Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion

Endocrinology

Volumn 148, Issue 6, 2007, Pages 2644-2652

  Romero, Damian G ^a   Yanes, Licy L ^a   De Rodriguez, Angela F ^a   Plonczynski, Maria W ^a   Welsh, Bronwyn L ^a   Reckelhoff, Jane F ^a   Gomez Sanchez, Elise P ^a   Gomez Sanchez, Celso E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN II; COMPLEMENTARY DNA; DISABLED 2 PROTEIN; MESSENGER RNA; PHOSPHOPROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ADRENAL GLAND; ALDOSTERONE RELEASE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; EMBRYO DEVELOPMENT; ENDOCYTOSIS; GENE AMPLIFICATION; LASER CAPTURE MICRODISSECTION; MALE; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SALT INTAKE; SIGNAL TRANSDUCTION; SODIUM RESTRICTION; UPREGULATION; ZONA GLOMERULOSA;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ALDOSTERONE; ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CYTOCHROME P-450 ENZYME SYSTEM; DIET, SODIUM-RESTRICTED; GENE EXPRESSION REGULATION; HUMANS; INFUSION PUMPS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STEROID HYDROXYLASES; ZONA GLOMERULOSA;

EID: 34250885936     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1509     Document Type: Article

References (72)

1. Stewart PM 2003 The adrenal cortex. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams textbook of endocrinology. 10th ed. Philadelphia: Elsevier; 491-551
2. Arab O'Brien DM 2001 Morphology of the adrenal cortex and medulla. In: Becker KL, ed. Principles and practice of endocrinology and metabolism. 3rd ed. Philadelphia: Lippincott Williams, Wilkins; 698-704
3. Nussey S, Whitehead S 2001 The adrenal gland. In: Nussey S, Whitehead S, eds. Endocrinology: an integrated approach. 1st ed. BIOS Scientific Publishers Ltd.; 115-170
4. Vinson GP 2003 Adrenocortical zonation and ACTH. Microsc Res Tech 61:227-239
5. Rainey WE 1999 Adrenal zonation: clues from 11β-hydroxylase and aldosterone synthase. Mol Cell Endocrinol 151:151-160
6. Ennen WB, Levay-Young BK, Engeland WC 2005 Zone-specific cell proliferation during adrenocortical regeneration after enucleation in rats. Am J Physiol Endocrinol Metab 289:E883-E891
7. Hammer GD, Parker KL, Schimmer BP 2005 Minireview: transcriptional regulation of adrenocortical development. Endocrinology 146:1018-1024
8. Keegan CE, Hammer GD 2002 Recent insights into organogenesis of the adrenal cortex. Trends Endocrinol Metab 13:200-208
9. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y 2003 The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim Biophys Acta 1619:317-324
10. Howe PH 2005 Dab2. AfCS-Nature Molecule Pages 10.1038/mp.a000748. 01
11. Xu XX, Yang W, Jackowski S, Rock CO 1995 Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem 270:14184-14191
12. Mok SC, Wong KK, Chan RK, Lau CC, Tsao SW, Knapp RC, Berkowitz RS 1994 Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. Gynecol Oncol 52:247-252
13. Fazili Z, Sun W, Mittelstaedt S, Cohen C, Xu XX 1999 Disabled-2 inactivation is an early step in ovarian tumorigenicity. Oncogene 18:3104-3113
14. Mok SC, Chan WY, Wong KK, Cheung KK, Lau CC, Ng SW, Baldini A, Colitti CV, Rock CO, Berkowitz RS 1998 DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. Oncogene 16:2381-2387
15. Sheng Z, Sun W, Smith E, Cohen C, Xu XX 2000 Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells. Oncogene 19:4847-4854
16. He J, Smith ER, Xu XX 2001 Disabled-2 exerts its tumor suppressor activity by uncoupling c-Fos expression and MAP kinase activation. J Biol Chem 276:26814-26818
17. Smith ER, Capo-chichi CD, He J, Smedberg JL, Yang DH, Prowse AH, Godwin AK, Hamilton TC, Xu XX 2001 Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells. J Biol Chem 276:47303-47310
18. Schwahn DJ, Medina D 1998 p96, a MAPK-related protein, is consistently downregulated during mouse mammary carcinogenesis. Oncogene 17:1173-1178
19. Fulop V, Colitti CV, Genest D, Berkowitz RS, Yiu GK, Ng SW, Szepesi J, Mok SC 1998 DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases. Oncogene 17:419-424
20. Tseng CP, Ely BD, Li Y, Pong RC, Hsieh JT 1998 Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Endocrinology 139:3542-3553
21. Morris SM, Cooper JA 2001 Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic 2:111-123
22. Mishra SK, Keyel PA, Hawryluk MJ, Agostinelli NR, Watkins SC, Traub LM 2002 Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J 21:4915-4926
23. Inoue A, Sato O, Homma K, Ikebe M 2002 DOC-2/DAB2 is the binding partner of myosin VI. Biochem Biophys Res Commun 292:300-307
24. Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F 2002 Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic 3:331-341
25. Oleinikov AV, Zhao J, Makker SP 2000 Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem J 347(Pt 3):613-621
26. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, Hammer RE, Richardson JA, Herz J 1999 Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97:689-701
27. Howell BW, Lanier LM, Frank R, Gertler FB, Cooper JA 1999 The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol Cell Biol 19:5179-5188
28. Hocevar BA, Prunier C, Howe PH 2005 Disabled-2 (Dab2) mediates transforming growth factor β (TGFβ)-stimulated fibronectin synthesis through TGFβ-activated kinase 1 and activation of the JNK pathway. J Biol Chem 280:25920-25927
29. Hocevar BA, Smine A, Xu XX, Howe PH 2001 The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway. EMBO J 20:2789-2801
30. Zhou J, Hsieh JT 2001 The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem 276:27793-27798
31. Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R 1996 Sequence, genomic structure, and chromosomal assignment of human DOC-2. Genomics 33:207-213
32. Morris SM, Tallquist MD, Rock CO, Cooper JA 2002 Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J 21:1555-1564
33. Yang DH, Smith ER, Roland IH, Sheng Z, He J, Martin WD, Hamilton TC, Lambeth JD, Xu XX 2002 Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol 251:27-44
34. MacKenzie SM, Clark CJ, Fraser R, Gomez-Sanchez CE, Connell JMC, Davies E 2000 Expression of 11β-hydroxylase and aldosterone synthase genes in rat brain. J Mol Endocr 24:321-328
35. De Jong AS, Van Kessel-van Vark M, Raap AK 1985 Sensitivity of various visualization methods for peroxidase and alkaline phosphatase activity in immunoenzyme histochemistry. Histochem J 17:1119-1130
36. Romero DG, Plonczynski M, Vergara GR, Gomez-Sanchez EP, Gomez-Sanchez CE 2004 Angiotensin II early regulated genes in H295R human adrenocortical cells. Physiol Genomics 19:106-116
37. Yanes LL, Romero DG, Cucchiarelli VE, Fortepiani LA, Gomez-Sanchez CE, Santacruz F, Reckelhoff JF 2005 Role of endothelin in mediating postmenopausal hypertension in a rat model. Am J Physiol Regul Integr Comp Physiol 288:R229-R233
38. Rozen S, Skaletsky H 2000 Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132:365-386
39. Gomez-Sanchez EP, Ahmad N, Romero DG, Gomez-Sanchez CE 2004 Origin of aldosterone in the rat heart. Endocrinology 145:4796-4802
40. Pfaffl MW 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
41. Sirianni R, Seely JB, Attia G, Stocco DM, Carr BR, Pezzi V, Rainey WE 2002 Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes. J Endocrinol 174:R13-R17
42. Romero DG, Plonczynski MW, Gomez-Sanchez EP, Yanes LL, Gomez-Sanchez CE 2006 RGS2 is regulated by angiotensin II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells. Endocrinology 147:3889-3897
43. Timares L, Takashima A, Johnston SA 1998 Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc Natl Acad Sci USA 95:13147-13152
44. Bird IM, Hanley NA, Word RA, Mathis JM, McCarthy JL, Mason JI, Rainey WE 1993 Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion. Endocrinology 133:1555-1561
45. Romero DG, Welsh BL, Gomez-Sanchez EP, Yanes LL, Rilli S, Gomez-Sanchez CE 2006 Angiotensin II-mediated protein kinase D activation stimulates aldosterone and cortisol secretion in H295R human adrenocortical cells. Endocrinology 147:6046-6055
46. Gomez-Sanchez CE, Foecking MF, Ferris MW, Chavarri MR, Uribe L, Gomez-Sanchez EP 1987 The production of monoclonal antibodies against aldosterone. Steroids 49:581-587
47. Halder SK, Takemori H, Hatano O, Nonaka Y, Wada A, Okamoto M 1998 Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells. Endocrinology 139:3316-3328
48. Rainey WE, Saner K, Schimmer BP 2004 Adrenocortical cell lines. Mol Cell Endocrinol 228:23-38
49. Cater DB, Lever JD 1954 The zona intermedia of the adrenal cortex. A correlation of possible functional significance with development, morphology and histochemistry. J Anat 88:437-454
50. Mitani F, Suzuki H, Hata J, Ogishima T, Shimada H, Ishimura Y 1994 A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role. Endocrinology 135:431-438
51. Laborda J 2000 The role of the epidermal growth factor-like protein dlk in cell differentiation. Histol Histopathol 15:119-129
52. Cooper MJ, Hutchins GM, Cohen PS, Helman LJ, Mennie RJ, Israel MA 1990 Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts. Cell Growth Differ 1:149-159
53. Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K 1993 Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. Hum Reprod 8:635-641
54. Laborda J, Sausville EA, Hoffman T, Notario V 1993 dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 268:3817-3820
55. Tornehave D, Jensen CH, Teisner B, Larsson LI 1996 FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas: negative correlation with glucagon expression. Histochem Cell Biol 106:535-542
56. Floridon C, Jensen CH, Thorsen P, Nielsen O, Sunde L, Westergaard JG, Thomsen SG, Teisner B 2000 Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 66:49-59
57. Smas CM, Sul HS 1993 Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73:725-734
58. Boney CM, Fiedorek Jr FT, Paul SR, Gruppuso PA 1996 Regulation of preadipocyte factor-1 gene expression during 3T3-L1 cell differentiation. Endocrinology 137:2923-2928
59. Garces C, Ruiz-Hidalgo MJ, Bonvini E, Goldstein J, Laborda J 1999 Adipocyte differentiation is modulated by secreted Δ-like (dlk) variants and requires the expression of membrane-associated dlk. Differentiation 64:103-114
60. Moore KA, Pytowski B, Witte L, Hicklin D, Lemischka IR 1997 Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 94:4011-4016
61. Bauer SR, Ruiz-Hidalgo MJ, Rudikoff EK, Goldstein J, Laborda J 1998 Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements. Mol Cell Biol 18:5247-5255
62. Kaneta M, Osawa M, Sudo K, Nakauchi H, Farr AG, Takahama Y 2000 A role for pref-1 and HES-1 in thymocyte development. J Immunol 164:256-264
63. Gaetano C, Matsumoto K, Thiele CJ 1992 In vitro activation of distinct molecular and cellular phenotypes after induction of differentiation in a human neuroblastoma cell line. Cancer Res 52:4402-4407
64. Samulewicz SJ, Seitz A, Clark L, Heber-Katz E 2002 Expression of preadipocyte factor-1(Pref-1), a Δ-like protein, in healing mouse ears. Wound Repair Regen 10:215-221
65. Schmidt JV, Matteson PG, Jones BK, Guan XJ, Tilghman SM 2000 The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev 14:1997-2002
66. Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson MH, Paulsen M, Ferguson-Smith AC 2000 Δ-Like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr Biol 10:1135-1138
67. Moon YS, Smas CM, Lee K, Villena JA, Kim KH, Yun EJ, Sul HS 2002 Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol 22:5585-5592
68. Payne AH, Hales DB 2004 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25:947-970
69. Cho SY, Jeon JW, Lee SH, Park SS 2000 p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem J 352(Pt 3):645-650
70. Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH 2003 Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J 22:3084-3094
71. Garwitz ET, Jones AW 1982 Aldosterone infusion into the rat and dose-dependent changes in blood pressure and arterial ionic transport. Hypertension 4:374-381
72. Brilla CG, Weber KT 1992 Mineralocorticoid excess, dietary sodium and myocardial fibrosis. J Lab Clin Med 120:893-901