Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases

Expert Review of Clinical Immunology

Volumn 10, Issue 2, 2014, Pages 243-256

  Pelham, Christopher J ^a   Agrawal, Devendra K ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cardiovascular disease; DNAX activation protein of 12 kDa; high mobility group box 1; inflammation; metabolic syndrome; Toll like receptors; triggering receptor expressed on myeloid cells

Indexed keywords

ENDOTOXIN; HIGH MOBILITY GROUP B1 PROTEIN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LIGAND; MEMBRANE RECEPTOR; TOLL LIKE RECEPTOR 4; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ALZHEIMER DISEASE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; DISEASE MARKER; HEART DISEASE; HUMAN; INFLAMMATORY DISEASE; INNATE IMMUNITY; METABOLIC DISORDER; NONHUMAN; OBESITY; RESPIRATORY TRACT DISEASE; REVIEW;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNE SYSTEM DISEASES; IMMUNITY, INNATE; INFLAMMATION; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; POLYMORPHISM, GENETIC; RECEPTOR CROSS-TALK; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84893072503     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2014.866519     Document Type: Review

References (93)

1. Klesney-Tait J, Colonna M. Uncovering the TREM-1-TLR connection. Am. J. Physiol. Lung Cell. Mol. Physiol. 293(6), L1374-L1376 (2007
2. Ford JW, McVicar DW. TREM and TREMlike receptors in inflammation and disease. Curr. Opin. Immunol. 21(1), 38-46 (2009
3. Takaki R, Watson SR, Lanier LL. DAP12: An adapter protein with dual functionality. Immunol. Rev. 214, 118-129 (2006
4. Clark GJ, Ju X, Tate C, Hart DN. The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. Trends Immunol. 30(5), 209-217 (2009
5. Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391(6668), 703-707 (1998
6. Tomasello E, Desmoulins PO, Chemin K, Guia S, Cremer H, Ortaldo J et al. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 13(3), 355-364 (2000
7. Tomasello E, Vivier E. KARAP/DAP12/ TYROBP: Three names and a multiplicity of biological functions. Eur. J. Immunol. 35(6), 1670-1677 (2005
8. Bouchon A, Dietrich J, Colonna M. Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164(10), 4991-4995 (2000
9. Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur. J. Immunol. 33(2), 567-577 (2003
10. Molloy EJ. Triggering receptor expressed on myeloid cells (TREM) family and the application of its antagonists. Recent Pat. Antiinfect. Drug Discov. 4(1), 51-56 (2009
11. Sharif O, Knapp S. From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology 213(9-10), 701-713 (2008
12. Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410(6832), 1103-1107 (2001
13. Gibot S, Kolopp-Sarda MN, Bene MC et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med. 200(11), 1419-1426 (2004
14. Gibot S, Massin F, Marcou M et al. TREM-1 promotes survival during septic shock in mice. Eur. J. Immunol. 37(2), 456-466 (2007
15. Molad Y, Pokroy-Shapira E, Carmon V. CpG-oligodeoxynucleotide-induced TLR9 activation regulates macrophage TREM-1 expression and shedding. Innate Immun. 19(6), 623-630 (2013
16. Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J. Leukoc. Biol. 80(6), 1454-1461 (2006
17. Dower K, Ellis DK, Saraf K, Jelinsky SA, Lin LL. Innate immune responses to TREM-1 activation: Overlap, divergence, and positive and negative cross-Talk with bacterial lipopolysaccharide. J. Immunol. 180(5), 3520-3534 (2008
18. Watarai H, Sekine E, Inoue S, Nakagawa R, Kaisho T, Taniguchi M. PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Proc. Natl Acad. Sci. USA 105(8), 2993-2998 (2008
19. Wong-Baeza I, Gonzalez-Roldan N, Ferat-Osorio E et al. Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-Transcriptionally and its ligand is present in the sera of some septic patients. Clin. Exp. Immunol. 145(3), 448-455 (2006
20. Haselmayer P, Grosse-Hovest L, von Landenberg P, Schild H, Radsak MP. TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 110(3), 1029-1035 (2007
21. Gomez-Pina V, Soares-Schanoski A, Rodriguez-Rojas A et al. Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J. Immunol. 179(6), 4065-4073 (2007
22. Dimopoulou I, Pelekanou A, Mavrou I et al. Early serum levels of soluble triggering receptor expressed on myeloid cells-1 in septic patients: Correlation with monocyte gene expression. J. Crit. Care 27(3), 294-300 (2012
23. Bopp C, Bierhaus A, Hofer S et al. Bench-To-bedside review: The inflammation-perpetuating patternrecognition receptor RAGE as a therapeutic target in sepsis. Crit. Care 12(1), 201 (2008
24. El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol. Lett. 111(1), 36-44 (2007
25. Wu J, Li J, Salcedo R, Mivechi NF, Trinchieri G, Horuzsko A. The proinflammatory myeloid cell receptor TREM-1 controls kupffer cell activation and development of hepatocellular carcinoma. Cancer Res. 72(16), 3977-3986 (2012
26. Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N. Engl. J. Med. 350(5), 451-458 (2004
27. Yasuda T, Takeyama Y, Ueda T et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. Crit. Care Med. 36(7), 2048-2053 (2008
28. Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H. Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum. 60(6), 1615-1623 (2009
29. Schenk M, Bouchon A, Seibold F, Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 117(10), 3097-3106 (2007
30. Ho CC, Liao WY, Wang CY et al. TREM-1 expression in tumor-Associated macrophages and clinical outcome in lung cancer. Am. J. Respir. Crit. Care Med. 177(7), 763-770 (2008
31. Karapanagiotou EM, Pelekanou E, Charpidou A et al. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: A prognostic marker for lung metastases from solid malignancies. Anticancer Res. 28(2B), 1411-1415 (2008
32. Turnbull IR, Gilfillan S, Cella M et al. Cutting edge: TREM-2 attenuates macrophage activation. J. Immunol. 177(6), 3520-3524 (2006
33. Ito H, Hamerman JA. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. Eur. J. Immunol. 42(1), 176-185 (2012
34. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: Binding of anionic ligands. J. Immunol. 171(2), 594-599 (2003
35. N'Diaye EN, Branda CS, Branda SS et al. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J. Cell Biol. 184(2), 215-223 (2009
36. Chen Q, Zhang K, Jin Y et al. Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance. Am. J. Respir. Crit. Care Med. 188(2), 201-212 (2013
37. Washington AV, Schubert RL, Quigley L et al. A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets. Blood 104(4), 1042-1047 (2004
38. Barrow AD, Astoul E, Floto A et al. Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. J. Immunol. 172(10), 5838-5842 (2004
39. Washington AV, Gibot S, Acevedo I et al. TREM-like transcript-1 protects against inflammation-Associated hemorrhage by facilitating platelet aggregation in mice and humans. J. Clin. Invest. 119(6), 1489-1501 (2009
40. Derive M, Bouazza Y, Sennoun N et al. Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis. J. Immunol. 188(11), 5585-5592 (2012
41. Paloneva J, Manninen T, Christman G et al. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71(3), 656-662 (2002
42. Tanaka J. Leukoencephalopathic alteration in membranous lipodystrophy. Acta Neuropathol. 50(3), 193-197 (1980
43. Kalimo H, Sourander P, Jarvi O, Hakola P. Vascular changes and blood-brain barrier damage in the pathogenesis of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (membranous lipodystrophy). Acta Neurol. Scand. 89(5), 353-361 (1994
44. Bird TD, Koerker RM, Leaird BJ, Vlcek BW, Thorning DR. Lipomembranous polycystic osteodysplasia (brain, bone, and fat disease): A genetic cause of presenile dementia. Neurology 33(1), 81-86 (1983
45. Paloneva J, Kestila M, Wu J et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat. Genet. 25(3), 357-361 (2000
46. Cella M, Buonsanti C, Strader C, Kondo T, Salmaggi A, Colonna M. Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J. Exp. Med. 198(4), 645-651 (2003
47. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E et al. TREM2 variants in alzheimer's disease. N. Engl. J. Med. 368(2), 117-127 (2013
48. Piccio L, Buonsanti C, Mariani M et al. Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur. J. Immunol. 37(5), 1290-1301 (2007
49. Cani PD, Amar J, Iglesias MA et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56(7), 1761-1772 (2007
50. Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16(6), 1248-1255 (2008
51. Suganami T, Tanimoto-Koyama K, Nishida J et al. Role of the toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 27(1), 84-91 (2007
52. Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J. Intern. Med. 245(6), 621-625 (1999
53. Arts RJ, Joosten LA, Dinarello CA, Kullberg BJ, van der Meer JW, Netea MG. TREM-1 interaction with the LPS/ TLR4 receptor complex. Eur. Cytokine Netw. 22(1), 11-14 (2011
54. Fortin CF, Lesur O, Fulop T Jr. Effects of TREM-1 activation in human neutrophils: Activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int. Immunol. 19(1), 41-50 (2007
55. Kim SJ, Choi Y, Choi YH, Park T. Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice. J. Nutr. Biochem. 23(2), 113-122 (2012
56. Kim EJ, Choi MR, Park H et al. Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice. Breast Cancer Res. 13(4), R78 (2011
57. Gea-Sorli S, Bonjoch L, Closa D. Differences in the inflammatory response induced by acute pancreatitis in different white adipose tissue sites in the rat. PLoS ONE 7(8), e41933 (2012
58. Dowal L, Yang W, Freeman MR, Steen H, Flaumenhaft R. Proteomic analysis of palmitoylated platelet proteins. Blood 118(13), e62-e73 (2011
59. Cannon JP, O'Driscoll M, Litman GW. Specific lipid recognition is a general feature of CD300 and TREM molecules. Immunogenetics 64(1), 39-47 (2012
60. Klesney-Tait J, Keck K, Li X et al. Transepithelial migration of neutrophils into the lung requires TREM-1. J. Clin. Invest. 123(1), 138-149 (2013
61. Chen LC, Laskin JD, Gordon MK, Laskin DL. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp. Mol. Pathol. 84(2), 145-155 (2008
62. Rigo I, McMahon L, Dhawan P et al. Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)(2) vitamin D (3). Innate Immun. 18(2), 250-257 (2012
63. del Fresno C, Gomez-Pina V, Lores V et al. Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: Down-regulation of TREM-1 as putative underlying mechanism. PLoS ONE 3(7), e2667 (2008
64. Boufenzer A, Sennoun N, Bouazza Y, Derive M, Bollaert P, Gibot S. Role of TREM-1 in endothelial dysfunction during experimental sepsis. Crit. Care 16(Suppl. 3), 49 (2012
65. Gunnett CA, Lund DD, McDowell AK, Faraci FM, Heistad DD. Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction. Arterioscler. Thromb. Vasc. Biol. 25(8), 1617-1622 (2005
66. Gibot S, Buonsanti C, Massin F et al. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Infect. Immun. 74(5), 2823-2830 (2006
67. Derive M, Boufenzer A, Bouazza Y et al. Effects of a TREM-like transcript 1-derived peptide during hypodynamic septic shock in pigs. Shock 39(2), 176-182 (2013
68. Umemoto E, Tanaka T, Kanda H et al. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. J. Exp. Med. 203(6), 1603-1614 (2006
69. Jin S, Umemoto E, Tanaka T et al. Nepmucin/CLM-9, an ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro. FEBS Lett. 582(20), 3018-3024 (2008
70. Bhasin M, Huang Z, Pradhan-Nabzdyk L et al. Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury. PLoS ONE 7(6), e39123 (2012
71. Youssef RE, Ledingham MA, Bollapragada SS et al. The role of toll-like receptors (TLR-2 and-4) and triggering receptor expressed on myeloid cells 1 (TREM-1) in human term and preterm labor. Reprod. Sci. 16(9), 843-856 (2009
72. de Souza AW, Westra J, Limburg PC, Bijl M, Kallenberg CG. HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis. Autoimmun. Rev. 11(12), 909-917 (2012
73. Kanellakis P, Agrotis A, Kyaw TS et al. High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice. Arterioscler. Thromb. Vasc. Biol. 31(2), 313-319 (2011
74. Limana F, Germani A, Zacheo A et al. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+cell proliferation and differentiation. Circ. Res. 97(8), e73-e83 (2005
75. Kitahara T, Takeishi Y, Harada M et al. High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice. Cardiovasc. Res. 80(1), 40-46 (2008
76. Kim F, Pham M, Luttrell I et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ. Res. 100(11), 1589-1596 (2007
77. Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ. Expression of toll-like receptors in human atherosclerotic lesions: A possible pathway for plaque activation. Circulation 105(10), 1158-1161 (2002
78. Michelsen KS, Wong MH, Shah PK et al. Lack of toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl Acad. Sci. USA 101(29), 10679-10684 (2004
79. Gareus R, Kotsaki E, Xanthoulea S et al. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab. 8(5), 372-383 (2008
80. Nicholls SJ, Hazen SL. Myeloperoxidase and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 25(6), 1102-111 (2005
81. Zhang X, Wang XG, Xie YQ et al. Role of triggering receptor expressed on myeloid cells-1 on coxsackievirus B3-induced inflammation and cardiomyocyte injury. Zhonghua Xin Xue Guan Bing Za Zhi 40(5), 411-415 (2012
82. Schiechl G, Brunner SM, Kesselring R et al. Inhibition of innate co-receptor TREM-1 signaling reduces CD4(+) T cell activation and prolongs cardiac allograft survival. Am. J. Transplant. 13(5),1168-1180 (2013
83. Hosoda H, Tamura H, Kida S, Nagaoka I. Transcriptional regulation of mouse TREM-1 gene in RAW264.7 macrophage-like cells. Life Sci. 89(3-4), 115-122 (2011
84. Zeng H, Ornatowska M, Joo MS, Sadikot RT. TREM-1 expression in macrophages is regulated at transcriptional level by NF-kappaB and PU.1. Eur. J. Immunol. 37(8), 2300-2308 (2007
85. Bosco MC, Pierobon D, Blengio F et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: Identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood 117(9), 2625-2639 (2011
86. Murat A, Migliavacca E, Hussain SF et al. Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia. PLoS ONE 4(6), e5947 (2009
87. Paloneva J, Mandelin J, Kiialainen A et al. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. J. Exp. Med. 198(4), 669-675 (2003
88. Roumier A, Bechade C, Poncer JC et al. Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24(50), 11421-11428 (2004
89. Kaifu T, Nakahara J, Inui M et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111(3), 323-332 (2003
90. Hamerman JA, Tchao NK, Lowell CA, Lanier LL. Enhanced toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6(6), 579-586 (2005
91. Turnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J. Exp. Med. 202(3), 363-369 (2005
92. Lucas M, Daniel L, Tomasello E et al. Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/ DAP12-Transgenic mice. Eur. J. Immunol. 32(9), 2653-2663 (2002
93. Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS. Efficient colonic mucosal wound repair requires Trem2 signaling. Proc. Natl Acad. Sci. USA 106(1), 256-261 (2009