-693.
39. Zeiser A., Bédard C., Voyer R., Jardin B., Tom R., Kamen A.A. On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements. Biotechnol. Bioeng. 1999, 63:122-126.
40. Zeiser A., Elias C.B., Voyer R., Jardin B., Kamen A.A. On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process. Biotechnol. Prog. 2000, 16:803-808.