II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 2, 1997, Pages 1020-1027

  Primus, Renee J ^a   Thurkauf, Andrew ^a   Xu, Jing ^a   Yevich, Eileen ^a   Mcinerney, Sean ^a   Shaw, Kenneth ^a   Tallman, John F ^a   Gallager, Dorothy W ^a  

^a NEUROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYLMETHYL]IMIDAZOLE; 2 PHENYL 4 [4 (2 PYRIMIDYL)PIPERAZINYL]METHYLIMIDAZOLE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR AFFECTING AGENT; RECEPTOR SUBTYPE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG RECEPTOR BINDING; ENTORHINAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; ISOTOPE LABELING; MALE; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BRAIN; DOPAMINE ANTAGONISTS; HUMANS; IMIDAZOLES; MALE; PYRIMIDINES; RACLOPRIDE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SALICYLAMIDES; TETRAHYDRONAPHTHALENES; TRITIUM;

EID: 0030754103     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BENES, F. M.: Is there a neuroanatomical basis for schizophrenia? An old question revisited. The Neuroscientist. 1: 104-115, 1995.
2. 50) of an enzymatic reaction. Biochem. Pharmacol. 22: 3099-3108, 1973.
3. CIVELLI, O.: Molecular biology of the dopamine receptor subtypes. In Psychopharmacology: The Fourth Generation of Progress, ed. by F. E. Bloom and D. J. Kupfer, pp.155-161, Raven Press, New York, 1995.
4. GOLDSMITH, J. N. AND JOYCE, J. N.: Alterations in hippocampal mossy fiber pathway in schizophrenia and alzheimer's disease. Biol. Psychiatry 37: 122-126, 1995.
5. 4 receptor antagonist. Abstr. Soc. Neurosci. 21: 469, 1995.
6. JAKOB, H. AND BECKMANN, H.: Circumscribed malformation and nerve cell alterations in the entorhinal cortex of schizophrenics. J. Neural Transm. 98: 83-106, 1994.
7. 2-type dopamine receptors in postmortem human brain sections from normal and schizophrenic subjects. Neuroreport 7:1945-1948, 1996.
8. 3H]NGD 94-1. Soc. Neurosci. Abstr. 21, 1995a.
9. LAHTI, R. A., ROBERTS, R. C. AND TAMMINGA, C. A.: D2-Family receptor distribution in human postmortem tissue: an autoradiographic study. Neuroreport 6: 2502-2512, 1995b.
10. 2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur. J. Pharmacol. 236: 483-486, 1993.
11. 3 receptors. Synapse 14: 90-95, 1993.
12. 3H]HYDROXY-N.,N-DI-N-PROPYL-2-AMINOTETRALIN. PROC. NATL. ACAD. SCI. U.S A. 89:8155-8159, 1992.
13. MANSOUR, A. AND WATSON, S. J.: Dopamine receptor expression in the central nervous system. In Psychopharmacology: The Fourth Generation of Progress, ed. by F. E. Bloom and D. J. Kupfer, pp. 207-219, Raven Press, New York, 1995.
14. MEADOR-WOODRUFF, J. H., GRANDY, D. K., VAN TOL, H. H. M., DAMASK, S. P., LITTLE, K. Y., CIVELLI, O. AND WATSON, S. J.: Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 10: 239-248, 1994.
15. MRZIJAK, L., BERGSON, C., PAPPY, M., HUFF, R., LEVENSON, R. AND GOLDMANRAKIC, P. S.: Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 381: 245-248, 1996.
16. 4 dopamine receptors in postmortem striatum from patients with schizophrenia. J. Neurosci. 15: 2186-2191, 1995.
17. 4 receptor: Sequence, gene structure, and demonstration of expression in the cardiovascular system. The New Biologist. 4: 137-146, 1992.
18. PAXINOS, G. AND WATSON, C.: The Rat Brain in Stereotaxic Coordinates, Academic Press, Inc., San Diego, CA, 1986.
19. 4 receptors in the action and development of antipsychotic agents. Drugs 51: 7-11, 1996.
20. 4 receptors in drug-treated schizophrenia. Eur. J. Pharmacol. 281: R5-R6, 1995.
21. SEEMAN, P.: Therapeutic receptor-blocking concentrations of neuroleptics. Int. Clin. Psychopharmacology 10: 5-13, 1995.
22. 4 receptors elevated in schizophrenia. Nature 365: 441-445, 1993.
23. 4 receptor in postmortem caudate nucleus of subjects with schizophrenia. Soc. Neurosci. Abstr. 20: 912, 1994.
24. 4 receptor. J. Pharmacol. Exp. Ther. 282: 1011-1019, 1997.
25. 4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610-614, 1991.
26. WEINBERGER, D. R. AND LIPSKA, B. K.: Cortical maldevelopment, antipsychotic drugs, and schizophrenia: a search for common ground. Schizophr. Res. 16: 87-110, 1995.