Subtype selectivity of dopamine receptor ligands: Insights from structure and ligand-based methods

Journal of Chemical Information and Modeling

Volumn 50, Issue 11, 2010, Pages 1970-1985

  Wang, Qi ^a   MacH, Robert H ^a   Luedtke, Robert R ^b   Reichert, David E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING ENERGY; BINDING SITES; COMPUTATIONAL CHEMISTRY; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULAR GRAPHICS; NEUROPHYSIOLOGY; PREDICTIVE ANALYTICS;

BINDING CONFORMATIONS; BINDING SPECIFICITIES; EXTRACELLULAR LOOPS; HYDROPHOBIC INTERACTIONS; MOLECULAR MECHANISM; NEUROLOGIC DISORDERS; RECEPTOR-LIGAND INTERACTIONS; THREE DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (3D QSAR);

LIGANDS;

BETA 2 ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; LIGAND; RHODOPSIN;

ANIMAL; ARTICLE; CATTLE; CHEMISTRY; DRUG DEVELOPMENT; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR DYNAMICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENCE HOMOLOGY;

ANIMALS; CATALYTIC DOMAIN; CATTLE; DRUG DISCOVERY; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RHODOPSIN; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 78649512221     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci1002747     Document Type: Article

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