Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance

American Journal of Respiratory and Critical Care Medicine

Volumn 188, Issue 2, 2013, Pages 201-212

  Chen, Qixing ^a   Zhang, Kai ^a   Jin, Yue ^a   Zhu, Tao ^b   Cheng, Baoli ^a   Shu, Qiang ^b   Fang, Xiang Ming ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Children's Hospital   (China)

Author keywords

Infection; Inflammation; Macrophage; Phagocytosis; Receptor

Indexed keywords

ADENOVIRUS VECTOR; LIPOPOLYSACCHARIDE; MEMBRANE RECEPTOR; PERITONEAL DIALYSIS FLUID; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; BONE MARROW CELL; CECUM; CELL PROTECTION; ENDOTOXEMIA; HOST RESISTANCE; HUMAN; LIGATION; MICROBIOLOGICAL EXAMINATION; MORTALITY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUNCTURE; RECEPTOR UPREGULATION; SEPSIS; TISSUE SECTION;

ADENOVIRIDAE; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ASCITES; BACTERIAL LOAD; COINFECTION; FEMALE; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MIDDLE AGED; MYELOID CELLS; PHAGOCYTOSIS; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; SEPSIS; UP-REGULATION;

EID: 84881121229     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201211-1967OC     Document Type: Article

References (43)

1. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348: 138-150.
2. Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet 2005;365: 63-78.
3. Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J Clin Invest 2003;112: 460-467.
4. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348: 1546-1554.
5. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D; Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006;34: 344-353.
6. Cheng B, Xie G, Yao S, Wu X, Guo Q, Gu M, Fang Q, Xu Q, Wang D, Jin Y, et al. Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit Care Med 2007;35: 2538-2546.
7. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008;8: 776-787.
8. Baron RM, Baron MJ, Perrella MA. Pathobiology of sepsis: are we still asking the same questions? Am J Respir Cell Mol Biol 2006;34: 129-134.
9. Riedemann NC, Guo RF, Ward PA. Novel strategies for the treatment of sepsis. Nat Med 2003;9: 517-524.
10. Rivers EP, McIntyre L, Morro DC, Rivers KK. Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity. CMAJ 2005;173: 1054-1065.
11. Mullard A. Drug withdrawal sends critical care specialists back to basics. Lancet 2011;378:1769.
12. Daws MR, Lanier LL, Seaman WE, Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol 2001;31: 783-791.
13. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003;3: 445-453.
14. Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009;21: 38-46.
15. Bouchon A, Hernández-Munain C, Cella M, Colonna MA. A DAP12- mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J Exp Med 2001;194: 1111-1122.
16. Helming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E. Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal 2008;1:ra11.
17. Aoki N, Kimura S, Xing Z. Role of DAP12 in innate and adaptive immune responses. Curr Pharm Des 2003;9: 7-10.
18. Turnbull IR, Gilfillan S, Cella M, Aoshi T,Miller M, Piccio L, HernandezM, Colonna M. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol 2006;177: 3520-3524.
19. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 2006;177: 2051-2055.
20. Ito H, Hamerman JA. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. Eur J Immunol 2012;42: 176-185.
21. Hamerman JA, Tchao NK, Lowell CA, Lanier LL. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 2005;6:579-586. [Published erratum appears in Nat Immunol 2009;10:223.]
22. Piccio L, Buonsanti C, Mariani M, Cella M, Gilfillan S, Cross AH, Colonna M, Panina-Bordignon P. Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol 2007; 37: 1290-1301.
23. Gao X, Dong Y, Liu Z, Niu B. Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide. Mol Med Rep 2013;7: 921-926.
24. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol 2009;184: 215-223.
25. Quan DN, Cooper MD, Potter JL, Roberts MH, Cheng H, Jarvis GA. TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. Mucosal Immunol 2008;1: 229-238.
26. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol 2003;171: 594-599.
27. Chen Q, Zhang K, Cai M, Fang X. The expression pattern of Trem-2 in tissue macrophage of septic mice [abstract]. Crit Care Med 2012;39: 181.
28. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM/ESICM/ACCP/ ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31: 1250-1256.
29. Shu Q, Shi Z, Zhao Z, Chen Z, Yao H, Chen Q, Hoeft A, Stuber F, Fang X. Protection against Pseudomonas aeruginosa pneumonia and sepsisinduced lung injury by overexpression of beta-defensin-2 in rats. Shock 2006;26: 365-371.
30. Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H. TREM2- transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 2007;4:e124.
31. Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD. Granulocytemacrophage colony-stimulating factor (CSF) and macrophage CSFdependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol 2007;178: 5245-5252.
32. Eckle T, Grenz A, Laucher S, Eltzschig HK. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest 2008;118: 3301-3315.
33. D'Alessio FR, Tsushima K, Aggarwal NR, West EE, Willett MH, Britos MF, Pipeling MR, Brower RG, Tuder RM, McDyer JF, et al. CD41CD251Foxp31 Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 2009;119: 2898-2913.
34. Papa S, Zazzeroni F, Fu YX, Bubici C, Alvarez K, Dean K, Christiansen PA, Anders RA, Franzoso G. Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J Clin Invest 2008;118: 1911-1923.
35. He S, Atkinson C, Qiao F, Cianflone K, Chen X, Tomlinson S. A complementdependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice. J Clin Invest 2009;119: 2304-2316.
36. FierenMW. The local inflammatory responses to infection of the peritoneal cavity in humans: their regulation by cytokines, macrophages, and other leukocytes. Mediators Inflamm 2012;2012:976-41.
37. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012;122: 787-795.
38. Piccio L, Buonsanti C, Cella M, Tassi I, Schmidt RE, Fenoglio C, Rinker J II, Naismith RT, Panina-Bordignon P, Passini N, et al. Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain 2008;131: 3081-3091.
39. Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 2009;461: 1287-1291.
40. Benoit M, Desnues B, Mege JL. Macrophage polarization in bacterial infections. J Immunol 2008;181: 3733-3739.
41. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 2005;23: 344-346.
42. Sieber MW, Jaenisch N, Brehm M, Guenther M, Linnartz-Gerlach B, Neumann H, Witte OW, Frahm C. Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke. PLoS ONE 2013;8:e52982.
43. Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A, Arena V, Biroulet LP, Caprioli F, Passini N, et al. Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response. Gastroenterology 2012;144: 346-356.