Inhibition of innate co-receptor TREM-1 signaling reduces CD4+ T cell activation and prolongs cardiac allograft survival

American Journal of Transplantation

Volumn 13, Issue 5, 2013, Pages 1168-1180

  Schiechl, G ^a   Brunner, S M ^a   Kesselring, R ^a   Martin, M ^a   Ruemmele, P ^a   Mack, M ^a   Hirt, S W ^a   Schlitt, H J ^a   Geissler, E K ^a   Fichtner Feigl, S ^a,b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b Regensburg Centre for Interventional Immunology (RCI)   (Germany)

Author keywords

Allograft survival; chronic rejection; heart transplantation; innate immunity; TREM 1

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELOID DIFFERENTIATION FACTOR 88; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; BASE MISPAIRING; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GRAFT SURVIVAL; HEART GRAFT; HEART MUSCLE FIBROSIS; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; LEUKOCYTE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; RNA; SIGNAL TRANSDUCTION; TRANSPLANTATION, HOMOLOGOUS;

EID: 84876937945     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12186     Document Type: Article

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