Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D2/3 receptors in their high-affinity state

Journal of Medicinal Chemistry

Volumn 57, Issue 2, 2014, Pages 391-410

  Van Wieringen, Jan Peter ^a   Shalgunov, Vladimir ^b   Janssen, Henk M ^c   Fransen, P Michel ^c   Janssen, Anton G M ^d   Michel, Martin C ^e   Booij, Jan ^a   Elsinga, Philip H ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c SyMO Chem   (Netherlands)

^d GE HEALTHCARE   (United Kingdom)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 (2 FLUOROETHOXY)PHENYL) 4 ((7 (METHOXYMETHOXY)CHROMAN 2 YL)METHYL)PIPERAZINE; 1 (4 (2 FLUOROETHOXY)PHENYL) 4 ((7 HYDROXYCHROMAN 2 YL)METHYL)PIPERAZINE; 1 (4 (2 FLUOROETHOXY)PHENYL) 4 (4 (7 (METHOXYMETHOXY)CHROMAN 2 YL) 3 AZABUTYL)PIPERAZINE; 1 (4 (2 FLUOROETHOXY)PHENYL) 4 (4 (7 HYDROXYCHROMAN 2 YL) 3 AZABUTYL)PIPERAZINE; 1 (4 IODOPHENYL) 4 ((7 HYDROXYCHROMAN 2 YL)METHYL)PIPERAZINE; 1 (4 IODOPHENYL) 4 (4 (7 (METHOXYMETHOXY)CHROMAN 2YL) 3 AZABUTYL)PIPERAZINE; 1 (4 IODOPHENYL) 4 (4 (7 HYDROXYCHROMAN 2 YL) 3 AZABUTYL)PIPERAZINE; 2 [(2 (4 FLUOROBUTOXY)BENZYLAMINO)METHYL]CHROMAN 7 OL; 2 [(2 IODOBENZYLAMINO)METHYL]CHROMAN 7 OL; 2 [(3 IODOBENZYLAMINO)METHYL]CHROMAN 7 OL; 2 [(4 IODOBENZYLAMINO)METHYL]CHROMAN 7 OL; 2 [(BENZYLAMINO)METHYL]CHROMAN 7 OL; 2 [(HEXYLAMINO)METHYL]CHROMAN 7 OL; 7 (METHOXYMETHOXY)CHROMAN 2 CARBOXYLIC ACID ETHYL ESTER; 7 HYDROXYCHROMAN 2 CARBOXYLIC ACID ETHYL ESTER; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR STIMULATING AGENT; FLUORINE 18; IODINE 123; N [7 (METHOXYMETHOXY)CHROMAN 2 YL]METHYL 1 HEXYL AMINE; N [7 (METHOXYMETHOXY)CHROMAN 2 YL]METHYL 2 (4 FLUOROBUTOXY)BENZYL AMINE; N [7 (METHOXYMETHOXY)CHROMAN 2 YL]METHYL 2 IODOBENZYL AMINE; N [7 (METHOXYMETHOXY)CHROMAN 2 YL]METHYL 4 (4 FLUOROBUTOXY)BENZYL AMINE; N [7 (METHOXYMETHOXY)CHROMAN 2 YL]METHYL 4 IODOBENZYL AMINE; PIPERAZINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TOLUENE 4 SULFONIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BRAIN SLICE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CARBON RADIOISOTOPES; CHROMANS; CYCLIC AMP; DOPAMINE AGONISTS; HEK293 CELLS; HUMANS; MALE; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893034871     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401384w     Document Type: Article

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