Use of at-line and in-situ near-infrared spectroscopy to monitor biomass in an industrial fed-batch Escherichia coli process

Biotechnology and Bioengineering

Volumn 80, Issue 4, 2002, Pages 405-413

  Arnold, S Alison ^a   Gaensakoo, Rumpai ^a   Harvey, Linda M ^a   McNeil, Brian ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Biomass; E.coli; NIRS; On line

Indexed keywords

BIOMASS; BIOREACTORS; ESCHERICHIA COLI; INFRARED SPECTROSCOPY; OPTIMIZATION;

WAVELENGTH;

BIOTECHNOLOGY;

ARTICLE; BIOMASS; BIOPROCESS; ESCHERICHIA COLI; FED BATCH REACTOR; MODEL; MONITORING; NEAR INFRARED SPECTROSCOPY; NONHUMAN; TEMPERATURE DEPENDENCE;

BIOREACTORS; CALIBRATION; COMPUTER SIMULATION; ESCHERICHIA COLI; FERMENTATION; GLUCOSE; LEAST-SQUARES ANALYSIS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY, NEAR-INFRARED;

ESCHERICHIA COLI;

EID: 0037145636     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10383     Document Type: Article

References (28)

1. Arnold SA, Crowley J, Vaidyanathan S, Matheson L, Mohan P, Hall JW, Harvey LM, McNeil B. 2000. At-line monitoring of a submerged filamentous bacterial cultivation using near-infrared spectroscopy. Enzyme Microb Technol 27:691-697.
2. Austin GD, Rodney WJ, D'Amore T. 1994. Studies of on-line viable yeast biomass with a capacitance biomass monitor. Biotechnol Bioeng 43:337-341.
3. Brimmer PJ, Hall JW. 1993. Determination of nutrient levels in a bioprocess using near infrared spectroscopy. Can J Spectrosc 38:155-162.
4. Brookes IK, Gedge BN, Hammond SV. 1996. Applications of near infrared spectroscopy to fermentation process analysis. In: Davies, Williams, editors. Near Infrared Spectroscopy: The Future Waves. Chichester, UK: NIR publications. p 259-267.
5. Cavinato AG, Mayes DM, Ge Z, Callis JB. 1990. Noninvasive method for monitoring ethanol in fermentation processes using fiber-optic near-infrared spectroscopy. Anal Chem 62:1977-1982.
6. Christian GA. 1994. Spectrometry. In: Faduska C, editor. Analytical Chemistry. New York: John Wiley & Sons. p 398-461.
7. Cockshott AR. 1993. Modelling of Recombinant Escherichia Coli Fermentations at Medium and High Cell Density Producing Bovine Somatotropin. PhD Thesis, University College London.
8. Crowley J, Arnold SA, Harvey LM, McNeil B. 2000. Near infrared spectroscopy - The key to improved biopharmaceutical manufacturing from animal cell culture? Eur Pharm Rev 5:39-42.
9. Fehrenbach R, Comberbach M, Petre JO. 1992. On-line biomass monitoring by capacitance measurement. J Biotechnol 23:303-314.
10. Ge Z, Cavinato AG, Callis JB. 1994. Noninvasive spectroscopy for monitoring cell density in a fermentation process. Anal Chem 60:1354-1362.
11. Hall JW, Rollins MJ, Macaloney G. 1994. Analyzing bioprocess systems using near-infrared spectroscopy methods. Genet Eng News 14:18.
12. Hall JW, McNeil B, Rollins M, Draper I, Thompson BG, Macaloney G. 1996. Near-infrared spectroscopic determination of acetate, ammonium, biomass and glycerol in an industrial Escherichia coli fermentation. Appl Spectrosc 50:102-108.
13. Hammond SV. 1992. NIR analysis of antibiotic fermentation. In: Murray I, Cowe IA, editors. Making Light Work: Advances in Near Infra-Red Spectroscopy. Weinheim: VCH. p 584-589.
14. Harris CM, Todd RW, Bungard SJ, Lovitt RW, Morris JG, Kell, DB. 1987. Dielectric permittivity of microbial suspensions at radio frequencies - A novel method for the real-time estimation of microbial biomass. Enzyme Microb Technol 9:181-186.
15. Harthun S, Matischak K, Friedl P. 1997. Determination of recombinant protein in animal cell culture supernatant by near-infrared spectroscopy. Anal Biochem 251:73-78.
16. Kell DB, Markx GH, Davey CL, Todd RW. 1990. Real-time monitoring of cellular biomass - Methods and applications. Trends Anal Chem 9:190-194.
17. Macaloney G. NIR. 1996a. Chemical engineer-London. 619:35-37.
18. Macaloney G. 1996b. Near infrared spectroscopy: The technology, its growing use in biotechnology and evaluation of its utility. Soc Ind Microbiol 46:129-132.
19. Macaloney G, Hall JW, Rollins MJ, Draper I, Thompson BG, McNeil B. 1994. Monitoring biomass and glycerol in an Escherichia coli fermentation using near infrared spectroscopy. Biotechnol Tech 8:281-286.
20. Macaloney G, Draper I, Preston J, Anderson KB, Rollins MJ, Thompson BG, Hall JW, McNeil B. 1996. At-line control and fault analysis in an industrial high cell density Escherichia coli fermentation, using NIR spectroscopy. Trans Inst Chem Eng 74:C212-218.
21. Macaloney G, Hall JW, Rollins MJ, Draper I, Anderson KB, Preston J, Thompson BG, McNeil B. 1997. The utility and performance of near-infrared spectroscopy in simultaneous monitoring of multiple components in a high density recombinant Escherichia coli production process. Bioproc Eng 17:157-167.
22. Sarra M, Ison AP, Lilly MD. 1996. The relationship between biomass concentration, determined by a capacitance-based probe, rheology and morphology of Saccharopolyspora erythraea cultures. J Biotechnol 51:157-165.
23. Vaccari G, Dosi E, Campi AL, Gonzalez-Vara A, Matteuzzi D, Mantovani G. 1994. A near-infrared spectroscopy technique for the control of fermentation processes: An application to lactic acid fermentation. Biotechnol Bioeng 43:913-917.
24. Vaidyanathan S, McNeil B. 1998. Near infrared spectroscopy - A panacea in pharmaceutical bioprocessing. Eur Pharm Rev 3:43-48.
25. Vaidyanathan S, Macaloney G, Vaughan J, McNeil B, Harvey LM. 1999a. Monitoring of submerged bioprocesses. Crit Rev Biotechnol 19:277-316.
26. Vaidyanathan S, Macaloney G, McNeil B. 1999b. Fundamental investigations on the near-infrared spectra of microbial biomass as applicable to bioprocess monitoring. Analyst 124:157-162.
27. Vaidyanathan S, Arnold SA, Matheson L, Mohan P, Macaloney G, McNeil B, Harvey LM. 2000. Critical evaluation of models developed for monitoring an industrial submerged bioprocess for antibiotic production using near-infrared spectroscopy. Biotechnol Prog 16:1098-1105.
28. Vaidyanathan S, Arnold SA, Matheson L, Mohan P, McNeil B, Harvey LM. 2001. Assessment of near-infrared spectral information for rapid monitoring of bioprocess quality. Biotechnol Bioeng 74:376-388.