메뉴 건너뛰기




Volumn 23, Issue 4, 2014, Pages 889-905

WNT/β-catenin signalling is activated in aldosteroneproducing adenomas and controls aldosterone production

(19)  Berthon, Annabel a,b,c   Drelon, Coralie a,b,c   Ragazzon, Bruno d,e   Boulkroun, Sheerazed f,g   Tissier, Frédérique d,e,h,i   Amar, Laurence f,g,j   Samson Couterie, Benoît f,g   Zennaro, Maria Christina f,g,j   Plouin, Pierre François f,g,j   Skah, Seham b   Plateroti, Michelina b   Lefèbvre, Hervé k,l   Sahut Barnola, Isabelle a,b,c   Batisse Lignier, Marie a,b,c,m   Assié, Guillaume d,e,n   Martinez, Anne MarieLefrançois a,b,c   Bertherat, Jérôme d,e,n   Martinez, Antoine a,b,c   Val, Pierre a,b,c  

b CNRS   (France)
e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BETA CATENIN; NUCLEAR RECEPTOR NUR77; NUCLEAR RECEPTOR RELATED FACTOR 1; SECRETED FRIZZLED RELATED PROTEIN 2; STEROID 21 MONOOXYGENASE; WNT PROTEIN;

EID: 84892984544     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt484     Document Type: Article
Times cited : (158)

References (65)
  • 1
    • 11144355719 scopus 로고    scopus 로고
    • Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertension
    • Plouin, P.-F., Amar, L. and Chatellier,G. (2004) Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertension. Nephrol. Dial. Transplant., 19, 774-777.
    • (2004) Nephrol. Dial. Transplant. , vol.19 , pp. 774-777
    • Plouin, P.-F.1    Amar, L.2    Chatellier, G.3
  • 2
    • 77952307464 scopus 로고    scopus 로고
    • Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism
    • Amar, L., Plouin, P.-F. and Steichen, O. (2010) Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism. Orphanet J. Rare Dis., 5, 9.
    • (2010) Orphanet J. Rare Dis. , vol.5 , pp. 9
    • Amar, L.1    Plouin, P.-F.2    Steichen, O.3
  • 3
    • 84868266958 scopus 로고    scopus 로고
    • Changes in the perceived epidemiology of primary hyperaldosteronism
    • Fagugli, R.M. and Taglioni, C. (2011) Changes in the perceived epidemiology of primary hyperaldosteronism. Int. J. Hypertens., 2011, 162804.
    • (2011) Int. J. Hypertens. , vol.2011 , pp. 162804
    • Fagugli, R.M.1    Taglioni, C.2
  • 4
    • 84857946771 scopus 로고    scopus 로고
    • Outcomes of adrenalectomy in patients with unilateral primary aldosteronism: a review
    • Steichen, O., Zinzindohoué, F., Plouin, P.-F. and Amar, L. (2012) Outcomes of adrenalectomy in patients with unilateral primary aldosteronism: a review. Horm. Metab. Res., 44, 221-227.
    • (2012) Horm. Metab. Res. , vol.44 , pp. 221-227
    • Steichen, O.1    Zinzindohoué, F.2    Plouin, P.-F.3    Amar, L.4
  • 5
    • 79956119132 scopus 로고    scopus 로고
    • Diagnosis and treatment of primary aldosteronism
    • Rossi, G.P.D. (2011) Diagnosis and treatment of primary aldosteronism. Rev. Endocr. Metab. Disord., 12, 27-36.
    • (2011) Rev. Endocr. Metab. Disord. , vol.12 , pp. 27-36
    • Rossi, G.P.D.1
  • 7
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism
    • Amar, L., Azizi, M., Menard, J., Peyrard, S., Watson, C. and Plouin, P.-F. (2010) Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension, 56, 831-838.
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3    Peyrard, S.4    Watson, C.5    Plouin, P.-F.6
  • 8
    • 80255141746 scopus 로고    scopus 로고
    • Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo and active-controlled phase 2 trial
    • Calhoun, D.A., White, W.B., Krum, H., Guo, W., Bermann, G., Trapani, A., Lefkowitz, M.P. and Ménard, J. (2011) Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo and active-controlled phase 2 trial. Circulation, 124, 1945-1955.
    • (2011) Circulation , vol.124 , pp. 1945-1955
    • Calhoun, D.A.1    White, W.B.2    Krum, H.3    Guo, W.4    Bermann, G.5    Trapani, A.6    Lefkowitz, M.P.7    Ménard, J.8
  • 12
    • 84865427053 scopus 로고    scopus 로고
    • The potassium channel, Kir3.4 participates in Angiotensin II-stimulated aldosterone production by a human adrenocortical cell line
    • Oki, K., Plonczynski, M.W., Lam, M.L., Gomez-Sanchez, E.P. and Gomez-Sanchez, C.E. (2012) The potassium channel, Kir3.4 participates in Angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. Endocrinology, 153, 4328-4335.
    • (2012) Endocrinology , vol.153 , pp. 4328-4335
    • Oki, K.1    Plonczynski, M.W.2    Lam, M.L.3    Gomez-Sanchez, E.P.4    Gomez-Sanchez, C.E.5
  • 15
    • 84860776956 scopus 로고    scopus 로고
    • Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa and zona fasciculata-like tumors
    • Azizan, E.A.B., Lam, B.Y.H., Newhouse, S.J., Zhou, J., Kuc, R.E., Clarke, J., Happerfield, L., Marker, A., Hoffman, G.J. and Brown, M.J. (2012) Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa and zona fasciculata-like tumors. J. Clin. Endocrinol. Metab., 97, E819-E829.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97
    • Azizan, E.A.B.1    Lam, B.Y.H.2    Newhouse, S.J.3    Zhou, J.4    Kuc, R.E.5    Clarke, J.6    Happerfield, L.7    Marker, A.8    Hoffman, G.J.9    Brown, M.J.10
  • 18
  • 20
    • 84857118216 scopus 로고    scopus 로고
    • Wnt/b-catenin signalling in adrenal physiology and tumour development
    • Berthon, A., Martinez, A., Bertherat, J. and Val, P. (2011) Wnt/b-catenin signalling in adrenal physiology and tumour development. Mol. Cell. Endocrinol., 351, 87-95.
    • (2011) Mol. Cell. Endocrinol. , vol.351 , pp. 87-95
    • Berthon, A.1    Martinez, A.2    Bertherat, J.3    Val, P.4
  • 26
    • 24744454197 scopus 로고    scopus 로고
    • Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors
    • Tissier, F., Cavard, C., Groussin, L., Perlemoine, K., Fumey, G., Hagnere, A.M., Rene-Corail, F., Jullian, E., Gicquel, C., Bertagna, X. et al. (2005) Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. Cancer Res., 65, 7622-7627.
    • (2005) Cancer Res. , vol.65 , pp. 7622-7627
    • Tissier, F.1    Cavard, C.2    Groussin, L.3    Perlemoine, K.4    Fumey, G.5    Hagnere, A.M.6    Rene-Corail, F.7    Jullian, E.8    Gicquel, C.9    Bertagna, X.10
  • 28
    • 0842334477 scopus 로고    scopus 로고
    • The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production
    • Bassett, M.H., Suzuki, T., Sasano, H., White, P.C. and Rainey, W.E. (2004) The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol. Endocrinol., 18, 279-290.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 279-290
    • Bassett, M.H.1    Suzuki, T.2    Sasano, H.3    White, P.C.4    Rainey, W.E.5
  • 29
    • 78651376455 scopus 로고    scopus 로고
    • Regulation of Nur77 expression by beta-catenin and its mitogenic effect in colon cancer cells
    • Wu, H., Lin, Y., Li, W., Sun, Z., Gao, W., Zhang, H., Xie, L., Jiang, F., Qin, B., Yan, T. et al. (2011) Regulation of Nur77 expression by beta-catenin and its mitogenic effect in colon cancer cells. FASEB J., 25, 192-205.
    • (2011) FASEB J. , vol.25 , pp. 192-205
    • Wu, H.1    Lin, Y.2    Li, W.3    Sun, Z.4    Gao, W.5    Zhang, H.6    Xie, L.7    Jiang, F.8    Qin, B.9    Yan, T.10
  • 31
    • 79251475279 scopus 로고    scopus 로고
    • beta-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma
    • Gaujoux, S., Grabar, S., Fassnacht, M., Ragazzon, B., Launay, P., Libe, R., Chokri, I., Audebourg, A., Royer, B., Sbiera, S. et al. (2011) beta-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma. Clin. Cancer Res., 17, 328-336.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 328-336
    • Gaujoux, S.1    Grabar, S.2    Fassnacht, M.3    Ragazzon, B.4    Launay, P.5    Libe, R.6    Chokri, I.7    Audebourg, A.8    Royer, B.9    Sbiera, S.10
  • 32
    • 79951719257 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and nonsecreting tumors
    • Bonnet, S., Gaujoux, S., Launay, P., Baudry, C., Chokri, I., Ragazzon, B., Libe, R., Rene-Corail, F., Audebourg, A., Vacher-Lavenu, M.C. et al. (2011) Wnt/beta-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and nonsecreting tumors. J. Clin. Endocrinol. Metab., 96, E419-E426.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96
    • Bonnet, S.1    Gaujoux, S.2    Launay, P.3    Baudry, C.4    Chokri, I.5    Ragazzon, B.6    Libe, R.7    Rene-Corail, F.8    Audebourg, A.9    Vacher-Lavenu, M.C.10
  • 33
  • 34
    • 25444497707 scopus 로고    scopus 로고
    • The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis
    • Li, Q., Ishikawa, T.-O., Oshima, M. and Taketo, M.M. (2005) The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res., 65, 8622-8627.
    • (2005) Cancer Res. , vol.65 , pp. 8622-8627
    • Li, Q.1    Ishikawa, T.-O.2    Oshima, M.3    Taketo, M.M.4
  • 36
    • 0037096906 scopus 로고    scopus 로고
    • The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
    • Albuquerque, C., Breukel, C., van der Luijt, R., Fidalgo, P., Lage, P., Slors, F.J.M., Leitao, C.N., Fodde, R. and Smits, R. (2002) The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum. Mol. Genet., 11, 1549-1560.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1549-1560
    • Albuquerque, C.1    Breukel, C.2    van der Luijt, R.3    Fidalgo, P.4    Lage, P.5    Slors, F.J.M.6    Leitao, C.N.7    Fodde, R.8    Smits, R.9
  • 39
    • 42549096546 scopus 로고    scopus 로고
    • Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
    • Bovolenta, P., Esteve, P., Ruiz, J.M., Cisneros, E. and Lopez-Rios, J. (2008) Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J. Cell. Sci., 121, 737-746.
    • (2008) J. Cell. Sci. , vol.121 , pp. 737-746
    • Bovolenta, P.1    Esteve, P.2    Ruiz, J.M.3    Cisneros, E.4    Lopez-Rios, J.5
  • 43
    • 77955492538 scopus 로고    scopus 로고
    • miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop
    • Kapinas, K., Kessler, C., Ricks, T., Gronowicz, G. and Delany, A.M. (2010) miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J. Biol. Chem., 285, 25221-25231.
    • (2010) J. Biol. Chem. , vol.285 , pp. 25221-25231
    • Kapinas, K.1    Kessler, C.2    Ricks, T.3    Gronowicz, G.4    Delany, A.M.5
  • 44
    • 84870658122 scopus 로고    scopus 로고
    • MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration
    • Snyder, C.M., Rice, A.L., Estrella, N.L., Held, A., Kandarian, S.C. and Naya, F.J. (2013) MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration. Development, 140, 31-42.
    • (2013) Development , vol.140 , pp. 31-42
    • Snyder, C.M.1    Rice, A.L.2    Estrella, N.L.3    Held, A.4    Kandarian, S.C.5    Naya, F.J.6
  • 45
    • 84862200068 scopus 로고    scopus 로고
    • Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis
    • Fu, J., Tang, W., Du, P., Wang, G., Chen, W., Li, J., Zhu, Y., Gao, J. and Cui, L. (2012) Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. BMC Syst. Biol., 6, 68.
    • (2012) BMC Syst. Biol. , vol.6 , pp. 68
    • Fu, J.1    Tang, W.2    Du, P.3    Wang, G.4    Chen, W.5    Li, J.6    Zhu, Y.7    Gao, J.8    Cui, L.9
  • 46
    • 50649101532 scopus 로고    scopus 로고
    • Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex
    • Kim, A.C., Reuter, A.L., Zubair, M., Else, T., Serecky, K., Bingham, N.C., Lavery, G.G., Parker, K.L. and Hammer, G.D. (2008) Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development, 135, 2593-2602.
    • (2008) Development , vol.135 , pp. 2593-2602
    • Kim, A.C.1    Reuter, A.L.2    Zubair, M.3    Else, T.4    Serecky, K.5    Bingham, N.C.6    Lavery, G.G.7    Parker, K.L.8    Hammer, G.D.9
  • 47
    • 0036827930 scopus 로고    scopus 로고
    • Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production
    • Heikkila, M., Peltoketo, H., Leppaluoto, J., Ilves, M., Vuolteenaho, O. and Vainio, S. (2002) Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Endocrinology, 143, 4358-4365.
    • (2002) Endocrinology , vol.143 , pp. 4358-4365
    • Heikkila, M.1    Peltoketo, H.2    Leppaluoto, J.3    Ilves, M.4    Vuolteenaho, O.5    Vainio, S.6
  • 48
    • 33750003692 scopus 로고    scopus 로고
    • Adenovirus-deliveredDKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells
    • Chen,M. and Hornsby, P.J. (2006) Adenovirus-deliveredDKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells. Horm. Metab. Res., 38, 549-555.
    • (2006) Horm. Metab. Res. , vol.38 , pp. 549-555
    • Chen, M.1    Hornsby, P.J.2
  • 49
    • 70350321017 scopus 로고    scopus 로고
    • Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/ beta-catenin signaling in corpus luteum progesterone synthesis
    • Roy, L., McDonald, C.A., Jiang, C., Maroni, D., Zeleznik, A.J., Wyatt, T.A., Hou, X. and Davis, J.S. (2009) Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/ beta-catenin signaling in corpus luteum progesterone synthesis. Endocrinology, 150, 5036-5045.
    • (2009) Endocrinology , vol.150 , pp. 5036-5045
    • Roy, L.1    McDonald, C.A.2    Jiang, C.3    Maroni, D.4    Zeleznik, A.J.5    Wyatt, T.A.6    Hou, X.7    Davis, J.S.8
  • 51
    • 73249124003 scopus 로고    scopus 로고
    • WNT signaling in ovarian follicle biology and tumorigenesis
    • Boyer, A., Goff, A.K. and Boerboom, D. (2010) WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol. Metab., 21, 25-32.
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 25-32
    • Boyer, A.1    Goff, A.K.2    Boerboom, D.3
  • 53
    • 66149125539 scopus 로고    scopus 로고
    • Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility
    • Hernandez Gifford, J.A., Hunzicker-Dunn, M.E. and Nilson, J.H. (2009) Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility. Biol. Reprod., 80, 1282-1292.
    • (2009) Biol. Reprod. , vol.80 , pp. 1282-1292
    • Hernandez Gifford, J.A.1    Hunzicker-Dunn, M.E.2    Nilson, J.H.3
  • 54
    • 84861528159 scopus 로고    scopus 로고
    • Inhibition of b-catenin signaling by nongenomic action of orphan nuclear receptor Nur77
    • Sun, Z., Cao, X., Jiang, M.-M., Qiu, Y., Zhou, H., Chen, L., Qin, B., Wu, H., Jiang, F., Chen, J. et al. (2012) Inhibition of b-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene, 31, 2653- 2667.
    • (2012) Oncogene , vol.31
    • Sun, Z.1    Cao, X.2    Jiang, M.-M.3    Qiu, Y.4    Zhou, H.5    Chen, L.6    Qin, B.7    Wu, H.8    Jiang, F.9    Chen, J.10
  • 55
    • 79954431772 scopus 로고    scopus 로고
    • Cross-talk between NR4A orphan nuclear receptors and b-catenin signaling pathway in osteoblasts
    • Rajalin, A.-M. and Aarnisalo, P. (2011) Cross-talk between NR4A orphan nuclear receptors and b-catenin signaling pathway in osteoblasts. Arch. Biochem. Biophys., 509, 44-51.
    • (2011) Arch. Biochem. Biophys. , vol.509 , pp. 44-51
    • Rajalin, A.-M.1    Aarnisalo, P.2
  • 56
    • 77956295989 scopus 로고    scopus 로고
    • Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth
    • Lee, S.-O., Abdelrahim, M., Yoon, K., Chintharlapalli, S., Papineni, S., Kim, K., Wang, H. and Safe, S. (2010) Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Res., 70, 6824-6836.
    • (2010) Cancer Res. , vol.70 , pp. 6824-6836
    • Lee, S.-O.1    Abdelrahim, M.2    Yoon, K.3    Chintharlapalli, S.4    Papineni, S.5    Kim, K.6    Wang, H.7    Safe, S.8
  • 59
    • 67649946192 scopus 로고    scopus 로고
    • Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway
    • Shan, B.E., Wang, M.X. and Li, R.Q. (2009) Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest., 27, 604-612.
    • (2009) Cancer Invest. , vol.27 , pp. 604-612
    • Shan, B.E.1    Wang, M.X.2    Li, R.Q.3
  • 60
    • 81855164783 scopus 로고    scopus 로고
    • The flavonoid quercetin in disease prevention and therapy: facts and fancies
    • Russo, M., Spagnuolo, C., Tedesco, I., Bilotto, S. and Russo, G.L. (2012)The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem. Pharmacol., 83, 6-15.
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 6-15
    • Russo, M.1    Spagnuolo, C.2    Tedesco, I.3    Bilotto, S.4    Russo, G.L.5
  • 62
    • 84862251868 scopus 로고    scopus 로고
    • Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms
    • Larson, A.J., Symons, J.D. and Jalili, T. (2012) Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv. Nutr., 3, 39-46.
    • (2012) Adv. Nutr. , vol.3 , pp. 39-46
    • Larson, A.J.1    Symons, J.D.2    Jalili, T.3
  • 63
    • 77953715690 scopus 로고    scopus 로고
    • TargetingWntsignaling: canwe safely eradicate cancer stem cells? Clin
    • Takahashi-Yanaga, F. and Kahn, M.(2010) TargetingWntsignaling: canwe safely eradicate cancer stem cells? Clin. Cancer Res., 16, 3153-3162.
    • (2010) Cancer Res. , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 65
    • 33847661809 scopus 로고    scopus 로고
    • Protocol for the fast chromatin immunoprecipitation (ChIP) method
    • Nelson, J.D., Denisenko, O. and Bomsztyk, K. (2006) Protocol for the fast chromatin immunoprecipitation (ChIP) method. Nat. Protoc., 1, 179-185.
    • (2006) Nat. Protoc. , vol.1 , pp. 179-185
    • Nelson, J.D.1    Denisenko, O.2    Bomsztyk, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.