메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages 61-72

Targeting the intestinal L-cell for obesity and type 2 diabetes treatment

Author keywords

appetite regulation; gut hormones; gut brain axis; L cell; obesity

Indexed keywords

AMINO ACID; BILE ACID; CARBOHYDRATE; CHOLECYSTOKININ; GLICENTIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; HORMONE; LIPID; NEUROTENSIN; OXYNTOMODULIN; PEPTIDE; PEPTIDE YY; PROGLUCAGON; PROTEIN;

EID: 84893138518     PISSN: 17446651     EISSN: 17448417     Source Type: Journal    
DOI: 10.1586/17446651.2014.862152     Document Type: Review
Times cited : (26)

References (132)
  • 1
    • 84871090162 scopus 로고    scopus 로고
    • Global obesity: Trends, risk factors and policy implications
    • Malik VS, Willett WC, Hu FB. Global obesity: Trends, risk factors and policy implications. Nat. Rev. Endocrinol. 9(1), 13-27 (2013
    • (2013) Nat. Rev. Endocrinol , vol.9 , Issue.1 , pp. 13-27
    • Malik, V.S.1    Willett, W.C.2    Hu, F.B.3
  • 2
    • 84877803696 scopus 로고    scopus 로고
    • Pharmacologic treatment options for obesity: What is old is new again
    • Ryan D, Bray G. Pharmacologic treatment options for obesity: What is old is new again. Curr. Hypertens. Rep. 15(3), 182-189 (2013
    • (2013) Curr. Hypertens. Rep , vol.15 , Issue.3 , pp. 182-189
    • Ryan, D.1    Bray, G.2
  • 3
    • 37249083878 scopus 로고    scopus 로고
    • Long term pharmacotherapy for obesity and overweight: Updated meta-analysis
    • Diana R, Raj P, Stephanie KL, Cintia C, David CWL. Long term pharmacotherapy for obesity and overweight: Updated meta-analysis. BMJ 335, 1194 (2007
    • (2007) BMJ , vol.335 , pp. 1194
    • Diana, R.1    Raj, P.2    Stephanie, K.L.3    Cintia, C.4    David, C.W.L.5
  • 4
    • 84857051743 scopus 로고    scopus 로고
    • Effective weight management practice: A review of the lifestyle intervention evidence
    • Kirk SFL, Penney TL, McHugh TL, Sharma AM. Effective weight management practice: A review of the lifestyle intervention evidence. Int. J. Obes. 36(2), 178-185 (2012
    • (2012) Int. J. Obes , vol.36 , Issue.2 , pp. 178-185
    • Kirk, S.F.L.1    Penney, T.L.2    McHugh, T.L.3    Sharma, A.M.4
  • 6
    • 79960773090 scopus 로고    scopus 로고
    • Preservation of beta-cell function: The key to diabetes prevention
    • DeFronzo RA, Abdul-Ghani MA. Preservation of beta-cell function: The key to diabetes prevention. J. Clin. Endocrinol. Metab. 96(8), 2354-2366 (2011
    • (2011) J. Clin. Endocrinol. Metab , vol.96 , Issue.8 , pp. 2354-2366
    • DeFronzo, R.A.1    Abdul-Ghani, M.A.2
  • 7
    • 77449140027 scopus 로고    scopus 로고
    • Overview of newer agents: Where treatment is going
    • DeFronzo RA. Overview of newer agents: Where treatment is going. Am. J. Med. 123(3 Suppl.), S38-S48 (2010
    • (2010) Am. J. Med , vol.123 , Issue.3 SUPPL.
    • DeFronzo, R.A.1
  • 8
    • 84881543697 scopus 로고    scopus 로고
    • Novel therapies for management of type 2 diabetes mellitus part 2 - Addressing the incretin defect in clinical setting in 2013
    • Grunberger G. Novel therapies for management of type 2 diabetes mellitus part 2 - Addressing the incretin defect in clinical setting in 2013. J. Diabetes 5(3), 241-253 (2013
    • (2013) J. Diabetes , vol.5 , Issue.3 , pp. 241-253
    • Grunberger, G.1
  • 9
    • 84870225450 scopus 로고    scopus 로고
    • A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
    • Egerod KL, Engelstoft MS, Grunddal KV et al. A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology 153(12), 5782-5795 (2012
    • (2012) Endocrinology , vol.153 , Issue.12 , pp. 5782-5795
    • Egerod, K.L.1    Engelstoft, M.S.2    Grunddal, K.V.3
  • 10
    • 84877763148 scopus 로고    scopus 로고
    • Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells
    • Habib AM, Richards P, Rogers GJ, Reimann F, Gribble FM. Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia 56(6), 1413-1416 (2013
    • (2013) Diabetologia , vol.56 , Issue.6 , pp. 1413-1416
    • Habib, A.M.1    Richards, P.2    Rogers, G.J.3    Reimann, F.4    Gribble, F.M.5
  • 11
    • 84862743498 scopus 로고    scopus 로고
    • Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry
    • Habib AM, Richards P, Cairns LS et al. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology 153(7), 3054-3065 (2012
    • (2012) Endocrinology , vol.153 , Issue.7 , pp. 3054-3065
    • Habib, A.M.1    Richards, P.2    Cairns, L.S.3
  • 12
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • Mortensen K, Christensen LL, Holst JJ, Orskov C. GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul. Pep. 114(2G), 189-196 (2003
    • (2003) Regul. Pep , vol.114 , Issue.2 G , pp. 189-196
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Orskov, C.4
  • 13
    • 84883754628 scopus 로고    scopus 로고
    • Incretin hormones and the satiation signal
    • Holst JJ. Incretin hormones and the satiation signal. Int. J. Obes. 37(9), 1161-1168 (2013
    • (2013) Int. J. Obes , vol.37 , Issue.9 , pp. 1161-1168
    • Holst, J.J.1
  • 14
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol. Rev. 87(4), 1409-1439 (2007
    • (2007) Physiol. Rev , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 15
    • 0023910424 scopus 로고
    • Oxyntomodulin (glicentin-(33-69)): Pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs
    • Baldissera FG, Holst JJ, Knuhtsen S, Hilsted L, Nielsen OV. Oxyntomodulin (glicentin-(33-69)): Pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regul. Pept. 21(1-2), 151-166 (1988
    • (1988) Regul. Pept , vol.21 , Issue.1-2 , pp. 151-166
    • Baldissera, F.G.1    Holst, J.J.2    Knuhtsen, S.3    Hilsted, L.4    Nielsen, O.V.5
  • 16
    • 84871895669 scopus 로고    scopus 로고
    • Glucose metabolism is altered after loss of L cells and alfa cells but not influenced by loss of K cells
    • Pedersen J, Ugleholdt RK, Jorgensen SM et al. Glucose metabolism is altered after loss of L cells and alfa cells but not influenced by loss of K cells. Am. J. Physio. Endocrinol. Metab. 304(1), e60-e73 (2013
    • (2013) Am. J. Physio. Endocrinol. Metab , vol.304 , Issue.1
    • Pedersen, J.1    Ugleholdt, R.K.2    Jorgensen, S.M.3
  • 19
    • 84878854783 scopus 로고    scopus 로고
    • The role of leptin in the control of insulin-glucose axis
    • Amitani M, Asakawa A, Amitani H, Inui A. The role of leptin in the control of insulin-glucose axis. Front. Neurosci. 7, 51 (2013
    • (2013) Front. Neurosci , vol.7 , Issue.51
    • Amitani, M.1    Asakawa, A.2    Amitani, H.3    Inui, A.4
  • 20
  • 21
    • 84872120798 scopus 로고    scopus 로고
    • The defence of body weight: A physiological basis for weight regain after weight loss
    • Sumithran P, Proietto J. The defence of body weight: A physiological basis for weight regain after weight loss. Clin. Sci. (Lond.) 124(4), 231-241 (2013
    • (2013) Clin. Sci. (Lond , vol.124 , Issue.4 , pp. 231-241
    • Sumithran, P.1    Proietto, J.2
  • 23
    • 77952243631 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
    • Wang C, Bomberg E, Billington CJ, Levine AS, Kotz CM. Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. Brain Res. 1336, 66-77 (2010
    • (2010) Brain Res , vol.1336 , pp. 66-77
    • Wang, C.1    Bomberg, E.2    Billington, C.J.3    Levine, A.S.4    Kotz, C.M.5
  • 24
    • 69049095170 scopus 로고    scopus 로고
    • Transcription factors in the development of medial hypothalamic structures
    • Jo YH, Chua S Jr. Transcription factors in the development of medial hypothalamic structures. Am. J. Physiol. Endocrinol. Metab. 297(3), e563-e567 (2009
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297 , Issue.3
    • Jo, Y.H.1    Chua Jr., S.2
  • 25
    • 33845875966 scopus 로고    scopus 로고
    • Gut hormones and the regulation of energy homeostasis
    • Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature 444(7121), 854-859 (2006
    • (2006) Nature , vol.444 , Issue.7121 , pp. 854-859
    • Murphy, K.G.1    Bloom, S.R.2
  • 26
    • 84856102513 scopus 로고    scopus 로고
    • GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
    • Alhadeff AL, Rupprecht LE, Hayes MR. GLP-1 Neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake. Endocrinology 153(2), 647-658 (2012
    • (2012) Endocrinology , vol.153 , Issue.2 , pp. 647-658
    • Alhadeff, A.L.1    Rupprecht, L.E.2    Hayes, M.R.3
  • 27
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-7-36)amide is transformed to glucagon-like peptide-1-9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L, Deacon CF, Orskov C, Holst JJ. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9- 36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140(11), 5356-5363 (1999
    • (1999) Endocrinology , vol.140 , Issue.11 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Holst, J.J.4
  • 28
    • 79960900778 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs
    • Hjollund KR, Deacon CF, Holst JJ. Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs. Diabetologia 54(8), 2206-2208 (2011
    • (2011) Diabetologia , vol.54 , Issue.8 , pp. 2206-2208
    • Hjollund, K.R.1    Deacon, C.F.2    Holst, J.J.3
  • 29
    • 67649636449 scopus 로고    scopus 로고
    • Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
    • Ruttimann EB, Arnold M, Hillebrand JJ, Geary N, Langhans W. Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms. Endocrinology 150(3), 1174-1181 (2009
    • (2009) Endocrinology , vol.150 , Issue.3 , pp. 1174-1181
    • Ruttimann, E.B.1    Arnold, M.2    Hillebrand, J.J.3    Geary, N.4    Langhans, W.5
  • 30
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott CR, Monteiro M, Small CJ et al. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res. 1044(1), 127-131 (2005
    • (2005) Brain Res , vol.1044 , Issue.1 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3
  • 31
    • 67449169287 scopus 로고    scopus 로고
    • Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat
    • 978-e78
    • Bucinskaite V, Tolessa T, Pedersen J et al. Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat. Neurogastroenterol. Motil. 21(9), 978-e78 (2009
    • (2009) Neurogastroenterol. Motil , vol.21 , Issue.9
    • Bucinskaite, V.1    Tolessa, T.2    Pedersen, J.3
  • 32
    • 0030985882 scopus 로고    scopus 로고
    • Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin
    • Moran TH, Baldessarini AR, Salorio CF, Lowery T, Schwartz GJ. Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am. J. Physiol. 272(4), R1245-R1251 (1997
    • (1997) Am. J. Physiol , vol.272 , Issue.4
    • Moran, T.H.1    Baldessarini, A.R.2    Salorio, C.F.3    Lowery, T.4    Schwartz, G.J.5
  • 33
    • 20244369116 scopus 로고    scopus 로고
    • The role of the vagal nerve in peripheral PYY3-36 induced feeding reduction in rats
    • Koda S, Date Y, Murakami N et al. The role of the vagal nerve in peripheral PYY3-36 induced feeding reduction in rats. Endocrinology 146(5), 2369-2375 (2005
    • (2005) Endocrinology , vol.146 , Issue.5 , pp. 2369-2375
    • Koda, S.1    Date, Y.2    Murakami, N.3
  • 34
    • 84879189059 scopus 로고    scopus 로고
    • The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
    • Plamboeck A, Veedfald S, Deacon CF et al. The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty. Am. J. Physiol. Gastrointest. Liver Physiol. 304(12), G1117-G1127 (2013
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol , vol.304 , Issue.12
    • Plamboeck, A.1    Veedfald, S.2    Deacon, C.F.3
  • 35
    • 0842325280 scopus 로고    scopus 로고
    • Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells
    • Nakagawa A, Satake H, Nakabayashi H et al. Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells. Auton. Neurosci. 110(1), 36-43 (2004
    • (2004) Auton. Neurosci , vol.110 , Issue.1 , pp. 36-43
    • Nakagawa, A.1    Satake, H.2    Nakabayashi, H.3
  • 36
    • 34748898831 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    • Vahl TP, Tauchi M, Durler TS et al. Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology 148(10), 4965-4973 (2007
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4965-4973
    • Vahl, T.P.1    Tauchi, M.2    Durler, T.S.3
  • 37
    • 84864760434 scopus 로고    scopus 로고
    • Tight junction in blood-brain barrier: An overview of structure, regulation, and regulator substances
    • Liu WY, Wang ZB, Zhang LC, Wei X, Li L. Tight junction in blood-brain barrier: An overview of structure, regulation, and regulator substances. CNS Neurosci. Ther. 18(8), 609-615 (2012
    • (2012) CNS Neurosci. Ther , vol.18 , Issue.8 , pp. 609-615
    • Liu, W.Y.1    Wang, Z.B.2    Zhang, L.C.3    Wei, X.4    Li, L.5
  • 38
    • 34347358488 scopus 로고    scopus 로고
    • The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior
    • Fry M, Ferguson AV. The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior. Physiol. Behav. 91(4), 413-423 (2007
    • (2007) Physiol. Behav , vol.91 , Issue.4 , pp. 413-423
    • Fry, M.1    Ferguson, A.V.2
  • 39
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    • Orskov C, Poulsen SS, Moller M, Holst JJ Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I. Diabetes 45(6), 832-835 (1996
    • (1996) Diabetes , vol.45 , Issue.6 , pp. 832-835
    • Orskov, C.1    Poulsen, S.S.2    Moller, M.3    Holst, J.J.4
  • 40
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin A, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18(1-2), 7-14 (2002
    • (2002) J. Mol. Neurosci , vol.18 , Issue.1-2 , pp. 7-14
    • Kastin, A.1    Akerstrom, V.2    Pan, W.3
  • 41
    • 63849248275 scopus 로고    scopus 로고
    • Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    • Williams DL, Baskin DG, Schwartz MW. Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 150(4), 1680-1687 (2009
    • (2009) Endocrinology , vol.150 , Issue.4 , pp. 1680-1687
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 42
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J. Clin. Invest. 101(3), 515-520 (1998
    • (1998) J. Clin. Invest , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 43
    • 27744584314 scopus 로고    scopus 로고
    • Effect of peptide YY 3-36 on food intake in humans
    • Degen L, Oesch S, Casanova M et al. Effect of peptide YY 3-36 on food intake in humans. Gastroenterology 129(5), 1430-1436 (2005
    • (2005) Gastroenterology , vol.129 , Issue.5 , pp. 1430-1436
    • Degen, L.1    Oesch, S.2    Casanova, M.3
  • 44
    • 0028836552 scopus 로고
    • Satiety effects of a physiological dose of cholecystokinin in humans
    • Lieverse RJ, Jansen JB, Masclee AA, Lamers CB. Satiety effects of a physiological dose of cholecystokinin in humans. Gut 36(2), 176-179 (1995
    • (1995) Gut , vol.36 , Issue.2 , pp. 176-179
    • Lieverse, R.J.1    Jansen, J.B.2    Masclee, A.A.3    Lamers, C.B.4
  • 45
    • 77949837737 scopus 로고    scopus 로고
    • Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist
    • Baraboi ED, Smith P, Ferguson AV, Richard D. Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298(4), R1098-R1110 (2010
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.298 , Issue.4
    • Baraboi, E.D.1    Smith, P.2    Ferguson, A.V.3    Richard, D.4
  • 46
    • 35649021752 scopus 로고    scopus 로고
    • Gut hormones as mediators of appetite and weight loss after roux-en-Y gastric bypass
    • le Roux CW, Welbourn R, Werling M et al. Gut hormones as mediators of appetite and weight loss after roux-en-Y gastric bypass. Ann. Surg. 246(5), 780-785 (2007
    • (2007) Ann. Surg , vol.246 , Issue.5 , pp. 780-785
    • Le Roux, C.W.1    Welbourn, R.2    Werling, M.3
  • 47
    • 84887830930 scopus 로고    scopus 로고
    • Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass
    • doi:10.1038/ijo.2013.15 Epub ahead of print
    • Dirksen C, Jorgensen NB, Bojsen-Moller KN et al. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int. J. Obes. (Lond.) doi:10.1038/ijo.2013.15 (2013) (Epub ahead of print
    • (2013) Int. J. Obes. (Lond
    • Dirksen, C.1    Jorgensen, N.B.2    Bojsen-Moller, K.N.3
  • 48
    • 83255193972 scopus 로고    scopus 로고
    • Unsulfated cholecystokinin: An overlooked hormone?
    • Rehfeld JF, Agersnap M. Unsulfated cholecystokinin: An overlooked hormone? Regul. Pept. 173(1-3), 1-5 (2012
    • (2012) Regul. Pept , vol.173 , Issue.1-3 , pp. 1-5
    • Rehfeld, J.F.1    Agersnap, M.2
  • 49
    • 0026672627 scopus 로고
    • Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression
    • Wank SA, Pisegna JR, de WA. Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression. Proc. Natl Acad. Sci. USA 89(18), 8691-8695 (1992
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , Issue.18 , pp. 8691-8695
    • Wank, S.A.1    Pisegna, J.R.2    De, W.A.3
  • 50
    • 0031782440 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
    • Deacon CF, Knudsen LB, Madsen K, Wiberg FC, Jacobsen O, Holst JJ. Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. Diabetologia 41(3), 271-278 (1998
    • (1998) Diabetologia , vol.41 , Issue.3 , pp. 271-278
    • Deacon, C.F.1    Knudsen, L.B.2    Madsen, K.3    Wiberg, F.C.4    Jacobsen, O.5    Holst, J.J.6
  • 51
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J. Clin. Endocrinol. Metab. 80(3), 952-957 (1995
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , Issue.3 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 52
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J. Clin. Endocrinol. Metab. 63(2), 492-498 (1986
    • (1986) J. Clin. Endocrinol. Metab , vol.63 , Issue.2 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 53
    • 79959781838 scopus 로고    scopus 로고
    • Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes
    • Holst JJ, Knop FK, Vilsboll T, Krarup T, Madsbad S. Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care 34(Suppl. 2), S251-S257 (2011
    • (2011) Diabetes Care 34(Suppl. 2 , vol.S251-S257
    • Holst, J.J.1    Knop, F.K.2    Vilsboll, T.3    Krarup, T.4    Madsbad, S.5
  • 54
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • Heer J, Rasmussen C, Coy DH, Holst JJ. Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 51(12), 2263-2270 (2008
    • (2008) Diabetologia , vol.51 , Issue.12 , pp. 2263-2270
    • Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 55
    • 77954250537 scopus 로고    scopus 로고
    • The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
    • Hare KJ, Vilsboll T, Asmar M, Deacon CF, Knop FK, Holst JJ. The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes 59(7), 1765-1770 (2010
    • (2010) Diabetes , vol.59 , Issue.7 , pp. 1765-1770
    • Hare, K.J.1    Vilsboll, T.2    Asmar, M.3    Deacon, C.F.4    Knop, F.K.5    Holst, J.J.6
  • 56
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of Incretins: GLP-1 and GIP. Gastroenterology 132(6), 2131-2157 (2007
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 57
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup A, Rössner S, Van Gaal L et al. Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study. Lancet 374(9701), 1606-1616 (2007
    • (2007) Lancet , vol.374 , Issue.9701 , pp. 1606-1616
    • Astrup, A.1    Rössner, S.2    Van Gaal, L.3
  • 58
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    • Astrup A, Carraro R, Finer N et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int. J. Obes. 36(6), 843-854 (2012
    • (2012) Int. J. Obes , vol.36 , Issue.6 , pp. 843-854
    • Astrup, A.1    Carraro, R.2    Finer, N.3
  • 59
    • 77956301808 scopus 로고    scopus 로고
    • Preproglucagon derived peptides GLP-1 GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
    • Vrang N, Larsen PJ. Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides. Prog. Neurobiol. 92(3), 442-462 (2010
    • (2010) Prog. Neurobiol , vol.92 , Issue.3 , pp. 442-462
    • Vrang, N.1    Larsen, P.J.2
  • 60
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications
    • Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications. Am. J. Med. 124(1 Suppl.), S3-S18 (2011
    • (2011) Am. J. Med , vol.124 , Issue.1 SUPPL.
    • Nauck, M.A.1
  • 61
    • 74349122900 scopus 로고    scopus 로고
    • Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors
    • Davidson JA. Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors. Cleve. Clin. J. Med. 76(Suppl. 5), S28-S38 (2009
    • (2009) Cleve. Clin. J. Med , vol.76 , Issue.SUPPL. 5
    • Davidson, J.A.1
  • 62
    • 79959773411 scopus 로고    scopus 로고
    • DPP-4 inhibitors: Impact on glycemic control and cardiovascular risk factors
    • Dicker D. DPP-4 inhibitors: Impact on glycemic control and cardiovascular risk factors. Diabetes Care 34(Suppl. 2), S276-S278 (2011
    • (2011) Diabetes Care 34(Suppl. 2 , vol.S276-S278
    • Dicker, D.1
  • 63
    • 77950221874 scopus 로고    scopus 로고
    • Glucagon and glucagon-like peptides 1 and 2
    • Holst JJ. Glucagon and glucagon-like peptides 1 and 2. Results Probl. Cell Differ. 50, 121-135 (2010
    • (2010) Results Probl. Cell Differ , vol.50 , pp. 121-135
    • Holst, J.J.1
  • 64
    • 84863448504 scopus 로고    scopus 로고
    • Exogenous glucagon-like peptide-2 (GLP-2) prevents chemotherapy-induced mucositis in rat small intestine
    • Kissow H, Viby NE, Hartmann B et al. Exogenous glucagon-like peptide-2 (GLP-2) prevents chemotherapy-induced mucositis in rat small intestine. Cancer Chemother. Pharmacol. 70(1), 39-48 (2012
    • (2012) Cancer Chemother. Pharmacol , vol.70 , Issue.1 , pp. 39-48
    • Kissow, H.1    Viby, N.E.2    Hartmann, B.3
  • 65
    • 84872466358 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure
    • Askov-Hansen C, Jeppesen PB, Lund P, Hartmann B, Holst JJ, Henriksen DB. Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure. Regul. Pept. 181, 4-8 (2013
    • (2013) Regul. Pept , vol.181 , pp. 4-8
    • Askov-Hansen, C.1    Jeppesen, P.B.2    Lund, P.3    Hartmann, B.4    Holst, J.J.5    Henriksen, D.B.6
  • 66
    • 0033914183 scopus 로고    scopus 로고
    • The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake
    • Tang-Christensen M, Larsen PJ, Thulesen J, Romer J, Vrang N. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat. Med. 6(7), 802-807 (2000
    • (2000) Nat. Med , vol.6 , Issue.7 , pp. 802-807
    • Tang-Christensen, M.1    Larsen, P.J.2    Thulesen, J.3    Romer, J.4    Vrang, N.5
  • 67
    • 0242499995 scopus 로고    scopus 로고
    • No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects
    • Sorensen LB, Flint A, Raben A, Hartmann B, Holst JJ, Astrup A. No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. Int. J. Obes. Relat. Metab. Disord. 27(4), 450-456 (2003
    • (2003) Int. J. Obes. Relat. Metab. Disord , vol.27 , Issue.4 , pp. 450-456
    • Sorensen, L.B.1    Flint, A.2    Raben, A.3    Hartmann, B.4    Holst, J.J.5    Astrup, A.6
  • 68
    • 0242266558 scopus 로고    scopus 로고
    • Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety
    • Schmidt PT, Näslund E, Grybäck P et al. Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. Regul. Pep. 116(1-3), 21-25 (2003
    • (2003) Regul. Pep , vol.116 , Issue.1-3 , pp. 21-25
    • Schmidt, P.T.1    Näslund, E.2    Grybäck, P.3
  • 72
    • 0026732813 scopus 로고
    • Extrinsic neural contribution to ileal peptide YY (PYY) release
    • Rudnicki M, Kuvshinoff BW, McFadden DW. Extrinsic neural contribution to ileal peptide YY (PYY) release. J. Surg. Res. 52(6), 591-595 (1992
    • (1992) J. Surg. Res , vol.52 , Issue.6 , pp. 591-595
    • Rudnicki, M.1    Kuvshinoff, B.W.2    McFadden, D.W.3
  • 73
    • 21344468734 scopus 로고    scopus 로고
    • Physiology: Does gut hormone PYY3-36 decrease food intake in rodents?
    • (reply
    • Batterham RL, Cowley MA, Small CJ et al. Physiology: Does gut hormone PYY3-36 decrease food intake in rodents? (reply). Nature 430, 6996 (2004
    • (2004) Nature , vol.430 , pp. 6996
    • Batterham, R.L.1    Cowley, M.A.2    Small, C.J.3
  • 74
    • 0041859261 scopus 로고    scopus 로고
    • Inhibition of food intake in obese subjects by peptide YY3
    • Batterham RL, Cohen MA, Ellis SM et al. Inhibition of food intake in obese subjects by peptide YY3. N. Engl. J. Med. 349(10), 941-948 (2003
    • (2003) N. Engl. J. Med , vol.349 , Issue.10 , pp. 941-948
    • Batterham, R.L.1    Cohen, M.A.2    Ellis, S.M.3
  • 75
    • 84856080046 scopus 로고    scopus 로고
    • Gut hormones and appetite control: A focus on PYY and GLP-1 as therapeutic targets in obesity
    • De SA, Bloom SR. Gut hormones and appetite control: A focus on PYY and GLP-1 as therapeutic targets in obesity. Gut Liver 6(1), 10-20 (2012
    • (2012) Gut Liver , vol.6 , Issue.1 , pp. 10-20
    • De, S.A.1    Bloom, S.R.2
  • 76
    • 27744469753 scopus 로고    scopus 로고
    • PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors
    • Ghamari-Langroudi M, Colmers WF, Cone RD. PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors. Cell Metab. 2(3), 191-199 (2005
    • (2005) Cell Metab , vol.2 , Issue.3 , pp. 191-199
    • Ghamari-Langroudi, M.1    Colmers, W.F.2    Cone, R.D.3
  • 77
    • 0030901415 scopus 로고    scopus 로고
    • Enteroglucagon
    • Holst JJ. Enteroglucagon. Ann. Rev. Physiol. 59, 257-271 (1997
    • (1997) Ann. Rev. Physiol , vol.59 , pp. 257-271
    • Holst, J.J.1
  • 78
    • 0028107226 scopus 로고
    • The role of the gut in regulating food intake in man
    • Read N, French S, Cunningham K. The role of the gut in regulating food intake in man. Nutr. Rev. 52(1), 1-10 (1994
    • (1994) Nutr. Rev , vol.52 , Issue.1 , pp. 1-10
    • Read, N.1    French, S.2    Cunningham, K.3
  • 79
    • 0020456354 scopus 로고
    • Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin
    • Holst JJ. Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin. Biochem. J. 207(3), 381-388 (1982
    • (1982) Biochem. J. , vol.207 , Issue.3 , pp. 381-388
    • Holst, J.J.1
  • 80
    • 0019766354 scopus 로고
    • Bioactive Enteroglucagon (oxyntomodulin): Present knowledge on its chemical structure and its biological activities
    • Bataille D, Gespach C, Tatemoto K et al. Bioactive enteroglucagon (oxyntomodulin): Present knowledge on its chemical structure and its biological activities. Peptides 2(Suppl. 2), 41-44 (1981
    • (1981) Peptides , vol.2 , Issue.SUPPL. 2 , pp. 41-44
    • Bataille, D.1    Gespach, C.2    Tatemoto, K.3
  • 81
    • 84872175094 scopus 로고    scopus 로고
    • Unraveling oxyntomodulin GLP-1's enigmatic brother
    • Pocai A. Unraveling Oxyntomodulin, GLP-1's enigmatic brother. J. Endocrinology 215(3), 335-346 (2012
    • (2012) J. Endocrinology , vol.215 , Issue.3 , pp. 335-346
    • Pocai, A.1
  • 82
    • 33750628142 scopus 로고    scopus 로고
    • The role of oxyntomodulin and peptide tyrosine-tyrosine (PYY) in appetite control
    • Wynne K, Bloom SR. The role of oxyntomodulin and peptide tyrosine-tyrosine (PYY) in appetite control. Nat. Clin. Pract. Endocrinol. Metab. 2(11), 612-620 (2006
    • (2006) Nat. Clin. Pract. Endocrinol. Metab , vol.2 , Issue.11 , pp. 612-620
    • Wynne, K.1    Bloom, S.R.2
  • 83
    • 0021259313 scopus 로고
    • A pure enteroglucagon, oxyntomodulin (glucagon 37), stimulates insulin release in perfused rat pancreas
    • Jarrousse C, Bataille D, Jeanrenaud B. A pure enteroglucagon, oxyntomodulin (glucagon 37), stimulates insulin release in perfused rat pancreas. Endocrinology 115(1), 102-105 (1984
    • (1984) Endocrinology , vol.115 , Issue.1 , pp. 102-105
    • Jarrousse, C.1    Bataille, D.2    Jeanrenaud, B.3
  • 84
    • 77957592532 scopus 로고    scopus 로고
    • The mechanism of action for oxyntomodulin in the regulation of obesity
    • Wynne K, Field BC, Bloom SR. The mechanism of action for oxyntomodulin in the regulation of obesity. Curr. Opin. Investig. Drugs 11(10), 1151-1157 (2010
    • (2010) Curr. Opin. Investig. Drugs , vol.11 , Issue.10 , pp. 1151-1157
    • Wynne, K.1    Field, B.C.2    Bloom, S.R.3
  • 85
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • Wynne K, Park AJ, Small CJ et al. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial. Int. J. Obes. (Lond.) 30(12), 1729-1736 (2006
    • (2006) Int. J. Obes. (Lond , vol.30 , Issue.12 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3
  • 86
    • 2542460293 scopus 로고    scopus 로고
    • Peripheral oxyntomodulin reduces food intake and body weight gain in rats
    • Dakin CL, Small CJ, Batterham RL et al. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 145(6), 2687-2695 (2004
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2687-2695
    • Dakin, C.L.1    Small, C.J.2    Batterham, R.L.3
  • 87
    • 0034807498 scopus 로고    scopus 로고
    • Oxyntomodulin inhibits food intake in the rat
    • Dakin CL, Gunn I, Small CJ et al. Oxyntomodulin inhibits food intake in the rat. Endocrinology 142(10), 4244-4250 (2001
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4244-4250
    • Dakin, C.L.1    Gunn, I.2    Small, C.J.3
  • 88
    • 84864351901 scopus 로고    scopus 로고
    • The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin
    • Kosinski JR, Hubert J, Carrington PE et al. The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin. Obes. (Silver Spring) 20(8), 1566-1571(2012
    • (2012) Obes. (Silver Spring , vol.20 , Issue.8 , pp. 1566-1571
    • Kosinski, J.R.1    Hubert, J.2    Carrington, P.E.3
  • 89
    • 70349644658 scopus 로고    scopus 로고
    • Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
    • Pocai A, Carrington PE, Adams JR et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 58(10), 2258-2266 (2009
    • (2009) Diabetes , vol.58 , Issue.10 , pp. 2258-2266
    • Pocai, A.1    Carrington, P.E.2    Adams, J.R.3
  • 90
    • 33749368018 scopus 로고    scopus 로고
    • Oxyntomodulin: A novel potential treatment for obesity
    • Druce MR, Bloom SR. Oxyntomodulin: A novel potential treatment for obesity. Treat. Endocrinol. 5(5), 265-272 (2006
    • (2006) Treat. Endocrinol , vol.5 , Issue.5 , pp. 265-272
    • Druce, M.R.1    Bloom, S.R.2
  • 92
    • 0024236086 scopus 로고
    • Oxyntomodulin and glicentin: Brain-gut peptides in the rat
    • Blache P, Kervran A, Bataille D. Oxyntomodulin and glicentin: Brain-gut peptides in the rat. Endocrinology 123(6), 2782-2787 (1988
    • (1988) Endocrinology , vol.123 , Issue.6 , pp. 2782-2787
    • Blache, P.1    Kervran, A.2    Bataille, D.3
  • 93
    • 25844462858 scopus 로고    scopus 로고
    • Role of recombinant human glicentin in the normal human jejunum: An in vitro study
    • Tomita R, Igarashi S, Tanjoh K, Fujisaki S. Role of recombinant human glicentin in the normal human jejunum: An in vitro study. Hepatogastroenterology 52(65), 1459-1462 (2005
    • (2005) Hepatogastroenterology , vol.52 , Issue.65 , pp. 1459-1462
    • Tomita, R.1    Igarashi, S.2    Tanjoh, K.3    Fujisaki, S.4
  • 96
    • 33748742627 scopus 로고    scopus 로고
    • Effect of gastric bypass and gastric banding on neurotensin levels in morbidly obese patients
    • Christ-Crain M, Stoeckli R, Ernst A et al Effect of gastric bypass and gastric banding on neurotensin levels in morbidly obese patients. J. Clin. Endocrinol. Metab. 91(9), 3544-3547 (2006
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , Issue.9 , pp. 3544-3547
    • Christ-Crain, M.1    Stoeckli, R.2    Ernst, A.3
  • 97
    • 0026510891 scopus 로고
    • Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man
    • Eissele R, Goke R, Willemer S et al. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur. J. Clin. Invest. 22(4), 283-291 (1992
    • (1992) Eur. J. Clin. Invest , vol.22 , Issue.4 , pp. 283-291
    • Eissele, R.1    Goke, R.2    Willemer, S.3
  • 99
    • 0028575660 scopus 로고
    • Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line
    • Drucker DJ, Jin T, Asa SL, Young TA, Brubaker PL. Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Mol. Endocrinol. 8(12), 1646-1655 (1994
    • (1994) Mol. Endocrinol , vol.8 , Issue.12 , pp. 1646-1655
    • Drucker, D.J.1    Jin, T.2    Asa, S.L.3    Young, T.A.4    Brubaker, P.L.5
  • 100
    • 0025296197 scopus 로고
    • Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice Heterogeneity of hormone expression
    • Rindi G, Grant SG, Yiangou Y et al. Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am. J. Pathol. 136(6), 1349-1363 (1990
    • (1990) Am. J. Pathol , vol.136 , Issue.6 , pp. 1349-1363
    • Rindi, G.1    Grant, S.G.2    Yiangou, Y.3
  • 102
    • 84862604197 scopus 로고    scopus 로고
    • Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects
    • Jacobsen SH, Olesen SC, Dirksen C et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Obes. Surg. 22(7), 1084-1096 (2012
    • (2012) Obes. Surg , vol.22 , Issue.7 , pp. 1084-1096
    • Jacobsen, S.H.1    Olesen, S.C.2    Dirksen, C.3
  • 103
    • 84555186977 scopus 로고    scopus 로고
    • Na+-d-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
    • Gorboulev V, Schürmann A, Vallon V et al. Na+-d-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61(1), 187-196 (2012
    • (2012) Diabetes , vol.61 , Issue.1 , pp. 187-196
    • Gorboulev, V.1    Schürmann, A.2    Vallon, V.3
  • 104
    • 84866065884 scopus 로고    scopus 로고
    • Predominant role of active versus facilitative glucose transport for glucagon-like peptide- 1 secretion
    • Parker HE, Adriaenssens A, Rogers G et al. Predominant role of active versus facilitative glucose transport for glucagon-like peptide- 1 secretion. Diabetologia 55(9), 2445-2455 (2012
    • (2012) Diabetologia , vol.55 , Issue.9 , pp. 2445-2455
    • Parker, H.E.1    Adriaenssens, A.2    Rogers, G.3
  • 105
    • 84860436360 scopus 로고    scopus 로고
    • Nutrient detection by incretin hormone secreting cells
    • Diakogiannaki E, Gribble FM, Reimann F. Nutrient detection by incretin hormone secreting cells. Physiol. Behav. 106(3), 387-393 (2012
    • (2012) Physiol. Behav , vol.106 , Issue.3 , pp. 387-393
    • Diakogiannaki, E.1    Gribble, F.M.2    Reimann, F.3
  • 107
    • 0029352151 scopus 로고
    • Postprandial lipid and hormone responses to meals of varying fat contents: Modulatory role of lipoprotein lipase?
    • Murphy MC, Isherwood SG, Sethi S et al. Postprandial lipid and hormone responses to meals of varying fat contents: Modulatory role of lipoprotein lipase? Eur. J. Clin. Nutr. 49(8), 578-588 (1995
    • (1995) Eur J. Clin. Nutr , vol.49 , Issue.8 , pp. 578-588
    • Murphy, M.C.1    Isherwood, S.G.2    Sethi, S.3
  • 108
    • 56749154840 scopus 로고    scopus 로고
    • A gut feeling for obesity: 7TM sensors on enteroendocrine cells
    • Engelstoft MS, Egerod KL, Holst B, Schwartz TW. A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab. 8(6), 447-449 (2008
    • (2008) Cell Metab , vol.8 , Issue.6 , pp. 447-449
    • Engelstoft, M.S.1    Egerod, K.L.2    Holst, B.3    Schwartz, T.W.4
  • 109
    • 42449126696 scopus 로고    scopus 로고
    • A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide- 1 and glucose-dependent insulinotropic peptide release
    • Chu ZL, Carroll C, Alfonso J et al. A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide- 1 and glucose-dependent insulinotropic peptide release. Endocrinol. 149(5), 2038-2047 (2008
    • (2008) Endocrinol , vol.149 , Issue.5 , pp. 2038-2047
    • Chu, Z.L.1    Carroll, C.2    Alfonso, J.3
  • 110
    • 0035829625 scopus 로고    scopus 로고
    • An anorexic lipid mediator regulated by feeding
    • Rodriguez de Fonseca F, Navarro M, Gomez R et al. An anorexic lipid mediator regulated by feeding. Nature 414(6860), 209-212 (2001
    • (2001) Nature , vol.414 , Issue.6860 , pp. 209-212
    • Rodriguez De Fonseca, F.1    Navarro, M.2    Gomez, R.3
  • 111
    • 80052521074 scopus 로고    scopus 로고
    • 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
    • Hansen KB, Rosenkilde MM, Knop FK et al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J. Clin. Endocrinol. Metab. 96(9), E1409-E1417 (2011
    • (2011) J. Clin. Endocrinol. Metab , vol.96 , Issue.9
    • Hansen, K.B.1    Rosenkilde, M.M.2    Knop, F.K.3
  • 112
    • 33644627958 scopus 로고    scopus 로고
    • Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
    • Overton HA, Babbs AJ, Doel SM et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3(3), 167-175 (2006
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 167-175
    • Overton, H.A.1    Babbs, A.J.2    Doel, S.M.3
  • 113
  • 114
    • 84871097990 scopus 로고    scopus 로고
    • Effect of bile acid sequestrants on glycaemic control: Protocol for a systematic review with meta-analysis of randomised controlled trials
    • Hansen M, Sonne DP, Mikkelsen KH, Gluud LL, Vilsböll T, Knop FK. Effect of bile acid sequestrants on glycaemic control: Protocol for a systematic review with meta-analysis of randomised controlled trials. BMJ Open 2(6) (2012
    • (2012) BMJ Open , vol.2 , Issue.6
    • Hansen, M.1    Sonne, D.P.2    Mikkelsen, K.H.3    Gluud, L.L.4    Vilsböll, T.5    Knop, F.K.6
  • 115
    • 33751069321 scopus 로고    scopus 로고
    • Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases
    • Reimer RA. Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases. J. Endocrinol. 191(1), 159-170 (2006
    • (2006) J. Endocrinol , vol.191 , Issue.1 , pp. 159-170
    • Reimer, R.A.1
  • 116
    • 0031750108 scopus 로고    scopus 로고
    • Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene
    • Cordier-Bussat M, Bernard C, Levenez F et al. Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene. Diabetes 47(7), 1038-1045 (1998
    • (1998) Diabetes , vol.47 , Issue.7 , pp. 1038-1045
    • Cordier-Bussat, M.1    Bernard, C.2    Levenez, F.3
  • 117
    • 75349091535 scopus 로고    scopus 로고
    • Molecular mechanisms underlying nutrient detection by incretin-secreting cells
    • Reimann F. Molecular mechanisms underlying nutrient detection by incretin-secreting cells. Int. Dairy J. 20(4), 236-242 (2010
    • (2010) Int. Dairy J. , vol.20 , Issue.4 , pp. 236-242
    • Reimann, F.1
  • 118
    • 5644240984 scopus 로고    scopus 로고
    • Glutamine potently stimulates glucagon-like peptide- 1 secretion from GLUTag cells
    • Reimann F, Williams L, Silva Xavier G, Rutter GA, Gribble FM. Glutamine potently stimulates glucagon-like peptide- 1 secretion from GLUTag cells. Diabetologia 47(9), 1592-1601 (2004
    • (2004) Diabetologia , vol.47 , Issue.9 , pp. 1592-1601
    • Reimann, F.1    Williams, L.2    Silva Xavier, G.3    Rutter, G.A.4    Gribble, F.M.5
  • 119
    • 58149373780 scopus 로고    scopus 로고
    • Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects
    • Greenfield JR, Farooqi IS, Keogh JM et al. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. Am. J. Clin. Nutr. 89(1), 106-113 (2009
    • (2009) Am. J. Clin. Nutr , vol.89 , Issue.1 , pp. 106-113
    • Greenfield, J.R.1    Farooqi, I.S.2    Keogh, J.M.3
  • 120
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • Zambrowicz B, Freiman J, Brown PM et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin. Pharmacol. Ther. 92(2), 158-169 (2012
    • (2012) Clin. Pharmacol. Ther , vol.92 , Issue.2 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 121
    • 84874977086 scopus 로고    scopus 로고
    • Effects of LX4211, a dual SGLT1/ SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes
    • Zambrowicz B, Ding ZM, Ogbaa I et al. Effects of LX4211, a dual SGLT1/ SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes. Clin. Ther. 35(3), 273-285 (2013
    • (2013) Clin. Ther , vol.35 , Issue.3 , pp. 273-285
    • Zambrowicz, B.1    Ding, Z.M.2    Ogbaa, I.3
  • 122
    • 84876519168 scopus 로고    scopus 로고
    • LX4211 Increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)- mediated absorption of intestinal glucose
    • Powell DR, Smith M, Greer J et al. LX4211 Increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)- mediated absorption of intestinal glucose. J. Pharmacol. Exp. Ther. 345(2), 250-259 (2013
    • (2013) J. Pharmacol. Exp. Ther , vol.345 , Issue.2 , pp. 250-259
    • Powell, D.R.1    Smith, M.2    Greer, J.3
  • 123
    • 84864118760 scopus 로고    scopus 로고
    • KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models
    • Shibazaki T, Tomae M, Ishikawa-Takemura Y et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J. Pharmacol. Exp. Ther. 342(2), 288-296 (2012
    • (2012) J. Pharmacol. Exp. Ther , vol.342 , Issue.2 , pp. 288-296
    • Shibazaki, T.1    Tomae, M.2    Ishikawa-Takemura, Y.3
  • 124
    • 80054988309 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects
    • Katz LB, Gambale JJ, Rothenberg PL et al. Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects. Clin. Pharmacol. Ther. 90(5), 685-692 (2011
    • (2011) Clin. Pharmacol. Ther , vol.90 , Issue.5 , pp. 685-692
    • Katz, L.B.1    Gambale, J.J.2    Rothenberg, P.L.3
  • 125
    • 79951636303 scopus 로고    scopus 로고
    • GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms
    • Flock G, Holland D, Seino Y, Drucker DJ. GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms. Endocrinology 152(2), 374-383 (2011
    • (2011) Endocrinology , vol.152 , Issue.2 , pp. 374-383
    • Flock, G.1    Holland, D.2    Seino, Y.3    Drucker, D.J.4
  • 126
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 10(3), 167-177 (2009
    • (2009) Cell Metab , vol.10 , Issue.3 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 127
    • 77249142314 scopus 로고    scopus 로고
    • Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1
    • Shang Q, Saumoy M, Holst JJ, Salen G, Xu G. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. Am. J. Physiol. Gastrointest. Liver Physiol. 298(3), G419-G424 (2010
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol , vol.298 , Issue.3
    • Shang, Q.1    Saumoy, M.2    Holst, J.J.3    Salen, G.4    Xu, G.5
  • 128
    • 84866125785 scopus 로고    scopus 로고
    • Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
    • Adrian TE, Gariballa S, Parekh KA et al. Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers. Diabetologia 55(9), 2343-2347 (2012
    • (2012) Diabetologia , vol.55 , Issue.9 , pp. 2343-2347
    • Adrian, T.E.1    Gariballa, S.2    Parekh, K.A.3
  • 129
    • 84875054928 scopus 로고    scopus 로고
    • Activation of FFA1 mediates GLP-1 secretion in mice evidence for allosterism at FFA1
    • Xiong Y, Swaminath G, Cao Q et al. Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. Mol. Cell. Endocrinol. 369(1-2), 119-129 (2013
    • (2013) Mol. Cell. Endocrinol , vol.369 , Issue.1-2 , pp. 119-129
    • Xiong, Y.1    Swaminath, G.2    Cao, Q.3
  • 130
    • 84867290314 scopus 로고    scopus 로고
    • A Potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents
    • Luo J, Swaminath G, Brown SP et al. A Potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents. PLoS ONE 7(10), e46300 (2012
    • (2012) PLoS ONE , vol.7 , Issue.10
    • Luo, J.1    Swaminath, G.2    Brown, S.P.3
  • 131
    • 84865383561 scopus 로고    scopus 로고
    • Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice
    • Ahlkvist L, Vikman J, Pacini G, Ahren B. Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice. Regul. Pep. 178(1-3), 29-35 (2012
    • (2012) Regul. Pep , vol.178 , Issue.1-3 , pp. 29-35
    • Ahlkvist, L.1    Vikman, J.2    Pacini, G.3    Ahren, B.4
  • 132
    • 78449274342 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1
    • Migoya EM, Bergeron R, Miller JL et al. Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1. Clin. Pharmacol. Ther. 88(6), 801-808 (2010
    • (2010) Clin. Pharmacol. Ther , vol.88 , Issue.6 , pp. 801-808
    • Migoya, E.M.1    Bergeron, R.2    Miller, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.