Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells

Hormone and Metabolic Research

Volumn 38, Issue 9, 2006, Pages 549-555

  Chen, M ^a   Hornsby, Peter J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Adrenal cortex; CYP11B2 (aldosterone synthase); Dickkopf proteins; Real time PCR; Wnt signaling

Indexed keywords

3 BETA HYDROXYSTEROID DEHYDROGENASE 2; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ADENOVIRUS VECTOR; ALDOSTERONE; ALDOSTERONE SYNTHASE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYCLIC AMP; GREEN FLUORESCENT PROTEIN; HYDROCORTISONE; MESSENGER RNA; PROTEIN DICKKOPF 3; STEROID 11BETA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT4 PROTEIN;

ADRENAL CORTEX CELL; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS; ZONA GLOMERULOSA;

ADENOVIRIDAE; ADRENAL CORTEX; ALDOSTERONE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; HUMANS; HYDROCORTISONE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; RNA, MESSENGER; WNT PROTEINS;

ADENOVIRIDAE;

EID: 33750003692     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-950500     Document Type: Article

References (37)

1. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20: 781-810
2. Wang J, Wynshaw-Boris A. The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation. Curr Opin Genet Dev 2004; 14: 533-539
3. Megason SG, McMahon AP. A mitogen gradient of dorsal midline Writs organizes growth in the CNS. Development 2002; 129: 2087-2098
4. Charron F, Tessier-Lavigne M. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development 2005; 132: 2251-2262
5. Suwa T, Chen M, Hawks CL, Hornsby PJ. Zonal expression of Dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J Endocrinol 2003; 178: 149-158
6. Heikkila M, Peltoketo H, Leppaluoto J, lives M, Vuolteenaho O, Vainio S. Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Endocrinology 2002; 143: 4358-4365
7. Curnow KM, Tusie-Luna M-T, Pascoe L, Natarajan R, Gu J-L, Nadler JL, White PC. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol Endocrinol 1991; 5: 1513-1522
8. Vainio SJ, Itaranta PV, Perasaari JP, Uusitalo MS. Wnts as kidney tubule inducing factors. Int J Dev Biol 1999; 43: 419-423
9. Park SY, Jameson JL. Minireview: transcriptional regulation of gonadal development and differentiation. Endocrinology 2005; 146: 1035-1042
10. Heikkila M, Prunskaite R, Naillat F, Itaranta P, Vuoristo J, Leppaluoto J, Peltoketo H, Vainio S. The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action. Endocrinology 2005; 146: 4016-4023
11. Stark K, Vainio S, Vassileva G, McMahon AP. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 1994; 372: 679-683
12. Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG. Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 1998; 12: 1691-1704
13. Brisken C, Heineman A, Chavarria T, Elenbaas B, Tan J, Dey SK, McMahon JA, McMahon AP, Weinberg RA. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 2000; 14: 650-654
14. Mulroy T, McMahon JA, Burakoff SJ, McMahon AP, Sen J. Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol 2002; 32: 967-971
15. Jordan BK, Shen JH, Olaso R, Ingraham HA, Vilain E. Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci USA 2003; 100: 10866-10871
16. Gummow BM, Winnay JN, Hammer GD. Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene. J Biol Chem 2003; 278: 26572-26579
17. Kuhnert F, Davis CR, Wang HT, Chu P, Lee M, Yuan J, Nusse R, Kuo CJ. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci USA 2004; 101: 266-271
18. Miller WL. Regulation of messenger RNAs for human steroidogenic enzymes. Endocrine Res 1989; 15: 1-16
19. Ilvesmaki V, Voutilainen R. Interaction of phorbol ester and adrenocorticotropin in the regulation of steroidogenic P450 genes in human fetal and adult adrenal cell cultures. Endocrinology 1991; 128: 1450-1458
20. Staels B, Hum DW, Miller WL. Regulation of steroidogenesis in NCI-H295 cells: A cellular model of the human fetal adrenal. Mol Endocrinol 1993; 7: 423-433
21. Yagci A, Oertle M, Seiler H, Schmid D, Campofranco C, Muller J. Potassium induces multiple steroidogenic enzymes in cultured rat zona glomerulosa cells. Endocrinology 1996; 137: 2406-2414
22. Holland OB, Mathis JM, Bird IM, Rainey WE. Angiotensin increases aldosterone synthase mRNA levels in human NCI-H295 cells. Mol Cell Endocrinol 1993; 94: R9-R13
23. Denner K, Rainey WE, Pezzi V, Bird IM, Bernhardt R, Mathis JM. Differential regulation of 11 beta-hydroxylase and aldosterone synthase in human adrenocortical H295R cells. Mol Cell Endocrinol 1996; 121: 87-91
24. Hilscherova K, Jones PD, Gracia T, Newsted JL, Zhang X, Sanderson JT, Yu RM, Wu RS, Giesy JP. Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicol Sci 2004; 81: 78-89
25. Clyne CD, Zhang Y, Slutsker L, Mathis JM, White PC, Rainey WE. Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. Mol Endocrinol 1997; 11: 638-649
26. Bassett MH, White PC, Rainey WE. The regulation of aldosterone synthase expression. Mol Cell Endocrinol 2004; 217: 67-74
27. Endoh A, Kristiansen SB, Casson PR, Buster JE, Hornsby PJ. The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 1996; 81: 3558-3565
28. Hornsby PJ, McAllister JM. Culturing steroidogenic cells. In: Waterman MR, Johnson EF (eds). Methods in Enzymology Vol 206. San Diego: Academic, 1991; 371-380
29. Lennon G, Auffray C, Polymeropoulos M, Soares MB. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 1996; 33: 151-152
30. Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvenga S, Trimarchi F, Ehrhart-Bornstein M. Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy. Proc Natl Acad Sci USA 2002; 99: 7484-7489
31. Mornet E, Vitek A, Dupont J, White PC. Characterization of two genes encoding human steroid 11 β-hydroxylase (P-450 11β). J Biol Chem 1989; 264: 20961-20967
32. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA Functional and structural diversity of the human Dickkopf gene family. Gene 1999; 238: 301-313
33. Naseeruddin SA, Hornsby PJ. Regulation of 11β- and 17α-hydroxylases in cultured bovine adrenocortical cells: cyclic adenosine 3′, 5′-monophosphate, insulin-like growth factor-I, and activators of protein kinase C. Endocrinology 1990; 127: 1673-1681
34. Cheng CY, Flasch MV, Hornsby PJ. Expression of 17α-hydroxylase and 3β-hydroxysteroid dehydrogenase in fetal human adrenocortical cells transfected with SV40T antigen. J Mol Endocrinol 1992; 9: 7-17
35. Jefcoate C. High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex. J Clin Invest 2002; 110: 881-890
36. Papadopoulos V. In search of the function of the peripheral-type benzodiazepine receptor. Endocr Res 2004; 30: 677-684
37. Stocco DM, Wang X, Jo Y, Manna PR. Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol Endocrinol 2005; 19: 2647-2659